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1. 发明公开

US20240115742A1 FLUORINATED FIBERS FOR MULTIMODAL 1H AND 19F MRI, ULTRASOUND, FLUORESCENCE DETECTION AND CONFORMATIONAL AND TEMPERATURE DETECTION BY 19F MRS 审中-公开
公开(公告)号：US20240115742A1
公开(公告)日：2024-04-11
申请号：US18460519
申请日：2023-09-01
申请人： New York University
发明人： Jin Kim Montclare , Dustin Britton , Youssef Zaim Wadghiri , Farbod Mahmoudinobar
IPC分类号： A61K49/18 , A61K49/14 , A61K49/22 , C07K14/245 , G01N24/08 , G01N29/34 , G16B40/00
CPC分类号： A61K49/1884 , A61K49/14 , A61K49/222 , C07K14/245 , G01N24/08 , G01N29/34 , G16B40/00 , B82Y40/00
摘要： Provided are proteins/peptides. The proteins or peptides comprise a sequence designed by the methods described herein. The proteins and peptides may have one or more trifluoroleucine (LTF, which may be referred to as TFL or LTF throughout) residues. The proteins may have or contain the following sequence:

VX1X2X3X4X5X6X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21X22X23X24X25X26X27X28X29X30X31X32X33X34X35X36X37 (SEQ ID NO:1), where X1 is A, E, D, R, H, K, Q, N, or S; X2 is A, E, N, or Q; X3 is A, V, L, I, Q, M, or LT; X4 is A, E, R, D, H, I, L, T, K, Q, N, or LT; X5 is A, F, Q, R, K, H, D, S, or E; X6 is A, L, I, or LTF; X7 is A, K, or E; X8 is A, K, E, D, R, H, Q, or N; X9 is A, T, I, L, Q, or LTF; X10 is A, L, I, or LT; X11 is A, E, D, H, P, I, L, K, Y, N, Q, R, or LT; X12 is A, Q, H, E, D, K, R, or N; X13 is A, M, I, L, Q, T, or LTF; X14 is A, L, D, E, K, I, or LTF; X15 is A, E, D, H, Y, I, L, R, K, Q, N, or Lu; X16 is A, E, or Q; X17 is A, L, M, I, V, or LTF; X18 is A, K, E, D, K, R, H, N, or Q; X19 is A, N, D, K, R, H, Q, or E; X20 is A, L, T, I, M, R, or LTF; X21 is A, N, or Q; X22 is K, A, E, I, L, M, R, H, D, Q, N, S, or LTF; X23 is A, Q, N, I, L, or LTF; X24 is A, L, I, M, T, or LT; X25 is A, H, Q, R, K, D, N, Y, I, E, L, T, or LT; X26 is A, D, E, R, K, Q, H, N, or T; X27 is A, V, I, Q, L, T, or LTF; X28 is A, R, E, D, K, H, N, Q, or T; X29 is A, H, E, R, D, K, I, L, N, Q, T, Y, or LTF; X30 is L, A, D, K, I, N, Q, or LTF; X31 is A, L, Q, I, or LTF; X32 is E, D, K, H, N, Q, A, L, R, I, Y, or LTF; X33 is A, N, Q, D, E, H, K, R, or S; X34 is Q, I, L, A, M, or LT; X35 is S, A, P, or Q; X36 is A, K, T, D, R, H, N, Q, or E; X37 is A, L, I, K, D, N, Q, R, or LTF; where at least one of X3, X4, X6, X9, X10, X11, X13, X14, X15, X16, X17, X20, X22, X23, X24, X25, X27, X29, X30, X31, X32, X34, X37 or any L is replaced with LTF. The proteins and peptides may have desirable self-assembling properties such that they form supramolecular structures (e.g., fibers or fibrils). The supramolecular structures may further gelate water such that a hydrogel is formed. The fibers and/or gels may be used to deliver drugs and/or as theranostic agents.

2. 发明授权

US11654204B2 Rod-shaped plant virus nanoparticles as imaging agent platforms 有权
公开(公告)号：US11654204B2
公开(公告)日：2023-05-23
申请号：US17335557
申请日：2021-06-01
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Nicole Steinmetz , Michael Bruckman
IPC分类号： A61K49/18 , A61K49/10 , A61K35/76 , A61K49/00 , B82Y5/00 , C12N7/00
CPC分类号： A61K49/1896 , A61K49/1884 , C12N7/00 , C12N2770/00031
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.

3. 发明申请

US20110274624A1 CONTRAST AGENTS IN POROUS PARTICLES 审中-公开
标题翻译：多孔颗粒中的对比剂
公开(公告)号：US20110274624A1
公开(公告)日：2011-11-10
申请号：US13084234
申请日：2011-04-11
申请人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
发明人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
IPC分类号： A61K49/06 , A61P43/00 , A61K49/18 , A61K49/08 , B82Y5/00
CPC分类号： B82Y15/00 , A61K49/1818 , A61K49/1884
摘要： MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed.
摘要翻译：公开了在至少一个多孔微粒或纳米颗粒的孔中包含非螯合的MRI造影剂的MRI成像组合物。发现本发明的组合物表现出增加的松弛度，因此增强MRI成像。非螯合造影剂包括T1造影剂，例如包括Gd（III）或Mn（II）的造影剂。还公开了MRI成像的方法和制备组合物的方法。

4. 发明申请

US20080003182A1 Shortened Carbon Nanotubes 审中-公开
标题翻译：缩短碳纳米管
公开(公告)号：US20080003182A1
公开(公告)日：2008-01-03
申请号：US11572079
申请日：2005-07-13
申请人： Lon Wilson , Robert Bolskar
发明人： Lon Wilson , Robert Bolskar
IPC分类号： A61K49/08 , A61K49/04 , B32B15/02
CPC分类号： B82Y30/00 , A61K49/1884 , A61K51/1251 , B82Y5/00 , Y10T428/2935
摘要： A shortened carbon nanotube and methods for preparing the same and contrast agents are disclosed. One embodiment includes a shortened carbon nanotube. The shortened carbon nanotube has a length of about 100 nm or less with a cargo. The shortened carbon nanotube is suitable for use in x-ray and MRI imaging as a contrast agent.
摘要翻译：公开了一种缩短的碳纳米管及其制备方法和造影剂。一个实施方案包括缩短的碳纳米管。缩短的碳纳米管与货物的长度约为100nm以下。缩短的碳纳米管适用于作为造影剂的X射线和MRI成像。

5. 发明申请

US20060051290A1 Short carbon nanotubes as adsorption and retention agents 审中-公开
标题翻译：短碳纳米管作为吸附和保留剂
公开(公告)号：US20060051290A1
公开(公告)日：2006-03-09
申请号：US11180088
申请日：2005-07-13
申请人： Lon J. Wilson , Michael G. Rosenblum
发明人： Lon J. Wilson , Michael G. Rosenblum
IPC分类号： A61K51/00 , A61N5/00
CPC分类号： B82Y30/00 , A61K49/1884 , A61K51/1251 , B82Y5/00 , Y10T428/2935
摘要： A method for delivering a radiotherapeutic agent to a target, comprises administering a composition comprising water-soluble nanotubes having an average length less than 50 nm and a radionuclide so as to expose the target to the composition. The nanotubes can be functionalized with a monoclonal antibody having an affinity for the target. The radionuclide can be contained in the nanotubes, which can be derivatized. The nanotubes can be loaded with I2 or 211AtI, another α-emitter, including but not limited to 211AtI, 225Ac, 212Bi, 213Bi, and combinations thereof. The nanotubes have an average length less than 40 nm, or an average length less than 30 nm.
摘要翻译：将放射治疗剂递送至靶的方法包括施用包含平均长度小于50nm的水溶性纳米管和放射性核素的组合物，以将靶暴露于组合物。纳米管可以用对靶具有亲和性的单克隆抗体进行功能化。放射性核素可以包含在可以衍生的纳米管中。纳米管可以加载另一个α发射体，其中包括但不限于二级，二级，二级，二级，二级， Bi，Bi，Bi，Bi，Bi及其组合。纳米管的平均长度小于40nm，平均长度小于30nm。

6. 发明授权

US09597677B2 Method for functionalizing carbon nano-objects, composition comprising functionalized carbon nano-objects suspended in an organic solvent and uses thereof 有权
公开(公告)号：US09597677B2
公开(公告)日：2017-03-21
申请号：US14377606
申请日：2013-02-13
申请人： COMMISSARIAT ÁL'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
发明人： Stéphane Campidelli , Guillaume Clave
IPC分类号： A61K9/14 , B01J37/04 , B01J13/14 , A61K49/18 , B01J31/06 , B01J31/12 , B01J35/00 , B01J37/02
CPC分类号： B01J37/04 , A61K49/1884 , B01J13/14 , B01J31/06 , B01J31/123 , B01J35/004 , B01J37/0219
摘要： The invention relates to a method allowing functionalization of carbon nano-objects and in particular carbon nanotubes and graphene nanosheets, a composition comprising nano-objects functionalized by this method, suspended in an organic solvent, as well as to the uses of this composition. Suitable applications include elaboration of composite materials and, in particular, of nano-composite materials, materials intended for photovoltaics, detection devices of the detector/sensor or biodetector/biosensor type, photocatalysis systems, targeted vectorization systems for compounds of therapeutic or diagnostic interest or further contrast agents for medical imaging.

7. 发明申请

US20150265729A1 ROD-SHAPED PLANT VIRUS NANOPARTICLES AS IMAGING AGENT PLATFORMS 审中-公开
标题翻译： ROD形成的植物病毒纳米粒子作为成像剂平台
公开(公告)号：US20150265729A1
公开(公告)日：2015-09-24
申请号：US14434435
申请日：2013-10-09
申请人： CASE WESTERN RESERVE UNIVERSITY
发明人： Nicole Steinmetz
IPC分类号： A61K49/18 , C12N7/00
CPC分类号： A61K49/1896 , A61K49/1884 , C12N7/00 , C12N2770/00031
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
摘要翻译：描述了具有内表面和外表面的杆状植物病毒，以及连接到内表面和/或外表面的至少一种成像剂。杆状病毒可以组合成较大的球形纳米粒子。包括成像剂的棒状植物病毒或球形纳米粒子可以用于通过向受试者施用病毒颗粒来产生受试者例如肿瘤或动脉粥样硬化组织的组织区域的图像的方法，并产生图像已分发病毒颗粒的受试者的组织区域。

8. 发明申请

US20140065200A1 NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE 有权
标题翻译：氮氧化物释放纳米体系及其使用方法
公开(公告)号：US20140065200A1
公开(公告)日：2014-03-06
申请号：US14011488
申请日：2013-08-27
申请人： The University of North Carolina at Chapel Hill
发明人： Mark H. Schoenfisch , Yuan Lu
IPC分类号： C07F7/08
CPC分类号： C07F7/0834 , A01N59/00 , A61K47/6925 , A61K49/1884 , B82Y5/00 , Y10T428/2975 , A01N25/08 , A01N25/18
摘要： In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile.
摘要翻译：在一个方面，本文公开的主题涉及具有期望的纵横比的NO释放功能化纳米棒。纳米棒也能够释放所需量的NO（一氧化氮）。在另一方面，本文公开的主题涉及包含释放NO释放纳米棒的组合物。在另一方面，本文公开的主题涉及制备具有特定纵横比的释放NO释放纳米棒的方法。在另一方面，本文公开的主题涉及抗感染的方法，包括向受试者施用包含释放NO释放纳米棒的组合物，其中所述纳米棒具有特定的长宽比和NO释放曲线。

9. 发明申请

US20090196826A1 COMPOSITIONS AND METHODS OF MAKING NON-SPHERICAL MICRO- AND NANO-PARTICLES 审中-公开
标题翻译：制备非球形微米和纳米颗粒的组合物和方法
公开(公告)号：US20090196826A1
公开(公告)日：2009-08-06
申请号：US12336876
申请日：2008-12-17
申请人： Jinming Gao , Wenchuang Hu , Mukti N. Aryal , Fatih Buyukserin , Xiao-Mei Zhao
发明人： Jinming Gao , Wenchuang Hu , Mukti N. Aryal , Fatih Buyukserin , Xiao-Mei Zhao
IPC分类号： A61K49/18 , A61K9/00
CPC分类号： A61K9/5146 , A61K9/0009 , A61K9/5153 , A61K9/5192 , A61K47/6907 , A61K47/6911 , A61K47/6925 , A61K49/0002 , A61K49/0095 , A61K49/1809 , A61K49/1884 , B82Y5/00
摘要： The present invention includes compositions, methods and pharmaceutical compositions formed by template-directed polymer molding by contacting a porous template with one or more layers of polymeric material coated on a release layer coated on a substrate, applying pressure to the porous template, the substrates or both and separating the porous template from the polymer material to form one or more polymer nonspherical nanostructures with one or more layers on the substrate. The template includes one or more nonspherical nanostructure features. The size and shape of the one or more single- or multi-layer polymeric nonspherical nanostructures are controlled by the one or more nonspherical nanostructure features and the polymer material optionally including one or more active agents with or without retardants, dyes, etc.
摘要翻译：本发明包括通过模板指导的聚合物模制而形成的组合物，方法和药物组合物，所述组合物，方法和药物组合物通过使多孔模板与涂覆在涂覆在基材上的剥离层上的一层或多层聚合材料接触，向多孔模板，并且将多孔模板与聚合物材料分离以形成在衬底上具有一层或多层的一个或多个聚合物非球形纳米结构。该模板包括一个或多个非球形纳米结构特征。一个或多个单层或多层聚合物非球形纳米结构的尺寸和形状由一个或多个非球形纳米结构特征控制，并且聚合物材料任选地包括一种或多种具有或不具有阻滞剂，染料等的活性剂。

10. 发明授权

US10617772B2 Hsp9O-targeted inflammation and infection imaging and therapy 有权
公开(公告)号：US10617772B2
公开(公告)日：2020-04-14
申请号：US15511701
申请日：2015-09-17
申请人： Memorial Sloan Kettering Cancer Center
发明人： Mark Dunphy , Gabriela Chiosis
IPC分类号： A61K51/04 , A61P35/00 , A61K49/00 , A61B5/0275 , A61B5/0402 , A61B5/08 , A61B5/00 , A61B6/03 , A61B6/00 , A61K31/52 , A61K49/18 , A61K51/00
CPC分类号： A61K51/0459 , A61B5/02755 , A61B5/0402 , A61B5/0813 , A61B5/4255 , A61B5/441 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/503 , A61B6/5288 , A61B6/541 , A61K31/52 , A61K49/0004 , A61K49/1884 , A61P35/00
摘要： The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.

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