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    • 4. 发明授权
    • Phenylpyridine derivative and medicinal agent comprising same
    • 苯基吡啶衍生物和含有它们的药剂
    • US08778954B2
    • 2014-07-15
    • US13394266
    • 2010-09-29
    • Toru MiuraSeiichi SatoHajime YamadaJunya TagashiraRyohei SekimotoRie IshidaHitomi AokiTadaaki Ohgiya
    • Toru MiuraSeiichi SatoHajime YamadaJunya TagashiraRyohei SekimotoRie IshidaHitomi AokiTadaaki Ohgiya
    • C07D401/14A61K31/422A61K31/4427
    • C07D401/14A61K31/422A61K31/4427C07D413/14
    • Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.
    • 公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物,因此可用作高血压,心脏病,动脉硬化,2型糖尿病,糖尿病并发症的预防和/或治疗剂 ,代谢综合征等; 和含有该化合物的药物组合物。 具体公开的是:由通式(I)表示的化合物(其中环A表示吡啶环;环B表示四唑环或恶二唑-5(4H) - 酮环; X表示C-R5或氮 原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3,R4,R5分别表示氢原子,卤素原子,C1-6烷基, 卤代C 1-6烷基或可具有取代基的C 1-6烷氧基),化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物,该盐或溶剂化物的药物组合物。