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1. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

2. 发明申请

US20050228479A1 Medical device delivery system 审中-公开
标题翻译：医疗器械输送系统
公开(公告)号：US20050228479A1
公开(公告)日：2005-10-13
申请号：US11149721
申请日：2005-06-09
申请人： Dusan Pavcnik , Brian Case , Christopher Dixon , Jacob Flagle , Michael Garrison , Andrew Hoffa , Ray Leonard
发明人： Dusan Pavcnik , Brian Case , Christopher Dixon , Jacob Flagle , Michael Garrison , Andrew Hoffa , Ray Leonard
IPC分类号： A61F2/01 , A61F2/06 , A61F2/24 , A61F2/84
CPC分类号： A61F2/95 , A61F2/2436 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. Delivery catheter (11) includes inner tube (122), flat wire coil (123) compression fitted therearound, and outer tube (112) mechanically connected to roughened outer surface (126) of the inner tube through the spacing of the coil. Delivery catheter (11) can be provided with a window (184) to allow fluoroscopic visualization of a stent valve within the delivery system.
摘要翻译：一种用于将诸如静脉瓣的医疗装置（30）植入患者脉管系统的输送系统（10）。递送系统包括具有与其远端（14）相邻的装置容纳部分（15）的输送导管（11）和延伸穿过导管并超出其远端的内部构件（16）到无创伤远端尖端部分（17）在导管远端的前方。输送导管（11）包括内管（122），压缩在其周围的扁平线圈（123）和通过线圈的间隔机械地连接到内管的粗糙化的外表面（126）的外管（112）。输送导管（11）可以设置有窗口（184），以允许支架瓣膜在输送系统内的荧光透视可视化。

3. 发明申请

US20050283178A1 Delivery system that facilitates visual inspection of an intraluminal medical device 有权
标题翻译：输送系统，便于目视检查管腔内医疗器械
公开(公告)号：US20050283178A1
公开(公告)日：2005-12-22
申请号：US11123312
申请日：2005-05-06
申请人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
发明人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61M25/10 , A61M29/00
CPC分类号： A61M25/0043 , A61F2/95 , A61F2250/0091 , A61M25/10 , A61M2025/1079
摘要： Delivery systems, methods of making delivery systems, and methods of treatment are provided. A delivery system according to the invention facilitates a visual inspection of an intraluminal medical device included in the delivery system.
摘要翻译：提供交付系统，交付系统的方法和处理方法。根据本发明的递送系统便于对包括在递送系统中的管腔内医疗装置的目视检查。

4. 发明申请

US20070260327A1 Artificial Valve Prosthesis with Improved Flow Dynamics 有权
标题翻译：人工瓣膜假体具有改善的流动动力学
公开(公告)号：US20070260327A1
公开(公告)日：2007-11-08
申请号：US10554494
申请日：2004-04-21
申请人： Brian Case , Michael Garrison , Andrew Hoffa , Darin Schaeffer , Jacob Flagle
发明人： Brian Case , Michael Garrison , Andrew Hoffa , Darin Schaeffer , Jacob Flagle
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2250/0037 , A61F2250/0039
摘要： An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
摘要翻译：一种可膨胀静脉瓣，其具有支撑结构，该支撑结构被配置为扩大邻近阀结构的区域，使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变，以防止滞留在静脉系统中的体液可导致血栓形成。扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成，或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分结构体。在另一组实施例中，相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分，并且远侧部分相对于相邻壁形成大角度，在传单的底部创造了一个大口袋。在一个实施例中，附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸，以产生延伸的小叶接触区域，然后沿着远侧连接支柱沿着周向和远端远离成形器，以限定传单的底部边缘。

5. 发明申请

US20060212111A1 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US20060212111A1
公开(公告)日：2006-09-21
申请号：US11260770
申请日：2005-10-27
申请人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
发明人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

6. 发明申请

US20050182483A1 Percutaneously placed prosthesis with thromboresistant valve portion 审中-公开
标题翻译：经皮放置假体与抗血栓阀部分
公开(公告)号：US20050182483A1
公开(公告)日：2005-08-18
申请号：US11056903
申请日：2005-02-11
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2424 , A61F2/2403 , A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008
摘要： A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.
摘要翻译：一种静脉瓣膜假体，其具有基本上不可扩张的阀部分，其包括阀关闭机构，例如一对相对的传单; 以及锚固部分，例如一个或多个自扩张框架或支架，其可扩张以在植入部位处锚固假体。在一个实施例中，刚性瓣膜部分包括诸如热解碳的材料的沉积，以降低血液接触表面的血栓形成。锚定部分优选地包括覆盖物，例如由合成或胶原衍生的材料（例如生物可重构的ECM材料）组成的管状构件，其附接在支撑结构上，使得当血液流过较大直径的锚固部分到假体的中间较小直径部分。在另一个实施例中，阀支撑壳体和阀关闭元件以折叠，折叠和/或拆卸状态被输送，其尺寸适于输送，然后在原位操作到第二扩张配置的后续部署。

7. 发明申请

US20050085900A1 Prosthetic valve for implantation in a body vessel 有权
标题翻译：用于植入体内的假体瓣膜
公开(公告)号：US20050085900A1
公开(公告)日：2005-04-21
申请号：US10903907
申请日：2004-07-31
申请人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
发明人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

8. 发明申请

US20070038291A1 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US20070038291A1
公开(公告)日：2007-02-15
申请号：US11545746
申请日：2006-10-10
申请人： Brian Case , Jacob Flagle , Michael Garrison
发明人： Brian Case , Jacob Flagle , Michael Garrison
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include one or more pairs of closely-spaced longitudinal connecting members aligned substantially parallel to the longitudinal axis of the implantable frame. The circumferential distance between the closely-spaced longitudinal connecting members preferably subtends an angle less than (2π/n) radians, where (n) is an integer equal to the total number of longitudinal connecting members connecting two longitudinally adjacent hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括一对或多对紧密间隔的纵向连接构件，其基本上平行于可植入框架的纵向轴线对准。紧密间隔的纵向连接构件之间的圆周距离优选地对角度小于（2pi / n）弧度的角度，其中（n）是等于连接两个纵向相邻的箍构件的纵向连接构件的总数的整数。

9. 发明申请

US20070021826A1 Intralumenally implantable frames 有权
标题翻译：心内植入式框架
公开(公告)号：US20070021826A1
公开(公告)日：2007-01-25
申请号：US11487629
申请日：2006-07-17
申请人： Brian Case , Jacob Flagle , Michael Garrison
发明人： Brian Case , Jacob Flagle , Michael Garrison
IPC分类号： A61F2/06 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2002/91575 , A61F2220/0016 , A61F2230/0054
摘要： Implantable frames for use in body passages are provided herein. The implantable frames comprise one or more of certain preferred structural features that are generally applicable to frames comprising a plurality of curved and straight member portions that together define an interior lumen extending along a longitudinal axis between a proximal end and a distal end. The implantable frames have an exterior surface comprising a plurality of openings between the interior lumen and the exterior surface, and preferably include one or more undulating hoop members attached to one or more longitudinal connecting members. The implantable frames can be formed from any suitable material, but preferably comprise material permitting the frame to radially self-expand from a radially compressed configuration to a radially expanded configuration. The implantable frames are useful for endolumenal implantation within a body vessel, for example as a stent or as a support frame of an implantable valve.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架包括一些优选结构特征中的一个或多个，其通常可应用于包括多个弯曲和直的构件部分的框架，所述多个弯曲和直的构件部分一起限定沿近端和远端之间的纵向轴线延伸的内腔。可植入框架具有包括在内腔和外表面之间的多个开口的外表面，并且优选地包括附接到一个或多个纵向连接构件的一个或多个起伏环箍构件。可植入框架可以由任何合适的材料形成，但优选地包括允许框架从径向压缩构型向径向扩张构型的径向自扩展的材料。可植入框架可用于体内容器内腔内植入，例如作为支架或可植入瓣膜的支撑框架。

10. 发明申请

US20060136044A1 Medical device with bioactive agent 有权
公开(公告)号：US20060136044A1
公开(公告)日：2006-06-22
申请号：US11244991
申请日：2005-10-06
申请人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
发明人： Thomas Osborne , Jacob Flagle , Brian Case , Joseph Obermiller , Ram Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

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