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    • 1. 发明申请
    • Percutaneously placed prosthesis with thromboresistant valve portion
    • 经皮放置假体与抗血栓阀部分
    • US20050182483A1
    • 2005-08-18
    • US11056903
    • 2005-02-11
    • Thomas OsborneBrian CaseJacob FlagleGrant Hoffman
    • Thomas OsborneBrian CaseJacob FlagleGrant Hoffman
    • A61F2/06A61F2/24
    • A61F2/2424A61F2/2403A61F2/2418A61F2/2475A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0054A61F2230/0078A61F2230/008
    • A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.
    • 一种静脉瓣膜假体,其具有基本上不可扩张的阀部分,其包括阀关闭机构,例如一对相对的传单; 以及锚固部分,例如一个或多个自扩张框架或支架,其可扩张以在植入部位处锚固假体。 在一个实施例中,刚性瓣膜部分包括诸如热解碳的材料的沉积,以降低血液接触表面的血栓形成。 锚定部分优选地包括覆盖物,例如由合成或胶原衍生的材料(例如生物可重构的ECM材料)组成的管状构件,其附接在支撑结构上,使得当血液流过 较大直径的锚固部分到假体的中间较小直径部分。 在另一个实施例中,阀支撑壳体和阀关闭元件以折叠,折叠和/或拆卸状态被输送,其尺寸适于输送,然后在原位操作到第二扩张配置的后续部署。