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1. 发明授权

US06546077B2 Miniature X-ray device and method of its manufacture 失效
公开(公告)号：US06546077B2
公开(公告)日：2003-04-08
申请号：US09760815
申请日：2001-01-17
申请人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
发明人： Victor I. Chornenky , Eunsung Park , Graham S. Kerslick , Ali Jaafar , Mark Gailloux
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , H01J35/32 , H01J2235/164
摘要： An emitter for a miniature X-ray apparatus comprises an insulating shell, an anode, and a cathode. The insulating shell includes a conical brazing surface, brazed to a conical brazing surface on the anode. The braze consists of a pure titanium layer and a pure tin layer. During brazing, the pure metals react and bond to the insulating shell and create a titanium-tin alloy between the pure layers. Pure tin is sputtered from tin sputter target onto the exposed brazing surfaces of the cathode cap and the anode. The insulating shell is placed in a vacuum chamber of deposition applicator, which deposits an active metal onto the shell brazing surface. In a brazing oven, the anode is placed within insulating shell such that the anode conical brazing surface and the shell conical brazing surface are contacting and aligned with each other. During brazing, the cathode is brought into contact with the insulating shell. The sealed emitters are placed in a sputtering machine's vacuum chamber. A metal is sputtered from a sputtering target to form a metal layer on the exterior of insulating shell.

2. 发明授权

US06771737B2 X-ray catheter with miniature emitter and focusing cup 失效
标题翻译：带微型发射器和聚焦杯的X射线导管
公开(公告)号：US06771737B2
公开(公告)日：2004-08-03
申请号：US09902659
申请日：2001-07-12
申请人： Graham S. Kerslick , Victor I. Chornenky , Ali Jaafar
发明人： Graham S. Kerslick , Victor I. Chornenky , Ali Jaafar
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , A61N5/1002 , H01J35/32 , H01J2235/062 , H01J2235/164
摘要： A cathode for a miniature X-ray device includes an insulating shell, a cathode and an anode. The cathode includes a focusing cup formed into an end. The focusing cup can include a thin metal layer that conforms to an inner surface of the cathode. An emitting material having a low work function, such as diamond, is deposited directly onto the internal surface of the focusing cup. The anode has a flat receiving surface for collecting electrons emitted from the anode. An interior coating is applied as a circumferential belt on the interior surface of the insulating shell. The interior coating, formed of a negative secondary emission yield material, extends lengthwise in the region of the cathode to an anode gap, covering the region of the insulating shell most likely to be subject to stray electrons emitted from the cathode.
摘要翻译：用于微型X射线装置的阴极包括绝缘壳，阴极和阳极。阴极包括形成在一端的聚焦杯。聚焦杯可以包括符合阴极内表面的薄金属层。具有低功函数的发射材料（例如金刚石）直接沉积在聚焦杯的内表面上。阳极具有用于收集从阳极发射的电子的平坦的接收表面。内部涂层作为周向带施加在绝缘壳体的内表面上。由负二次发射产生材料形成的内部涂层在阴极的区域中纵向延伸到阳极间隙，覆盖最可能经受从阴极发射的杂散电子的绝缘壳体的区域。

3. 发明授权

US06415016B1 Crystal quartz insulating shell for X-ray catheter 失效
标题翻译：用于X射线导管的水晶石英绝缘壳
公开(公告)号：US06415016B1
公开(公告)日：2002-07-02
申请号：US09756287
申请日：2001-01-09
申请人： Victor I. Chornenky , Ali Jaafar , Graham S. Kerslick
发明人： Victor I. Chornenky , Ali Jaafar , Graham S. Kerslick
IPC分类号： H01J3500
CPC分类号： A61N5/1001 , H01J35/32 , H01J2235/164
摘要： An insulating housing shell for a miniature x-ray emitter is provided. The housing shell is cut from a quartz monocrystal which is a suitable material for the insulating housing shell due to its resistivity and dielectric strength properties. The x-ray emitter can be inserted into a subject's body to deliver x-ray radiation. The emitter includes a cable, having a proximal and a distal portion. The insulating housing shell is coupled to the distal portion of the cable, and an anode and a cathode are disposed within the insulating housing shell. The cathode has a granular surface and is operative with the anode and the connector to produce the x-ray radiation. The cathode is composed of a material that also allows it to act as a getter.
摘要翻译：提供了一种用于微型x射线发射器的绝缘外壳。壳体由石英单晶切割，由于其电阻率和介电强度特性，绝缘外壳是合适的材料。 X射线发射器可插入受试者的身体以传送X射线辐射。发射器包括具有近端部分和远端部分的电缆。绝缘壳体壳体耦合到电缆的远端部分，阳极和阴极设置在绝缘外壳壳体内。阴极具有颗粒表面并且与阳极和连接器一起工作以产生x射线辐射。阴极由也可以用作吸气剂的材料组成。

4. 发明授权

US06473491B2 Method and x-ray device using adaptable power source 失效
标题翻译：使用适应电源的方法和x射线装置
公开(公告)号：US06473491B2
公开(公告)日：2002-10-29
申请号：US09748296
申请日：2000-12-21
申请人： Victor I. Chornenky , Graham S. Kerslick , Michael R. Satteson , Steven T. Meyer
发明人： Victor I. Chornenky , Graham S. Kerslick , Michael R. Satteson , Steven T. Meyer
IPC分类号： H05G134
CPC分类号： A61N5/1001 , H05G1/32
摘要： A method described includes positioning an x-ray emitter at a treatment area, where the x-ray emitter is connected to a cable, setting a voltage source at a source voltage, and measuring a current through the x-ray emitter. The method may include comparing a current flowing through the emitter with a limit and a low limit. The method further includes increasing the source voltage if the current is higher than the high limit. The method includes determining the high limit and the low limit based on the source voltage and the desired radiation. An apparatus of the invention includes an x-ray emitter with a voltage source and a current sensor. The apparatus may include a current comparison device for comparing the measured current with a high limit and a low limit, and further include a voltage source control. A current integrator for integrating a current from the x-ray emitter may also be included.
摘要翻译：所描述的方法包括将x射线发射器定位在处理区域，其中x射线发射器连接到电缆，将电压源设置为源极电压，并测量通过x射线发射器的电流。该方法可以包括比较流经发射器的电流与极限和下限。该方法还包括如果电流高于上限，则增加源极电压。该方法包括基于源电压和期望的辐射来确定上限和下限。本发明的装置包括具有电压源和电流传感器的x射线发射器。该装置可以包括用于将测量的电流与上限和下限进行比较的电流比较装置，并且还包括电压源控制。还可以包括用于积分来自x射线发射器的电流的电流积分器。

5. 发明申请

US20100262067A1 Method for Treatment of Neoplastic Cells in the Prostate of a Patient 有权
标题翻译：用于治疗患者前列腺中的肿瘤细胞的方法
公开(公告)号：US20100262067A1
公开(公告)日：2010-10-14
申请号：US12820955
申请日：2010-06-22
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61N1/30 , A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B2018/00029 , A61B2018/00285 , A61B2018/00434 , A61B2018/00517 , A61B2018/00547 , A61B2018/00613 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/325
摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.
摘要翻译：公开了一种用于治疗良性前列腺增生的装置和方法。该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

6. 发明授权

US07130697B2 Apparatus and method for the treatment of benign prostatic hyperplasia 有权
标题翻译：用于治疗良性前列腺增生的装置和方法
公开(公告)号：US07130697B2
公开(公告)日：2006-10-31
申请号：US10668775
申请日：2003-09-23
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61F2/00 , A61B18/18
CPC分类号： A61N1/325 , A61B18/1477 , A61B18/1485 , A61B2017/00274 , A61B2018/00547 , A61B2018/1425
摘要： An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.
摘要翻译：公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

7. 发明授权

US08647338B2 Method of destroying tissue cells by electroporation 有权
标题翻译：通过电穿孔破坏组织细胞的方法
公开(公告)号：US08647338B2
公开(公告)日：2014-02-11
申请号：US13556455
申请日：2012-07-24
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.
摘要翻译：提供了通过破坏组织细胞来治疗人体的方法。所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体，在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

8. 发明申请

US20110009860A1 Apparatus and Method for Reducing Subcutaneous Fat Deposits, Virtual Face Lift and Body Sculpturing by Electroporation 有权
标题翻译：用于减少皮下脂肪沉积的装置和方法，通过电穿孔进行虚拟面部提升和身体雕刻
公开(公告)号：US20110009860A1
公开(公告)日：2011-01-13
申请号：US12501225
申请日：2009-07-10
申请人： Victor I. Chornenky , Ali Jaafar
发明人： Victor I. Chornenky , Ali Jaafar
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/1445 , A61B18/1477 , A61B2018/00452 , A61B2018/00613 , A61B2018/1425 , A61B2018/143 , A61N1/0412
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.
摘要翻译：提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

9. 发明授权

US06892099B2 Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation 有权
标题翻译：用于减少皮下脂肪沉积物，虚拟面部提升和通过电穿孔进行身体雕刻的装置和方法
公开(公告)号：US06892099B2
公开(公告)日：2005-05-10
申请号：US09931672
申请日：2001-08-17
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： A61N1/32 , A61N1/34 , A61N1/18
CPC分类号： A61N1/325 , A61N1/0424 , A61N1/327 , A61N1/328 , A61N1/36014
摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.
摘要翻译：提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

10. 发明授权

US06699230B2 Apparatus and method for out-of-hospital thrombolytic therapy 失效
标题翻译：用于门诊溶栓治疗的装置和方法
公开(公告)号：US06699230B2
公开(公告)日：2004-03-02
申请号：US09849051
申请日：2001-05-07
申请人： Ali Jaafar , Victor I. Chornenky
发明人： Ali Jaafar , Victor I. Chornenky
IPC分类号： A61M3100
CPC分类号： A61M5/1456 , A61J3/002 , A61M5/1407 , A61M5/14244 , A61M5/1452 , A61M5/172 , A61M5/44 , A61M39/223 , A61M2005/1402 , A61M2205/3553 , A61M2205/3584 , A61M2205/3606 , A61M2205/50 , A61M2205/8206
摘要： This invention provides an apparatus and method for emergency administration or self-administration of thrombolytic therapy in early stage of a heart attack. The apparatus includes a needle injector for making a venipuncture, a battery operated micro cooler for maintaining low temperature environment for vials with lyophilized thrombolytic and adjuvant drugs, a container with a diluent for reconstitution of the lyophilized drugs, a programmable infusion pump, and a microprocessor for controlling the process of infusion and recording the data. As the system is activated, said container becomes fluidly communicable with the infusion pump and vials with drugs in the cooler. Designed for autonomous execution of several schedules of infusion, it also can be controlled remotely by a qualified operator via an Internet interface.
摘要翻译：本发明提供了一种在心脏病发作早期进行血栓溶解治疗的应急管理或自我管理的装置和方法。该装置包括用于制造静脉穿刺的针注射器，用于维持具有冻干溶栓剂和辅助药物的小瓶的低温环境的电池操作微冷却器，具有用于重构冻干药物的稀释剂的容器，可编程输液泵和微处理器用于控制输液和记录数据的过程。当系统被激活时，所述容器变得与输液泵流体连通，并将药物放在冷却器中。专为自动执行几个输液时间表而设计，也可以由合格的操作员通过互联网接口远程控制。

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