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1. 发明申请

US20120045396A1 POROUS STRUCTURES WITH MODIFIED BIODEGRADATION KINETICS 审中-公开
标题翻译：具有改良生物降解动力学的多孔结构
公开(公告)号：US20120045396A1
公开(公告)日：2012-02-23
申请号：US13144724
申请日：2009-01-15
申请人： Biana Godin-Vilentchouk , Mauro Ferrari
发明人： Biana Godin-Vilentchouk , Mauro Ferrari
IPC分类号： A61K49/00 , C07F7/10 , A61K47/24 , A61M5/00 , C08G65/00 , B82Y5/00 , B82Y30/00
CPC分类号： A61K9/1641 , A61K9/0024
摘要： Biodegradation kinetics of biodegradable porous objects, such as porous silicon objects, can be controlled by a molecular weight of polymer chains, such as polyethylene glycol chains, disposed on an outer surface of the object. Provided are biodegradable porous objects, which have their biodegradation kinetics controlled by a molecular weight of the disposed polymer chains. Also provided are methods of making such biodegradable porous objects as well as methods of using such biodegradable porous objects for delivery of active agents, such as therapeutic agents and/or imaging agents.
摘要翻译：可生物降解的多孔物体如多孔硅物体的生物降解动力学可以通过设置在物体的外表面上的聚合物链如聚乙二醇链的分子量来控制。提供了可生物降解的多孔物体，其具有由所设置的聚合物链的分子量控制的其生物降解动力学。还提供了制造这种可生物降解的多孔物体的方法以及使用这种可生物降解的多孔物体用于递送活性剂如治疗剂和/或成像剂的方法。

2. 发明申请

US20110274624A1 CONTRAST AGENTS IN POROUS PARTICLES 审中-公开
标题翻译：多孔颗粒中的对比剂
公开(公告)号：US20110274624A1
公开(公告)日：2011-11-10
申请号：US13084234
申请日：2011-04-11
申请人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
发明人： Paolo Decuzzi , Lon J. Wilson , Mauro Ferrari , Jeyarama S. Ananta , Biana Godin
IPC分类号： A61K49/06 , A61P43/00 , A61K49/18 , A61K49/08 , B82Y5/00
CPC分类号： B82Y15/00 , A61K49/1818 , A61K49/1884
摘要： MRI imaging compositions are disclosed comprising non-chelated MRI contrast agents in the pores of at least one porous microparticle or nanoparticle. The compositions of the invention have been found to exhibit increased relaxivity and therefore, enhanced MRI imaging. The non-chelated contrast agents include T1 contrast agents, such as those including Gd(III) or Mn(II). Methods of MRI imaging and methods of making the compositions are also disclosed.
摘要翻译：公开了在至少一个多孔微粒或纳米颗粒的孔中包含非螯合的MRI造影剂的MRI成像组合物。发现本发明的组合物表现出增加的松弛度，因此增强MRI成像。非螯合造影剂包括T1造影剂，例如包括Gd（III）或Mn（II）的造影剂。还公开了MRI成像的方法和制备组合物的方法。

3. 发明申请

US20090047234A1 Compositions for nasal delivery 有权
标题翻译：鼻腔输送组成
公开(公告)号：US20090047234A1
公开(公告)日：2009-02-19
申请号：US12078317
申请日：2008-03-28
申请人： Elka Touitou , Biana Godin , Shaher Duchi
发明人： Elka Touitou , Biana Godin , Shaher Duchi
IPC分类号： A61K47/44 , A61K31/439 , A61K38/28 , A61K31/5513 , A61K31/496 , A61K31/135 , A61K31/445 , A61K31/765 , A61K31/221 , A61K31/551 , A61K31/56 , A61K31/473 , A61P3/10 , A61P33/06 , A61P25/08 , A61P25/24 , A61P25/28 , A61P3/00 , A61P37/00 , A61P29/00 , A61P25/00
CPC分类号： A61K9/0043 , A61K9/0019 , A61K31/05 , A61K31/196 , A61K31/5513 , A61K38/02 , A61K38/16 , A61K47/10 , A61K47/24 , A61K47/34 , Y02A50/411 , A61K2300/00
摘要： The present invention concerns a method of administering at least one active pharmaceutical agent to a patient in need thereof, which method comprises the intranasal administration of a composition comprising a therapeutically effective amount of this agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of the phospholipids and the one or more alcohols in the composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, the phospholipids forming vesicles in said composition. Further are disclosed pharmaceutical compositions and combinations suitable for intranasal delivery.
摘要翻译：本发明涉及向有需要的患者施用至少一种活性药剂的方法，该方法包括鼻内施用包含治疗有效量的该试剂，磷脂，一种或多种C 2 -C 4醇和水的组合物其中组合物中磷脂和一种或多种醇的浓度分别在0.2至10％和12至30重量％的范围内，所述组合物的水含量不小于30重量％，所述组合物中形成囊泡的磷脂。还公开了适合于鼻内递送的药物组合物和组合。

4. 发明申请

US20060127967A1 In vitro test for studying compound predicting pharmacologic and/or harmacokinetic and/or pharmacodynamic parameters of a compound 审中-公开
标题翻译：用于研究化合物预测化合物的药理学和/或有害动力学和/或药效学参数的体外试验
公开(公告)号：US20060127967A1
公开(公告)日：2006-06-15
申请号：US10532021
申请日：2003-10-23
申请人： Elki Touitou , Biana Godin
发明人： Elki Touitou , Biana Godin
IPC分类号： C12Q1/18
CPC分类号： C12Q1/025 , C12Q1/18
摘要： The invention provides a method and an assay for predicting the pharmacologic and/or pharmacokinetic and/or pharmacodynamic activity and/or effective concentration of a test material using cell and/or protozoa and/or micro-organism by assessing the effect of the test material on the and/or protozoa and/or micro-organism. Further, the invention provides an apparatus or a system, which comprises a donor and a receiver compartments, separated by membrane, wherein cell and/or protozoa and/or micro-organism are present in the receiver compartments, for predicting the pharmacologic of pharmacokinetic effects such as effective concentration of a test material, by assessing the effect of the test material, on the cell and/or protozoa and/or micro-organism. In addition, the invention provides use of an artificial human skin for measuring the diffusion or the penetration of a test material through the skin.
摘要翻译：本发明提供了一种用于通过评估测试材料的效果来预测使用细胞和/或原生动物和/或微生物的测试材料的药物和/或药物动力学和/或药效学活性和/或有效浓度的方法和测定法在和/或原生动物和/或微生物上。此外，本发明提供了一种装置或系统，其包括由膜分离的供体和接收器隔室，其中细胞和/或原生动物和/或微生物存在于接收器室中，用于预测药代动力学效应的药理学例如通过评估测试材料对细胞和/或原生动物和/或微生物的影响来测试材料的有效浓度。此外，本发明提供人造人皮肤用于测量测试材料通过皮肤的扩散或穿透的用途。

5. 发明授权

US08911751B2 Compositions for nasal delivery 有权
标题翻译：鼻腔输送组成
公开(公告)号：US08911751B2
公开(公告)日：2014-12-16
申请号：US12078317
申请日：2008-03-28
申请人： Elka Touitou , Biana Godin , Shaher Duchi
发明人： Elka Touitou , Biana Godin , Shaher Duchi
IPC分类号： A61K9/00 , A61K47/24 , A61K31/196 , A61K31/05 , A61K47/34 , A61K47/10 , A61K38/16 , A61K31/5513
CPC分类号： A61K9/0043 , A61K9/0019 , A61K31/05 , A61K31/196 , A61K31/5513 , A61K38/02 , A61K38/16 , A61K47/10 , A61K47/24 , A61K47/34 , Y02A50/411 , A61K2300/00
摘要： The present invention concerns a method of administering at least one active pharmaceutical agent to a patient in need thereof, which method comprises the intranasal administration of a composition comprising a therapeutically effective amount of this agent, phospholipids, one or more C2-C4 alcohols and water, wherein the concentrations of the phospholipids and the one or more alcohols in the composition are in the ranges of 0.2 to 10% and 12 to 30% by weight, respectively, with the water content of said composition being not less than 30% by weight, the phospholipids forming vesicles in said composition. Further are disclosed pharmaceutical compositions and combinations suitable for intranasal delivery.
摘要翻译：本发明涉及向有需要的患者施用至少一种活性药剂的方法，该方法包括鼻内施用包含治疗有效量的该试剂，磷脂，一种或多种C 2 -C 4醇和水的组合物其中组合物中磷脂和一种或多种醇的浓度分别在0.2至10％和12至30重量％的范围内，所述组合物的水含量不小于30重量％，所述组合物中形成囊泡的磷脂。还公开了适合于鼻内递送的药物组合物和组合。

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