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1. 发明授权

US08575153B2 Pyridine-3-carboxyamide derivative 有权
标题翻译：吡啶-3-甲酰胺衍生物
公开(公告)号：US08575153B2
公开(公告)日：2013-11-05
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

2. 发明申请

US20110237590A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE 有权
标题翻译：吡啶-3-羧酰胺衍生物
公开(公告)号：US20110237590A1
公开(公告)日：2011-09-29
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/5377 , C07D213/74 , C07D401/12 , C07D413/12 , C07D211/46 , A61K31/44 , A61K31/497 , A61K31/4545 , A61P37/02 , A61P37/06
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂合物。

3. 发明申请

US20120108581A1 FUSED PIPERIDINE COMPOUND AND PHARMACEUTICAL CONTAINING SAME 失效
标题翻译：熔融哌啶化合物和含有药物的化合物
公开(公告)号：US20120108581A1
公开(公告)日：2012-05-03
申请号：US13260711
申请日：2010-03-25
申请人： Masanori Ashikawa , Toshiharu Morimoto , Hajime Yamada , Shunji Takemura , Tatsuaki Nishiyama , Takeshi Doi , Hiroyuki Ishiwata
发明人： Masanori Ashikawa , Toshiharu Morimoto , Hajime Yamada , Shunji Takemura , Tatsuaki Nishiyama , Takeshi Doi , Hiroyuki Ishiwata
IPC分类号： A61K31/473 , A61K31/4375 , C12N5/02 , C07D495/04 , A61K31/4365 , A61P7/06 , A61K31/4745 , C07D491/052 , A61K31/4741 , C07D491/056 , C07D498/04 , A61K31/5383 , C07D471/04 , C07D221/10
CPC分类号： C07D221/06 , C07D471/04 , C07D491/052 , C07D491/056 , C07D498/04
摘要： The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a C10-14 aryl group or 5- to 10-membered heterocyclic group, X represents N—R7, a sulfur atom or an oxygen atom, R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, C1-6 alkyl group or C3-6 cycloalkyl group, and R4, R5 and R6 independently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.
摘要翻译：本发明提供具有EPO生产促进作用和/或血红蛋白生产促进作用的低分子量化合物。本发明涉及由以下通式（1）表示的稠合哌啶化合物：其中环A表示C10-14芳基或5-至10-元杂环基，X表示N-R7，硫原子或氧原子，R 1，R 2，R 2'，R 3和R 3'独立地表示氢原子，C 1-6烷基或C 3-6环烷基，R 4，R 5和R 6独立地表示氢原子或卤素原子）或其盐，或其溶剂合物。

4. 发明授权

US08604030B2 Fused piperidine compound and pharmaceutical containing same 失效
标题翻译：融合哌啶化合物和含有其的药物
公开(公告)号：US08604030B2
公开(公告)日：2013-12-10
申请号：US13260711
申请日：2010-03-25
申请人： Masanori Ashikawa , Toshiharu Morimoto , Hajime Yamada , Shunji Takemura , Tatsuaki Nishiyama , Takeshi Doi , Hiroyuki Ishiwata
发明人： Masanori Ashikawa , Toshiharu Morimoto , Hajime Yamada , Shunji Takemura , Tatsuaki Nishiyama , Takeshi Doi , Hiroyuki Ishiwata
IPC分类号： A61K31/5377 , A61K31/4706 , A61K31/47 , C07D215/08 , C07D413/12 , C07D215/233
CPC分类号： C07D221/06 , C07D471/04 , C07D491/052 , C07D491/056 , C07D498/04
摘要： The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a C10-14 aryl group or 5- to 10-membered heterocyclic group, X represents N—R7, a sulfur atom or an oxygen atom, R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, C1-6 alkyl group or C3-6 cycloalkyl group, and R4, R5 and R6 independently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.
摘要翻译：本发明提供具有EPO生产促进作用和/或血红蛋白生产促进作用的低分子量化合物。本发明涉及由以下通式（1）表示的稠合哌啶化合物：其中环A表示C10-14芳基或5-至10-元杂环基，X表示N-R7，硫原子或氧原子，R 1，R 2，R 2'，R 3和R 3'独立地表示氢原子，C 1-6烷基或C 3-6环烷基，R 4，R 5和R 6独立地表示氢原子或卤素原子）或其盐，或其溶剂合物。

5. 发明申请

US20070088021A1 4-haloisoquinoline derivative and drug containing the same 审中-公开
标题翻译： 4-卤代异喹啉衍生物和含有它们的药物
公开(公告)号：US20070088021A1
公开(公告)日：2007-04-19
申请号：US11518141
申请日：2006-09-11
申请人： Hiroyoshi Hidaka , Masahiro Tamura , Hiroshi Nakao , Hiromichi Sigyo , Hajime Yamada , Takatoshi Ozawa , Hideo Yoshizaki
发明人： Hiroyoshi Hidaka , Masahiro Tamura , Hiroshi Nakao , Hiromichi Sigyo , Hajime Yamada , Takatoshi Ozawa , Hideo Yoshizaki
IPC分类号： A61K31/551
CPC分类号： A61K31/551 , C07D401/12
摘要： The present invention relates to compounds which have a potent Rho-kinase inhibitory action and which are useful as therapeutic agents for treating diseases, such as hypertension, pulmonary hypertension, cerebral vasospasm, angina pectoris, cardiac failure, arteriosclerosis, glaucoma, dysuria, asthma, and erectile failure, and drugs containing the compounds. The present invention provides a 4-haloisoquinoline derivative represented by formula (1): an acid-added salt thereof, or a solvate of any of the foregoing, in which X is halogen, such as fluoro, chloro, bromo and iodo.
摘要翻译：本发明涉及具有强Rho激酶抑制作用的化合物，其可用作治疗疾病的治疗剂，例如高血压，肺动脉高压，脑血管痉挛，心绞痛，心力衰竭，动脉硬化，青光眼，排尿困难，哮喘，和勃起功能障碍，以及含有化合物的药物。本发明提供由式（1）表示的4-卤代异喹啉衍生物：其酸加成盐，或上述任何一种的溶剂合物，其中X为卤素，如氟，氯，溴和碘。

6. 发明申请

US20140011823A1 NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME 有权
标题翻译：新颖的吡啶衍生物和含有其的药物
公开(公告)号：US20140011823A1
公开(公告)日：2014-01-09
申请号：US14005046
申请日：2012-03-13
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D413/14 , A61K31/506 , C07D401/14
摘要： The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents an alkyl group; R2 represents an alkyl group or a cycloalkyl group; and R3, R4, and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.
摘要翻译：本发明提供：下述通式（I）表示的化合物，既具有血管紧张素II受体拮抗作用又具有PPARγ活化作用，可用作高血压，心脏病，动脉硬化等的预防和/或治疗剂， 2型糖尿病等; 和含有该化合物的药物组合物。通式（I）（式中，环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示烷基 ; R 2表示烷基或环烷基; R 3，R 4和R 5各自独立地表示氢原子，卤素原子，烷基，烷氧基等。

7. 发明申请

US20120165353A1 NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME 有权
标题翻译：新颖的苯丙氨酸衍生物和药物包括它们
公开(公告)号：US20120165353A1
公开(公告)日：2012-06-28
申请号：US13394266
申请日：2010-09-29
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/506 , C07D413/14 , A61P9/00 , A61P13/12 , A61P3/10 , A61P9/10 , A61P9/12 , C07D401/14 , A61P3/00
CPC分类号： C07D401/14 , A61K31/422 , A61K31/4427 , C07D413/14
摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.
摘要翻译：公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂，代谢综合征等; 和含有该化合物的药物组合物。具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3，R4，R5分别表示氢原子，卤素原子，C1-6烷基，卤代C 1-6烷基或可具有取代基的C 1-6烷氧基），化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物，该盐或溶剂化物的药物组合物。

8. 发明授权

US08778954B2 Phenylpyridine derivative and medicinal agent comprising same 有权
标题翻译：苯基吡啶衍生物和含有它们的药剂
公开(公告)号：US08778954B2
公开(公告)日：2014-07-15
申请号：US13394266
申请日：2010-09-29
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： C07D401/14 , A61K31/422 , A61K31/4427
CPC分类号： C07D401/14 , A61K31/422 , A61K31/4427 , C07D413/14
摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.
摘要翻译：公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂，代谢综合征等; 和含有该化合物的药物组合物。具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3，R4，R5分别表示氢原子，卤素原子，C1-6烷基，卤代C 1-6烷基或可具有取代基的C 1-6烷氧基），化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物，该盐或溶剂化物的药物组合物。

9. 发明授权

US09315493B2 Phenylpyridine derivative and drug containing same 有权
标题翻译：苯基吡啶衍生物和含有它们的药物
公开(公告)号：US09315493B2
公开(公告)日：2016-04-19
申请号：US14005046
申请日：2012-03-13
申请人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
发明人： Toru Miura , Seiichi Sato , Hajime Yamada , Junya Tagashira , Toshiaki Watanabe , Ryohei Sekimoto , Rie Ishida , Hitomi Aoki , Tadaaki Ohgiya
IPC分类号： A61K31/505 , C07D413/14 , C07D401/14 , A61K31/506
CPC分类号： C07D413/14 , A61K31/506 , C07D401/14
摘要： The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents an alkyl group; R2 represents an alkyl group or a cycloalkyl group; and R3, R4, and R5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.
摘要翻译：本发明提供：下述通式（I）表示的化合物，其具有血管紧张素II受体拮抗作用和PPARγ活化作用，可用作高血压，心脏病，动脉硬化等的预防和/或治疗剂， 2型糖尿病等; 和含有该化合物的药物组合物。通式（I）（式中，环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮原子; R1表示烷基 ; R 2表示烷基或环烷基; R 3，R 4和R 5各自独立地表示氢原子，卤素原子，烷基，烷氧基等。

10. 发明申请

US20150006624A1 CONTENT SERVICE SYSTEM 审中-公开
标题翻译：内容服务系统
公开(公告)号：US20150006624A1
公开(公告)日：2015-01-01
申请号：US14365350
申请日：2012-03-05
申请人： Hajime Yamada
发明人： Hajime Yamada
IPC分类号： H04L29/08 , H04L29/06
CPC分类号： H04L67/1036 , H04L63/102 , H04L67/42 , H04N21/2353 , H04N21/2541 , H04N21/25891 , H04N21/26283 , H04N21/2668
摘要： [Problem] A method by which a content-usage device connected to a network acquires a usable-service list from a server, and provides a service to a user on. the basis of the information shown on the service list, wherein it is not possible to change the services shown in response to conditions, and therefore the service does not conform to the user's needs and is not useful. [Solution] The present invention provides a content service system having a presentation-condition server device for transmitting presentation conditions for identifying a limited content list, the limited content list being a list of the part of the content, from a distributed content list, presented to the user on the content-usage device.
摘要翻译： [问题]连接到网络的内容使用装置通过该方法从服务器获取可用服务列表，并向用户提供服务。在服务列表上显示的信息的基础，其中不可能改变响应于条件显示的服务，因此服务不符合用户的需要，并且不是有用的。解决方案本发明提供了一种内容服务系统，其具有呈现条件服务器设备，用于从分布式内容列表发送用于识别有限内容列表的呈现条件，作为内容的一部分的列表的有限内容列表到内容使用设备上的用户。

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