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1. 发明授权

US08991882B2 Process and apparatus for coating a porous substrate with a coating liquid 有权
标题翻译：用涂布液涂覆多孔基材的方法和设备
公开(公告)号：US08991882B2
公开(公告)日：2015-03-31
申请号：US12993192
申请日：2008-05-22
申请人： Clifford Dey , Markus Bohn , Hans-Steffen Schacht , Ashley P. Deanglis , Robert W. Van Holten , Dwayne Looney , Gerard Llanos , Avner Brandes
发明人： Clifford Dey , Markus Bohn , Hans-Steffen Schacht , Ashley P. Deanglis , Robert W. Van Holten , Dwayne Looney , Gerard Llanos , Avner Brandes
IPC分类号： B25J15/00 , B05D1/18 , B05C13/02 , B05C3/02
CPC分类号： B05D1/18 , B05C3/02 , B05C13/02
摘要： An engagement head for engaging a porous substrate includes at least two pin sets, each pin set including a plurality of pins arranged in a plurality of parallel pin rows at a predetermined pin angle, wherein pins of immediately neighboring pin rows are arranged such that pin angles for the pins in a pin row are inversely symmetrical to pin angles for the pins in a neighboring pin row. The pins of a pin row move collectively in the same direction when a pin set is extended, which direction is determined by the pin angle of the pin row, whereby neighboring pin rows move in opposite longitudinal directions from one another when the pin set is extended. The pin sets may be extended and retracted in unison by a single actuation source.
摘要翻译：用于接合多孔基材的接合头包括至少两个销组，每个销组包括以预定销角布置在多个平行销列中的多个销，其中紧邻相邻销列的销布置成使得销角因为引脚列中的引脚与相邻引脚列中引脚的引脚角度成反向对称。当销组延伸时，销排的销钉以相同的方向共同移动，该方向由销列的销角确定，由此当销组延伸时相邻的销列彼此相反的纵向方向移动。销组可以通过单个致动源一致地延伸和缩回。

2. 发明申请

US20080051865A1 Medical Devices, Drug Coatings and Methods for Maintaining the Drug Coatings Thereon 无效
公开(公告)号：US20080051865A1
公开(公告)日：2008-02-28
申请号：US11941351
申请日：2007-11-16
申请人： Gerard Llanos , Mark Roller , Angelo Scopelianos
发明人： Gerard Llanos , Mark Roller , Angelo Scopelianos
IPC分类号： A61F2/06 , B05D3/02
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61L31/16 , A61L2300/00 , A61L2300/41 , A61L2300/416 , A61L2300/606 , B05D3/0254 , Y10T428/3154 , C08L27/12 , C08L27/16 , C08L27/14
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

3. 发明申请

US20070276476A1 Medical Devices, Drug Coatings and Methods for Maintaining the Drug Coatings Thereon 审中-公开
公开(公告)号：US20070276476A1
公开(公告)日：2007-11-29
申请号：US11782918
申请日：2007-07-25
申请人： Gerard Llanos , Mark Roller , Angelo Scopelianos
发明人： Gerard Llanos , Mark Roller , Angelo Scopelianos
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2/91 , A61F2/915 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61L31/16 , A61L2300/00 , A61L2300/41 , A61L2300/416 , A61L2300/606 , B05D3/0254 , Y10T428/3154 , C08L27/12 , C08L27/16 , C08L27/14
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

4. 发明申请

US20070179597A1 Medical Devices, Drug Coatings and Methods for Maintaining the Drug Coatings Thereon 审中-公开
标题翻译：医疗器械，药物涂层和维护药物涂层的方法
公开(公告)号：US20070179597A1
公开(公告)日：2007-08-02
申请号：US11736271
申请日：2007-04-17
申请人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
发明人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
IPC分类号： A61F2/90 , B05D3/00 , A61L33/00
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

5. 发明申请

US20070026036A1 Drug/Drug Delivery Systems for the Prevention and Treatment of Vascular Disease 审中-公开
标题翻译：用于预防和治疗血管疾病的药物/药物输送系统
公开(公告)号：US20070026036A1
公开(公告)日：2007-02-01
申请号：US11467099
申请日：2006-08-24
申请人： Robert Falotico , Gregory Kopia , Gerard Llanos
发明人： Robert Falotico , Gregory Kopia , Gerard Llanos
IPC分类号： A61K31/4745 , A61F2/02
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/4745 , A61K31/727 , A61K45/06 , A61L2300/252 , A61L2300/41 , A61L2300/416 , A61K2300/00
摘要： A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
摘要翻译：药物和药物递送系统可用于治疗血管疾病。局部递送系统用雷帕霉素或其他合适的药物，药剂或化合物包被并且经内镜递送用于治疗和预防经皮冠状动脉冠状动脉造影术后的新生内膜增生。药物或药剂的局部递送提供了更高的效力和更低的全身毒性。

6. 发明申请

US20060129225A1 Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium 审中-公开
标题翻译：用于将心脏保护剂递送至缺血再灌注心肌的装置
公开(公告)号：US20060129225A1
公开(公告)日：2006-06-15
申请号：US11013081
申请日：2004-12-15
申请人： Gregory Kopia , Gerard Llanos
发明人： Gregory Kopia , Gerard Llanos
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61B17/0644 , A61B17/0686 , A61B17/115 , A61B2017/00893 , A61B2017/0641 , A61F2/07 , A61F2/89 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/001 , A61F2230/0054 , A61F2250/0067 , A61L31/16 , A61L2300/00
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Implantable medical devices may be coated or otherwise have affixed thereto agents for healing ischemic tissue.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。治疗剂也可以递送到疾病部位的区域。在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，试剂和/或化合物的洗脱速率。植入式医疗装置可以被涂覆或以其它方式固定到其上用于治疗缺血组织的药剂。

7. 发明授权

US09056092B2 Hemostatic bioabsorbable device with polyethylene glycol binder 有权
标题翻译：具有聚乙二醇粘合剂的止血生物可吸收装置
公开(公告)号：US09056092B2
公开(公告)日：2015-06-16
申请号：US13324115
申请日：2011-12-13
申请人： Aaron D. Pesnell , Gerard Llanos
发明人： Aaron D. Pesnell , Gerard Llanos
IPC分类号： A61L15/28 , A61K38/36 , A61K38/48 , A61L15/26 , A61L15/32 , A61L15/64
CPC分类号： A61F13/00995 , A61K38/363 , A61K38/4833 , A61L15/26 , A61L15/28 , A61L15/32 , A61L15/42 , A61L15/64 , A61L2300/418 , A61L2400/04 , B05D1/02 , B05D1/18 , C08L71/02 , A61K2300/00 , C08L1/28 , C08L67/04
摘要： A hemostatic pad comprising a bioabsorbable scaffolding material; a lyophilized thrombin powder, a lyophilized fibrinogen powder, and a meltable binder powder, with all powders disposed on the bioabsorbable scaffolding material. A meltable binder such as PEG bonds the lyophilized thrombin powder and the lyophilized fibrinogen powder to the bioabsorbable scaffolding material for improved friability, wettability and performance in a use, such as for hemostatic treatment or sealing at a wound site.
摘要翻译：一种止血垫，包括生物可吸收的脚手架材料; 冻干的凝血酶粉末，冻干的纤维蛋白原粉末和可熔融的粘合剂粉末，其中所有粉末都设置在生物可吸收的脚手架材料上。可熔融粘合剂如PEG将冻干的凝血酶粉末和冻干的纤维蛋白原粉末粘合到生物可吸收的脚手架材料上，以提高使用中的脆性，润湿性和性能，例如在伤口部位进行止血治疗或密封。

8. 发明申请

US20070179596A1 Medical Devices, Drug Coatings And Methods for Maintaining the Drug Coatings Thereon 审中-公开
标题翻译：医疗器械，药物涂料和维护药物涂层的方法
公开(公告)号：US20070179596A1
公开(公告)日：2007-08-02
申请号：US11736137
申请日：2007-04-17
申请人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
发明人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
IPC分类号： A61F2/90
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。

9. 发明申请

US20070179595A1 Medical Devices, Drug Coatings and Methods for Maintaining the Drug Coatings Thereon 审中-公开
公开(公告)号：US20070179595A1
公开(公告)日：2007-08-02
申请号：US11736043
申请日：2007-04-17
申请人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
发明人： Luis Davila , David Lentz , Gerard Llanos , Jorge Mendez , Pallassana Narayanan , Alan Pelton , Mark Roller , Karl Scheidt , Angelo Scopelianos , William Shaw , James Silver , John Spaltro , Christine Trepanier , David Wilson
IPC分类号： A61F2/90 , A61L33/00 , B05D3/00
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/3008 , A61F2002/91533 , A61F2002/91558 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2250/0067 , A61F2250/0098 , A61F2310/0097 , A61F2310/00976 , A61K31/436 , A61K31/727 , A61K45/06 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/022 , A61L31/10 , A61L31/16 , A61L31/18 , A61L2300/416 , A61L2300/608 , B05D1/18 , B05D3/0254 , B05D3/0493 , A61K2300/00 , C08L27/14 , C08L27/12 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.

10. 发明申请

US20050002986A1 Drug/drug delivery systems for the prevention and treatment of vascular disease 审中-公开
标题翻译：用于预防和治疗血管疾病的药物/药物递送系统
公开(公告)号：US20050002986A1
公开(公告)日：2005-01-06
申请号：US10829044
申请日：2004-04-21
申请人： Robert Falotico , Gregory Kopia , Gerard Llanos , John Siekierka
发明人： Robert Falotico , Gregory Kopia , Gerard Llanos , John Siekierka
IPC分类号： A61F2/84 , A61B17/00 , A61F2/00 , A61F2/06 , A61F2/82 , A61F2/90 , A61K31/365 , A61K31/4353 , A61K31/436 , A61K31/453 , A61K31/553 , A61K31/727 , A61K38/00 , A61K45/00 , A61K45/06 , A61K47/30 , A61K47/32 , A61K47/48 , A61K48/00 , A61L31/00 , A61L31/16 , A61M31/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P21/00 , A61P29/00 , A61P43/00 , C07D401/04 , C07D498/18 , C07D498/22 , A61K31/4745
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/727 , A61K45/06 , A61L2300/252 , A61L2300/41 , A61L2300/416 , A61K2300/00
摘要： A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity.
摘要翻译：药物和药物递送系统可用于治疗血管疾病。局部递送系统用雷帕霉素或其他合适的药物，药剂或化合物包被并且经内镜递送用于治疗和预防经皮冠状动脉冠状动脉造影术后的新生内膜增生。药物或药剂的局部递送提供了更高的效力和更低的全身毒性。

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