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1. 发明申请

US20190240029A1 METHOD FOR ADJUSTING MECHANICAL PROPERTIES OF IMPLANT AND PATIENT SPECIFIC SURGICAL IMPLANTS 审中-公开
公开(公告)号：US20190240029A1
公开(公告)日：2019-08-08
申请号：US16263254
申请日：2019-01-31
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： Seung-Kyum Choi , Mahmoud Alzahrani , Recep Gorguluarslan
IPC分类号： A61F2/30 , A61F2/36 , A61F2/44 , G16H20/40
CPC分类号： A61F2/30942 , A61F2/36 , A61F2/4455 , A61F2002/30069 , A61F2002/30945 , A61F2002/30948 , A61F2002/30952 , G16H20/40
摘要： The present invention is for a systematic process of creating patient specific implants by matching target mechanical properties (e.g. elastic modulus of bone) based on a patient's CT scan images. The present invention creates a metamodel that matches the elastic modulus values of lattice scaffolds to desired values by using a homogenization approach to determine the characteristics of the lattice structure at the unit-cell level. This eliminates the computational cost associated with optimizing the lattice structures and works at structural level.The present invention includes the following featured steps to adjust a mechanical property (e.g., the elastic modulus) of the implant: 1) specifying a region requiring the implant operation from the CT scan images of the affected part, 2) determining the implant shape to be inserted into the specified region from the previous step, 3) dividing the implant shape into multiple partitioned three-dimensional regions, 4) assigning target elastic modulus values (Et) for each of the partitioned three-dimensional regions according to the bone density information obtained from the CT scan images, 5) selecting a specific type of unit-cell of lattice scaffolds with respect to the implant shape, 6) selecting a specific implant material, which has the elastic modulus of Eo, and 7) determining the required strut diameter and density of each unit-cell of the lattice scaffolds to minimize the error between the target elastic modulus (Et) and the homogenized elastic modulus (Eh), which is calculated from the implant material's elastic modulus value (Eo) obtained from the selected three-dimensional regions.The present invention creates patient specific surgical implants with precisely designed lattice scaffolds. The implants are designed for long term use because the stress shielding effect can be reduced by matching the elastic modulus of the implant to the elastic modulus of the bone of the affected area. Therefore, the present invention can significantly reduce the side effect of the implant and prevent reoperations.

2. 发明申请

US20190209331A1 SYSTEMS AND METHODS OF IMPLANTS TO RESTORE PATIENT SPECIFIC FUNCTON 审中-公开
公开(公告)号：US20190209331A1
公开(公告)日：2019-07-11
申请号：US16099114
申请日：2017-05-09
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Kartik Mangudi Varadarajan , Orhun K. Muratoglu , Henrik Malchau
IPC分类号： A61F2/30 , A61F2/40 , A61F2/38 , A61F2/42 , A61L27/48 , A61F2/36 , G16H20/40 , G06F16/51 , G16H30/20
CPC分类号： A61F2/30942 , A61F2/30 , A61F2/3601 , A61F2/38 , A61F2/3804 , A61F2/3859 , A61F2/3868 , A61F2/389 , A61F2/4059 , A61F2/4202 , A61F2/4261 , A61F2002/30945 , A61F2002/30948 , A61F2002/30952 , A61F2002/30963 , A61F2002/4633 , A61L27/48 , G06F16/51 , G16H20/40 , G16H30/20
摘要： A method of manufacturing at least one component of a joint prosthesis, the method comprising creating a first database representing an anatomy of an articulating bone of a joint of a subject; accessing a second database representing a geometry of a generic prosthetic component being sized to fit around an outer articulating surface of the articulating bone of the joint of the subject; creating a third database representing kinematic data of the subject's joint; merging the databases within a three-dimensional image-based medium. The generic prosthetic component is attached to the outer articulating surface of the articulating bone of the joint creating a prosthetic articulating surface that is moved through the kinematic data of the subject through a bearing template thereby modifying the bearing template to create a kinematically appropriate bearing surface; and manufacturing the component of the joint prosthesis to have a geometry corresponding to the kinematically appropriate bearing surface.

3. 发明申请

US20180349519A1 PERSONALIZED FIT AND FUNCTIONAL DESIGNED MEDICAL PROSTHESES AND SURGICAL INSTRUMENTS AND METHODS FOR MAKING 审中-公开
公开(公告)号：US20180349519A1
公开(公告)日：2018-12-06
申请号：US16047686
申请日：2018-07-27
申请人： James SCHROEDER
发明人： James SCHROEDER
IPC分类号： G06F17/50 , A61F2/30 , B33Y70/00 , B33Y80/00 , G16H50/50 , G16H10/60 , G06F19/00 , B33Y50/00 , A61F2/28 , A61F2/32
CPC分类号： G06F17/50 , A61F2/2875 , A61F2/30 , A61F2/32 , A61F2002/30948 , A61F2002/30952 , B33Y50/00 , B33Y70/00 , B33Y80/00 , G06F17/5009 , G06F19/00 , G06F2217/02 , G16H10/60 , G16H50/50
摘要： Methods, devices, systems, and instruments related to medical implants and surgical instruments produced to precisely fit and function as determined for individual subjects. In particular, the methods and devices utilize different combinations of medical imaging, quantitative image analysis, personalized drugs, stem cells, tissue grafts, various validation methods, and various manufacturing processes, to personalize biocompatible devices.

4. 发明申请

US20180303616A1 3-D PRINTING OF BONE GRAFTS 审中-公开
公开(公告)号：US20180303616A1
公开(公告)日：2018-10-25
申请号：US15493236
申请日：2017-04-21
申请人： Warsaw Orthopedic, Inc.
发明人： Subhabrata Bhattacharyya , David R. Kaes , Guobao Wei , Anil Mistry
IPC分类号： A61F2/30 , A61F2/28 , A61L27/04 , A61L27/58 , A61L27/36 , A61L27/54 , A61L27/14 , B29C67/00 , B33Y10/00 , B33Y50/02 , B33Y80/00
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/2846 , A61F2/4455 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2002/30948 , A61F2002/30952 , A61F2002/30962 , A61F2002/30971 , A61F2310/00041 , A61F2310/00359 , A61L27/04 , A61L27/14 , A61L27/3608 , A61L27/54 , A61L27/58 , A61L2430/02 , B29C67/0088 , B29K2995/0056 , B29L2031/7532 , B33Y10/00 , B33Y50/02 , B33Y80/00
摘要： Computer implemented methods of producing a bone graft are provided. These methods include obtaining a 3-D image of an intended bone graft site; generating a 3-D digital model of the bone graft based on the 3-D image of the intended bone graft site, the 3-D digital model of the bone graft being configured to fit within a 3-D digital model of the intended bone graft site; storing the 3-D digital model on a database coupled to a processor, the processor having instructions for retrieving the stored 3-D digital model of the bone graft and for combining a carrier material with, in or on a bone material based on the stored 3-D digital model and for instructing a 3-D printer to produce the bone graft. A layered 3-D printed bone graft prepared by the computer implemented method is also provided.

5. 发明申请

US20180263783A1 SYSTEM AND METHOD FOR FABRICATING A BODY PART MODEL USING MULTI-MATERIAL ADDITIVE MANUFACTURING 审中-公开
公开(公告)号：US20180263783A1
公开(公告)日：2018-09-20
申请号：US15984363
申请日：2018-05-20
申请人： Stratasys Ltd.
发明人： Daniel DIKOVSKY , Stanislav SHTILERMAN
IPC分类号： A61F2/30 , B29C64/112 , G06F19/00 , G06F17/50 , B33Y50/00 , A61C13/00
CPC分类号： A61F2/30942 , A61B5/055 , A61C13/0019 , A61F2002/30948 , A61F2002/30962 , A61F2002/30985 , B29C64/112 , B29L2031/7532 , B33Y50/00 , B33Y70/00 , G06F17/50 , G06F19/00
摘要： A method for physically reconstructing a body part using multi-material additive manufacturing includes receiving image data of the body part in the form of arrays of voxels, each array of voxels representing image data pertaining to cross-section of the body part, translating the image data in the arrays of voxels to printable bitmap images representing combinations of modeling materials for reconstructing the body part, and dispensing the combinations of modeling materials responsive to the bitmap images in a layerwise manner.

6. 发明申请

US20180256345A1 TOTAL KNEE REPLACEMENT IMPLANT BASED ON NORMAL ANATOMY AND KINEMATICS 审中-公开
公开(公告)号：US20180256345A1
公开(公告)日：2018-09-13
申请号：US15909749
申请日：2018-03-01
申请人： New York University
发明人： Peter Stanley Walker
IPC分类号： A61F2/38 , A61F2/30
CPC分类号： A61F2/38 , A61F2/3886 , A61F2002/30948 , A61F2002/30952
摘要： A total knee replacement prosthesis is presented whose bearing surfaces are derived from an anatomically representative femur and a modified baseline tibial surface. The contacting femoral and tibial bearing surfaces include the inter-condylar as well as condylar regions.

7. 发明申请

US20180256341A1 METALLIC STRUCTURES HAVING POROUS REGIONS FROM IMAGED BONE AT PRE-DEFINED ANATOMIC LOCATIONS 审中-公开
公开(公告)号：US20180256341A1
公开(公告)日：2018-09-13
申请号：US15980160
申请日：2018-05-15
申请人： Biomet Manufacturing, LLC
发明人： Tom Vanasse , Gautam Gupta , Jason D. Meridew
IPC分类号： A61F2/30 , B33Y50/00 , A61F2/40 , B33Y80/00 , A61F2/28
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/30767 , A61F2/4003 , A61F2002/30011 , A61F2002/3092 , A61F2002/30943 , A61F2002/30948 , A61F2002/30962 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/30985 , B33Y50/00 , B33Y80/00 , Y10T29/49
摘要： An additively manufactured medical implant, comprising a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone, and a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating.

8. 发明授权

US10070960B2 Method of generating a patient-specific bone shell 有权
公开(公告)号：US10070960B2
公开(公告)日：2018-09-11
申请号：US15264389
申请日：2016-09-13
申请人： ZIMMER, INC.
发明人： Mohamed Rashwan Mahfouz
IPC分类号： G06K9/00 , A61F2/30 , A61F2/38 , G06F17/18 , A61B8/00 , G06T19/00 , A61F2/36 , A61F2/40 , G16H50/50 , A61B34/10
CPC分类号： A61F2/30942 , A61B8/4245 , A61B34/10 , A61B2034/102 , A61B2034/108 , A61F2/3094 , A61F2/3601 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2/4003 , A61F2002/30943 , A61F2002/30948 , A61F2002/3863 , A61F2002/3895 , G06F17/18 , G06F19/00 , G06K9/00 , G06T19/00 , G06T2210/41 , G16H50/50
摘要： The exemplary embodiments of the present disclosure are described and illustrated below to encompass methods and devices for designing patient specific prosthetic cutting jigs and, more specifically, to devices and methods for segmenting bone of the knee and the resulting cutting guides themselves. Moreover, the present disclosure relates to systems and methods for manufacturing customized surgical devices, more specifically, the present disclosure relates to automated systems and methods of arthroplasty cutting guides, systems and methods for image segmentation in generating computer models of knee joint.

9. 发明授权

US10035308B2 Bone regeneration material 有权
公开(公告)号：US10035308B2
公开(公告)日：2018-07-31
申请号：US14419075
申请日：2013-08-05
申请人： NOBEL BIOCARE SERVICES AG
发明人： Günter Uhr
IPC分类号： A61F2/00 , B29C67/00 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/42 , A61L27/54 , G05B15/02 , G06F17/50 , B33Y50/00 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B33Y80/00
CPC分类号： B29C64/386 , A61F2/28 , A61F2/2803 , A61F2/30942 , A61F2002/2817 , A61F2002/2835 , A61F2002/30948 , A61F2002/30952 , A61L27/3616 , A61L27/425 , A61L27/54 , B33Y10/00 , B33Y30/00 , B33Y50/00 , B33Y50/02 , B33Y70/00 , B33Y80/00 , G05B15/02 , G06F17/50
摘要： A method of manufacturing a bone substitute structure for reconstruction of bone material in a patient. The method comprises the steps of providing data reflecting a cavity in a bone of a patient, defining and modelling a three dimensional structure corresponding to the cavity in the bone; and providing an individualized bone substitute structure, corresponding to the defined and modeled three dimensional structure, by combining calcium phosphate cement, growth factors and the patient's own un-coagulated blood.

10. 发明授权

US09993341B2 Metallic structures having porous regions from imaged bone at pre-defined anatomic locations 有权
公开(公告)号：US09993341B2
公开(公告)日：2018-06-12
申请号：US14475682
申请日：2014-09-03
申请人： Biomet Manufacturing, LLC
发明人： Tom Vanasse , Gautam Gupta , Jason Meridew
IPC分类号： A61F2/30 , B33Y50/00 , B33Y80/00 , A61F2/28 , A61F2/40
CPC分类号： A61F2/30942 , A61F2/28 , A61F2/30767 , A61F2/4003 , A61F2002/30011 , A61F2002/3092 , A61F2002/30943 , A61F2002/30948 , A61F2002/30962 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/30985 , B33Y50/00 , B33Y80/00 , Y10T29/49
摘要： An additively manufactured medical implant, comprising a metallic body having at least one porous surface configured to promote bony on-growth or in-growth of tissue, the porous surface being replicated from a high resolution scan of bone, and a biological surface coating configured to create a barrier to particulate debris, the biological surface coating being produced from a titanium porous plasma spray surface coating or a biomimetic coating.

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