专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100261933A1 METHOD FOR PREPARING CARBOXYLIC ACID COMPOUND 审中-公开
标题翻译：制备羧酸化合物的方法
公开(公告)号：US20100261933A1
公开(公告)日：2010-10-14
申请号：US12293570
申请日：2007-03-29
申请人： Manabu Katsurada , Yasuko Nakajima , Yuzo Kasuga , Kazuhiro Onogi , Toshiaki Oda
发明人： Manabu Katsurada , Yasuko Nakajima , Yuzo Kasuga , Kazuhiro Onogi , Toshiaki Oda
IPC分类号： C07C59/84
CPC分类号： C07C45/63 , C07C45/676 , C07C49/233 , C07C51/09 , C07C51/373 , C07C67/343 , C07C69/738 , Y02P20/55 , C07C59/88
摘要： A method for conveniently preparing 2,2-dichloro-12-(4-chlorophenyl)-10-hydroxydodecanoic acid useful as an active ingredient of therapeutic agents for diseases such as diabetes at a high yield, which comprises the step of reacting a compound represented by the following general formula (A): wherein X represents a halogen atom, and a compound represented by the following general formula (B): CHCl2COOR1 wherein R1 represents hydrogen atom or a protective group of carboxyl group, to prepare a compound represented by the following general formula (C): wherein R1 has the same meaning as that defined above.
摘要翻译：方便地制备用作高收率糖尿病等治疗剂的活性成分的2,2-二氯-12-（4-氯苯基）-10-羟十二烷的方法，其包括使代表的化合物通过下列通式（A）表示的化合物：其中X表示卤素原子，和由以下通式（B）表示的化合物：CHCl 2 COOR 1其中R 1表示氢原子或羧基保护基，以制备由以下通式（C）：其中R1具有与上述相同的含义。

2. 发明授权

US06509329B1 Cyclic diamine compound with 6-membered ring groups 失效
标题翻译：具有6元环基的环状二胺化合物
公开(公告)号：US06509329B1
公开(公告)日：2003-01-21
申请号：US09893697
申请日：2001-06-29
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Takeshi Doi , Yoshinori Kyotani
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Takeshi Doi , Yoshinori Kyotani
IPC分类号： C07D25112
CPC分类号： C07D295/096 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/551 , C07D213/38
摘要： A cyclic diamine compound of formula (1): wherein A is a single bond or C≡C; X and Y are individually CH or a nitrogen atom; m is 1 or 2; and n is a number of 1 to 5; an acid-addition salt thereof, or a hydrate thereof. The compound has excellent inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.
摘要翻译：式（1）的环状二胺化合物：其中A是单键或C = C; X和Y分别是CH或氮原子; m为1或2; n为1〜5的数; 其酸加成盐或其水合物。该化合物对细胞粘附和细胞浸润具有优异的抑制作用，可用作预防或治疗诸如过敏，哮喘，风湿病，动脉硬化和炎症等疾病的药物。

3. 发明授权

US06393301B1 Radio telephone system within a vehicle with enhanced safety features 失效
标题翻译：车内无线电话系统具有增强的安全特性
公开(公告)号：US06393301B1
公开(公告)日：2002-05-21
申请号：US09203588
申请日：1998-12-02
申请人： Toshiaki Oda
发明人： Toshiaki Oda
IPC分类号： H04B138
CPC分类号： H04M1/6091 , H04B1/3822 , H04M1/66
摘要： A radio telephone system for use in a vehicle is composed of an accessory mounted in the vehicle and a radio telephone that is separated from the accessory. The accessory transmits a mode switch signal indicating an operation state of the vehicle to the radio telephone by wireless means such as radio or infrared. When receiving the mode switch signal from the accessory, the radio telephone changes its operation mode depending on the mode switch signal. The operation state of the vehicle is an on/off state of an ignition key or a speed of the vehicle.
摘要翻译：用于车辆的无线电话系统由安装在车辆中的附件和与附件分离的无线电话组成。附件通过诸如无线电或红外线之类的无线装置向无线电话发送指示车辆的操作状态的模式切换信号。当从附件接收到模式切换信号时，无线电话根据模式切换信号改变其操作模式。车辆的操作状态是点火钥匙的开/关状态或车辆的速度。

4. 发明授权

US6118333A Clock buffer circuit and clock signal buffering method which can suppress current consumption 失效
标题翻译：时钟缓冲电路和时钟信号缓冲方法，可以抑制电流消耗
公开(公告)号：US6118333A
公开(公告)日：2000-09-12
申请号：US183408
申请日：1998-10-30
申请人： Toshiaki Oda
发明人： Toshiaki Oda
IPC分类号： H03K19/0175 , G06F1/10 , G11C7/22 , G06G7/26
CPC分类号： G11C7/22 , G06F1/10
摘要： A clock buffer circuit includes an amplifier section and a control section. The amplifier section amplifies a clock signal in response to a control signal. The control section generates the control signal based on an amplitude of the clock signal.
摘要翻译：时钟缓冲电路包括放大器部分和控制部分。放大器部分响应于控制信号放大时钟信号。控制部根据时钟信号的振幅来生成控制信号。

5. 发明授权

US5541169A Azoxy compound 失效
标题翻译：偶氮化合物
公开(公告)号：US5541169A
公开(公告)日：1996-07-30
申请号：US232245
申请日：1994-05-10
申请人： Takeo Deushi , Yoshio Takahashi , Hiroyuki Ishiwata , Yukihiro Okuno , Toshiaki Oda , Masami Shiratsuchi , Katsuhiro Yamamoto
发明人： Takeo Deushi , Yoshio Takahashi , Hiroyuki Ishiwata , Yukihiro Okuno , Toshiaki Oda , Masami Shiratsuchi , Katsuhiro Yamamoto
IPC分类号： A01N51/00 , C07C291/08 , A61K31/655
CPC分类号： C07C291/08 , A01N51/00
摘要： An azoxy compound represented by the following general formula ##STR1## wherein R.sub.1 denotes a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkoxy-lower alkoxy group or a group of the formula X.sub.1 --C.tbd.C--CH.sub.2 O-- wherein X.sub.1 is a hydrogen atom or a halogen atom;R.sub.2 denotes a hydrogen atom or a lower alkyl group;R.sub.3 denotes a hydrogen atom or a lower alkyl group;R.sub.4 denotes a hydrogen atom or a group of the formula X.sub.2 --C.tbd.C--CH.sub.2 -- wherein X.sub.2 is a hydrogen atom or a halogen atom;R.sub.5 denotes a hydrogen atom or a lower alkyl group;andn is 0 or 1.This compound has an excellent antifungal activity against fungi infectious to warm-blooded animals and fungi infectious to agrohorticultural crops or fruit trees, and is useful as a medicine, a veterinary drug and an agrohorticultural antifungal agent.
摘要翻译： PCT No.PCT / JP93 / 01295 Sec。 371日期1994年5月10日 102（e）日期1994年5月10日PCT提交1993年9月10日PCT公布。出版物WO94 / 05629 日期：1994年3月17日由以下通式表示的氧化偶氮化合物（Ⅰ）其中R1表示氢原子，卤原子，羟基，低级烷氧基，低级烷氧基 - 低级烷氧基或基团式X1-C3Bic C-CH2O-，其中X1是氢原子或卤素原子; R2表示氢原子或低级烷基; R3表示氢原子或低级烷基; R4表示氢原子或式X2-C 3BOND C-CH2-的基团，其中X2是氢原子或卤素原子; R5表示氢原子或低级烷基; 并且n为0或1.该化合物对感染了农作物或果树的温血动物和真菌感染真菌具有优异的抗真菌活性，并且可用作药物，兽药和农业园艺抗真菌剂。

6. 发明授权

US5510366A Indole derivatives, salts thereof, and congestive heart failure therapeutic agents comprising the same 失效
标题翻译：吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
公开(公告)号：US5510366A
公开(公告)日：1996-04-23
申请号：US330670
申请日：1994-10-28
申请人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
发明人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
IPC分类号： C07D491/04 , C07D491/048 , A61K31/40 , C07D491/056
CPC分类号： C07D491/04
摘要： An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
摘要翻译：由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

7. 发明申请

US20050176764A1 Medicine for treating cancer 审中-公开
标题翻译：用于治疗癌症的药物
公开(公告)号：US20050176764A1
公开(公告)日：2005-08-11
申请号：US10510759
申请日：2003-04-11
申请人： Chikage Mataki , Tatsuhiko Kodama , Takeshi Doi , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Masao Ohkuch
发明人： Chikage Mataki , Tatsuhiko Kodama , Takeshi Doi , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Masao Ohkuch
IPC分类号： C07D295/12 , A61K31/445 , A61K31/4545 , A61K48/00 , A61P35/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D491/10
CPC分类号： C07D401/06 , A61K31/445 , A61K31/4545 , C04B35/632 , C07D295/12 , C07D401/12 , C07D401/14 , C07D405/14 , C07D491/10
摘要： Abstract The present invention is directed to a method for treating cancer, a method for inhibiting histone deacetylase, and a method for facilitating gene therapy, comprising administering an effective amount of a cyclic amine compound represented by the following formula (1):(wherein R1, R2, and R3 each independently represent a hydrogen atom, a halogen atom, a hydroxy group, an alkyl group, a halogen-substituted alkyl group, an alkoxy group, an alkylthio group, a carboxyl group, an alkoxycarbonyl group, or an alkanoyl group; W1 and W2, which are identical to or different from each other, represent N or CH; X represents O, NR4, CONR4, or NR4CO; R4 represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted heteroaralkyl group; and l, m, and n each represent a number of 0 or 1), a salt thereof, or a hydrate thereof.208
摘要翻译：摘要本发明涉及一种治疗癌症的方法，一种抑制组蛋白脱乙酰酶的方法和一种促进基因治疗的方法，包括给予有效量的由下式（1）表示的环胺化合物:(其中R1 R 2和R 3各自独立地表示氢原子，卤素原子，羟基，烷基，卤素取代的烷基，烷氧基，烷硫基，羧基，烷氧基羰基或烷酰基基团W 1和W 2彼此相同或不同，表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4表示氢原子，烷基，烯基，炔基，取代或未取代的芳基，取代或未取代的杂芳基，取代或未取代的芳烷基或取代或未取代的杂芳烷基; l，m和n各自表示0或1的数），其盐， o 其水合物

8. 发明授权

US06605620B1 Cyclic amine compounds and pharmaceutical composition containing the same 有权
标题翻译：环胺化合物和含有其的药物组合物
公开(公告)号：US06605620B1
公开(公告)日：2003-08-12
申请号：US10107180
申请日：2002-03-28
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Shunji Takemura , Takeshi Doi , Yoshinori Kyotani , Masao Ohkuchi
IPC分类号： A61K314545
CPC分类号： C07D401/06 , C07D211/58 , C07D213/38 , C07D401/12 , C07D401/14
摘要： A cyclic amine compound by the following general formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom or an alkoxy group W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 represents a hydrogen atom, or an alkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl group; and l, m and n each represents a number of 0 or 1, a salt thereof and a hydrate thereof are provided. These compounds have inhibitory effects on both cell adhesion and cell infiltration and are useful as anti-asthmatic agents, anti-allergic agents, anti-rheumatic agents, anti-arteriosclerotic agents, anti-inflammatory agents, anti-Sjogren's syndrome agents or the like.
摘要翻译：通式（1）表示的环状胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子或烷氧基，W 1和W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4 表示氢原子，或烷基，芳基，杂芳基，芳烷基或杂芳烷基; 和l，m和n各自表示0或1的数，其盐和其水合物。这些化合物对细胞粘附和细胞浸润具有抑制作用，并且可用作抗哮喘药，抗过敏剂，抗风湿剂，抗动脉硬化剂，抗炎剂，抗干燥素综合征剂等。

9. 发明授权

US06548656B1 Frame adjust linkers 失效
标题翻译：帧调整接头
公开(公告)号：US06548656B1
公开(公告)日：2003-04-15
申请号：US09914445
申请日：2001-11-26
申请人： Toshiaki Oda
发明人： Toshiaki Oda
IPC分类号： C12N1511
CPC分类号： C12N15/63 , C12N15/66
摘要： This application provides frame-adjusting linkers FAL-1 and FAL-2 which are single-stranded DNA consisting of a palindrome base sequence of SEQ ID NO. 1 and SEQ ID NO. 2, respectively. These linkers are able to prepare mutant DNA sequences having correct translation frames before and behind the any cleaved sites, therefore, time and cost for preparation of mutant protein, etc. can be greatly reduced.
摘要翻译：本申请提供了框架调节接头FAL-1和FAL-2，它们是由SEQ ID NO.1的回文碱基序列组成的单链DNA。 1和SEQ ID NO： 2。这些接头能够在任何切割位点之前和之后制备具有正确翻译框的突变DNA序列，因此可以大大降低制备突变蛋白等的时间和成本。

10. 发明授权

US06472386B1 Cyclic diamine compound with 5-membered ring groups 失效
标题翻译：具有5元环基团的环状二胺化合物
公开(公告)号：US06472386B1
公开(公告)日：2002-10-29
申请号：US09893682
申请日：2001-06-29
申请人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Takeshi Doi , Yoshinori Kyotani
发明人： Tatsuhiko Kodama , Masahiro Tamura , Toshiaki Oda , Yukiyoshi Yamazaki , Masahiro Nishikawa , Takeshi Doi , Yoshinori Kyotani
IPC分类号： A61K31551
CPC分类号： C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/46 , C07D333/20 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： A compound of formula (1): wherein A is a single bond, C≡C, CONH or NHCO; W is a carbon atom or a nitrogen atom; X is CH, a nitrogen atom, an oxygen atom or a sulfur atom; Y is CH, CHR1, in which R1 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group, a nitrogen atom, an oxygen atom, a sulfur atom or NR2, in which R2 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; Z is a nitrogen atom, an oxygen atom, a sulfur atom, CH or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; m is 1 or 2; and n is a number of 1 to 5, with the proviso that one or two of W, X, Y and Z are heteroatoms; an acid-addition salt thereof, or a hydrate thereof. The compounds have inhibitory effects on cell adhesion and are useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.
摘要翻译：式（1）的化合物：其中A是单键，C = C，CONH或NHCO; W是碳原子或氮原子; X是CH，氮原子，氧原子或硫原子; Y是CH，CHR1，其中R1是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或杂芳基 - 低级 - 烷基，氮原子，氧原子，硫原子或NR 2，其中R2是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或杂芳基 - 低级 - 烷基; Z是氮原子，氧原子，硫原子，CH或NR 3，其中R3是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或杂芳基 - 低级烷基; m为1或2; 并且n是1至5的数，条件是W，X，Y和Z中的一个或两个是杂原子; 其酸加成盐或其水合物。这些化合物对细胞粘附具有抑制作用，可用于预防或治疗诸如过敏，哮喘，风湿病，动脉硬化和炎症等疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式