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1. 发明申请

US20060259118A1 Delivery system and devices for the rapid insertion of self-expanding devices 审中-公开
标题翻译：交付系统和设备，用于快速插入自扩张设备
公开(公告)号：US20060259118A1
公开(公告)日：2006-11-16
申请号：US11408121
申请日：2006-04-20
申请人： Dharmendra Pal , Charles Agnew , Jacob Flagle , David Lentz , Jeffry Melsheimer , Thomas Osborne , Fred Parker
发明人： Dharmendra Pal , Charles Agnew , Jacob Flagle , David Lentz , Jeffry Melsheimer , Thomas Osborne , Fred Parker
IPC分类号： A61F2/06
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0045 , A61M25/005 , A61M25/0053
摘要： Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.
摘要翻译：提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其它医疗器械通过的后膛位置开口的过渡区域附近。外部构件相对于内部构件可轴向滑动以展开自扩张装置。还提供了使用和制造方法。

2. 发明申请

US20050085900A1 Prosthetic valve for implantation in a body vessel 有权
标题翻译：用于植入体内的假体瓣膜
公开(公告)号：US20050085900A1
公开(公告)日：2005-04-21
申请号：US10903907
申请日：2004-07-31
申请人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
发明人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

3. 发明申请

US20060135983A1 Catheter with tapered end balloon 审中-公开
标题翻译：导管带锥形末端气球
公开(公告)号：US20060135983A1
公开(公告)日：2006-06-22
申请号：US11313593
申请日：2005-12-13
申请人： Jeffry Melsheimer , Thomas Osborne
发明人： Jeffry Melsheimer , Thomas Osborne
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61F2/958 , A61F2250/0039 , A61M25/1002 , A61M25/1027 , A61M2025/0039
摘要： A delivery system, including a balloon catheter having a balloon with distal and proximal ends and a guide catheter for delivering the balloon catheter to a treatment site, is disclosed. The balloon tapers from at least one of the distal and proximal ends of the balloon to an active region on the surface of the balloon. The active region has a diameter D1 which is greater than a diameter of the balloon at one or more of the distal and proximal ends of the balloon. Preferably, one or more of the lengths L1, which is the distance from the proximal end of the balloon to the active region, and L2, which is the distance from the distal end of the balloon to the active region, are between three to thirty times the diameter D1.
摘要翻译：公开了一种输送系统，包括具有远端和近端的球囊的球囊导管和用于将球囊导管输送到治疗部位的导向导管。气囊从气囊的远端和近端中的至少一个渐缩成气球表面上的有效区域。活性区域的直径D 1大于球囊在远端和近端的一个或多个处的直径。优选地，长度L 1 1中的一个或多个，其是从球囊的近端到有源区域的距离和L 2 2，其是距离球囊的远端到活动区域，是直径D 1〜3的三到三十倍之间。

4. 发明申请

US20070198002A1 Implant retrieval assembly and method for retrieving an implant 有权
标题翻译：植入物检索组件和用于检索植入物的方法
公开(公告)号：US20070198002A1
公开(公告)日：2007-08-23
申请号：US11708235
申请日：2007-02-20
申请人： Jeffry Melsheimer , Thomas Osborne
发明人： Jeffry Melsheimer , Thomas Osborne
IPC分类号： A61B17/00
CPC分类号： A61B17/221 , A61B17/32056 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/2919
摘要： An implant retrieval frame for advancement of a retrieval device to snare an implant is disclosed. The frame comprises a first arm and a second arm. The first arm has a first handle end and a first pivot end. The second arm has a second handle end and a second pivot end. The second pivot end is connected to the first pivot end to define a pivot axis about which the first and second arm pivotally move. The frame further comprises a connector to which the retrieval device is attached. The connector is configured to cooperate with the first and second arms to translate pivotal movement of one of the first and second arms to linear movement of the retrieval device relative to the pivot point.
摘要翻译：公开了一种用于推进提取装置以圈套植入物的植入物检索框架。框架包括第一臂和第二臂。第一臂具有第一手柄端和第一枢转端。第二臂具有第二手柄端和第二枢转端。第二枢转端连接到第一枢转端以限定枢转轴线，第一和第二臂枢转运动。该框架还包括一个连接器，拾取装置附接到该连接器。连接器构造成与第一和第二臂配合以将第一和第二臂之一的枢转运动转换成相对于枢转点的线性运动。

5. 发明申请

US20070244440A1 Medical device with expandable tip 审中-公开
标题翻译：具有可扩展尖端的医疗设备
公开(公告)号：US20070244440A1
公开(公告)日：2007-10-18
申请号：US11728528
申请日：2007-03-26
申请人： Dharmendra Pal , Thomas Osborne
发明人： Dharmendra Pal , Thomas Osborne
IPC分类号： A61M29/00 , A61M5/178 , A61M25/00
CPC分类号： A61M25/0074 , A61M25/0068
摘要： A catheter for use with at least two different sizes of wire guides is described. The catheter includes a wire guide lumen sized to receive a first wire guide of a first diameter. The catheter may also include a tip lumen that extends in a distal direction from a first opening in communication with the wire guide lumen to a second opening. The first opening is sized to receive the first wire guide, and the second opening is sized to receive a second wire guide of a smaller diameter than the first wire guide. The catheter also includes one or more longitudinal expansion features capable of radially expanding the tip lumen to receive a wire guide of a diameter up to the first diameter through the second opening. An adapter that may be attached to the catheter by a medical professional is also described.
摘要翻译：描述了与至少两种不同尺寸的导线器一起使用的导管。导管包括尺寸适于接收第一直径的第一线引导件的线引导腔。导管还可以包括尖端腔，其从远离方向延伸，与第一开口连通，该第一开口与导线管腔连通到第二开口。第一开口的尺寸被设计成接收第一线引导件，并且第二开口的尺寸被设计成接纳直径小于第一线引导件的第二线引导件。该导管还包括一个或多个纵向膨胀特征，其能够径向扩张尖端内腔，以通过第二开口接纳直径直到第一直径的线引导件。还描述了可由医学专业人员附接到导管的适配器。

6. 发明申请

US20060184194A1 Embolic protection device 审中-公开
标题翻译：栓塞保护装置
公开(公告)号：US20060184194A1
公开(公告)日：2006-08-17
申请号：US11353380
申请日：2006-02-14
申请人： Dharmendra Pal , Thomas Osborne , Ram Paul
发明人： Dharmendra Pal , Thomas Osborne , Ram Paul
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2002/068 , A61F2230/0006 , A61F2230/0069 , A61F2230/0091 , A61F2230/0095
摘要： An embolic protection device generally includes an elongated hub and at least one projection. The projection defines a tortuous pathway between the hub and the vessel wall to prevent emboli from following the pathway and passing beyond the device. The tortuous pathway is structured to permit the bodily fluid to follow the pathway and pass beyond the device.
摘要翻译：栓塞保护装置通常包括细长轮毂和至少一个突起。突出部分限定了轮毂和血管壁之间的曲折路径，以防止栓塞跟随通路并超出设备。曲折路径被构造成允许体液跟随通路并超出设备。

7. 发明申请

US20070083257A1 Aneurysm occlusion device 有权
标题翻译：动脉瘤闭塞装置
公开(公告)号：US20070083257A1
公开(公告)日：2007-04-12
申请号：US11519366
申请日：2006-09-12
申请人： Dharmendra Pal , Roy Collins , Andrew Conder , Kian Olsen , Thomas Osborne
发明人： Dharmendra Pal , Roy Collins , Andrew Conder , Kian Olsen , Thomas Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/1215 , A61B2017/1205 , A61F2002/823
摘要： A system and method for occluding an aneurysm formed in a dilatation area of a body vessel are disclosed. The system comprises a wire guide, a core wire, and an occlusion device. The wire guide comprises a proximal end and a distal end, and has a passageway that extends from the proximal end to the distal end. The core wire comprises a distal end and a proximal end, and is disposed through the passageway so that the proximal end of the core wire proximally extends beyond the proximal end of the wire guide. The occlusion device comprises a distal end and a proximal end, and has a deployed state and an undeployed state. The occlusion device has a pre-set spiraled coil shape when in the deployed state in the vessel. The occlusion device is disposed distally from the core wire in the passageway.
摘要翻译：公开了一种用于闭塞在身体容器的扩张区域中形成的动脉瘤的系统和方法。该系统包括导线器，芯线和闭塞装置。线引导件包括近端和远端，并且具有从近端延伸到远端的通道。芯线包括远端和近端，并且穿过通道设置，使得芯线的近端近端延伸超过线引导件的近端。闭塞装置包括远端和近端，并且具有展开状态和未部署状态。当在容器中处于展开状态时，遮挡装置具有预定的螺旋形线圈形状。闭塞装置在通道中远离芯线设置。

8. 发明申请

US20060136044A1 Medical device with bioactive agent 有权
公开(公告)号：US20060136044A1
公开(公告)日：2006-06-22
申请号：US11244991
申请日：2005-10-06
申请人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
发明人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

9. 发明申请

US20050131316A1 Guidewire with flexible tip 审中-公开
标题翻译：导丝带柔性尖端
公开(公告)号：US20050131316A1
公开(公告)日：2005-06-16
申请号：US10736047
申请日：2003-12-15
申请人： Jacob Flagle , Thomas Osborne
发明人： Jacob Flagle , Thomas Osborne
IPC分类号： A61B5/00 , A61M25/00 , A61M25/01 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/0081 , A61M2025/09166 , A61M2025/09175
摘要： A guidewire with a flexible tip is provided. The flexible tip comprises a portion of a coating that axially extends beyond a distal end of an elongate member of the guidewire. The length of the flexible tip can be defined in relation to a diameter of the elongate member of the guidewire. Also, the length of the flexible tip can be defined in relation to a length of a distal tip portion of the elongate member of the guidewire. The flexible tip may include agents that facilitate visualization, such as an opacifying agent in the coating and/or a radiopaque marker disposed in the flexible tip.
摘要翻译：提供了具有柔性尖端的导丝。柔性尖端包括轴向延伸超过导丝的细长构件的远端的涂层的一部分。柔性尖端的长度可以相对于导丝的细长构件的直径来限定。此外，柔性末端的长度可以相对于导丝的细长构件的远侧末端部分的长度来限定。柔性末端可以包括促进可视化的试剂，例如涂层中的遮光剂和/或设置在柔性末端中的不透射线的标记。

10. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

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