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1. 再颁专利

USRE43858E1 Substituted cycloalkene derivative 有权
标题翻译：取代的环烯烃衍生物
公开(公告)号：USRE43858E1
公开(公告)日：2012-12-11
申请号：US13224745
申请日：2006-09-13
申请人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
发明人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
IPC分类号： A61K31/335 , C07D317/72
摘要： A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.
摘要翻译：式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗激活。

2. 发明申请

US20090233952A1 SUBSTITUTED CYCLOALKENE DERIVATIVE 有权
公开(公告)号：US20090233952A1
公开(公告)日：2009-09-17
申请号：US12066813
申请日：2006-09-13
申请人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
发明人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
IPC分类号： A61K31/443 , C07D317/72 , A61K31/357 , C07D405/08 , A61K31/4025 , C07D319/04 , C07D405/10
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
摘要： [Object] To provide a substituted cycloalkene derivative having an action to suppress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a medicament containing them as an active ingredient, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.[Solution] A compound represented by the general formula (I): {whereinX and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A (the ring is 3- to 7-membered heterocyclyl ring or 3- to 7-membered cycloalkyl ring), each represents a hydrogen atom, or X and Y together represent a substituent of ring B. l and m, independently from each other, represent an integer of 0 to 3, and l+m is 1 to 3. R1 is an aliphatic hydrocarbon group and the like which may be substituted with a group selected from Substituent group β and Substituent group γ. n represents an integer of 0 to 3. R2 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. R3 is a phenyl group, 5- to 6-membered heteroaryl group and the like which may be substituted with a group selected from Substituent group ε. R5 is a C1-C6 alkyl group and the like which may be substituted with a group selected from a hydrogen atom and Substituent group β. Provided that in the case where R3 is a phenyl group which may be substituted with a group selected from Substituent group ε, X and Y represent a group in which X and Y together with a carbon atom to which they are bound form ring A, or X and Y together represent a substituent of ring B.

3. 发明授权

US07935835B2 Substituted cycloalkene derivative 有权
标题翻译：取代的环烯烃衍生物
公开(公告)号：US07935835B2
公开(公告)日：2011-05-03
申请号：US12066813
申请日：2006-09-13
申请人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
发明人： Tomio Kimura , Nobuyuki Ohkawa , Takayoshi Nagasaki , Atsuhiro Sugidachi , Osamu Ando
IPC分类号： C07D319/00 , C07D315/00 , C07D327/00
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
摘要： A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.
摘要翻译：式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗激活。

4. 发明授权

US5290649A Electrophotographic photoreceptor comprising a photosensitive layer containing a naphthylhydrazone compound 失效
标题翻译：包含含有萘基腙化合物的感光层的电子照相感光体
公开(公告)号：US5290649A
公开(公告)日：1994-03-01
申请号：US246916
申请日：1988-09-16
申请人： Tetsumi Suzuki , Hitoshi Ono , Osamu Ando
发明人： Tetsumi Suzuki , Hitoshi Ono , Osamu Ando
IPC分类号： C09B26/02 , G03G5/06
CPC分类号： C09B26/02 , G03G5/0668
摘要： An electrophotographic photoreceptor is formed by a photosensitive layer containing a naphtylhydrazone compound of the formula: ##STR1## wherein X and Y are independently a hydrogen atom, lower alkyl group, lower alkoxy group, phenoxy group or arylalkoxy group; R.sup.1 is a naphtyl group; R.sup.2 is a hydrogen atom, lower alkyl group, allyl group, substituted or unsubstituted phenyl group, or aralkyl group; and l and m are 1 or 2. The photoreceptor thus formed is not only highly sensitive but resistant to ozone deterioration, which markedly improves the durability thereof.
摘要翻译：电子照相感光体由含有下式的化合物（*化学结构*）的感光层形成，其中X和Y独立地为氢原子，低级烷基，低级烷氧基，苯氧基或芳基烷氧基; R1是萘基; R2是氢原子，低级烷基，烯丙基，取代或未取代的苯基或芳烷基; l和m为1或2.由此形成的感光体不仅高度敏感，而且耐臭氧劣化，这显着提高了其耐久性。

5. 发明授权

US5166030A Electrostatic image-developing toner containing a quaternary ammonium charge controlling agent 失效
标题翻译：含有季铵盐电荷控制剂的静电图像显影剂
公开(公告)号：US5166030A
公开(公告)日：1992-11-24
申请号：US757211
申请日：1991-09-10
申请人： Hitoshi Ono , Osamu Ando , Masako Takeuchi
发明人： Hitoshi Ono , Osamu Ando , Masako Takeuchi
IPC分类号： G03G9/097
CPC分类号： G03G9/09758 , G03G9/0975
摘要： An electrostatic image-developing toner comprising at least a resin and a colorant, which contains at least one member selected from the group consisting of compounds of the following formulas (I) and (II): ##STR1## wherein each of R.sup.1, R.sup.2, Ar.sup.1 and Ar.sup.2 is a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aralkyl group, and A is (B) (SO.sub.3.sup..crclbar.).sub.2 or MX.sub.6.sup.2.crclbar., wherein B is ##STR2## (wherein each of R.sup.3 and R.sup.4 is a hydrogen atom, an alkyl group, a hydroxyl group or an amino group), M is a titanium atom, a zirconium atom or a silicon atom, and X is a fluorine atom, a chlorine atom or a bromine atom.

6. 发明申请

US20090246672A1 TONER FOR THE DEVELOPMENT OF ELECTROSTATIC IMAGE AND THE PRODUCTION PROCESS THEREOF 审中-公开
标题翻译：静电图像的发展及其生产工艺的优点
公开(公告)号：US20090246672A1
公开(公告)日：2009-10-01
申请号：US12108790
申请日：2008-04-24
申请人： Tomoko Ishikawa , Yuqing Xu , Katsuo Koizumi , Noriaki Takahashi , Osamu Ando
发明人： Tomoko Ishikawa , Yuqing Xu , Katsuo Koizumi , Noriaki Takahashi , Osamu Ando
IPC分类号： G03G9/09 , G03G9/08 , G03G9/087 , G03G9/00
CPC分类号： G03G9/091 , G03G9/08 , G03G9/0808 , G03G9/08782 , G03G9/08795 , G03G9/08797
摘要： A toner for the development of an electrostatic image is provided wherein at least one layer of a particulate resin is coated onto a substantial portion of the surface of an agglomerate of particles made from at least primary polymer particles and primary colorant particles, wherein at least one of the primary polymer particles and the particulate resin contains a wax, and the particulate resin of the outermost layer is substantially free of wax and a process for producing the toner.
摘要翻译：提供了用于显影静电图像的调色剂，其中至少一层颗粒树脂涂覆在由至少一次聚合物颗粒和初级着色剂颗粒制成的颗粒团聚体的大部分表面的表面上，其中至少一个的初级聚合物颗粒和颗粒状树脂含有蜡，最外层的颗粒状树脂基本上不含蜡和调色剂的制造方法。

7. 发明申请

US20070221448A1 Sealing material 审中-公开
公开(公告)号：US20070221448A1
公开(公告)日：2007-09-27
申请号：US11804513
申请日：2007-05-18
申请人： Masashi Kudo , Kenichi Fujimoto , Atsushi Koga , Yoshifumi Kojima , Osamu Ando , Yoshiki Nakagawa
发明人： Masashi Kudo , Kenichi Fujimoto , Atsushi Koga , Yoshifumi Kojima , Osamu Ando , Yoshiki Nakagawa
IPC分类号： C09K3/10 , F01M11/00
CPC分类号： F16J15/102 , C08F220/18 , C08G77/12 , C08L33/14 , C08L57/04 , C08L83/04 , C09J133/08 , C09K3/10 , C09K2200/0208 , C09K2200/0625 , F01M2011/0091 , F16J15/14 , C08L2666/04 , C08F2220/285 , C08F236/02
摘要： A sealing material, which comprises a curing product of a composition comprising (A) an acrylic polymer having at least one alkenyl group capable of undergoing hydrosilylation reaction, (B) a hydrosilyl group-containing compound and (C) a hydrosilylation catalyst as essential components, is suitable for use as cam cover seals and oil pan seals for automobile engines, fuel cell cooling medium seals, automobile wire harnesses seals, HDD cover gasket or vibration-insulating HDD cover gasket seals, etc.

8. 发明授权

US5422483A Near infrared analyzer 失效
标题翻译：近红外分析仪
公开(公告)号：US5422483A
公开(公告)日：1995-06-06
申请号：US88453
申请日：1993-07-07
申请人： Osamu Ando , Atsuhiro Iida , Kan Nakamura , Yasuo Tsukuda
发明人： Osamu Ando , Atsuhiro Iida , Kan Nakamura , Yasuo Tsukuda
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01N21/3563 , G01N2201/065
摘要： A near infrared analyzer has, arranged on a base, a halogen tungsten lamp as light source, an optical stop for light from the source, an optical system for converging a flux of light for measuring and directing it to a measuring section and a system including an integrating sphere at which a sample is set. A spectrometer part has its entrance slit placed on the bottom surface of the integrating sphere, and includes a diffraction grating for diffraction and dispersion of incident light flux from the entrance slit, an arrayed detector and a reflective mirror for reflecting the diffracted light from the diffraction grating so as to be dispersed and focused on the surface of the detector. Signals from the detector can be sequentially retrieved for electronically scanning wavelengths without mechanically oscillating or rotating the grating. This makes it possible to maintain high accuracy in wavelengths over a long period of time. As the speed of measurement is increased, measurements can be repeated and obtained data integrated for reducing noise and improving accuracy of measurement.
摘要翻译：一种近红外线分析器，其设置在卤素钨灯作为光源的基座上，用于来自光源的光的停止点，用于会聚用于测量的光束并将其引导到测量部分的光学系统，以及包括设置样品的积分球。光谱仪部分的入射狭缝位于积分球的底面，并包括衍射光栅，用于从入射狭缝衍射和分散入射光束，阵列检测器和反射镜，用于反射来自衍射的衍射光光栅以分散和聚焦在检测器的表面上。可以顺序地检索来自检测器的信号用于电子扫描波长，而无需机械振荡或旋转光栅。这使得可以在长时间内保持高精度的波长。随着测量速度的提高，可以重复测量并获得集成的数据，以减少噪音和提高测量精度。

9. 发明授权

US5311292A Transmissivity measuring apparatus for a color separation prism 失效
标题翻译：用于分色棱镜的透射率测量装置
公开(公告)号：US5311292A
公开(公告)日：1994-05-10
申请号：US915599
申请日：1992-07-21
申请人： Tatsumi Sato , Osamu Ando
发明人： Tatsumi Sato , Osamu Ando
IPC分类号： G01M11/00 , G01J3/08 , G01J3/50 , G01N21/25 , G01N21/27 , G01N21/31 , G01N21/59 , G01J3/46
CPC分类号： G01N21/25 , G01J3/0251 , G01J3/08 , G01J3/50 , G01N2021/3166 , G01N2201/065
摘要： An apparatus for measuring color transmissivities of a color separation prism P includes (where the color separation prism P receives a measurement light S on an incident path and emits three color lights Sr, Sg and Sb on three exit paths of different directions): a photomultiplier 21 and an integrating sphere I for measuring an intensity of light entering the integrating sphere I on an entrance path, where the entrance path is set detached from an extension of the incident path; a first movable mirror 9 located in one of four paths including an extension of the incident path and the three exit paths for reflecting the light on each path to the second movable mirror 10; and a second movable mirror 10 placed on the entrance path of the integrating sphere I (with the photomultiplier 21) and oriented in one of four directions for reflecting the light from the first movable mirror 9 to the integrating sphere I. Because the 100%-transmission light and the three color lights transmitted through the color separation prism P undergo the same optical history, absolute transmissivities of the color lights can be measured, and the two-beam method can be used since the integrating sphere I is fixed.
摘要翻译：用于测量分色棱镜P的颜色透射率的装置包括（其中分色棱镜P接收入射路径上的测量光S并在不同方向的三个出口处发射三色光Sr，Sg和Sb）：光电倍增管 21和用于测量在入射路径上进入积分球I的光的强度的积分球I，其中入射路径与入射路径的延伸部分离开; 第一可移动镜9，其位于包括入射路径的延伸部的四个路径中的一个中，以及用于将每条路径上的光反射到第二可移动镜10的三个出射路径; 以及放置在积分球I（与光电倍增管21）的入射路径上的第二可移动镜10，并且在四个方向中的一个方向上定向，以将来自第一可移动镜9的光反射到积分球I.由于100％ - 透射光和通过分色棱镜P透射的三色光经历相同的光学历史，可以测量彩色光的绝对透射率，并且可以使用双积分方法，因为积分球I是固定的。

10. 发明授权

US5223913A Spectrophotometer 失效
标题翻译：分光光度计
公开(公告)号：US5223913A
公开(公告)日：1993-06-29
申请号：US858631
申请日：1992-03-27
申请人： Osamu Ando , Toshiaki Fukuma
发明人： Osamu Ando , Toshiaki Fukuma
IPC分类号： G01J3/00 , G01J3/02 , G01J3/06 , G01J3/10 , G01J3/12 , G01J3/18
CPC分类号： G01J3/10 , G01J3/02 , G01J3/0235 , G01J3/027 , G01J3/06 , G01J2003/063 , G01J2003/064 , G01J2003/1213 , G01J3/18
摘要： A spectrophotometer including: a) a light source switching mechanism for switching a plurality of light sources by swinging a light source mirror; b) a filter selecting mechanism; c) a diffraction grating rotating mechanism; and d) a controller for determining the operation origins of the three driving mechanisms using a rough origin sensor provided for the diffraction grating rotating mechanism and a photometer. The operation of the controller is to: i) determine an origin of the movement of the filter by making an end of the filter frame to touch a stopper; ii) determine a rough origin of the diffraction grating using the rough origin sensor; and iii) determine an origin of the movement of the light source mirror and a precise origin of the movement of the diffraction grating by detecting the position at which the photometer detects the maximum intensity of light.

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