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1. 发明授权

US6044981A Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters 有权
标题翻译：具有专门构造的通道壁的微型过滤器，以及由这种过滤器构成的容纳井和胶囊
公开(公告)号：US6044981A
公开(公告)日：2000-04-04
申请号：US139883
申请日：1998-08-25
申请人： Wen-Hwa Chu , Mauro Ferrari
发明人： Wen-Hwa Chu , Mauro Ferrari
IPC分类号： A61K9/00 , A61K9/22 , A61K9/50 , A61K9/52 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B1/00 , B81C1/00 , C04B41/45 , C23C16/01 , G03F7/00 , B01D69/10 , B01D69/06 , C23F1/00
CPC分类号： G03F7/0015 , A61K9/0024 , A61K9/0097 , B01D39/1692 , B01D39/20 , B01D67/0058 , B01D67/0062 , B01D67/0072 , B01D67/0083 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B3/007 , B81C1/00087 , B81C1/00246 , C04B41/4582 , C23C16/01 , G03F7/00 , B01D2323/08 , B01D2323/10 , B01D2325/02 , B01D2325/04 , B81B2201/10 , B81C2201/014 , B81C2201/032 , B81C2203/0728 , B81C2203/075
摘要： Microfabricated filters utilizing a bulk substrate structure and a thin film structure and a method for constructing such filters. The pores of the filters are defined by spaces between the bulk substrate structure and the thin film structure and are of substantially uniform width, length and distribution. The width of the pores is defined by the thickness of a sacrificial layer and therefore may be smaller than the limit of resolution obtainable with photolithography. The filters provide enhanced mechanical strength, chemical inertness, biological compatibility, and throughput. The filters are constructed using relatively simple fabrication techniques. Also, microfabricated containment wells and capsules constructed with such filters for the immunological isolation of cell transplants and a method for constructing such containment wells and capsules. The pores of the wells and capsules are large enough to let a desired biologically-active molecular product through, while blocking the passage of all larger immunological molecules. The containment wells and capsules provide enhanced biological compatibility and useful life.
摘要翻译：利用大块基板结构和薄膜结构的微型滤波器及其构造方法。过滤器的孔由体基板结构和薄膜结构之间的空间限定，并且具有基本均匀的宽度，长度和分布。孔的宽度由牺牲层的厚度限定，因此可以小于通过光刻可获得的分辨率的极限。过滤器提供增强的机械强度，化学惰性，生物相容性和生产能力。使用相对简单的制造技术构造滤波器。而且，用这种用于免疫分离细胞移植的过滤器构造的微制造安全壳和胶囊以及用于构建这种安全壳和胶囊的方法。孔和胶囊的孔隙足够大以使期望的生物活性分子产物通过阻止所有较大免疫分子的通过。安全壳和胶囊提供增强的生物相容性和使用寿命。

2. 发明授权

US5770076A Micromachined capsules having porous membranes and bulk supports 失效
标题翻译：微加工胶囊具有多孔膜和大量支撑
公开(公告)号：US5770076A
公开(公告)日：1998-06-23
申请号：US482237
申请日：1995-06-07
申请人： Wen-Hwa Chu , Mauro Ferrari
发明人： Wen-Hwa Chu , Mauro Ferrari
IPC分类号： A61F2/02 , A61K9/00 , A61K9/50 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/02 , B01J13/00 , B01J13/02 , B81B1/00 , B81C1/00 , C04B41/45 , C23C16/01 , G03F7/00 , H01L21/205 , H01L21/302 , H01L21/306 , H01L21/3065 , H01L21/31 , A61K9/52
CPC分类号： A61K9/0097 , A61K9/0024 , B01D39/1692 , B01D39/20 , B01D67/003 , B01D67/0034 , B01D67/0058 , B01D67/0062 , B01D67/0072 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B3/007 , B81C1/00087 , C04B41/4582 , C23C16/01 , G03F7/00 , G03F7/0015 , B01D2325/04 , B81B2201/10 , B81C2201/014
摘要： Surface micromachining and bulk micromachining are employed for realizing a porous membrane with bulk support for a microparticle fiter. The filter is sufficiently sturdy to allow for easy handling. It may be used as a diffusion barrier and under high pressures. The disclosed fabrication method is simple, reliable, and integrated-circuit compatible, and thus amenable to mass production. Electronic circuitry may be integrated on the filter surface, as may be desired for several purposes, such as fluid characterization, filter self-cleaning, or charging of the filter surfaces. Methods are shown for the realization of biological containment capsules based on this microfilter.
摘要翻译：采用表面微机械加工和体积微加工技术来实现用于微粒子的大量支撑的多孔膜。过滤器足够坚固以便于处理。它可以用作扩散屏障并在高压下使用。所公开的制造方法简单，可靠，并且集成电路兼容，因此适合批量生产。电子电路可以集成在过滤器表面上，如可能需要多种目的，例如流体表征，过滤器自清洁或过滤表面的充电。显示了基于该微型过滤器实现生物遏制胶囊的方法。

3. 发明授权

US5798042A Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters 失效
公开(公告)号：US5798042A
公开(公告)日：1998-08-25
申请号：US663644
申请日：1996-06-14
申请人： Wen-Hwa Chu , Mauro Ferrari
发明人： Wen-Hwa Chu , Mauro Ferrari
IPC分类号： A61K9/00 , A61K9/22 , A61K9/50 , A61K9/52 , B01D39/16 , B01D39/20 , B01D67/00 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B1/00 , B81C1/00 , C04B41/45 , C23C16/01 , G03F7/00 , B01D69/10
CPC分类号： G03F7/0015 , A61K9/0024 , A61K9/0097 , B01D39/1692 , B01D39/20 , B01D67/0058 , B01D67/0062 , B01D67/0072 , B01D67/0083 , B01D69/02 , B01D69/12 , B01D71/02 , B01J13/02 , B81B3/007 , B81C1/00087 , B81C1/00246 , C04B41/4582 , C23C16/01 , G03F7/00 , B01D2323/08 , B01D2323/10 , B01D2325/02 , B01D2325/04 , B81B2201/10 , B81C2201/014 , B81C2201/032 , B81C2203/0728 , B81C2203/075
摘要： Microfabricated filters utilizing a bulk substrate structure and a thin film structure and a method for constructing such filters. The pores of the filters are defined by spaces between the bulk substrate structure and the thin film structure and are of substantially uniform width, length and distribution. The width of the pores is defined by the thickness of a sacrificial layer and therefore may be smaller than the limit of resolution obtainable with photolithography. The filters provide enhanced mechanical strength, chemical inertness, biological compatibility, and throughput. The filters are constructed using relatively simple fabrication techniques. Also, microfabricated containment wells and capsules constructed with such filters for the immunological isolation of cell transplants and a method for constructing such containment wells and capsules. The pores of the wells and capsules are large enough to let a desired biologically-active molecular product through, while blocking the passage of all larger immunological molecules. The containment wells and capsules provide enhanced biological compatibility and useful life.

4. 发明授权

US08568877B2 Porous and non-porous nanostructures 有权
标题翻译：多孔和无孔纳米结构
公开(公告)号：US08568877B2
公开(公告)日：2013-10-29
申请号：US13044250
申请日：2011-03-09
申请人： Mauro Ferrari , Xuewu Liu , Ciro Chiappini , Jean Raymond Fakhoury
发明人： Mauro Ferrari , Xuewu Liu , Ciro Chiappini , Jean Raymond Fakhoury
IPC分类号： H01L21/311
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L2924/0002 , H01L2924/00
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.
摘要翻译：公开了各种微观和纳米尺度的多孔和无孔线状结构。例如，公开了包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。还公开了制造和使用这种结构的方法。例如，本发明提供了制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

5. 发明授权

US08563022B2 Particles for cell targeting 有权
标题翻译：用于细胞靶向的粒子
公开(公告)号：US08563022B2
公开(公告)日：2013-10-22
申请号：US11870077
申请日：2007-10-10
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A01N25/26 , A01N25/28 , A61K49/00
CPC分类号： A61K9/1611 , A61K9/143 , A61K47/6923 , A61K47/6929 , A61K49/0002
摘要： Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.
摘要翻译：本发明提供一种组合物，其包含包含活性剂的扁球形颗粒，例如治疗或显像剂，以及通过将该组合物施用于有需要的受试者来治疗或监测生理状况如疾病的方法。还提供了制备具有体积的颗粒的方法，该体积可以增强颗粒对受试者体内的靶位置的粘附性，用于颗粒的预选形状，以及用于制备具有能够增强颗粒粘附性的形状的颗粒的方法到受试者体内的预定体积的颗粒的靶位点。

6. 发明申请

US20130071329A1 THERANOSTIC DELIVERY SYSTEMS WITH MODIFIED SURFACES 审中-公开
标题翻译：具有改性表面的传感器输送系统
公开(公告)号：US20130071329A1
公开(公告)日：2013-03-21
申请号：US13635530
申请日：2011-03-17
申请人： Mauro Ferrari , Ennio Tasciotti , Nicoletta Quattrocchi
发明人： Mauro Ferrari , Ennio Tasciotti , Nicoletta Quattrocchi
IPC分类号： A61K9/14 , A61K49/00 , A61K9/127
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/1271 , A61K9/5068 , A61K9/5115 , A61K9/5123 , A61K9/5176 , A61K49/00 , Y02A50/423
摘要： The present invention pertains to therapeutic compositions and delivery systems comprising at least one microparticle or nanoparticle. In various embodiments, the surface of the microparticle or nanoparticle is modified or functionalized with at least a portion of an isolated cellular membrane, such as an isolated plasma membrane. In addition, the microparticle or nanoparticle contains at least one active agent, such as a therapeutic and/or imaging agent. In additional embodiments, the compositions and delivery systems of the present invention may be used for targeted delivery of an active agent. Also provided are methods of making the therapeutic compositions and delivery systems of the present invention.
摘要翻译：本发明涉及包含至少一种微粒或纳米颗粒的治疗组合物和递送系统。在各种实施方案中，微粒或纳米颗粒的表面被分离的细胞膜，例如分离的质膜的至少一部分修饰或官能化。此外，微粒或纳米颗粒含有至少一种活性剂，例如治疗和/或成像剂。在另外的实施方案中，本发明的组合物和递送系统可用于活性剂的靶向递送。还提供了制备本发明的治疗组合物和递送系统的方法。

7. 发明申请

US20120116307A1 DIFFUSION DELIVERY SYSTEMS AND METHODS OF FABRICATION 审中-公开
标题翻译：扩散输送系统和制造方法
公开(公告)号：US20120116307A1
公开(公告)日：2012-05-10
申请号：US13289177
申请日：2011-11-04
申请人： Mauro Ferrari , Xuewu Liu , Piyush Mohan Sinha , Bryan Smith , Sadhana Sharma
发明人： Mauro Ferrari , Xuewu Liu , Piyush Mohan Sinha , Bryan Smith , Sadhana Sharma
IPC分类号： A61M5/00
CPC分类号： A61K9/0097 , A61F2/022 , A61M31/002 , A61N1/306 , B82Y30/00
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nanoengineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
摘要翻译：本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程设备。该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。本发明还涉及含有扩散递送系统的胶囊。本发明还涉及制造扩散递送系统的方法。

8. 发明申请

US20110274624A1 CONTRAST AGENTS IN POROUS PARTICLES 审中-公开
标题翻译：多孔颗粒中的对比剂
公开(公告)号：US20110274624A1
公开(公告)日：2011-11-10
申请号：US13084234
申请日：2011-04-11
申请人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
发明人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
IPC分类号： A61K49/06 , A61P43/00 , A61K49/18 , A61K49/08 , B82Y5/00
CPC分类号： B82Y15/00 , A61K49/1818 , A61K49/1884
摘要： MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed.
摘要翻译：公开了在至少一个多孔微粒或纳米颗粒的孔中包含非螯合的MRI造影剂的MRI成像组合物。发现本发明的组合物表现出增加的松弛度，因此增强MRI成像。非螯合造影剂包括T1造影剂，例如包括Gd（III）或Mn（II）的造影剂。还公开了MRI成像的方法和制备组合物的方法。

9. 发明申请

US20110137596A1 QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES 审中-公开
标题翻译：质量控制方法和微/纳米通道设备
公开(公告)号：US20110137596A1
公开(公告)日：2011-06-09
申请号：US12990411
申请日：2009-04-28
申请人： Alessandro Grattoni , Mauro Ferrari , Xeuwu Liu
发明人： Alessandro Grattoni , Mauro Ferrari , Xeuwu Liu
IPC分类号： G06F19/00
CPC分类号： B81C99/005 , B81B2201/058 , B81B2203/0338 , G01N11/08 , G01N35/00663
摘要： Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure-driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential.
摘要翻译：本发明的实施例包括用于测试微通道或纳米通道器件的质量控制系统和方法。该系统和方法可以利用压力驱动气流来检测和定量结构缺陷。测试方法和系统是非破坏性的，并且基于测量因素（例如给定压力差的质量流率）来快速检测和分类缺陷。

10. 发明申请

US20110065207A1 COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 有权
标题翻译：组合多元醇多糖和一种分解，稳定和储存生物分子的方法
公开(公告)号：US20110065207A1
公开(公告)日：2011-03-17
申请号：US12839606
申请日：2010-07-20
申请人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
发明人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
IPC分类号： G01N33/53 , G01N33/00 , G01N33/68 , H01J49/26 , G01N30/02
CPC分类号： G01N1/405 , G01N33/552
摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.
摘要翻译：新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs有效地从短至30分钟的时间内将复杂的生物样品中的可重复提取物产生少至10μl。它们制造成本便宜，并且允许放大生产以获得大量样品的同时处理。 MSCs是复合的，无标记的诊断工具，具有生物识别部分修饰的潜力，以增强特异性。 MSC可以存储，保护和稳定生物液体，从而简化和成本有效地收集和运输临床样品。基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于个性化治疗组合的选择，治疗功效和毒性的实时评估，以及基于与蛋白质网络相关联的蛋白质网络的变化的合理调节治疗预后和耐药性的疾病。

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