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1. 发明授权

US5510366A Indole derivatives, salts thereof, and congestive heart failure therapeutic agents comprising the same 失效
标题翻译：吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
公开(公告)号：US5510366A
公开(公告)日：1996-04-23
申请号：US330670
申请日：1994-10-28
申请人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
发明人： Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
IPC分类号： C07D491/04 , C07D491/048 , A61K31/40 , C07D491/056
CPC分类号： C07D491/04
摘要： An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
摘要翻译：由式（1）表示的吲哚衍生物，本文R10为氢或低级烷基，虚线可以任选存在，R 1 -R 9表示各种取代基。化合物（1）对心肌呈现正性肌力作用，抗心律失常作用和血管舒张作用而不增加心率。包含该化合物作为有效成分的心脏治疗剂对于治疗心力衰竭和心律失常是非常有效的。

2. 发明授权

US4394382A Dihydrobenzopyran compounds and pharmaceutical composition comprising said compounds 失效
标题翻译：二氢苯并吡喃化合物和包含所述化合物的药物组合物
公开(公告)号：US4394382A
公开(公告)日：1983-07-19
申请号：US271927
申请日：1981-06-09
申请人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
发明人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
IPC分类号： C07D311/04 , A61K31/353 , A61P9/02 , A61P9/04 , A61P21/02 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/66 , A61K31/35
CPC分类号： C07D311/22 , C07D311/58 , C07D311/64 , C07D311/66 , Y10S514/821
摘要： A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,R.sub.1 represents a member selected from the group consisting of a C.sub.3 -C.sub.5 alkyl group, a hydroxy-(C.sub.3 -C.sub.5 alkyl) group, a lower alkylamino-lower alkyl group, a nitrato-(C.sub.3 -C.sub.5 alkyl) group and a phenyl-(C.sub.1 -C.sub.5) alkyl group, provided that the phenyl may be substituted by a lower alkoxy group, R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, NO.sub.2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group and acetyl group,R.sub.3 represents hydrogen or NO.sub.2,B represents a direct bond, a C.sub.1 -C.sub.7 alkylene group, a --O-lower alkylene group or a --CONH-lower alkylene group, andn represents 1 or 2;and an acid addition salt thereof and a pharmaceutical composition comprising aforesaid compound.
摘要翻译：由下式（I）表示的苯并吡喃化合物，其中A表示直接键或键-CH2-O-，R1表示选自C3-C5烷基，羟基 - （C3 -C 5烷基）基，低级烷基氨基 - 低级烷基，硝基 - （C 3 -C 5烷基）基和苯基 - （C 1 -C 5）烷基，条件是苯基可以被低级烷氧基取代，R 2 表示选自氢，卤素，OH，NO 2，氨基甲酰基，低级烷基，低级烷氧基，低级亚烷基氧基和乙酰基的成员，R 3表示氢或NO 2，B表示直接键，C 1 -C 7亚烷基，-O-低级亚烷基或-CONH-低级亚烷基，n表示1或2; 及其酸加成盐和包含上述化合物的药物组合物。

3. 发明授权

US4482562A Aromatic aminoethanol compounds, and utilization thereof as cardiovascular agents 失效
标题翻译：芳香族氨基乙醇化合物及其作为心血管药物的用途
公开(公告)号：US4482562A
公开(公告)日：1984-11-13
申请号：US414819
申请日：1982-09-03
申请人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
发明人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
IPC分类号： A61K31/21 , A61K31/135 , A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/00 , A61P9/12 , A61P25/02 , A61P25/28 , C07C67/00 , C07C203/04 , C07C213/00 , C07C217/32 , C07C217/70 , C07C219/16 , C07C219/34 , C07C225/16 , C07C231/00 , C07C231/12 , C07C235/42 , C07C235/46 , C07C237/30 , C07C301/00 , C07C303/40 , C07C311/17 , C07C311/29 , C07C313/00 , C07C315/04 , C07C317/22 , C07C317/24 , C07C317/32 , C07C319/20 , C07C323/25 , C07D213/30 , C07D213/60 , C07D213/64 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12 , C07D213/74
CPC分类号： C07D213/64 , C07C203/04 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12
摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.

4. 发明授权

US4374840A Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate moieties 失效
标题翻译：含有烷基 - 硝酸盐部分的某些苯基或吡啶基 - 丙醇 - 胺
公开(公告)号：US4374840A
公开(公告)日：1983-02-22
申请号：US233643
申请日：1981-02-11
申请人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
发明人： Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
IPC分类号： A61K31/21 , A61K31/135 , A61K31/165 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/00 , A61P9/12 , A61P25/02 , A61P25/28 , C07C67/00 , C07C203/04 , C07C213/00 , C07C217/32 , C07C217/70 , C07C219/16 , C07C219/34 , C07C225/16 , C07C231/00 , C07C231/12 , C07C235/42 , C07C235/46 , C07C237/30 , C07C301/00 , C07C303/40 , C07C311/17 , C07C311/29 , C07C313/00 , C07C315/04 , C07C317/22 , C07C317/24 , C07C317/32 , C07C319/20 , C07C323/25 , C07D213/30 , C07D213/60 , C07D213/64 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12 , C07D213/74
CPC分类号： C07D213/64 , C07C203/04 , C07D213/69 , C07D303/24 , C07D303/26 , C07D309/12
摘要： A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.
摘要翻译：由下式表示的化合物：其中A表示直接键或-O-CH 2 - 键，B表示与芳环D的碳原子键合的C1-C11亚烷基直接或-O- ，-S-，-SO-或-NH-，W表示碳原子或氮原子，R1表示C3-C7烷基，羟基-C1-C6烷基或苯基或二苯基 - 烷基，其中具有1至4个碳原子的烷基，R 2表示选自氢，卤素，OH，C 1 -C 4烷基，NO 2，C 1 -C 4烷氧基，乙酰基，烯丙氧基，氨基甲酰基和氨磺酰基的成员，当两个或更多个 R2基团存在，它们可以相同或不同，n表示1,2或3，m表示1或2，条件是n + m> = 4; 及其酸加成盐; 其制造方法; 和包含上述化合物的药物组合物。

5. 发明授权

US4737506A Anti-arteriosclerotic pyridyl or imidazolyl derivatives of carbonyloxyalkyl hantzsch esters 失效
标题翻译：羧基烷基羟胺酯的抗动脉硬化吡啶基或咪唑基衍生物
公开(公告)号：US4737506A
公开(公告)日：1988-04-12
申请号：US851134
申请日：1986-04-07
申请人： Noboru Shimizu , Hiroyuki Ishiwata , Tomio Ohta , Hiroshi Ishihama , Yasumi Uchida
发明人： Noboru Shimizu , Hiroyuki Ishiwata , Tomio Ohta , Hiroshi Ishihama , Yasumi Uchida
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/455 , A61P7/02 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D401/14
CPC分类号： C07D211/90
摘要： This invention relates to a 1,4-dihydropyridine-3,5-dicarboxylate derivative represented by the following general formula (I): ##STR1## wherein R means an imidazolyl or pyridyl group, R.sub.1 denotes a hydrogen or halogen atom or a nitro or trifluoromethyl group, R.sub.2 is a lower alkyl group, X is CH or N, A means a lower alkylene group, ##STR2## B being a lower alkylene or O-lower alkylene group, ##STR3## R.sub.4 being a hydrogen atom or lower alkyl group, or ##STR4## m denotes a number of 1-3, and n stands for 1 or 2. The derivative has vasodilative effects, hyperkinemic effects, platelet aggregation inhibitory effects, thromboxane A.sub.2 formation inhibitory effects and so on, and are hence useful as a pharmaceutical product such as vasodilator, antihypertensive, antithrombotic agent, antiarteriosclerotic agent or the like.
摘要翻译： PCT No.PCT / JP85 / 00449 Sec。一九八六年四月七日 102（e）日期1986年4月7日PCT提交1985年8月12日PCT公布。公开号WO86 / 01206 PCT 日本特愿1986年2月27日。本发明涉及由以下通式（I）表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物：其中R表示咪唑基或吡啶基，R1 表示氢或卤素原子或硝基或三氟甲基，R 2为低级烷基，X为CH或N，A表示低级亚烷基，B为低级亚烷基或O-低级亚烷基，IMA图 > R4是氢原子或低级烷基，或者表示1-3个数，n代表1或2.该衍生物具有血管扩张作用，超动力作用，血小板聚集抑制作用，血栓素A2形成抑制效果等，因此可用作药物产品如血管扩张剂，抗高血压剂，抗血栓形成剂，抗动脉硬化剂等。

6. 发明授权

US4115398A Isoindoline derivatives and the acid addition salts thereof and process for the preparation of same 失效
标题翻译：异二氢吲哚衍生物及其酸加成盐及其制备方法
公开(公告)号：US4115398A
公开(公告)日：1978-09-19
申请号：US757028
申请日：1977-01-05
申请人： Koji Nakamura , Haruo Otaki , Yutaka Yamamoto , Noboru Shimizu , Kiyoshi Kawamura , Seiichi Sato
发明人： Koji Nakamura , Haruo Otaki , Yutaka Yamamoto , Noboru Shimizu , Kiyoshi Kawamura , Seiichi Sato
IPC分类号： C07D209/44
CPC分类号： C07D209/44
摘要： Isoindoline derivatives of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R represents a moiety selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, nitro, hydroxy and hydroxy lower alkyl, and n is a positive number from 1 to 3, which R's may be the same or different when n is 2 or 3, and when n is 2, the two R's may be joined to the carbon atom vicinal to the phenyl ring to which the two R's are joined and may taken together form lower alkylenedioxy and the group ##STR2## and R.sub.1 is a member of the group consisting of hydrogen and lower alkyl.The compounds of this invention can be readily prepared by reacting a compound of the formula ##STR3## wherein R represents, in addition to the above defined, alkoxycarbonyloxy; R.sub.1 and n are as defined above; and X is halogen or the groups --O--SO.sub.2 --Y where Y is either lower alkyl or aryl, with isoindoline of the formula ##STR4## or a minemal acid salt thereof. The compounds are useful in such fields as, for example cardiovascular drugs.
摘要翻译：式（I）的异二氢吲哚衍生物及其药学上可接受的酸加成盐，其中R表示选自氢，卤素，低级烷基，低级烷氧基，硝基，羟基和羟基低级烷基的部分，和 n是1至3的正数，当n为2或3时，R可以相同或不同，当n为2时，两个R可以连接到苯环附近的碳原子上， R的连接可以一起形成低级亚烷基二氧基和基团，R 1是由氢和低级烷基组成的组的成员。

7. 发明授权

US07847589B2 Configuration data feeding device 有权
标题翻译：配置数据送料装置
公开(公告)号：US07847589B2
公开(公告)日：2010-12-07
申请号：US12625730
申请日：2009-11-25
申请人： Toshihisa Kyouno , Kenichi Miyama , Nobuyuki Kobayashi , Noboru Shimizu
发明人： Toshihisa Kyouno , Kenichi Miyama , Nobuyuki Kobayashi , Noboru Shimizu
IPC分类号： H03K19/177
CPC分类号： H03K19/17748 , H03K19/17764
摘要： A configuration data feeding device for feeding configuration data to a plurality of FPGAs includes a memory for storing configuration data that are fed to the plurality of FPGAs, a plurality of interface units for outputting the configuration data read out from the memory, according to their specific configuration layouts, an interface selection unit for selecting, out of the plurality of interface units, an interface unit that is to be used for configuring each of the plurality of FPGAs, and a circuit-switching unit for switching the circuits that connect the FPGAs to the interface units depending upon the selection by the interface selection unit.
摘要翻译：用于将配置数据馈送到多个FPGA的配置数据馈送装置包括用于存储馈送到多个FPGA的配置数据的存储器，用于输出从存储器读出的配置数据的多个接口单元，配置布局;接口选择单元，用于从所述多个接口单元中选择要用于配置所述多个FPGA中的每一个的接口单元;以及电路切换单元，用于将连接所述FPGA的电路切换到接口单元取决于接口选择单元的选择。

8. 发明申请

US20100066408A1 CONFIGURATION DATA FEEDING DEVICE 有权
标题翻译：配置数据送料装置
公开(公告)号：US20100066408A1
公开(公告)日：2010-03-18
申请号：US12625730
申请日：2009-11-25
申请人： Toshihisa Kyouno , Kenichi Miyama , Nobuyuki Kobayashi , Noboru Shimizu
发明人： Toshihisa Kyouno , Kenichi Miyama , Nobuyuki Kobayashi , Noboru Shimizu
IPC分类号： H03K19/173
CPC分类号： H03K19/17748 , H03K19/17764
摘要： A configuration data feeding device for feeding configuration data to a plurality of FPGAs includes a memory for storing configuration data that are fed to the plurality of FPGAs, a plurality of interface units for outputting the configuration data read out from the memory, according to their specific configuration layouts, an interface selection unit for selecting, out of the plurality of interface units, an interface unit that is to be used for configuring each of the plurality of FPGAs, and a circuit-switching unit for switching the circuits that connect the FPGAs to the interface units depending upon the selection by the interface selection unit.
摘要翻译：用于将配置数据馈送到多个FPGA的配置数据馈送装置包括用于存储馈送到多个FPGA的配置数据的存储器，用于输出从存储器读出的配置数据的多个接口单元，配置布局，用于从所述多个接口单元中选择要用于配置所述多个FPGA中的每一个的接口单元的接口选择单元，以及用于将连接所述FPGA的电路切换到接口单元取决于接口选择单元的选择。

9. 发明授权

US07408475B2 Power supply monitoring device 有权
标题翻译：电源监控装置
公开(公告)号：US07408475B2
公开(公告)日：2008-08-05
申请号：US11491226
申请日：2006-07-24
申请人： Koichi Sugama , Noboru Shimizu , Tsutomu Chikazawa , Ryuji Kayama , Kenichi Yajima , Yukio Katayanagi , Takashi Kaiga
发明人： Koichi Sugama , Noboru Shimizu , Tsutomu Chikazawa , Ryuji Kayama , Kenichi Yajima , Yukio Katayanagi , Takashi Kaiga
IPC分类号： G08B21/00
CPC分类号： G01R31/3004 , G01R31/31721
摘要： In a power supply monitoring device, a power supply voltage monitoring portion always monitors a power supply voltage supplied to a monitored circuit and outputs a voltage reduction signal when detecting that the power supply voltage is reduced below a predetermined threshold (e.g. a second voltage higher than a voltage guaranteeing a normal operation of the monitored circuit and lower than a rated voltage). A monitoring controller having received the voltage reduction signal determines whether or not an operational malfunction has occurred in the monitored circuit by comparing operation data of the monitored circuit with reference data of the monitoring controller itself. Also, the monitoring controller executes recovery processing (reset processing or reference data overwrite processing) suitable for the monitored circuit referring to a prestored recovery processing type specific to the monitored circuit when detecting an operational malfunction of the monitored circuit.
摘要翻译：在电源监视装置中，当检测到电源电压降低到预定阈值以下时，电源电压监视部分总是监视提供给被监测电路的电源电压并输出电压降低信号（例如，高于一个电压，保证被监测电路的正常运行并低于额定电压）。已经接收到电压降低信号的监视控制器通过将监视电路的操作数据与监视控制器本身的参考数据进行比较来确定监视电路中是否发生了操作故障。而且，当检测到所监视的电路的操作故障时，监视控制器参考专用于被监测电路的预先存储的恢复处理类型，执行适合被监视电路的恢复处理（复位处理或参考数据重写处理）。

10. 发明授权

US06887101B2 Differential transmission connector 失效
标题翻译：差动传动连接器
公开(公告)号：US06887101B2
公开(公告)日：2005-05-03
申请号：US10832347
申请日：2004-04-27
申请人： Takeshi Ito , Mitsuru Kobayashi , Hideo Miyazawa , Noboru Shimizu
发明人： Takeshi Ito , Mitsuru Kobayashi , Hideo Miyazawa , Noboru Shimizu
IPC分类号： G02B6/42 , H01R13/46 , H01R31/06 , H01R33/945
CPC分类号： H01R33/945 , H01R31/065 , H01R2201/06
摘要： A connector for differential transmission is disclosed. The connector includes a connector housing, a connector main body attached thereto, and a photoelectric conversion module provided to the connector housing to be electrically connected to the connector main body. The connector main body includes a differential transmission electric connector part connectable to the connector of an apparatus. Ground contact members and signal contact pairs each including first and second signal contact members are arranged alternately in the connector main body. The photoelectric conversion module includes a photoelectric conversion part and an optical fiber cable connector part to which an optical fiber cable is connectable. The differential transmission electric connector part and the optical fiber cable connector part are provided to the opposite ends of the connector housing.
摘要翻译：公开了一种用于差动传动的连接器。连接器包括连接器壳体，连接器主体，以及设置在连接器壳体上并与连接器主体电连接的光电转换模块。连接器主体包括可连接到设备的连接器的差分传输电连接器部分。每个包括第一和第二信号接触构件的接地构件和信号接触对交替布置在连接器主体中。光电转换模块包括可光纤电缆可连接的光电转换部分和光纤电缆连接器部分。差动传输电连接器部分和光纤电缆连接器部分设置在连接器壳体的相对端。

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