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1. 发明申请

US20060235512A1 Valve device with inflatable chamber 有权
公开(公告)号：US20060235512A1
公开(公告)日：2006-10-19
申请号：US11394303
申请日：2006-03-30
申请人： Thomas Osborne , Jacob Flagle , John Brumleve
发明人： Thomas Osborne , Jacob Flagle , John Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.

2. 发明申请

US20060259118A1 Delivery system and devices for the rapid insertion of self-expanding devices 审中-公开
标题翻译：交付系统和设备，用于快速插入自扩张设备
公开(公告)号：US20060259118A1
公开(公告)日：2006-11-16
申请号：US11408121
申请日：2006-04-20
申请人： Dharmendra Pal , Charles Agnew , Jacob Flagle , David Lentz , Jeffry Melsheimer , Thomas Osborne , Fred Parker
发明人： Dharmendra Pal , Charles Agnew , Jacob Flagle , David Lentz , Jeffry Melsheimer , Thomas Osborne , Fred Parker
IPC分类号： A61F2/06
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0045 , A61M25/005 , A61M25/0053
摘要： Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.
摘要翻译：提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其它医疗器械通过的后膛位置开口的过渡区域附近。外部构件相对于内部构件可轴向滑动以展开自扩张装置。还提供了使用和制造方法。

3. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

4. 发明申请

US20050182483A1 Percutaneously placed prosthesis with thromboresistant valve portion 审中-公开
标题翻译：经皮放置假体与抗血栓阀部分
公开(公告)号：US20050182483A1
公开(公告)日：2005-08-18
申请号：US11056903
申请日：2005-02-11
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2424 , A61F2/2403 , A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008
摘要： A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.
摘要翻译：一种静脉瓣膜假体，其具有基本上不可扩张的阀部分，其包括阀关闭机构，例如一对相对的传单; 以及锚固部分，例如一个或多个自扩张框架或支架，其可扩张以在植入部位处锚固假体。在一个实施例中，刚性瓣膜部分包括诸如热解碳的材料的沉积，以降低血液接触表面的血栓形成。锚定部分优选地包括覆盖物，例如由合成或胶原衍生的材料（例如生物可重构的ECM材料）组成的管状构件，其附接在支撑结构上，使得当血液流过较大直径的锚固部分到假体的中间较小直径部分。在另一个实施例中，阀支撑壳体和阀关闭元件以折叠，折叠和/或拆卸状态被输送，其尺寸适于输送，然后在原位操作到第二扩张配置的后续部署。

5. 发明申请

US20050085900A1 Prosthetic valve for implantation in a body vessel 有权
标题翻译：用于植入体内的假体瓣膜
公开(公告)号：US20050085900A1
公开(公告)日：2005-04-21
申请号：US10903907
申请日：2004-07-31
申请人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
发明人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

6. 发明申请

US20060136044A1 Medical device with bioactive agent 有权
公开(公告)号：US20060136044A1
公开(公告)日：2006-06-22
申请号：US11244991
申请日：2005-10-06
申请人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
发明人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

7. 发明申请

US20050131316A1 Guidewire with flexible tip 审中-公开
标题翻译：导丝带柔性尖端
公开(公告)号：US20050131316A1
公开(公告)日：2005-06-16
申请号：US10736047
申请日：2003-12-15
申请人： Jacob Flagle , Thomas Osborne
发明人： Jacob Flagle , Thomas Osborne
IPC分类号： A61B5/00 , A61M25/00 , A61M25/01 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/0081 , A61M2025/09166 , A61M2025/09175
摘要： A guidewire with a flexible tip is provided. The flexible tip comprises a portion of a coating that axially extends beyond a distal end of an elongate member of the guidewire. The length of the flexible tip can be defined in relation to a diameter of the elongate member of the guidewire. Also, the length of the flexible tip can be defined in relation to a length of a distal tip portion of the elongate member of the guidewire. The flexible tip may include agents that facilitate visualization, such as an opacifying agent in the coating and/or a radiopaque marker disposed in the flexible tip.
摘要翻译：提供了具有柔性尖端的导丝。柔性尖端包括轴向延伸超过导丝的细长构件的远端的涂层的一部分。柔性尖端的长度可以相对于导丝的细长构件的直径来限定。此外，柔性末端的长度可以相对于导丝的细长构件的远侧末端部分的长度来限定。柔性末端可以包括促进可视化的试剂，例如涂层中的遮光剂和/或设置在柔性末端中的不透射线的标记。

8. 发明申请

US20120078133A1 VACUUM ASSISTED BIOPSY DEVICE 有权
标题翻译：真空辅助生物设备
公开(公告)号：US20120078133A1
公开(公告)日：2012-03-29
申请号：US13243419
申请日：2011-09-23
申请人： Zachary R. Nicoson , Jacob Flagle , Michael E. Miller , Joseph L. Mark
发明人： Zachary R. Nicoson , Jacob Flagle , Michael E. Miller , Joseph L. Mark
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0208
摘要： A biopsy device having a stylet, an outer cannula, and a vacuum chamber is disclosed. The stylet includes a lumen with an open proximal end and a tissue receiving opening near a distal end thereof. The outer cannula is slidably disposed over the stylet and has an open distal end with a cutting edge formed thereon. The vacuum chamber is in communication with the lumen of the stylet. Actuation of the outer cannula causes a vacuum to be delivered to the tissue receiving opening through the lumen of the stylet before the outer cannula advances distally.
摘要翻译：公开了一种具有探针，外套管和真空室的活检装置。探针包括具有开放近端的腔和在其远端附近的组织接收孔。外套管可滑动地设置在通心针上方并且具有形成在其上的切割边缘的敞开的远端。真空室与探针的内腔连通。在外套管向远侧前进之前，外套管的致动导致真空通过探针的内腔被输送到组织接收口。

9. 发明授权

US08048003B2 Vacuum assisted biopsy device 有权
标题翻译：真空辅助活检装置
公开(公告)号：US08048003B2
公开(公告)日：2011-11-01
申请号：US12205291
申请日：2008-09-05
申请人： Zachary R. Nicoson , Jacob Flagle , Michael E. Miller , Joseph L. Mark
发明人： Zachary R. Nicoson , Jacob Flagle , Michael E. Miller , Joseph L. Mark
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B10/0283 , A61B2010/0208
摘要： A biopsy device is disclosed that comprises a cutting element mounted to a handpiece and a vacuum chamber. The cutting element comprises a stylet assembly and an outer cannula assembly. The stylet assembly includes a stylet that includes an open proximal end and a tissue opening at a distal end thereof. The distal end of the stylet is blunt-shaped. The tissue receiving opening is in communication with a lumen extending through the stylet. The outer cannula assembly includes an outer cannula that is slidably mounted over the stylet and has an open distal end with a cutting edge formed thereon. The vacuum chamber is in communication with the lumen of the stylet. The stylet is selectively advanced distally outwardly with respect to outer cannula to expose the tissue opening to targeted tissue. The outer cannula is selectively advanced over the tissue opening to sever tissue, while vacuum is generated in the vacuum chamber and delivered to the tissue opening through the lumen. The vacuum causes tissue to be drawn into and maintained in the tissue opening while the outer cannula severs tissue to obtain a biopsy core.
摘要翻译：公开了一种活检装置，其包括安装到手持件和真空室的切割元件。切割元件包括探针组件和外套管组件。探针组件包括探针，该探针包括开放的近端和在其远端的组织开口。探针的远端是钝的。组织接收口与延伸穿过通丝针的内腔连通。外套管组件包括外套管，其可滑动地安装在通球针上方并且具有形成在其上的切削刃的敞开的远端。真空室与探针的内腔连通。探针相对于外套管选择性向外远端向外推进，以将组织开口暴露于目标组织。选择性地将外套管推进到组织开口上以切断组织，同时在真空室中产生真空并通过内腔输送到组织开口。真空使得组织被拉入并保持在组织开口中，同时外套管切断组织以获得活组织检查核心。

10. 发明申请

US20080051879A1 METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用流动修改植入式医疗装置处理通气阀相关条件的方法
公开(公告)号：US20080051879A1
公开(公告)日：2008-02-28
申请号：US11844003
申请日：2007-08-23
申请人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
发明人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2002/068
摘要： Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.
摘要翻译：本文提供了适于改变体内容器内的流体流动的植入式医疗装置。医疗装置可以包括流体流动限制通道，该流体流动限制通道构造成减小沿逆行方向或顺行方向的纵向流体流动。优选地，医疗装置是流动改变装置，其减少流体通过医疗装置的流体在逆行方向上比在顺行方向上更大程度地流动。还提供了包括在身体容器内植入流动改变医疗装置的步骤的治疗方法。流动改变装置例如在治疗静脉瓣相关病症中是有用的。

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