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1. 发明申请

US20060195059A1 Delivery of therapeutic through multiple delivery members 有权
公开(公告)号：US20060195059A1
公开(公告)日：2006-08-31
申请号：US11038241
申请日：2005-01-21
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , William Shaw
IPC分类号： A61M29/00
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.

2. 发明申请

US20060206062A1 Rotatable multi-port therapeutic delivery device 有权
公开(公告)号：US20060206062A1
公开(公告)日：2006-09-14
申请号：US11074850
申请日：2005-03-09
申请人： Wendy Naimark , Maria Palasis , Toby Freyman , William Shaw
发明人： Wendy Naimark , Maria Palasis , Toby Freyman , William Shaw
IPC分类号： A61M25/00
CPC分类号： A61M25/0069
摘要： A therapeutic delivery device is provided wherein a delivery body is supported by an elongate member such that the body may rotate as it delivers therapeutic to a target site. Therapeutic may be delivered by deploying delivery heads into a target site as well as by dispensing therapeutic from the delivery head. The delivery body may be cylindrically shaped, spherically shaped or shaped in various other configurations. In one embodiment the delivery body contains tracks that may roll back and forth over a target site to dispense therapeutic. In another embodiment, the delivery heads of the delivery body have internal valves that open and close in order to dispense therapeutic.

3. 发明申请

US20050222485A1 System for administering a combination of therapies to a body lumen 有权
标题翻译：用于将治疗组合施用于体腔的系统
公开(公告)号：US20050222485A1
公开(公告)日：2005-10-06
申请号：US11131001
申请日：2005-05-16
申请人： William Shaw , James Barry , Paul Goll , Maria Palasis
发明人： William Shaw , James Barry , Paul Goll , Maria Palasis
IPC分类号： A61B17/22 , A61B18/02 , A61B18/04 , A61K9/00 , A61K9/22 , A61N5/10 , A61N5/00
CPC分类号： A61K9/0024 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/046 , A61F2/82 , A61N5/1002
摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.
摘要翻译：本发明提供了一种系统，其包括递送治疗组合的医疗装置。这些疗法包括辐射，生物活性物质，冷冻疗法和热疗法的管理。本发明还涉及使用本发明的系统来治疗体腔表面的方法。提供了一种用于将生物活性材料递送到暴露于放射源的体腔表面的系统。一方面，该系统包括可植入医疗装置，其具有两个相对的端部，每个端部具有表面和中间部分。两个相对端包括生物活性材料，并且医疗装置的中间部分基本上不含任何生物活性物质。在另一方面，系统将遗传物质递送到暴露于放射源的体腔表面。提供了一种用于处理体腔表面的另一系统，其中该系统包括可植入医疗装置，其包括生物活性材料和用于将治疗源施加到与相对侧接触的体腔表面部分的装置医疗器械的末端。治疗源可以是冷冻治疗源或热疗源。

4. 发明申请

US20070156117A1 Catheter assembly and method for internally anchoring a catheter in a patient 有权
标题翻译：导管组件和用于将导管内部锚定在患者体内的方法
公开(公告)号：US20070156117A1
公开(公告)日：2007-07-05
申请号：US11323913
申请日：2005-12-30
申请人： Mark Adams , William Shaw , Donald Hovey , Luis Maseda
发明人： Mark Adams , William Shaw , Donald Hovey , Luis Maseda
IPC分类号： A61M39/10 , A61M29/00 , A61M39/00 , A61M25/16 , A61M25/18
CPC分类号： A61J15/0015 , A61J15/0034 , A61M25/04 , A61M39/0247 , A61M39/10 , A61M2025/0233 , A61M2025/028 , A61M2039/0261 , A61M2039/0273 , A61M2039/0282 , A61M2039/1027
摘要： A catheter assembly and method for internally anchoring a catheter in a patient. According to one embodiment, the catheter assembly includes a catheter, a tubular fitting coupled to one end of the catheter, and an internal bolster coaxially mounted around the tubular fitting. The tubular fitting has a waist portion, and the internal bolster is secured thereto by a snap-fit. To internally anchor the catheter in a patient, one inserts the end of the catheter to which the fitting is coupled into the patient and then, while the fitting and its coupled end of the catheter are within the patient, inserts the internal bolster over the fitting until it snap-fits into place over the waist portion, thereby internally anchoring the catheter within the patient.
摘要翻译：导管组件和用于将导管内部锚固在患者体内的方法。根据一个实施例，导管组件包括导管，联接到导管的一端的管状配件以及同轴地安装在管状配件周围的内部垫。管状配件具有腰部，并且内部枕头通过卡扣配合固定在其上。为了将导管内部锚定在患者体内，将导管的端部插入到患者体内，然后在导管的配件及其耦合的端部位于患者体内的同时将内部枕垫插入配件直到其卡扣配合到腰部上方，从而将导管内部锚定在患者体内。

5. 发明申请

US20060222756A1 Medical devices, drug coatings and methods of maintaining the drug coatings thereon 审中-公开
标题翻译：医疗器械，药物涂层以及维持药物涂层的方法
公开(公告)号：US20060222756A1
公开(公告)日：2006-10-05
申请号：US11437572
申请日：2006-05-19
申请人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
发明人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
IPC分类号： B05D3/00 , A61L33/00
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

6. 发明申请

US20060173244A1 System and method of obstruction removal 有权
标题翻译：障碍物清除系统和方法
公开(公告)号：US20060173244A1
公开(公告)日：2006-08-03
申请号：US11241829
申请日：2005-09-30
申请人： Dennis Boulais , Michael Banik , Vincent Turturro , Christopher Rowland , David Hoffman , John O'Connor , Lucien Couvillon , Luis Maseda , Donald Hovey , Mark Adams , William Shaw , Laurence Brenner
发明人： Dennis Boulais , Michael Banik , Vincent Turturro , Christopher Rowland , David Hoffman , John O'Connor , Lucien Couvillon , Luis Maseda , Donald Hovey , Mark Adams , William Shaw , Laurence Brenner
IPC分类号： A61B1/12 , A61B1/00
CPC分类号： A61B1/12 , A61B1/00085 , A61B1/00087 , A61B1/00091 , A61B1/00094 , A61B1/015 , A61B1/018 , A61B1/05 , A61B1/0607 , A61B1/0676 , A61B1/0684 , A61B1/125 , A61B1/126 , A61B1/31 , A61B2017/22092 , A61B2017/320775 , A61M3/0279 , A61M3/0283
摘要： In one aspect, the present invention is a system for preparing a patient for an endoscopy procedure, such as a colonoscopy. The endoscopic preparation and examination system includes an endoscope, a source of irrigation and aspiration, and a control unit. The endoscope includes an elongated flexible shaft with a distal tip and a proximal end, at least one aspiration lumen and at least one irrigation lumen. A plurality of irrigation ports are functionally connected to the at least one irrigation lumen and a plurality of aspiration ports are functionally connected to the at least one aspiration lumen. In another aspect, the invention provides a method of clearing an obstructed view in a patient prior to, or during an endoscopic examination.
摘要翻译：一方面，本发明是用于制备用于内窥镜检查程序的患者的系统，例如结肠镜检查。内窥镜准备和检查系统包括内窥镜，灌注源和抽吸源，以及控制单元。内窥镜包括具有远侧末端和近端的细长柔性轴，至少一个抽吸腔和至少一个冲洗腔。多个冲洗口在功能上连接到所述至少一个冲洗腔，并且多个抽吸端口在功能上连接到所述至少一个抽吸腔。在另一方面，本发明提供一种在内窥镜检查之前或期间清除患者中的阻塞视图的方法。

7. 发明申请

US20050070888A1 Medical device systems and methods 有权
标题翻译：医疗器械系统和方法
公开(公告)号：US20050070888A1
公开(公告)日：2005-03-31
申请号：US10977255
申请日：2004-10-29
申请人： Kristian Dimatteo , William Shaw , Robert Rioux
发明人： Kristian Dimatteo , William Shaw , Robert Rioux
IPC分类号： A61F2/958 , A61B18/14
CPC分类号： A61B18/1492 , A61B17/22012 , A61B17/32 , A61B2018/00214 , A61B2018/0022 , A61B2018/1467 , A61B2018/1475
摘要： Medical devices and related methods are disclosed.
摘要翻译：公开了医疗器械及相关方法。

8. 发明授权

US07513892B1 Guidewire compatible port and method for inserting same 有权
标题翻译：导丝兼容端口和插入方法
公开(公告)号：US07513892B1
公开(公告)日：2009-04-07
申请号：US09690473
申请日：2000-10-18
申请人： Brett Haarala , William Shaw , Chris Davey
发明人： Brett Haarala , William Shaw , Chris Davey
IPC分类号： A61M31/00 , A61M37/00
CPC分类号： A61M39/0208 , A61M2039/0235
摘要： An access port assembly having an attachable catheter allows for inserting a guidewire into the catheter to aid in the placement of the integral catheter while still attached to the access port assembly. A method is described for placing an access port fixedly attached to a catheter into a patient using a guidewire inserted into the catheter.
摘要翻译：具有可附接导管的入口端口组件允许将导丝插入导管中以有助于整体导管的放置，同时仍然附接到进入端口组件。描述了一种使用插入到导管中的导丝将入口固定地连接到患者的入口的方法。

9. 发明申请

US20050033417A1 Coating for controlled release of a therapeutic agent 审中-公开
标题翻译：用于治疗剂的控制释放的涂层
公开(公告)号：US20050033417A1
公开(公告)日：2005-02-10
申请号：US10883328
申请日：2004-07-01
申请人： John Borges , Maritza Carballo , Pallassana Narayanan , William Shaw , Christopher Widenhouse
发明人： John Borges , Maritza Carballo , Pallassana Narayanan , William Shaw , Christopher Widenhouse
IPC分类号： A61B17/04 , A61B17/11 , A61B17/115 , A61F2/84 , A61K9/00 , A61K31/395 , A61K31/436 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/10 , A61L31/16 , A61P9/10 , A61F2/06
CPC分类号： A61K9/0024 , A61K31/395 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

10. 发明授权

US06613013B2 Guidewire compatible port and method for inserting same 失效
公开(公告)号：US06613013B2
公开(公告)日：2003-09-02
申请号：US09231075
申请日：1999-01-14
申请人： Brett Haarala , William Shaw , Chris Davey
发明人： Brett Haarala , William Shaw , Chris Davey
IPC分类号： A61M1100
CPC分类号： A61M39/0208 , A61M2039/0235
摘要： An access port assembly having an attachable catheter allows for inserting a guidewire into the catheter to aid in the placement of the integral catheter while still attached to the access port assembly. A method is described for placing an access port fixedly attached to a catheter into a patient using a guidewire inserted into the catheter.

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