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1. 发明授权

US08575153B2 Pyridine-3-carboxyamide derivative 有权
标题翻译：吡啶-3-甲酰胺衍生物
公开(公告)号：US08575153B2
公开(公告)日：2013-11-05
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂化物。

2. 发明申请

US20110237590A1 PYRIDINE-3-CARBOXYAMIDE DERIVATIVE 有权
标题翻译：吡啶-3-羧酰胺衍生物
公开(公告)号：US20110237590A1
公开(公告)日：2011-09-29
申请号：US13131561
申请日：2009-11-27
申请人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
发明人： Takahiro Kitamura , Hajime Yamada , Shunji Takemura , Masanori Ashikawa , Tetsuya Ishikawa , Yoshiharu Miyake , Akiyasu Kouketsu , Seiichi Sato , Hiroyuki Ishiwata , Yuichiro Tabunoki , Manabu Shibasaki , Takatoshi Ozawa , Ryota Shigemi , Takeshi Doi , Masahiro Tamura
IPC分类号： A61K31/5377 , C07D213/74 , C07D401/12 , C07D413/12 , C07D211/46 , A61K31/44 , A61K31/497 , A61K31/4545 , A61P37/02 , A61P37/06
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： To provide a novel JAK3 inhibitor that is useful as a preventive and/or therapeutic agent for rejection and graft versus host disease (GvHD) in organ transplantation, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjögren syndrome, Behcet's disease, type I diabetes mellitus, autoimmune thyroiditis, idiopathic thrombocytopenic purpura, ulcerative colitis, Crohn's disease, asthma, allergic rhinitis, atopic dermatitis, contact dermatitis, urticaria, eczema, psoriasis, allergic conjunctivitis, uveitis, cancer, leukemia and the like. The pyridine-3-carboxyamide derivative represented by the general formula (1): or its salt or a solvate thereof.
摘要翻译：提供可用作器官移植，类风湿关节炎，多发性硬化症，系统性红斑狼疮，Sjögren综合征，Behcet氏病，I型糖尿病的排斥反应和宿主疾病（GvHD）的预防和/或治疗剂的新型JAK3抑制剂过敏性甲状腺炎，特发性血小板减少性紫癜，溃疡性结肠炎，克罗恩病，哮喘，过敏性鼻炎，特应性皮炎，接触性皮炎，荨麻疹，湿疹，牛皮癣，过敏性结膜炎，葡萄膜炎，癌症，白血病等。由通式（1）表示的吡啶-3-甲酰胺衍生物或其盐或其溶剂合物。

3. 发明授权

US08273766B2 Tetrahydroisoquinoline compound 失效
标题翻译：四氢异喹啉化合物
公开(公告)号：US08273766B2
公开(公告)日：2012-09-25
申请号：US12531318
申请日：2008-04-03
申请人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
发明人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
IPC分类号： C07D217/18 , A61K31/47
CPC分类号： C07D217/04 , A61K31/472 , A61K31/4725 , C07D217/02 , C07D217/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates a specific tetrahydroisoquinoline compound which is useful as a chemokine receptor type 3 (CCR3) antagonist, and a pharmaceutical composition comprising the same as an active ingredient. The tetrahydroisoquinoline compound of the present invention is useful for the treatment or prevention of a disease in which CCR3 participates.
摘要翻译：本发明涉及可用作3型趋化因子受体（CCR3）拮抗剂的特定四氢异喹啉化合物，以及包含其作为活性成分的药物组合物。本发明的四氢异喹啉化合物可用于治疗或预防CCR3参与的疾病。

4. 发明申请

US20100120844A1 TETRAHYDROISOQUINOLINE COMPOUND 失效
标题翻译：四氢喹啉化合物
公开(公告)号：US20100120844A1
公开(公告)日：2010-05-13
申请号：US12531318
申请日：2008-04-03
申请人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
发明人： Seiichi Sato , Junya Tagashira , Shunji Takemura , Yoshiharu Miyake , Tetsuya Ishikawa , Toshiharu Arai , Takahiro Ito , Takuya Hara
IPC分类号： A61K31/4709 , C07D401/02 , C07D217/18 , A61K31/47 , A61P11/06 , A61P31/18 , A61P37/06 , A61P1/00
CPC分类号： C07D217/04 , A61K31/472 , A61K31/4725 , C07D217/02 , C07D217/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates a specific tetrahydroisoquinoline compound which is useful as a chemokine receptor type 3 (CCR3) antagonist, and a pharmaceutical composition comprising the same as an active ingredient. The tetrahydroisoquinoline compound of the present invention is useful for the treatment or prevention of a disease in which CCR3 participates.
摘要翻译：本发明涉及可用作3型趋化因子受体（CCR3）拮抗剂的特定四氢异喹啉化合物，以及包含其作为活性成分的药物组合物。本发明的四氢异喹啉化合物可用于治疗或预防CCR3参与的疾病。

5. 发明授权

US07109242B2 Carboxylic compound and medicine comprising the same 失效
标题翻译：羧酸化合物及其组合物
公开(公告)号：US07109242B2
公开(公告)日：2006-09-19
申请号：US10849778
申请日：2004-05-21
申请人： Keisuke Inoue , Tsutomu Toma , Takahiro Kitamura , Yukiyoshi Yamazaki , Tetsuya Ishikawa
发明人： Keisuke Inoue , Tsutomu Toma , Takahiro Kitamura , Yukiyoshi Yamazaki , Tetsuya Ishikawa
IPC分类号： A01N37/00
CPC分类号： C07C59/56 , Y02P20/55 , Y10S514/866
摘要： A compound represented by the following general formula (1), a salt thereof, or an ester thereof: wherein m represents an integer of 0 to 4, n represents an integer of 5 to 9, and R represents hydrogen atom or a protective group of hydroxyl group, which has reducing actions of blood glucose, plasma insulin, and triglyceride, and is useful for preventive and/or therapeutic treatment of diabetes, complications of diabetes, hyperlipemia and others.
摘要翻译：由下述通式（1）表示的化合物或其盐或其酯：其中m表示0〜4的整数，n表示5〜9的整数，R表示氢原子或保护基具有血糖，血浆胰岛素和甘油三酯降低作用的羟基，可用于预防和/或治疗糖尿病，糖尿病并发症，高脂血症等。

6. 发明申请

US20050009909A1 Carboxylic compound and medicine comprising the same 失效
标题翻译：羧酸化合物及其组合物
公开(公告)号：US20050009909A1
公开(公告)日：2005-01-13
申请号：US10849778
申请日：2004-05-21
申请人： Keisuke Inoue , Tsutomu Toma , Takahiro Kitamura , Yukiyoshi Yamazaki , Tetsuya Ishikawa
发明人： Keisuke Inoue , Tsutomu Toma , Takahiro Kitamura , Yukiyoshi Yamazaki , Tetsuya Ishikawa
IPC分类号： C07C59/56 , A61K31/20 , C07C59/64
CPC分类号： C07C59/56 , Y02P20/55 , Y10S514/866
摘要： A compound represented by the following general formula (1), a salt thereof, or an ester thereof: wherein m represents an integer of 0 to 4, n represents an integer of 5 to 9, and R represents hydrogen atom or a protective group of hydroxyl group, which has reducing actions of blood glucose, plasma insulin, and triglyceride, and is useful for preventive and/or therapeutic treatment of diabetes, complications of diabetes, hyperlipemia and others.
摘要翻译：由下述通式（1）表示的化合物或其盐或其酯：其中m表示0〜4的整数，n表示5〜9的整数，R表示氢原子或保护基具有血糖，血浆胰岛素和甘油三酯降低作用的羟基，可用于预防和/或治疗糖尿病，糖尿病并发症，高脂血症等。

7. 发明授权

US5883092A Pyrimidine derivatives as endothelin antagonists 失效
标题翻译：嘧啶衍生物作为内皮素拮抗剂
公开(公告)号：US5883092A
公开(公告)日：1999-03-16
申请号：US29244
申请日：1998-03-04
申请人： Mitsuteru Hirata , Takeo Deushi , Yoshio Takahashi , Masahiro Tamura , Takeshi Ohshima , Toshiaki Oda , Tetsuya Ishikawa , Hiroyuki Sonoki , Masami Shiratsuchi
发明人： Mitsuteru Hirata , Takeo Deushi , Yoshio Takahashi , Masahiro Tamura , Takeshi Ohshima , Toshiaki Oda , Tetsuya Ishikawa , Hiroyuki Sonoki , Masami Shiratsuchi
IPC分类号： C07D403/04 , A61K31/506 , A61P9/00 , A61P9/12 , C07D213/00 , C07D239/52 , C07D239/545 , C07D295/00 , C07D401/14 , C07D413/04 , A61K31/505 , A61K31/535
CPC分类号： C07D239/52
摘要： The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: ##STR1## �wherein R.sup.1 represents a hydroxyl group, a lower alkoxy group, a phenyloxy group which may have a substituent, an aralkyloxy group which may have a substituent, or --NR.sup.2 R.sup.3 ; X represents an oxygen atom or N--R.sup.4 ; m is 2 or 3; and n is 1 or 2 (wherein each of R.sup.2 and R.sup.3, which are identical to or different from each other, represents a hydrogen atom, a hydroxyl group, a lower alkyl group which may have a substituent, a phenyl group which may have a substituent, an aralkyl group which may have a substituent, or a heterocyclic group which may have a substituent; R.sup.4 represents a lower alkyl group, a phenyl group, a formyl group, or a lower alkoxycarbonyl group)!, as well as to a medicine containing the derivative or salt as the active ingredient. The compounds exhibit strong binding inhibitory activity against endothelin having potent vasoconstrictive effect. Therefore, the compounds are effective as remedies for various diseases including circulatory diseases.
摘要翻译： PCT No.PCT / JP96 / 02494 Sec。 371日期：1998年3月4日 102（e）1998年3月4日PCT PCT 1996年9月4日PCT公布。公开号WO97 / 09318 日期1997年3月13日本发明涉及下式（1）的嘧啶衍生物或衍生物的盐：其中R1表示羟基，低级烷氧基，苯氧基其可以具有取代基，可以具有取代基的芳烷氧基或-NR2R3; X表示氧原子或N-R4; m为2或3; n为1或2（式中，R2，R3各自相同或不同，表示氢原子，羟基，可具有取代基的低级烷基，可具有取代基的苯基，取代基，可以具有取代基的芳烷基或可以具有取代基的杂环基; R4表示低级烷基，苯基，甲酰基或低级烷氧基羰基）]以及药物含有衍生物或盐作为活性成分。该化合物对具有强烈血管收缩作用的内皮素表现出强烈的结合抑制活性。因此，该化合物作为包括循环系统疾病在内的各种疾病的治疗方法是有效的。

8. 发明授权

US09272642B2 Vehicle seat 有权
标题翻译：车座
公开(公告)号：US09272642B2
公开(公告)日：2016-03-01
申请号：US14477272
申请日：2014-09-04
申请人： Hideki Kobayashi , Tetsuya Ishikawa , Kazuhisa Nishimura
发明人： Hideki Kobayashi , Tetsuya Ishikawa , Kazuhisa Nishimura
IPC分类号： B60N2/30 , B60N2/36 , B60N2/48
CPC分类号： B60N2/3065 , B60N2/3013 , B60N2/3088 , B60N2/36 , B60N2/859 , B60N2/874 , B60N2205/40
摘要： In a vehicle seat (car seat 1) including a first seat portion (seat cushion 10) movable between a use position and a retracted position, and a second seat portion (seat back 20) movable between a use position and a retracted position, an actuator mechanism is configured to cause the second seat portion to start moving toward its retracted position at a time when the first seat portion passes a predetermined intermediate position that is on a way from the use position toward the retracted position. In one embodiment, the actuator mechanism includes a biasing member (torsion spring 13, 23) configured to bias each of the seat cushion 10 and the seat back 20 from the use position toward the retracted position, a lock member (lock arm 42) configured to lock the seat back 20 in the use position, and an unlock device (cable 44, 42A) configured to release the lock member to cause the seat back 20 to start moving toward the retracted position, at a time when the seat cushion 10 passes the predetermined intermediate position that is on the way from a posture in which the seat cushion is ready for use toward a posture in which the seat cushion 10 is tipped up.
摘要翻译：在包括在使用位置和缩回位置之间可移动的第一座椅部分（座垫10）和可在使用位置和缩回位置之间移动的第二座椅部分（座椅靠背20）的车辆座椅（汽车座椅1）中，致动器机构构造成使得第二座椅部分在第一座椅部分经过从使用位置朝向缩回位置的途中经过的预定中间位置时开始向其缩回位置移动。在一个实施例中，致动器机构包括构造成将座垫10和座椅靠背20中的每一个从使用位置朝向缩回位置偏置的偏置构件（扭转弹簧13,23），配置在锁定构件将座椅靠背20锁定在使用位置，以及解锁装置（电缆44,42A），其构造成在座垫10通过时释放锁定构件以使座椅靠背20开始向缩回位置移动在从座垫准备好使用的姿势朝向座垫10倾斜的姿势的途中的预定中间位置。

9. 发明授权

US08651638B2 Inkjet printing apparatus 有权
标题翻译：喷墨打印设备
公开(公告)号：US08651638B2
公开(公告)日：2014-02-18
申请号：US13218626
申请日：2011-08-26
申请人： Tetsuya Ishikawa
发明人： Tetsuya Ishikawa
IPC分类号： B41J2/175
CPC分类号： B41J2/17509 , B41J2/175 , B41J2/17513 , B41J2/1752 , B41J2/17523 , B41J2/17553 , B41J2/17596
摘要： An inkjet printing apparatus comprises an ink tank including an ink accommodating unit, an ink leading-out mechanism for leading out the ink in the ink accommodating unit to an outside, and a housing, and an ink tank holder for removably retaining the ink tank, wherein a space is formed between the ink leading-out mechanism and the housing, and when the ink tank is mounted to the ink tank holder, an ink flow passage is formed by contact of an outer periphery of an ink leading-out needle in the ink tank holder with a sealing member in the ink leading-out mechanism, further comprising restriction means for restricting a position of the ink tank to the ink tank holder such that when removing the ink tank from the ink tank holder, the ink tank stops in a state where a tip end of the ink leading-out needle is in the space.
摘要翻译：一种喷墨打印设备包括一个墨盒，包括墨水容纳单元，用于将墨水容纳单元中的墨水引导到外部的墨水引出机构和外壳以及用于可拆卸地保持墨水盒的墨水盒保持器，其中在所述墨水引出机构和所述壳体之间形成空间，并且当所述墨水罐安装到所述墨水盒保持器时，墨水流动通道通过所述墨水引出针的外周部在墨水引出机构中具有密封构件的墨水盒保持器还包括限制装置，用于将墨水罐的位置限制到墨水盒保持器，使得当从墨水盒保持器移除墨水盒时，墨水罐停止墨水引出针的前端位于空间中的状态。

10. 发明申请

US20130320353A1 METHOD OF FORMING A GROUP III-NITRIDE CRYSTALLINE FILM ON A PATTERNED SUBSTRATE BY HYDRIDE VAPOR PHASE EPITAXY (HVPE) 审中-公开
标题翻译：通过氢化钙相层析（HVPE）在形成图案的基底上形成III族氮化物膜的方法
公开(公告)号：US20130320353A1
公开(公告)日：2013-12-05
申请号：US13959469
申请日：2013-08-05
申请人： Olga Kryiouk , Yuriy Mehnik , Hidehiro Kojiri , Tetsuya Ishikawa
发明人： Olga Kryiouk , Yuriy Mehnik , Hidehiro Kojiri , Tetsuya Ishikawa
IPC分类号： H01L29/04
CPC分类号： H01L29/045 , H01L21/0237 , H01L21/0242 , H01L21/0243 , H01L21/02433 , H01L21/02439 , H01L21/02458 , H01L21/02488 , H01L21/0254 , H01L21/0262 , H01L21/02639 , H01L21/02647 , H01L29/04 , H01L33/007 , H01L33/12 , H01L33/16 , H01L33/22
摘要： A method of depositing a high quality low defect single crystalline Group III-Nitride film. A patterned substrate having a plurality of features with inclined sidewalls separated by spaces is provided. A Group III-Nitride film is deposited by a hydride vapor phase epitaxy (HVPE) process over the patterned substrate. The HVPE deposition process forms a Group III-Nitride film having a first crystal orientation in the spaces between features and a second different crystal orientation on the inclined sidewalls. The first crystal orientation in the spaces subsequently overgrows the second crystal orientation on the sidewalls and in the process turns over and terminates treading dislocations formed in the first crystal orientation.
摘要翻译：沉积高品质低缺陷单晶III-III族氮化物膜的方法。提供具有多个特征的图案化衬底，其具有由空间分开的倾斜侧壁。通过在图案化衬底上的氢化物气相外延（HVPE）工艺沉积III-III族氮化物膜。 HVPE沉积工艺在特征之间的空间中形成具有第一晶体取向的III族氮化物膜，并且在倾斜侧壁上形成第二不同的晶体取向。空间中的第一晶体取向随后在侧壁上过度生长第二晶体取向，并且在该过程中翻转并终止在第一晶体取向中形成的重力位错。

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