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1. 发明授权

US07405082B2 Methods and devices for measuring reticulocytes 有权
标题翻译：测量网织红细胞的方法和装置
公开(公告)号：US07405082B2
公开(公告)日：2008-07-29
申请号：US10655739
申请日：2003-09-05
申请人： Toshihiro Mizukami , Yusuke Mori , Kanako Horisaka , Sunao Atogami
发明人： Toshihiro Mizukami , Yusuke Mori , Kanako Horisaka , Sunao Atogami
IPC分类号： G01N33/48 , G01N21/64
CPC分类号： G01N21/51 , G01N15/1456 , G01N21/645 , G01N2015/0076 , G01N2015/1486 , G01N2021/1734 , G01N2021/174 , G01N2021/178 , G01N2021/4707 , Y10T436/10 , Y10T436/101666
摘要： Methods and devices are described for monitoring a therapeutic effect in a red blood cell-related disease by detecting the size of a reticulocyte using a full-automatic blood cell counting device.
摘要翻译：描述了通过使用全自动血细胞计数装置检测网织红细胞的大小来监测红细胞相关疾病的治疗效果的方法和装置。

2. 发明授权

US07923229B2 Method of classifying and counting leukocytes 有权
标题翻译：白细胞分类和计数方法
公开(公告)号：US07923229B2
公开(公告)日：2011-04-12
申请号：US11926918
申请日：2007-10-29
申请人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12N13/00
CPC分类号： G01N33/52 , G01N2015/1477
摘要： A method for classifying and counting leukocytes, which comprises steps of: staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; introducing the sample containing the stained cells into a flow cytometer to measure first scattered light, second scattered light different from the first scattered light and fluorescence of the respective cells; obtaining scattered light peak intensities and scattered light widths of the respective cells based on the measured first scattered light, obtaining scattered light intensities of the respective cells based on the measured second scattered light, and obtaining fluorescence intensities of the respective cells based on the measured fluorescence light; classifying the cells into a first group and a second group based on the scattered light peak intensities and the scattered light widths, the first group including leukocytes and second group including platelet clumps; classifying the leukocytes included in the first group into at least lymphocytes, monocytes and granulocytes based on the scattered light intensities and the fluorescence intensities; and counting the classified lymphocytes, the classified monocytes and the classified granulocytes.
摘要翻译：一种白细胞分类和计数方法，其特征在于包括以下步骤：用溶血剂用荧光染料染色从血液样品中获得的样品中的细胞; 将含有染色细胞的样品引入流式细胞仪中以测量第一散射光，与第一散射光不同的第二散射光和各细胞的荧光; 基于所测量的第一散射光获得各个单元的散射光峰强度和散射光宽度，基于测量的第二散射光获得各个单元的散射光强度，并且基于测量的荧光获得各个单元的荧光强度光; 基于散射光峰强度和散射光宽度将细胞分类为第一组和第二组，第一组包括白细胞和第二组包括血小板聚集; 基于散射光强度和荧光强度，将第一组中包含的白细胞分类为至少淋巴细胞，单核细胞和粒细胞; 并对分类的淋巴细胞，分类的单核细胞和分类的粒细胞进行计数。

3. 发明申请

US20050202400A1 Method of classifying counting leucocytes 有权
标题翻译：白细胞计数分类方法
公开(公告)号：US20050202400A1
公开(公告)日：2005-09-15
申请号：US10517422
申请日：2003-06-23
申请人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： G01N15/00 , G01N15/14 , G01N33/52 , C12Q1/00
CPC分类号： G01N33/52 , G01N2015/1477
摘要： There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the fluorescence intensity at least among mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure scattered light and fluorescence of the respective cells; (3) a step of classifying leukocytes and coincidence cells/platelet clumps utilizing a difference in the intensity of a scattered light peak and a difference in the scattered light width; (4) a step of classifying and counting mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes, utilizing a difference in the scattered light intensity and a difference in the fluorescence intensity of leukocytes classified in the step (3).
摘要翻译：提供了一种用于对异常DNA量进行白细胞分类和计数的方法，其包括：（1）通过用溶血剂处理从血液样品获得的样品中的细胞染色红细胞裂解红细胞的步骤，可以使用荧光染料至少在成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞之间的荧光强度差异; （2）将含有染色细胞的样品引入流式细胞仪中以测量各细胞的散射光和荧光的步骤; （3）利用散射光峰的强度和散射光宽度的差异来分类白细胞和符合细胞/血小板结块的步骤; （4）利用步骤（3）中分类的散射光强度和白细胞的荧光强度差异，对成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞进行分类和计数的步骤。

4. 发明申请

US20060223138A1 Method and apparatus for counting megakaryocytes 有权
标题翻译：计数巨核细胞的方法和装置
公开(公告)号：US20060223138A1
公开(公告)日：2006-10-05
申请号：US11392651
申请日：2006-03-30
申请人： Yusuke Mori , Toshihiro Mizukami , Tomohiro Tsuji , Yoshiro Ikeuchi
发明人： Yusuke Mori , Toshihiro Mizukami , Tomohiro Tsuji , Yoshiro Ikeuchi
IPC分类号： G01N33/48 , G01N1/30
CPC分类号： G01N15/147 , G01N33/5002 , G01N33/5094 , G01N33/80 , G01N2015/0073
摘要： A method for counting megakaryocytes in a specimen is described. In the method, first, erythrocytes in the specimen are lysed and nucleic acid in the megakaryocytes is stained with a fluorescent dye, and thereby, a measurement sample is prepared. Next, the cells in the measurement sample are irradiated with excited light so that the forward scattered light, the side scattered light and the fluorescence, which are emitted from the cells, are detected. Megakaryocytes are identified on the basis of the detected forward scattered light, the fluorescence and the side scattered light. Then, the identified megakaryocytes are counted.
摘要翻译：描述了一种用于计数样本中的巨核细胞的方法。在该方法中，首先将样品中的红细胞裂解，并用荧光染料染色巨核细胞中的核酸，由此制备测定样品。接下来，用激发光照射测量样品中的单元，从而检测从单元发射的前向散射光，侧向散射光和荧光。在检测到的前向散射光，荧光和侧向散射光的基础上鉴定巨核细胞。然后，计算鉴定的巨核细胞。

5. 发明授权

US07625730B2 Method for classifying and counting leukocytes 有权
标题翻译：白细胞分类和计数方法
公开(公告)号：US07625730B2
公开(公告)日：2009-12-01
申请号：US10517422
申请日：2003-06-23
申请人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12N13/00
CPC分类号： G01N33/52 , G01N2015/1477
摘要： There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the fluorescence intensity at least among mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure scattered light and fluorescence of the respective cells; (3) a step of classifying leukocytes and coincidence cells/platelet clumps utilizing a difference in the intensity of a scattered light peak and a difference in the scattered light width; (4) a step of classifying and counting mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes, utilizing a difference in the scattered light intensity and a difference in the fluorescence intensity of leukocytes classified in the step (3).
摘要翻译：提供了一种用于对异常DNA量进行白细胞分类和计数的方法，其包括：（1）通过用溶血剂处理从血液样品获得的样品中的细胞染色红细胞裂解红细胞的步骤，可以使用荧光染料至少在成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞之间的荧光强度差异; （2）将含有染色细胞的样品引入流式细胞仪中以测量各细胞的散射光和荧光的步骤; （3）利用散射光峰的强度和散射光宽度的差异来分类白细胞和符合细胞/血小板结块的步骤; （4）利用步骤（3）中分类的散射光强度和白细胞的荧光强度差异，对成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞进行分类和计数的步骤。

6. 发明授权

US07569373B2 Method for counting megakaryocytes 有权
标题翻译：巨核细胞计数方法
公开(公告)号：US07569373B2
公开(公告)日：2009-08-04
申请号：US11392651
申请日：2006-03-30
申请人： Yusuke Mori , Toshihiro Mizukami , Tomohiro Tsuji , Yoshiro Ikeuchi
发明人： Yusuke Mori , Toshihiro Mizukami , Tomohiro Tsuji , Yoshiro Ikeuchi
IPC分类号： C12N13/00
CPC分类号： G01N15/147 , G01N33/5002 , G01N33/5094 , G01N33/80 , G01N2015/0073
摘要： A method for counting megakaryocytes in a specimen is described. In the method, first, erythrocytes in the specimen are lysed and nucleic acid in the megakaryocytes is stained with a fluorescent dye, and thereby, a measurement sample is prepared. Next, the cells in the measurement sample are irradiated with excited light so that the forward scattered light, the side scattered light and the fluorescence, which are emitted from the cells, are detected. Megakaryocytes are identified on the basis of the detected forward scattered light, the fluorescence and the side scattered light. Then, the identified megakaryocytes are counted.
摘要翻译：描述了一种用于计数样本中的巨核细胞的方法。在该方法中，首先将样品中的红细胞裂解，并用荧光染料染色巨核细胞中的核酸，由此制备测定样品。接下来，用激发光照射测量样品中的单元，从而检测从单元发射的前向散射光，侧向散射光和荧光。在检测到的前向散射光，荧光和侧向散射光的基础上鉴定巨核细胞。然后，计算鉴定的巨核细胞。

7. 发明申请

US20080176274A1 METHOD OF CLASSIFYING AND COUNTING LEUCOCYTES 有权
标题翻译：分类和计数白细胞的方法
公开(公告)号：US20080176274A1
公开(公告)日：2008-07-24
申请号：US11926918
申请日：2007-10-29
申请人： Tomohiro TSUJI , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro TSUJI , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12Q1/04
CPC分类号： G01N33/52 , G01N2015/1477
摘要： 1. A method for classifying and counting leukocytes, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure first scattered light, second scattered light different from the first scattered light and fluorescence of the respective cells; (3) a step of obtaining scattered light peak intensities and scattered light widths of the respective cells based on the measured first scattered light, obtaining scattered light intensities of the respective cells based on the measured second scattered light, and obtaining fluorescece intensities of the respective cells based on the measured fluorescence light; (4) a step of classifying the cells into a first group and a second group based on the scattered light peak intensities and the scattered light widths, the first group including leukocytes and second group including platelet clumps; (5) a step of classifying the leukocytes included in the first group into at least lymphocytes, monocytes and granulocytes based on the scattered light intensities and the fluorescence intensities; and (6) a step of counting the classified lymphocytes, the classified monocytes and the classified granulocytes.
摘要翻译： 1.一种白细胞分类和计数方法，其特征在于：（1）通过用溶血剂用荧光染料处理从血液样品获得的样品中染色细胞的步骤; （2）将含有染色细胞的样品引入流式细胞仪中以测量第一散射光，与第一散射光不同的第二散射光和各细胞的荧光的步骤; （3）基于所测量的第一散射光获得各个单元的散射光峰强度和散射光宽度的步骤，基于测量的第二散射光获得各个单元的散射光强度，并获得各个单元的荧光强度基于测量荧光的细胞; （4）基于散射光峰强度和散射光宽度，将细胞分类为第一组和第二组的步骤，所述第一组包括白细胞，第二组包括血小板聚集; （5）基于散射光强度和荧光强度，将包含在第一组中的白细胞分类为至少淋巴细胞，单核细胞和粒细胞的步骤; 和（6）计数分类的淋巴细胞，分类的单核细胞和分类的粒细胞的步骤。

8. 发明授权

US08790929B2 Reagent for diluting blood sample and method for measuring mean corpuscular volume by using the same 有权
标题翻译：用于稀释血液样本的试剂和通过使用相同的方法测量平均红细胞体积
公开(公告)号：US08790929B2
公开(公告)日：2014-07-29
申请号：US12497952
申请日：2009-07-06
申请人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
发明人： Yusuke Mori , Kinya Uchihashi , Yasuhiro Sakai
IPC分类号： G01N33/48
CPC分类号： G01N1/38 , G01N15/1209 , G01N2015/1236
摘要： The invention provides a reagent for diluting a blood sample, comprising water, polyoxyethylene alkyl ether having a hydroxyl value of 52 to 60, and an osmo-regulator for regulating the osmotic pressure of the reagent in the range of 150 to 400 mOsm/kg, as well as a method for measuring the mean corpuscular volume of a blood sample.
摘要翻译：本发明提供了一种用于稀释血液样品的试剂，包括水，羟值为52至60的聚氧乙烯烷基醚和用于调节试剂渗透压的渗透压调节剂，范围为150-400mOsm / kg，以及用于测量血液样品的平均红细胞体积的方法。

9. 发明授权

US08443017B2 Digital data processor 有权
标题翻译：数字数据处理器
公开(公告)号：US08443017B2
公开(公告)日：2013-05-14
申请号：US12758198
申请日：2010-04-12
申请人： Ryoji Suzuki , Yusuke Mori
发明人： Ryoji Suzuki , Yusuke Mori
IPC分类号： G06F7/00
CPC分类号： G11B20/10527 , G06F5/01 , G10L21/0364
摘要： A digital data processor which receives an N-bit input signal from a data source and converts the N-bit input signal into an M-bit output signal, the M-bit being larger than the N-bit. The digital data processor includes: an weighted addition circuit which is operable to perform weighted addition on at least the input signal and a signal being time-shifted with respect to the input signal and output as a weighted added input signal; an arithmetic shift circuit which is operable to perform an arithmetic rightward shift operation on the weighted added input signal for a predetermined number of shifts and output as a processed input signal; a bit extension circuit which is operable to attach a predetermined bits to an LSD side of the input signal to generate an intermediate signal of M bits; and an addition circuit which is operable to perform addition of the intermediate signal and the processed input signal so as to generate the M-bit output signal.
摘要翻译：数字数据处理器，其从数据源接收N位输入信号，并将N位输入信号转换成M位输出信号，M位大于N位。所述数字数据处理器包括：加权加法电路，其可操作以至少对所述输入信号执行加权相加，以及相对于所述输入信号进行时移的信号，并作为加权相加输入信号输出; 算术移位电路，其可操作以对所述加权的相加输入信号执行预定数量的移位并作为经处理的输入信号输出的算术右移移位操作; 一个扩展电路，用于将预定的比特附加到输入信号的LSD侧，以产生M比特的中间信号; 以及加法电路，其可操作以执行中间信号和经处理的输入信号的相加以便产生M位输出信号。

10. 发明授权

US08372299B2 Substrate treating apparatus and substrate treating method 有权
标题翻译：基板处理装置及基板处理方法
公开(公告)号：US08372299B2
公开(公告)日：2013-02-12
申请号：US12411266
申请日：2009-03-25
申请人： Yasunori Nakajima , Yusuke Mori
发明人： Yasunori Nakajima , Yusuke Mori
IPC分类号： C03C15/00
CPC分类号： B08B3/08 , B08B3/048
摘要： A method and apparatus for performing treatment of substrates with a treating liquid. A first storage unit stores an initial life count specifying an allowable number of treatments of substrates to be carried out with treating liquid after an entire liquid replacement with a new supply of the treating liquid; a second storage device stores a normal life count specifying an allowable number of treatments to be carried out with the treating liquid after reaching the initial life count and after a partial liquid replacement; and a control device repeats treatment of the substrates after the entire liquid replacement until the initial life count is reached; and after the initial life count has been reached and the partial liquid replacement has been made, repeats treatment of the substrates until the normal life count is reached, and makes the partial liquid replacement each succeeding time the normal life count is reached.
摘要翻译：一种用处理液进行基材处理的方法和装置。第一存储单元存储初始寿命数，其指定在处理液的新供应之后，在整个液体置换之后，用待处理液进行处理的基板的允许数量; 第二存储装置在达到初始寿命计数之后和在部分液体置换之后存储指定要用处理液进行的处理的允许数量的正常寿命计数; 并且控制装置在整个液体置换之后重复对基板的处理，直到达到初始寿命计数; 在达到初始寿命计数并进行部分液体置换之后，重复对基板的处理，直到达到正常寿命计数，并且在随后的时间达到正常寿命计数之后进行部分液体置换。

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