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1. 发明授权

US06914960B2 Miniature x-ray emitter having independent current and voltage control 失效
标题翻译：具有独立电流和电压控制的微型x射线发射器
公开(公告)号：US06914960B2
公开(公告)日：2005-07-05
申请号：US10427349
申请日：2003-04-30
申请人： Vance Swanson , Zirao Zheng , Victor I. Chornenky , Eunsung Park , Matthew Rust
发明人： Vance Swanson , Zirao Zheng , Victor I. Chornenky , Eunsung Park , Matthew Rust
IPC分类号： A61N5/10 , H01J35/32 , H01J35/00
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32
摘要： An apparatus for emitting x-rays comprises a housing which contains an anode having an electron receiving surface and a cathode having an electron emitting surface. A cable couples the anode to a source of high voltage. An optical fiber secured to the cable has a proximal end coupled to a source of optical energy and a distal end configured to direct the optical energy onto the cathode's electron emitting surface. The cathode emits electrons which strike the anode to create x-ray radiation.
摘要翻译：用于发射X射线的装置包括壳体，其包含具有电子接收表面的阳极和具有电子发射表面的阴极。电缆将阳极耦合到高电压源。固定到电缆的光纤具有耦合到光能源的近端，以及被配置为将光能引导到阴极的电子发射表面上的远端。阴极发射撞击阳极的电子，以产生X射线辐射。

2. 发明授权

US06546077B2 Miniature X-ray device and method of its manufacture 失效
公开(公告)号：US06546077B2
公开(公告)日：2003-04-08
申请号：US09760815
申请日：2001-01-17
申请人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
发明人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , H01J35/32 , H01J2235/164
摘要： An emitter for a miniature X-ray apparatus comprises an insulating shell, an anode, and a cathode. The insulating shell includes a conical brazing surface, brazed to a conical brazing surface on the anode. The braze consists of a pure titanium layer and a pure tin layer. During brazing, the pure metals react and bond to the insulating shell and create a titanium-tin alloy between the pure layers. Pure tin is sputtered from tin sputter target onto the exposed brazing surfaces of the cathode cap and the anode. The insulating shell is placed in a vacuum chamber of deposition applicator, which deposits an active metal onto the shell brazing surface. In a brazing oven, the anode is placed within insulating shell such that the anode conical brazing surface and the shell conical brazing surface are contacting and aligned with each other. During brazing, the cathode is brought into contact with the insulating shell. The sealed emitters are placed in a sputtering machine's vacuum chamber. A metal is sputtered from a sputtering target to form a metal layer on the exterior of insulating shell.

3. 发明授权

US06866624B2 Apparatus and method for treatment of malignant tumors 失效
标题翻译：用于治疗恶性肿瘤的装置和方法
公开(公告)号：US06866624B2
公开(公告)日：2005-03-15
申请号：US09731925
申请日：2000-12-08
申请人： Victor I. Chornenky , Vance Swanson , Russell G. Hodge , Peter G. Davis
发明人： Victor I. Chornenky , Vance Swanson , Russell G. Hodge , Peter G. Davis
IPC分类号： A61B18/18 , A61N5/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1001 , A61B18/18 , A61B18/1815
摘要： The present invention relates to a device for simultaneously treating a tumor or cancerous growth with both hyperthermia and X-ray radiation using brachytherapy. The device includes a needle-like introducer serving as a microwave antenna. Microwaves are emitted from the introducer to increase the temperature of cancerous body tissue. The introducer is an inner conductor of a coaxial cable. The introducer contains a hollow core which houses an X-ray emitter. The X-ray emitter is connected to a high voltage miniature cable which extends from the X-ray emitter to a high voltage power source. The X-ray emitter emits ionizing radiation to irradiate cancerous tissue. A cooling system is included to control the temperature of the introducer. Temperature sensors placed around the periphery of the tumor monitor the temperature of the treated tissue.
摘要翻译：本发明涉及一种利用近距离放射治疗同时治疗肿瘤或癌性生长的装置，其中包括热疗和X射线辐射。该装置包括用作微波天线的针状导引器。微波从导引器发射，以增加癌组织的体温。引导器是同轴电缆的内部导体。导引器包含容纳X射线发射器的中空芯。 X射线发射器连接到从X射线发射器延伸到高压电源的高压微型电缆。 X射线发射器发射电离辐射以照射癌组织。包括冷却系统以控制导引器的温度。放置在肿瘤周围的温度传感器监测被处理组织的温度。

4. 发明申请

US20100262067A1 Method for Treatment of Neoplastic Cells in the Prostate of a Patient 有权
标题翻译：用于治疗患者前列腺中的肿瘤细胞的方法
公开(公告)号：US20100262067A1
公开(公告)日：2010-10-14
申请号：US12820955
申请日：2010-06-22
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61N1/30 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

5. 发明授权

US07130697B2 Apparatus and method for the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的装置和方法
公开(公告)号：US07130697B2
公开(公告)日：2006-10-31
申请号：US10668775
申请日：2003-09-23
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61F2/00 , A61B18/18
CPC分类号： A61N1/325 , A61B18/1477 , A61B18/1485 , A61B2017/00274 , A61B2018/00547 , A61B2018/1425
摘要： An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.
摘要翻译：公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

6. 发明授权

US06280413B1 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 失效
标题翻译：具有自膨胀部分的溶栓过滤和药物输送导管
公开(公告)号：US06280413B1
公开(公告)日：2001-08-28
申请号：US08889432
申请日：1997-07-08
申请人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
发明人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
IPC分类号： A61M2900
CPC分类号： A61M25/0082 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0071 , A61M25/0074 , A61M2025/0057
摘要： A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.
摘要翻译：公开了溶栓过滤和药物递送导管，其包括纵轴的轴。肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。例如，可以通过套筒或螺纹将肋压缩。药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

7. 发明授权

US5925016A Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure 失效
标题翻译：用于药物递送的系统和方法，包括通过压力通过血栓驱动药物或溶解剂来治疗血栓形成
公开(公告)号：US5925016A
公开(公告)日：1999-07-20
申请号：US534856
申请日：1995-09-27
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/09083 , A61M2025/1052 , A61M2205/36 , A61M25/007 , A61M25/1011
摘要： Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
摘要翻译：公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管血栓在压力下。优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。然后将过滤的药物或溶解剂再次送入远端区域。以这种方式回收药物或溶解剂降低了程序的成本。本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

8. 发明授权

US08647338B2 Method of destroying tissue cells by electroporation 有权
标题翻译：通过电穿孔破坏组织细胞的方法
公开(公告)号：US08647338B2
公开(公告)日：2014-02-11
申请号：US13556455
申请日：2012-07-24
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.
摘要翻译：提供了通过破坏组织细胞来治疗人体的方法。所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体，在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

9. 发明申请

US20110009860A1 Apparatus and Method for Reducing Subcutaneous Fat Deposits, Virtual Face Lift and Body Sculpturing by Electroporation 有权
标题翻译：用于减少皮下脂肪沉积的装置和方法，通过电穿孔进行虚拟面部提升和身体雕刻
公开(公告)号：US20110009860A1
公开(公告)日：2011-01-13
申请号：US12501225
申请日：2009-07-10
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.
摘要翻译：提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

10. 发明授权

US06892099B2 Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation 有权
标题翻译：用于减少皮下脂肪沉积物，虚拟面部提升和通过电穿孔进行身体雕刻的装置和方法
公开(公告)号：US06892099B2
公开(公告)日：2005-05-10
申请号：US09931672
申请日：2001-08-17
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： A61N1/32 , A61N1/34 , A61N1/18
CPC分类号： A61N1/325 , A61N1/0424 , A61N1/327 , A61N1/328 , A61N1/36014
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.
摘要翻译：提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

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