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1. 发明申请

US20140011823A1 NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME 有权
标题翻译：新颖的吡啶衍生物和含有其的药物
公开(公告)号：US20140011823A1
公开(公告)日：2014-01-09
申请号：US14005046
申请日：2012-03-13
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D413/14 , A61K31/506 , C07D401/14
摘要： The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents an alkyl group; R2 represents an alkyl group or a cycloalkyl group; and R3, R4, and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.
摘要翻译：本发明提供：下述通式（I）表示的化合物，既具有血管紧张素II受体拮抗作用又具有PPARγ活化作用，可用作高血压，心脏病，动脉硬化等的预防和/或治疗剂， 2型糖尿病等; 和含有该化合物的药物组合物。通式（I）（式中，环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示烷基 ; R 2表示烷基或环烷基; R 3，R 4和R 5各自独立地表示氢原子，卤素原子，烷基，烷氧基等。

2. 发明授权

US09315493B2 Phenylpyridine derivative and drug containing same 有权
标题翻译：苯基吡啶衍生物和含有它们的药物
公开(公告)号：US09315493B2
公开(公告)日：2016-04-19
申请号：US14005046
申请日：2012-03-13
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/505 , C07D413/14 , C07D401/14 , A61K31/506
CPC分类号： C07D413/14 , A61K31/506 , C07D401/14
摘要： The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents an alkyl group; R2 represents an alkyl group or a cycloalkyl group; and R3, R4, and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.
摘要翻译：本发明提供：下述通式（I）表示的化合物，其具有血管紧张素II受体拮抗作用和PPARγ活化作用，可用作高血压，心脏病，动脉硬化等的预防和/或治疗剂， 2型糖尿病等; 和含有该化合物的药物组合物。通式（I）（式中，环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示烷基 ; R 2表示烷基或环烷基; R 3，R 4和R 5各自独立地表示氢原子，卤素原子，烷基，烷氧基等。

3. 发明申请

US20120165353A1 NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME 有权
标题翻译：新颖的苯丙氨酸衍生物和药物包括它们
公开(公告)号：US20120165353A1
公开(公告)日：2012-06-28
申请号：US13394266
申请日：2010-09-29
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/506 , C07D413/14 , A61P9/00 , A61P13/12 , A61P3/10 , A61P9/10 , A61P9/12 , C07D401/14 , A61P3/00
CPC分类号： C07D401/14 , A61K31/422 , A61K31/4427 , C07D413/14
摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.
摘要翻译：公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂，代谢综合征等; 和含有该化合物的药物组合物。具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3，R4，R5分别表示氢原子，卤素原子，C1-6烷基，卤代C 1-6烷基或可具有取代基的C 1-6烷氧基），化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物，该盐或溶剂化物的药物组合物。

4. 发明授权

US08778954B2 Phenylpyridine derivative and medicinal agent comprising same 有权
标题翻译：苯基吡啶衍生物和含有它们的药剂
公开(公告)号：US08778954B2
公开(公告)日：2014-07-15
申请号：US13394266
申请日：2010-09-29
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： C07D401/14 , A61K31/422 , A61K31/4427
CPC分类号： C07D401/14 , A61K31/422 , A61K31/4427 , C07D413/14
摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.
摘要翻译：公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂，代谢综合征等; 和含有该化合物的药物组合物。具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3，R4，R5分别表示氢原子，卤素原子，C1-6烷基，卤代C 1-6烷基或可具有取代基的C 1-6烷氧基），化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物，该盐或溶剂化物的药物组合物。

5. 发明申请

US20120264753A1 NOVEL 1-(BIPHENYL-4-YL-METHYL)-1H-IMIDAZOLE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME 审中-公开
标题翻译：新颖的1-（联苯-4-基甲基）-1H-咪唑衍生物和含有它们的药物产品
公开(公告)号：US20120264753A1
公开(公告)日：2012-10-18
申请号：US13511876
申请日：2010-12-22
申请人： Toru Miura , Hajime Yamada , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Hajime Yamada , Junya Tagashira , Gen Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/4178 , A61K31/4245 , C07D413/14 , A61K31/506 , C07D403/14 , A61K31/5377 , C07D403/10 , A61P9/00 , A61P9/12 , A61P9/10 , A61P13/12 , A61P3/00 , A61P3/10 , A61P25/00 , C07D413/10
CPC分类号： C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14
摘要： Disclosed is a novel 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative represented by general formula (I), which has both angiotensin II receptor antagonist activity and PPAR-γ activating activity and is useful as a prophylactic and/or therapeutic agent for cardiovascular diseases and metabolic diseases. Also disclosed is a pharmaceutical composition which contains the novel 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative. In general formula (I), ring A represents a group represented by formula (II) or (III); R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group which may be substituted by a hydroxy group, or a group represented by formula —CO—R4 (wherein R4 represents a hydroxy group, a C1-6 alkoxy group, an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group, a morpholino group, a piperidino group or a pyrrolidino group); R3 represents a halogen atom or a C1-6 alkoxy group; and X and Y may be the same or different and each represents a nitrogen atom or CH.
摘要翻译：公开了由通式（I）表示的新颖的1-（联苯-4-基 - 甲基）-1H-咪唑衍生物，其具有血管紧张素II受体拮抗剂活性和PPAR-γ活化活性，可用作预防和/ 或用于心血管疾病和代谢疾病的治疗剂。还公开了含有新的1-（联苯-4-基 - 甲基）-1H-咪唑衍生物的药物组合物。在通式（I）中，环A表示由式（II）或（III）表示的基团; R1表示C1-6烷基; R2表示可以被羟基取代的C1-6烷基或由式-CO-R4表示的基团（其中R4表示羟基，C1-6烷氧基，氨基，单（C1 -6烷基）氨基，二（C 1-6烷基）氨基，吗啉代基，哌啶子基或吡咯烷子基）。 R3表示卤素原子或C1-6烷氧基; X和Y可以相同或不同，各自表示氮原子或CH。

6. 发明授权

US08575153B2 Pyridine-3-carboxyamide derivative 有权
标题翻译：吡啶-3-甲酰胺衍生物
公开(公告)号：US08575153B2
公开(公告)日：2013-11-05
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

7. 发明申请

US20110237590A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE 有权
标题翻译：吡啶-3-羧酰胺衍生物
公开(公告)号：US20110237590A1
公开(公告)日：2011-09-29
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/5377 , C07D213/74 , C07D401/12 , C07D413/12 , C07D211/46 , A61K31/44 , A61K31/497 , A61K31/4545 , A61P37/02 , A61P37/06
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂合物。

8. 发明申请

US20150006624A1 CONTENT SERVICE SYSTEM 审中-公开
标题翻译：内容服务系统
公开(公告)号：US20150006624A1
公开(公告)日：2015-01-01
申请号：US14365350
申请日：2012-03-05
申请人： Hajime Yamada
发明人： Hajime Yamada
IPC分类号： H04L29/08 , H04L29/06
CPC分类号： H04L67/1036 , H04L63/102 , H04L67/42 , H04N21/2353 , H04N21/2541 , H04N21/25891 , H04N21/26283 , H04N21/2668
摘要： [Problem] A method by which a content-usage device connected to a network acquires a usable-service list from a server, and provides a service to a user on. the basis of the information shown on the service list, wherein it is not possible to change the services shown in response to conditions, and therefore the service does not conform to the user's needs and is not useful. [Solution] The present invention provides a content service system having a presentation-condition server device for transmitting presentation conditions for identifying a limited content list, the limited content list being a list of the part of the content, from a distributed content list, presented to the user on the content-usage device.
摘要翻译： [问题]连接到网络的内容使用装置通过该方法从服务器获取可用服务列表，并向用户提供服务。在服务列表上显示的信息的基础，其中不可能改变响应于条件显示的服务，因此服务不符合用户的需要，并且不是有用的。解决方案本发明提供了一种内容服务系统，其具有呈现条件服务器设备，用于从分布式内容列表发送用于识别有限内容列表的呈现条件，作为内容的一部分的列表的有限内容列表到内容使用设备上的用户。

9. 发明申请

US20120246680A1 PROGRAM-INFORMATION DISPLAYING DEVICE, PROGRAM-INFORMATION DISPLAYING METHOD, PROGRAM, AND RECORDING MEDIUM 审中-公开
标题翻译：程序信息显示装置，程序信息显示方法，程序和记录介质
公开(公告)号：US20120246680A1
公开(公告)日：2012-09-27
申请号：US13514525
申请日：2010-12-08
申请人： Toru Hirota , Noriyuki Kudoh , Yukimi Kawaguchi , Yuhji Ohi , Yoshiyasu Ogasawara , Ryuhsuke Watanabe , Hajime Yamada , Nario Okuda , Takahiro Ogasawara
发明人： Toru Hirota , Noriyuki Kudoh , Yukimi Kawaguchi , Yuhji Ohi , Yoshiyasu Ogasawara , Ryuhsuke Watanabe , Hajime Yamada , Nario Okuda , Takahiro Ogasawara
IPC分类号： H04N5/445
CPC分类号： H04N21/47214 , H04N5/44543 , H04N21/4312 , H04N21/4334 , H04N21/458 , H04N21/4668 , H04N21/4821 , H04N21/4826 , H04N2005/44556
摘要： Provided is a program-information displaying device characterized by including: a program-information acquiring unit configured to acquire program information pieces; a full-program-display processing unit configured to respectively display the program information pieces in a plurality of program cells in a full-program display region, the program cells being defined by a temporal axis and a channel axis crossing the temporal axis; a recommended-program-information selecting unit configured to select particular program information pieces from the program information pieces acquired by the program-information acquiring unit; a recommended-program storage unit configured to store therein program information pieces of selected recommended programs in a manner associable the program information pieces for displaying the full-program display region; and a recommended-program-display processing unit configured to display the program information pieces of the recommended programs stored in the recommended program storage unit in a recommended-program display region in alignment with the temporal axis of the full-program display region.
摘要翻译：提供了一种节目信息显示装置，其特征在于包括：节目信息获取单元，被配置为获取节目信息片; 全程序显示处理单元，被配置为分别在全程序显示区域中在多个程序单元中显示程序信息，所述程序单元由时间轴和与所述时间轴交叉的通道轴定义; 推荐节目信息选择单元，被配置为从由节目信息获取单元获取的节目信息中选择特定节目信息; 推荐程序存储单元，其被配置为以可关联用于显示全程序显示区域的程序信息段的方式存储所选择的推荐程序的程序信息; 以及推荐程序显示处理单元，被配置为在与所述全程序显示区域的时间轴对准的推荐程序显示区域中显示存储在所述推荐程序存储单元中的推荐程序的程序信息。

10. 发明申请

US20090200149A1 Operation device for vehicle 有权
标题翻译：车辆操作装置
公开(公告)号：US20090200149A1
公开(公告)日：2009-08-13
申请号：US11989240
申请日：2006-07-25
申请人： Hajime Yamada
发明人： Hajime Yamada
IPC分类号： H01H25/04
CPC分类号： H01H25/008 , B60K37/06 , B60K2350/1004 , B60R11/0264 , B60R2011/0007 , B60R2011/0089 , G05G9/047 , G06F3/0338 , H01H25/04 , H01H2019/146 , Y10T74/20201
摘要： An operation device for a vehicle is provided that enables switching over of a plurality of operation menu display screens and switching over of a plurality of function display screens for in-vehicle equipment displayed on a monitor by tilting of an operating knob (30) in eight directions, pivoting of the operating knob (30) around its axis, and operation of a main switch (31) and a sub switch (32) provided on the operating knob (30). In this process, since the operating knob (30) is not pivoted around its axis without limit but it is restricted so that pivoting is possible only in a predetermined angle range, it is not necessary to change the grip on the operating knob (30) when pivoting the operating knob (30), the burden on the wrist is lessened, and the operability is improved. Moreover, since the main switch (31) and the sub switch (32) are provided on the operating knob (20), they can be operated without detaching the hand from the operating knob (30), thus further improving the operability.
摘要翻译：提供了一种用于车辆的操作装置，其能够通过在八分之一中倾斜操作旋钮（30）来切换多个操作菜单显示屏幕并切换显示在监视器上的车载设备的多个功能显示屏幕方向，操作旋钮（30）围绕其轴线枢转，以及设置在操作旋钮（30）上的主开关（31）和副开关（32）的操作。在该过程中，由于操作旋钮（30）没有限制地围绕其轴线枢转，而是受到限制，使得仅在预定角度范围内进行枢转，因此不需要改变操作旋钮（30）上的把手，当旋转操作旋钮（30）时，手腕上的负担减轻，并且可操作性得到改善。此外，由于主开关（31）和副开关（32）设置在操作旋钮（20）上，所以它们可以在不将手从操作旋钮（30）分离的情况下操作，从而进一步提高可操作性。

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