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1. 发明申请

US20090082855A1 COATING FOR CONTROLLED RELEASE OF A THERAPEUTIC AGENT 审中-公开
标题翻译：涂层用于治疗药物的控制释放
公开(公告)号：US20090082855A1
公开(公告)日：2009-03-26
申请号：US12327357
申请日：2008-12-03
申请人： John Borges , Maritza Carballo , Pallassana V. Narayanan , William D. Shaw, JR. , Christopher W. Widenhouse
发明人： John Borges , Maritza Carballo , Pallassana V. Narayanan , William D. Shaw, JR. , Christopher W. Widenhouse
IPC分类号： A61F2/82
CPC分类号： A61K9/0024 , A61K31/395 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

2. 发明申请

US20050033417A1 Coating for controlled release of a therapeutic agent 审中-公开
标题翻译：用于治疗剂的控制释放的涂层
公开(公告)号：US20050033417A1
公开(公告)日：2005-02-10
申请号：US10883328
申请日：2004-07-01
申请人： John Borges , Maritza Carballo , Pallassana Narayanan , William Shaw , Christopher Widenhouse
发明人： John Borges , Maritza Carballo , Pallassana Narayanan , William Shaw , Christopher Widenhouse
IPC分类号： A61B17/04 , A61B17/11 , A61B17/115 , A61F2/84 , A61K9/00 , A61K31/395 , A61K31/436 , A61L27/28 , A61L27/34 , A61L27/54 , A61L31/00 , A61L31/10 , A61L31/16 , A61P9/10 , A61F2/06
CPC分类号： A61K9/0024 , A61K31/395 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L33/10 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

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