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1. 发明申请

US20110274624A1 CONTRAST AGENTS IN POROUS PARTICLES 审中-公开
标题翻译：多孔颗粒中的对比剂
公开(公告)号：US20110274624A1
公开(公告)日：2011-11-10
申请号：US13084234
申请日：2011-04-11
申请人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
发明人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
IPC分类号： A61K49/06 , A61P43/00 , A61K49/18 , A61K49/08 , B82Y5/00
CPC分类号： B82Y15/00 , A61K49/1818 , A61K49/1884
摘要： MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed.
摘要翻译：公开了在至少一个多孔微粒或纳米颗粒的孔中包含非螯合的MRI造影剂的MRI成像组合物。发现本发明的组合物表现出增加的松弛度，因此增强MRI成像。非螯合造影剂包括T1造影剂，例如包括Gd（III）或Mn（II）的造影剂。还公开了MRI成像的方法和制备组合物的方法。

2. 发明申请

US20100029785A1 PARTICLE COMPOSITIONS WITH A PRE-SELECTED CELL INTERNALIZATION MODE 有权
标题翻译：具有预先选择的细胞内部模式的颗粒组合物
公开(公告)号：US20100029785A1
公开(公告)日：2010-02-04
申请号：US12181759
申请日：2008-07-29
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A61K47/00
CPC分类号： A61K9/10 , A61K9/0019 , A61K9/127 , A61K9/51 , A61K47/6911 , A61K47/6913 , B82Y5/00 , Y10S977/904 , Y10S977/962
摘要： A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre-selected cell internalization mode.
摘要翻译：配制具有预先选择的细胞内化模式的颗粒组合物的方法包括选择具有表面受体的靶细胞并获得具有i）表面部分的颗粒，其具有与细胞的表面受体的亲和力或能够结合细胞的表面受体和ii）预选形状，其中颗粒上的表面部分的表面分布和颗粒的形状对于预选的细胞内化模式是有效的。

3. 发明授权

US08173115B2 Particle compositions with a pre-selected cell internalization mode 有权
标题翻译：具有预选细胞内化模式的粒子组成
公开(公告)号：US08173115B2
公开(公告)日：2012-05-08
申请号：US12181759
申请日：2008-07-29
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A61K47/48
CPC分类号： A61K9/10 , A61K9/0019 , A61K9/127 , A61K9/51 , A61K47/6911 , A61K47/6913 , B82Y5/00 , Y10S977/904 , Y10S977/962
摘要： A method of formulating a particle composition having a pre-selected cell internalization mode involves selecting a target cell having surface receptors and obtaining particles that have i) surface moieties, that have an affinity for or are capable of binding to the surface receptors of the cell and ii) a preselected shape, where a surface distribution of the surface moieties on the particles and the shape of the particles are effective for the pre-selected cell internalization mode.
摘要翻译：配制具有预先选择的细胞内化模式的颗粒组合物的方法包括选择具有表面受体的靶细胞并获得具有i）表面部分的颗粒，其具有与细胞的表面受体的亲和力或能够结合细胞的表面受体和ii）预选形状，其中颗粒上的表面部分的表面分布和颗粒的形状对于预选的细胞内化模式是有效的。

4. 发明授权

US08563022B2 Particles for cell targeting 有权
标题翻译：用于细胞靶向的粒子
公开(公告)号：US08563022B2
公开(公告)日：2013-10-22
申请号：US11870077
申请日：2007-10-10
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A01N25/26 , A01N25/28 , A61K49/00
CPC分类号： A61K9/1611 , A61K9/143 , A61K47/6923 , A61K47/6929 , A61K49/0002
摘要： Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.
摘要翻译：本发明提供一种组合物，其包含包含活性剂的扁球形颗粒，例如治疗或显像剂，以及通过将该组合物施用于有需要的受试者来治疗或监测生理状况如疾病的方法。还提供了制备具有体积的颗粒的方法，该体积可以增强颗粒对受试者体内的靶位置的粘附性，用于颗粒的预选形状，以及用于制备具有能够增强颗粒粘附性的形状的颗粒的方法到受试者体内的预定体积的颗粒的靶位点。

5. 发明授权

US08361508B2 Endocytotic particles 有权
标题翻译：内吞颗粒
公开(公告)号：US08361508B2
公开(公告)日：2013-01-29
申请号：US12034259
申请日：2008-02-20
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A61K9/14 , A61K33/00 , C12Q1/02
CPC分类号： A61K9/10 , A61K9/0019 , G01N33/543 , G01N33/54346
摘要： Endocytosis of an active agent into a cell having surface receptors can be enhanced by using particles that have a radius no less than an endocytotic threshold determined based on a surface density of the receptors, a surface density of the moieties and interaction parameters that include at least one of a receptor-moiety spring constant and a non-specific interaction strength.
摘要翻译：可以通过使用半径不小于基于受体的表面密度确定的内吞阈值的颗粒，部分的表面密度和相互作用参数至少包括至少包含至少具有表面受体的细胞的活性剂的细胞内吞作用受体部分弹簧常数和非特异性相互作用强度之一。

6. 发明申请

US20100074958A1 METHODS AND COMPOSITIONS FOR TARGETING FENESTRATED VASCULATURE 审中-公开
标题翻译：用于靶向芬太尼血管的方法和组合物
公开(公告)号：US20100074958A1
公开(公告)日：2010-03-25
申请号：US12443230
申请日：2006-09-28
申请人： Paolo Decuzzi , Mauro Ferrari
发明人： Paolo Decuzzi , Mauro Ferrari
IPC分类号： A61K9/14 , A61K38/43 , A61K31/337 , A61K31/704 , A61P9/00 , A61P7/04
CPC分类号： A61K49/0002 , A61K31/00
摘要： Targeting of a fenestrated vasculature at a body site by micro or nanoparticles can be increased by using particles that have a radius substantially equal to a critical radius of a normal vasculature at the body site. The particles can be used for treating or monitoring a physiological condition responsible for the fenestrated vasculature. A method of improving an ability of micro or nanoparticles to target fenestrated blood vessels in a body site by selecting particles from a population of the micro or nanoparticles, where the selected particles have a radius that permits enhanced delivery into the fenestrated blood vessels.
摘要翻译：可以通过使用具有基本上等于身体部位正常脉管系统的临界半径的半径的粒子来增加通过微观或纳米颗粒在体部位置开窗口脉管系统的靶向。颗粒可用于治疗或监测负责开窗脉管系统的生理状况。通过从微粒或纳米颗粒的群体中选择颗粒来提高微粒体或纳米颗粒靶向体内部位的开窗血管的能力的方法，其中选定的颗粒具有允许增强输送到开窗血管的半径。

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