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1. 发明授权

US06772026B2 System and method for rapidly customizing design, manufacture and/or selection of biomedical devices 失效
公开(公告)号：US06772026B2
公开(公告)日：2004-08-03
申请号：US09972832
申请日：2001-10-05
申请人： Thomas J. Bradbury , Christopher M. Gaylo , James A. Fairweather , Kathleen D. Chesmel , Peter A. Materna , Adolphe Youssef
发明人： Thomas J. Bradbury , Christopher M. Gaylo , James A. Fairweather , Kathleen D. Chesmel , Peter A. Materna , Adolphe Youssef
IPC分类号： G06F1900
CPC分类号： G05B19/4099 , A61C8/0006 , A61C13/0004 , A61F2/2803 , A61F2/30942 , A61F2002/2817 , A61F2002/2835 , A61F2002/2878 , A61F2002/30062 , A61F2002/3008 , A61F2002/30616 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30953 , A61F2002/30968 , A61F2210/0004 , A61F2250/0098 , A61F2310/00293 , A61K9/2095 , B29C64/135 , B33Y50/00 , B33Y80/00 , B65G2207/14 , G05B2219/35008 , G05B2219/35053 , G05B2219/35054 , G05B2219/35219 , G05B2219/35223 , G05B2219/45166 , G05B2219/45168 , G05B2219/49023 , G06F19/00 , G06F19/321 , G06F19/3418 , G06F19/3456 , G06Q10/06 , G06Q30/0601 , G06Q50/22 , G16H10/60 , G16H50/50
摘要： The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.

2. 发明授权

US07445441B2 Three-dimensional printing apparatus and methods of manufacture including sterilization or disinfection, for example, using ultraviolet light 失效
标题翻译：三维印刷装置和制造方法，包括例如使用紫外线的灭菌或消毒
公开(公告)号：US07445441B2
公开(公告)日：2008-11-04
申请号：US10891440
申请日：2004-07-14
申请人： Thomas George West , Qing Liu , Peter A. Materna , Alfred Anthony Litwak , Christopher M. Gaylo
发明人： Thomas George West , Qing Liu , Peter A. Materna , Alfred Anthony Litwak , Christopher M. Gaylo
IPC分类号： B29C35/02 , B29C67/00 , B28B17/02
CPC分类号： A61L2/208 , A61L2/10 , A61L2/206 , B29C64/165 , B29C2035/0827 , B29C2791/005 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.
摘要翻译：本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料的形式被3DP机器处理和/或以各种表面或机器部件的任何一种方式适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。本发明还包括使用这种照明进行三维打印的方法。本发明还包括灭菌或消毒的其它方法与紫外线的组合。本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

3. 发明授权

US07073442B2 Apparatus, systems and methods for use in three-dimensional printing 失效
公开(公告)号：US07073442B2
公开(公告)日：2006-07-11
申请号：US10189166
申请日：2002-07-03
申请人： Jeffrey A. Fedor , Christopher M. Gaylo , Peter A. Materna
发明人： Jeffrey A. Fedor , Christopher M. Gaylo , Peter A. Materna
IPC分类号： B41F1/34 , B41F17/00 , B41J29/08 , F24C15/20
CPC分类号： B41J3/4073 , B22F3/1055 , B22F2003/1057 , B29C35/0288 , B29C41/36 , B29C41/46 , B29C41/52 , B29C43/34 , B29C64/165 , B29C2035/0822 , B29C2043/3494 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y50/00 , Y02P10/295
摘要： Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.

4. 发明授权

US08758658B2 System and method for uniaxial compression of an article, such as a three dimensionally printed dosage form 有权
标题翻译：用于单轴压缩制品的系统和方法，例如三维印刷的剂型
公开(公告)号：US08758658B2
公开(公告)日：2014-06-24
申请号：US12979484
申请日：2010-12-28
申请人： Wendy E. Pryce Lewis , Michael J Cima , Charles W Rowe , Peter A. Materna
发明人： Wendy E. Pryce Lewis , Michael J Cima , Charles W Rowe , Peter A. Materna
IPC分类号： B27N3/00 , B29C67/00 , A61K9/20 , A61J3/10 , B29L31/00
CPC分类号： A61K9/20 , A61J3/10 , A61K9/2095 , B29C64/00 , B29C64/165 , B29C67/0051 , B29C67/0081 , B29L2031/753 , B33Y70/00 , B33Y80/00
摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.
摘要翻译：通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。

5. 发明授权

US07300668B2 System for manufacturing controlled release dosage forms, such as a zero-order release profile dosage form manufactured by three-dimensional printing 有权
标题翻译：用于制造控制释放剂型的系统，例如通过三维印刷制造的零级释放曲线剂型
公开(公告)号：US07300668B2
公开(公告)日：2007-11-27
申请号：US10284039
申请日：2002-10-29
申请人： Wendy E. Pryce Lewis , Charles William Rowe , Michael J. Cima , Peter A. Materna
发明人： Wendy E. Pryce Lewis , Charles William Rowe , Michael J. Cima , Peter A. Materna
IPC分类号： A61K9/20 , A61K9/22 , A61K9/24
CPC分类号： A61K9/2893 , A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , B33Y70/00 , B33Y80/00
摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.
摘要翻译：本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。本发明还包括设计这种剂型的方法。可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。

6. 发明授权

US06945638B2 Method and system for controlling the temperature of a dispensed liquid 有权
标题翻译：用于控制分配液体的温度的方法和系统
公开(公告)号：US06945638B2
公开(公告)日：2005-09-20
申请号：US10284425
申请日：2002-10-29
申请人： Patrick Teung , Michael J. Cima , Timothy J. Pryor , Peter A. Materna
发明人： Patrick Teung , Michael J. Cima , Timothy J. Pryor , Peter A. Materna
IPC分类号： B01L3/02 , B41J2/02 , B41J2/05 , B41J29/377 , G05D23/19 , B41J2/07
CPC分类号： B01L3/0268 , B01L3/0265 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , B01L2400/0439 , B01L2400/0487 , B01L2400/0633 , B33Y40/00 , B41J2/02 , B41J2/04528 , B41J2/04563 , B41J29/377 , B41J2002/022 , G05D23/1919
摘要： A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.
摘要翻译：用于在分配点控制或改变液体的温度的装置。温度改变装置热耦合到分配装置以补偿在分配期间通过分配装置时散失到液体中的热量。分配装置可以是例如微型电磁阀（微型阀），压电打印头等。根据本发明的方面，改变温度的装置在分配点处提供或减少热量，以便改变，控制或维持所分配液体的恒定温度。结果，在分配的液滴流的流体状态的一致性方面获得了改进。温度改变装置可以是能够从分配结构移动热量的热电装置，也可以是加热器。即使当在室温附近进行分配并且液体不需要加热以保持其液体状态时，该装置也可以有利地使用。

7. 发明授权

US4499443A High-field double-pancake superconducting coils and a method of winding 失效
标题翻译：高场双煎饼超导线圈及绕组方法
公开(公告)号：US4499443A
公开(公告)日：1985-02-12
申请号：US575598
申请日：1984-01-31
申请人： Peter A. Materna
发明人： Peter A. Materna
IPC分类号： H01F6/06 , H01F7/22 , H01L39/24
CPC分类号： H01F6/06 , Y10S505/88 , Y10S505/887 , Y10T29/49014
摘要： A double-pancake coil having first and second pancakes may comprise a plurality of conductor means, each conductor means having a different grade and having one or more conductors, wherein each pancake of said double-pancake coil is comprised of inner and outer turns; wherein said inner turns are comprised of at least one of said conductor means wound about an axis and nested within one another; wherein said outer turns are comprised of said inner conductor means and at least one other conductor means co-wound about said inner turns and nested within one another; wherein each of said conductor means is wound along said axis from said first pancake to said second pancake at a different turn.
摘要翻译：具有第一和第二薄饼的双煎饼线圈可以包括多个导体装置，每个导体装置具有不同的等级并具有一个或多个导体，其中所述双煎饼线圈的每个薄饼包括内圈和外圈; 其中所述内圈由至少一个围绕轴线缠绕并嵌套在另一个中的所述导体装置构成; 其中所述外圈由所述内导体装置和至少一个其它导体装置构成，所述至少一个其它导体装置围绕所述内圈共缠绕并彼此嵌套; 其中每个所述导体装置沿着所述轴线从所述第一薄饼以不同的转动被卷绕到所述第二薄饼。

8. 发明授权

US08753396B1 Intervertebral implant having back-out prevention feature 有权
标题翻译：椎间植入物具有退出防止功能
公开(公告)号：US08753396B1
公开(公告)日：2014-06-17
申请号：US13211872
申请日：2011-08-17
申请人： Brian E. Hockett , Abid Qureshi , Steven Lee , Jeffrey A. Russo , Peter A. Materna
发明人： Brian E. Hockett , Abid Qureshi , Steven Lee , Jeffrey A. Russo , Peter A. Materna
IPC分类号： A61F2/44
CPC分类号： A61F2/447 , A61B17/8057 , A61F2/442 , A61F2002/2835 , A61F2002/3008 , A61F2002/30383 , A61F2002/30428 , A61F2002/30472 , A61F2002/30492 , A61F2002/30774 , A61F2002/30787 , A61F2002/30828 , A61F2310/00023
摘要： A spinal implant for implantation in an intervertebral space is provided, such that the implant may provide a back-out prevention feature and may also provide a visual indication of whether the back-out prevention feature is engaged. The visual indication may be a contrast between a circular visible shape of the screw head and a non-circular visible shape of the screw head. The back-out prevention feature may provide engagement of a tapered thread in the screw head with an internal thread of the implant. A hard stop may also be provided. Such back-out prevention feature may also provide a torque-based indication of engagement or non-engagement of the back-out prevention feature. The implant may possess a polymeric posterior body joined to a metallic anterior body.
摘要翻译：提供用于植入在椎间空间中的脊椎植入物，使得植入物可以提供防退回特征并且还可以提供是否参与防退避特征的视觉指示。视觉指示可以是螺钉头的圆形可见形状和螺钉头的非圆形可见形状之间的对比。防退避功能可以提供螺钉头中的锥形螺纹与植入物的内螺纹的接合。也可以提供硬停止。这种防退避功能还可以提供基于扭矩的指示，以防止退出防止特征的接合或非接合。植入物可以具有连接到金属前体的聚合物后体。

9. 发明授权

US07820201B2 System for manufacturing controlled release dosage forms, such as zero-order release profile dosage form manufactured by three-dimensional printing 有权
标题翻译：用于制造控制释放剂型的制剂，例如通过三维印刷制造的零级释放型剂量形式
公开(公告)号：US07820201B2
公开(公告)日：2010-10-26
申请号：US11876153
申请日：2007-10-22
申请人： Wendy E. Pryce Lewis , Charles W. Rowe , Michael J. Cima , Peter A. Materna
发明人： Wendy E. Pryce Lewis , Charles W. Rowe , Michael J. Cima , Peter A. Materna
IPC分类号： A61K9/24 , A61K9/20 , A61K9/22 , A61K9/48
CPC分类号： A61K9/2893 , A61J3/10 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/2095 , B33Y70/00 , B33Y80/00
摘要： The present invention includes controlled release dosage forms and methods of designing and manufacturing dosage forms to obtain specific release profiles, for example, zero-order release profiles, escalating release profiles or decreasing release profiles. The dosage forms of the present invention can include spatial variation of API concentration in the dosage form and can include nested regions. Dosage forms according to the present invention may be manufactured by any appropriate method for obtaining the internal structure as disclosed herein for producing zero-order release profiles and increasing or decreasing release profiles. The invention further includes methods of manufacturing such dosage forms, such as by three-dimensional printing, possibly also including compression of the dosage form after three-dimensional printing. The invention further includes methods of designing such dosage forms. Release profiles from non-uniform distributions of API concentration may be predicted based on simple experiments with uniform-concentration dosage forms.
摘要翻译：本发明包括控制释放剂型和设计和制造剂型以获得特定释放特征的方法，例如零级释放曲线，升级释放曲线或减少释放曲线。本发明的剂型可以包括剂型中API浓度的空间变化，并且可以包括嵌套区域。根据本发明的剂型可以通过用于获得本文公开的用于产生零级释放曲线和增加或减少释放曲线的内部结构的任何适当方法来制造。本发明还包括制造这种剂型的方法，例如通过三维印刷，可能还包括在三维印刷后压制剂型。本发明还包括设计这种剂型的方法。可以基于使用均匀浓度剂型的简单实验来预测API浓度不均匀分布的释放曲线。

10. 发明授权

US06454871B1 Method of cleaning passageways using a mixed phase flow of gas and a liquid 有权
标题翻译：使用气体和液体的混合相流清洁通道的方法
公开(公告)号：US06454871B1
公开(公告)日：2002-09-24
申请号：US09466714
申请日：1999-12-17
申请人： Mohamed Emam Labib , Ching-Yue Lai , Peter A. Materna , Geoffrey Lawrence Mahon
发明人： Mohamed Emam Labib , Ching-Yue Lai , Peter A. Materna , Geoffrey Lawrence Mahon
IPC分类号： B08B900
CPC分类号： C11D3/3956 , A61C1/0076 , A61L2/186 , A61L2/22 , A61L2202/24 , A61M1/1682 , A61M1/169 , B01D65/02 , B01D65/022 , B01D2321/04 , B01D2321/2066 , B08B9/032 , B08B9/0326 , B08B9/0327 , B08B2209/022 , C11D3/042 , C11D3/044 , C11D3/14 , C11D3/3947 , C11D3/48 , C11D11/0041 , C23G5/00
摘要： A method of cleaning surfaces using a mixed phase cleaning mixture of an aqueous solution and a flow of gas sufficient to produce droplets of the liquid which are entrained by the gas for a time sufficient to clean tubing of various lengths and geometries and porous membranes to remove biofilm, debris and contaminants.
摘要翻译：使用水溶液的混合相清洗混合物和足以产生被气体夹带的液体的液滴的时间足以清洁各种长度和几何形状的管道以及多孔膜以去除的液体的清洗表面的方法生物膜，碎屑和污染物。

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