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1. 发明申请

US20130071549A1 Dryers For Removing Solvent From A Drug-Eluting Coating Applied To Medical Devices 有权
标题翻译：用于从药物洗脱涂层中除去溶剂的干燥器应用于医疗器械
公开(公告)号：US20130071549A1
公开(公告)日：2013-03-21
申请号：US13235238
申请日：2011-09-16
申请人： Yung-Ming Chen , Matthew J. Gillick , Michael T. Martins , John E. Papp
发明人： Yung-Ming Chen , Matthew J. Gillick , Michael T. Martins , John E. Papp
IPC分类号： A61L33/00 , F26B25/06 , B05C13/02
CPC分类号： F26B25/066 , F26B9/003
摘要： A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a dryer having a telescoping plenum which provides a drying chamber for the stent or scaffold to reside while a heated gas is passed over the stent/scaffold. The drying chamber improves efficiency in drying, predictability or drug release rate, uniformity of coating material properties lengthwise over the stent/scaffold and provides a platform that can effectively support stents that are over 40 mm in length.
摘要翻译：用药物洗脱物质涂覆医疗装置的涂覆装置使用涂层之间的过程中的干燥站来改善药物释放曲线。干燥站包括具有伸缩式增压室的干燥器，其提供用于支架或支架的干燥室，同时加热的气体通过支架/支架。干燥室可以提高干燥效率，可预测性或药物释放速率，涂层材料性能在支架/支架上的长度均匀性，并提供可有效支撑长度超过40 mm的支架的平台。

2. 发明授权

US09909807B2 Dryers for removing solvent from a drug-eluting coating applied to medical devices 有权
公开(公告)号：US09909807B2
公开(公告)日：2018-03-06
申请号：US13235238
申请日：2011-09-16
申请人： Yung-Ming Chen , Matthew J. Gillick , Michael T. Martins , John E. Papp
发明人： Yung-Ming Chen , Matthew J. Gillick , Michael T. Martins , John E. Papp
IPC分类号： F26B25/06 , F26B9/00
CPC分类号： F26B25/066 , F26B9/003
摘要： A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a dryer having a telescoping plenum which provides a shield and drying region for the stent or scaffold to reside while a heated gas is passed over the stent/scaffold. The shield and drying region improve efficiency in drying, predictability or drug release rate, uniformity of coating material properties lengthwise over the stent/scaffold and provide a platform that can effectively support stents that are over 40 mm in length.

3. 发明授权

US08677650B2 Methods and devices for drying coated stents 有权
标题翻译：用于干燥涂层支架的方法和装置
公开(公告)号：US08677650B2
公开(公告)日：2014-03-25
申请号：US11764003
申请日：2007-06-15
申请人： Sidney Watterodt , Sang joon Park , David Rego , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Bryan D. Glenn , Matthew J. Gillick , John E. Papp
发明人： Sidney Watterodt , Sang joon Park , David Rego , Anthony S. Andreacchi , Yung-Ming Chen , Arnoldo M. Currlin , Antonio Garcia , Jason Van Sciver , Bryan D. Glenn , Matthew J. Gillick , John E. Papp
IPC分类号： F26B7/00
CPC分类号： F26B25/003 , A61F2/91 , B23K26/402 , B23K2103/42 , B23K2103/50 , F26B15/04 , F26B15/18 , F26B25/06 , F26B25/12
摘要： Various embodiments of methods and devices for drying coated stents in an oven are described herein.
摘要翻译：本文描述了用于在烘箱中干燥涂层支架的方法和装置的各种实施例。

4. 发明申请

US20110039013A1 System and Method for Coating a Medical Device 有权
标题翻译：医疗器械涂敷系统及方法
公开(公告)号：US20110039013A1
公开(公告)日：2011-02-17
申请号：US12540302
申请日：2009-08-12
申请人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
发明人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
IPC分类号： B05D3/04 , B05C5/00 , B05C13/02 , B05C11/00
CPC分类号： F26B9/06 , A61F2/82 , A61F2310/00389 , A61L2420/02 , B05B13/0221 , B05B13/0228 , B05B13/041 , B05B16/20 , B05B16/60 , B05B16/90 , B05D1/002 , B05D1/02 , B05D3/0413 , B05D3/0493 , B05D7/584
摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.
摘要翻译：一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。随着另一组移出并进入干燥区域，一组移入喷雾区域。此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。交替过程可以重复任意次数。喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

5. 发明授权

US08715771B2 Coated stent and method of making the same 失效
标题翻译：涂层支架及其制作方法
公开(公告)号：US08715771B2
公开(公告)日：2014-05-06
申请号：US12563045
申请日：2009-09-18
申请人： Dennis R. Orosa , John E. Papp , Hung T. Nguyen , Stephen D. Pacetti , Dudley Shelton Jayasinghe , Matthew J. Gillick
发明人： Dennis R. Orosa , John E. Papp , Hung T. Nguyen , Stephen D. Pacetti , Dudley Shelton Jayasinghe , Matthew J. Gillick
IPC分类号： B05D3/00
CPC分类号： A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/02 , A61L2420/08
摘要： A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents.
摘要翻译：公开了涂覆的可植入医疗装置和涂覆可植入医疗装置的方法，所述方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。公开了一种用于确定所需药物释放速率的药物涂层数量的涂层支架制造批次的预筛选方法。该方法包括涂覆和测试小组支架，并应用测试结果确定应用于支架制造批次的药物涂层数量。

6. 发明授权

US08567340B2 System and method for coating a medical device 有权
标题翻译：用于涂覆医疗装置的系统和方法
公开(公告)号：US08567340B2
公开(公告)日：2013-10-29
申请号：US12540302
申请日：2009-08-12
申请人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
发明人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
IPC分类号： B05C5/02
CPC分类号： F26B9/06 , A61F2/82 , A61F2310/00389 , A61L2420/02 , B05B13/0221 , B05B13/0228 , B05B13/041 , B05B16/20 , B05B16/60 , B05B16/90 , B05D1/002 , B05D1/02 , B05D3/0413 , B05D3/0493 , B05D7/584
摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.
摘要翻译：一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。随着另一组移出并进入干燥区域，一组移入喷雾区域。此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。交替过程可以重复任意次数。喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

7. 发明授权

US08429831B2 Drug-eluting coatings applied to medical devices by spraying and drying to remove solvent 有权
公开(公告)号：US08429831B2
公开(公告)日：2013-04-30
申请号：US12554820
申请日：2009-09-04
申请人： Matthew J. Gillick , John E. Papp , Kevin Seiki , Hung T. Nguyen
发明人： Matthew J. Gillick , John E. Papp , Kevin Seiki , Hung T. Nguyen
IPC分类号： F26B5/06
CPC分类号： F26B21/004 , A61F2/82 , B05B13/0207 , B05B15/00 , F26B3/04 , Y10T29/49433
摘要： A coating device for coating a medical device with a drug-eluting material uses an in-process drying station between coats to improve a drug release profile. The drying station includes a heat nozzle configured for applying a uniform drying gas. A coating process using the dryer includes a closed-loop control for the gas between drying steps and an improved nozzle for producing more consistent spray patterns.

8. 发明申请

US20080072653A1 Cold collapse method and apparatus 审中-公开
标题翻译：冷塌方法和装置
公开(公告)号：US20080072653A1
公开(公告)日：2008-03-27
申请号：US11524133
申请日：2006-09-20
申请人： Matthew J. Gillick , John E. Papp
发明人： Matthew J. Gillick , John E. Papp
IPC分类号： B21J7/16
CPC分类号： A61F2/95 , A61F2002/9522 , F25D3/10
摘要： A system and method are disclosed for collapsing medical devices, such as self-expanding, drug-eluting stents for loading into delivery catheters. The collapsing apparatus may be used for crimping expandable stents and other devices onto a balloon catheter. The medical device is cooled below the austenitic phase transformation temperature of the material forming the device, such as stainless steel or nitinol, and may be cooled until the material has fully transformed to the martenstitic state. For coated medical devices, the device is warmed to a temperature just below the beginning of austenite phase transformation prior to collapsing. An apparatus having a plurality of offset blades, linear bearings, radial bearings and an actuator mechanism is provided for collapsing the medical device. The system is configured with a mandrel subassembly to push the medical device into a catheter sheath, and with a nozzle subassembly to direct cold gas to the medical device.
摘要翻译：公开了用于折叠医疗装置的系统和方法，所述医疗装置例如用于装载到输送导管中的自扩张药物洗脱支架。塌缩装置可用于将可扩张支架和其它装置卷曲到球囊导管上。将医疗装置冷却到形成装置的材料（例如不锈钢或镍钛诺）的奥氏体相变温度以下，并且可以冷却直到材料完全转变为马氏体状态。对于涂覆的医疗装置，在折叠之前将装置升温到刚好低于奥氏体相变开始的温度。提供具有多个偏移叶片，直线轴承，径向轴承和致动器机构的装置，用于使医疗装置折叠。该系统配置有心轴子组件以将医疗装置推入导管护套中，并且具有喷嘴子组件以将冷气引导到医疗装置。

9. 发明授权

US06383206B1 Embolic protection system and method including filtering elements 有权
标题翻译：栓塞保护系统及方法包括过滤元件
公开(公告)号：US06383206B1
公开(公告)日：2002-05-07
申请号：US09475599
申请日：1999-12-30
申请人： Matthew J. Gillick , Scott J. Huter , Kent C. B. Stalker , Benjamin C. Huter , Anuja Patel
发明人： Matthew J. Gillick , Scott J. Huter , Kent C. B. Stalker , Benjamin C. Huter , Anuja Patel
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61F2230/0093
摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The system includes filtering elements which are capable of occluding a blood vessel distal to an interventional procedure site, while enabling the blood to flow past the occlusion and filtering the blood to capture embolic material which may be released into the blood during a therapeutic interventional procedure. The filtering elements include an expandable member which is capable of being expanded distal to the area of treatment at the interventional procedure site for occluding the blood vessel and for enabling the blood to pass therethrough while preventing emboli from passing therethrough. The system also includes a sheath movable distally and proximally to enable the filtering elements to expand into position distal to the interventional procedure site for capturing embolic material and to collapse the filtering elements to retain the captured embolic material therein.
摘要翻译：当在狭窄或闭塞区域进行介入手术以捕获在手术期间可能产生和释放到血流中的任何栓塞物质时，在血管中使用的系统。该系统包括能够封闭介入手术部位远端的血管的过滤元件，同时使血液能够流过闭塞并过滤血液以捕获在治疗介入手术过程中可释放到血液中的栓塞物质。过滤元件包括可扩张构件，该可膨胀构件能够在介入手术部位处远离扩张区域扩张，用于阻塞血管并使血液能够通过，同时防止栓塞通过。该系统还包括可向远侧和近侧移动的护套，以使得过滤元件能够扩展到介入手术部位的远端位置，用于捕获栓塞材料并使过滤元件折叠以将捕获的栓塞材料保持在其中。

10. 发明授权

US06599296B1 Ratcheting handle for intraluminal catheter systems 有权
标题翻译：腔内导管系统棘轮手柄
公开(公告)号：US06599296B1
公开(公告)日：2003-07-29
申请号：US09917189
申请日：2001-07-27
申请人： Matthew J. Gillick , Christopher J. Tarapata , Christopher A. Stout
发明人： Matthew J. Gillick , Christopher J. Tarapata , Christopher A. Stout
IPC分类号： A61B1700
CPC分类号： A61B17/3207 , A61B2017/1205 , A61B2017/22074 , A61F2/95 , A61F2002/9517
摘要： A ratcheting handle actuator provides for a tool to actuate an intraluminal catheter system for treatment at an intraluminal site by repeated movements of the handle. This allows for actuation over a greater distance than a physician might be able to perform in a single motion while preserving a direct correspondence between the movements of the ratcheting handle and the actuation of the intraluminal device.
摘要翻译：棘轮手柄致动器提供工具来致动管腔内导管系统，以通过手柄的重复移动在腔内部位进行治疗。这允许在医生可能能够以单个运动执行的距离上更大的距离，同时保持棘轮手柄的运动和管腔内装置的致动之间的直接对应。

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