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1. 发明授权

US06280413B1 Thrombolytic filtration and drug delivery catheter with a self-expanding portion 失效
标题翻译：具有自膨胀部分的溶栓过滤和药物输送导管
公开(公告)号：US06280413B1
公开(公告)日：2001-08-28
申请号：US08889432
申请日：1997-07-08
申请人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
发明人： David W. Clark , Souise S. Clark , Victor I. Chornenky , Michael R. Forman , Jeffrey A. Lee
IPC分类号： A61M2900
CPC分类号： A61M25/0082 , A61F2/013 , A61F2230/0006 , A61F2230/005 , A61M25/0071 , A61M25/0074 , A61M2025/0057
摘要： A thrombolytic filtration and drug delivery catheter is disclosed comprising a shaft which longitudinal ribs. The ribs are compressed while being advanced to the site of interest and are released at the site, flaring to a diameter greater than the diameter of the shaft. The ribs can be compressed by a sleeve or thread, for example. Drugs or other agents can be delivered through lumens in the shaft and ribs, out through ports in the ribs. Preferably, the ports are positioned to deliver the drugs or other agents between the ribs and within the region defined by the ribs.
摘要翻译：公开了溶栓过滤和药物递送导管，其包括纵轴的轴。肋骨被压缩，同时前进到感兴趣的部位，并在现场释放，扩张到比轴的直径大。例如，可以通过套筒或螺纹将肋压缩。药物或其他药剂可以通过轴和肋中的腔进出，通过肋中的端口排出。优选地，端口被定位成在肋之间并且在由肋限定的区域内递送药物或其它药剂。

2. 发明授权

US5925016A Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure 失效
标题翻译：用于药物递送的系统和方法，包括通过压力通过血栓驱动药物或溶解剂来治疗血栓形成
公开(公告)号：US5925016A
公开(公告)日：1999-07-20
申请号：US534856
申请日：1995-09-27
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/09 , A61M25/10 , A61M2025/0047 , A61M2025/09008 , A61M2025/09083 , A61M2025/1052 , A61M2205/36 , A61M25/007 , A61M25/1011
摘要： Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
摘要翻译：公开了通过压力驱动药物或溶解剂通过血栓来治疗血栓形成的系统和方法。该系统优选地包括具有用于隔离接近血栓的区域的阻塞球囊的引导导管，具有用于隔离远离血栓的区域的闭塞气囊的导丝和用于将药物或其它药剂递送到远端的区域的输注导管血栓在压力下。优选地，引导导管的内腔用于抽吸靠近血栓的材料，从而降低血栓近端的压力。管腔可以联接到血栓过滤器以从药物或从近端区域排出的溶解剂中除去血栓溶解物质。然后将过滤的药物或溶解剂再次送入远端区域。以这种方式回收药物或溶解剂降低了程序的成本。本发明的系统和方法可用于治疗身体内腔或血管中的其它阻塞物，或者将药物或其它药物递送至体内的流明，血管或空腔。

3. 发明授权

US06377846B1 Device for delivering localized x-ray radiation and method of manufacture 失效
标题翻译：用于递送局部X射线辐射的装置和制造方法
公开(公告)号：US06377846B1
公开(公告)日：2002-04-23
申请号：US08806244
申请日：1997-02-21
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61N130
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32 , H01J2235/205
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。该器件包括具有薄的金刚石膜作为阴极的阴极结构。该装置还包括真空壳体和阳极。描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

4. 发明授权

US07338487B2 Device for delivering localized x-ray radiation and method of manufacture 失效
标题翻译：用于递送局部X射线辐射的装置和制造方法
公开(公告)号：US07338487B2
公开(公告)日：2008-03-04
申请号：US10010911
申请日：2001-11-20
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61B18/18 , A61B5/10
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for fabricating such a device. The device includes a cathode structure that has a thin, diamond film as a cathode. The device further comprises a vacuum housing and an anode. A method for fabricating a device for localized x-ray radiation is described which includes the formation of a thin diamond film on a getter at temperatures below an activation temperature of the getter.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及用于制造这种装置的方法。该器件包括具有薄的金刚石膜作为阴极的阴极结构。该装置还包括真空壳体和阳极。描述了一种用于制造用于局部x射线辐射的装置的方法，其包括在低于吸气剂的活化温度的温度下在吸气剂上形成薄金刚石膜。

5. 发明授权

US06799075B1 X-ray catheter 失效
标题翻译： X光导管
公开(公告)号：US06799075B1
公开(公告)日：2004-09-28
申请号：US08701764
申请日：1996-08-22
申请人： Victor I. Chornenky , Michael R. Forman
发明人： Victor I. Chornenky , Michael R. Forman
IPC分类号： A61B1818
CPC分类号： A61N5/1001 , A61N5/1002 , A61N2005/1003 , H01J35/32 , H01J2201/304 , H01J2201/306
摘要： A catheter for emitting radiation is disclosed, comprising a catheter shaft and an x-ray unit attached to the distal end of the catheter shaft. The x-ray unit comprises an anode and a cathode coupled to an insulator to define a vacuum chamber. The cathode is preferably a field emission cathode of graphite or graphite coated with titanium carbide, for example. The anode is preferably tungsten and the insulator is preferably pyrolytic boron nitride. The x-ray unit is preferably coupled to a voltage source through a coaxial cable. The anode is preferably a heavy metal such as tungsten. The cathode may also be a ferroelectric material. The x-ray unit can have a diameter less than about 4 mm and a length less than about 15 mm. Methods of use of the catheter are also disclosed. The catheter of the present invention can be used to irradiate the site of an angioplasty procedure to prevent restenosis. It can also be used to treat other conditions in any vessel, lumen or cavity of the body.
摘要翻译：公开了一种用于发射辐射的导管，包括导管轴和附接到导管轴的远端的x射线单元。 x射线单元包括阳极和阴极，其耦合到绝缘体以限定真空室。阴极优选为例如涂覆有碳化钛的石墨或石墨的场致发射阴极。阳极优选为钨，绝缘体优选为热解氮化硼。 X射线单元优选地通过同轴电缆耦合到电压源。阳极优选为重金属，例如钨。阴极也可以是铁电材料。 x射线单元的直径可以小于约4毫米，长度小于约15毫米。还公开了导管的使用方法。本发明的导管可用于照射血管成形术程序的部位以防止再狭窄。它也可以用于治疗身体的任何血管，腔或腔中的其他病症。

6. 发明授权

US6095966A X-ray device having a dilation structure for delivering localized radiation to an interior of a body 失效
标题翻译：具有用于将局部辐射传送到身体内部的扩张结构的X射线装置
公开(公告)号：US6095966A
公开(公告)日：2000-08-01
申请号：US27010
申请日：1998-02-20
申请人： Victor I. Chornenky , Michael R. Forman , Robert A. Ganz
发明人： Victor I. Chornenky , Michael R. Forman , Robert A. Ganz
IPC分类号： A61N5/10 , H01J35/32
CPC分类号： A61N5/1001 , H01J35/32 , A61N5/1002 , H01J2235/205
摘要： Generally, the present invention provides a device for insertion into a body of a subject being treated to deliver localized x-ray radiation, and a method for use of such a device. The device includes an anode and a cathode, disposed within a vacuum housing. The device further includes a balloon coupled to and circumferentially surrounding the vacuum housing, and a fluid loop for circulating a cooling fluid proximate to the vacuum housing. A method for delivering localized x-ray radiation to an interior passage of a body is also described, including the steps of positioning an x-ray device at the passage to be treated and applying a high voltage to the x-ray producing unit to produce localized x-ray radiation.
摘要翻译：通常，本发明提供一种用于插入被处理以递送局部x射线辐射的对象的身体的装置，以及使用这种装置的方法。该装置包括设置在真空壳体内的阳极和阴极。该装置还包括联接到并围绕真空壳体并围绕真空壳体的气囊，以及用于使靠近真空壳体的冷却流体循环的流体回路。还描述了将局部X射线辐射递送到身体的内部通道的方法，包括以下步骤：将X射线装置定位在待治疗的通道处，并向x射线产生单元施加高电压以产生局部x射线辐射。

7. 发明授权

US5854822A Miniature x-ray device having cold cathode 失效
标题翻译：具有冷阴极的微型x射线装置
公开(公告)号：US5854822A
公开(公告)日：1998-12-29
申请号：US900609
申请日：1997-07-25
申请人： Victor I. Chornenky , Dale L. Schreiner , Michael R. Forman
发明人： Victor I. Chornenky , Dale L. Schreiner , Michael R. Forman
IPC分类号： H01J35/06 , A61N5/10 , H01J35/20 , H01J35/32
CPC分类号： A61N5/1001 , H01J35/32 , A61N5/1002
摘要： Generally, the present invention provides a device for insertion into a body and delivery of x-ray radiation, and a method for fabricating such a device. The device includes a connector, the vacuum housing, an anode and a cathode having a granular surface and being composed of a material that allows it to act as a getter. The cathode may also contain diamond material in one embodiment.
摘要翻译：通常，本发明提供了一种用于插入身体和X射线辐射的输送的装置，以及用于制造这种装置的方法。该装置包括连接器，真空壳体，具有颗粒表面的阳极和阴极，并且由允许其用作吸气剂的材料组成。在一个实施方案中，阴极还可以含有金刚石材料。

8. 发明申请

US20100262067A1 Method for Treatment of Neoplastic Cells in the Prostate of a Patient 有权
标题翻译：用于治疗患者前列腺中的肿瘤细胞的方法
公开(公告)号：US20100262067A1
公开(公告)日：2010-10-14
申请号：US12820955
申请日：2010-06-22
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61N1/30 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

9. 发明授权

US07130697B2 Apparatus and method for the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的装置和方法
公开(公告)号：US07130697B2
公开(公告)日：2006-10-31
申请号：US10668775
申请日：2003-09-23
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61F2/00 , A61B18/18
CPC分类号： A61N1/325 , A61B18/1477 , A61B18/1485 , A61B2017/00274 , A61B2018/00547 , A61B2018/1425
摘要： An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.
摘要翻译：公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

10. 发明授权

US08647338B2 Method of destroying tissue cells by electroporation 有权
标题翻译：通过电穿孔破坏组织细胞的方法
公开(公告)号：US08647338B2
公开(公告)日：2014-02-11
申请号：US13556455
申请日：2012-07-24
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.
摘要翻译：提供了通过破坏组织细胞来治疗人体的方法。所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体，在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

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