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1. 发明授权

US07445441B2 Three-dimensional printing apparatus and methods of manufacture including sterilization or disinfection, for example, using ultraviolet light 失效
标题翻译：三维印刷装置和制造方法，包括例如使用紫外线的灭菌或消毒
公开(公告)号：US07445441B2
公开(公告)日：2008-11-04
申请号：US10891440
申请日：2004-07-14
申请人： Thomas George West , Qing Liu , Peter A. Materna , Alfred Anthony Litwak , Christopher M. Gaylo
发明人： Thomas George West , Qing Liu , Peter A. Materna , Alfred Anthony Litwak , Christopher M. Gaylo
IPC分类号： B29C35/02 , B29C67/00 , B28B17/02
CPC分类号： A61L2/208 , A61L2/10 , A61L2/206 , B29C64/165 , B29C2035/0827 , B29C2791/005 , B33Y10/00 , B33Y30/00 , B33Y40/00
摘要： The invention includes a three-dimensional printing (3DP) machine that has at least one ultraviolet (UV) light source directed at powder or slurry being processed by the 3DP machine and/or directed at any of various surfaces or machine components, in a manner suitable to kill or damage microorganisms to a desired extent. The UV light sources may be either stationary or movable, and may be either pulsed or substantially continuous, and may operate in any desired sequence and timing with respect to other operations performed by the machine. The invention may include ultraviolet illumination in such a way as to interact with powder to sterilize or disinfect powder either while the powder is stationary or, alternatively, as powder is being moved from one place to another within the 3DP machine, or both. The invention also includes methods of performing three-dimensional printing using such illumination. The invention also includes the combination of other methods of sterilization or disinfection with the use of ultraviolet light. The invention also includes the use of ultraviolet light sources for a combination of polymerization/cross-linking in addition to sterilization/disinfection.
摘要翻译：本发明包括三维打印（3DP）机器，其具有至少一个紫外线（UV）光源，其以粉末或浆料的形式被3DP机器处理和/或以各种表面或机器部件的任何一种方式适合杀死或损害微生物至所需程度。 UV光源可以是静止的或可移动的，并且可以是脉冲的或基本上连续的，并且可以相对于由机器执行的其它操作以任何期望的顺序和定时操作。本发明可以包括紫外线照射，以便与粉末相互作用以在粉末静止时或者当粉末在3DP机器内从一个位置移动到另一个位置时消除粉末或二者兼而有之。本发明还包括使用这种照明进行三维打印的方法。本发明还包括灭菌或消毒的其它方法与紫外线的组合。本发明还包括除灭菌/消毒之外使用紫外光源用于聚合/交联的组合。

2. 发明授权

US07122057B2 Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications 失效
标题翻译：用于骨愈合应用的工程再生生物结构的方法和装置，例如羟基磷灰石底物
公开(公告)号：US07122057B2
公开(公告)日：2006-10-17
申请号：US10122129
申请日：2002-04-12
申请人： Heather Ann Beam , Thomas J. Bradbury , Kathleen D. Chesmel , Christopher M. Gaylo , Alfred Anthony Litwak , Qing Liu , Peter Albert Materna , Donald Monkhouse , Jennifer Patterson , Timothy J. Pryor , Sunil Saini , Henry Leon Surprenant , Chen-Chao Wang , Thomas George West , Jaedeok Yoo
发明人： Heather Ann Beam , Thomas J. Bradbury , Kathleen D. Chesmel , Christopher M. Gaylo , Alfred Anthony Litwak , Qing Liu , Peter Albert Materna , Donald Monkhouse , Jennifer Patterson , Timothy J. Pryor , Sunil Saini , Henry Leon Surprenant , Chen-Chao Wang , Thomas George West , Jaedeok Yoo
IPC分类号： A61F2/28
CPC分类号： A61L27/46 , A61F2/28 , A61F2002/30034 , A61F2002/30059 , A61F2002/30062 , A61F2002/30225 , A61F2002/30271 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2250/0031 , A61F2310/00293 , A61L27/12 , A61L27/50 , A61L27/56 , A61L2430/02 , B33Y30/00 , B33Y80/00 , C04B28/34 , C04B35/447 , C04B35/634 , C04B35/638 , C04B38/06 , C04B2111/00181 , C04B2111/00836 , C04B2235/3212 , C04B2235/447 , C04B2235/5436 , C04B2235/6026 , C04B2235/616 , C04B2235/6567 , C04B2235/80 , C04B2235/96 , C04B35/00 , C04B38/0054 , C04B38/0074
摘要： An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.
摘要翻译：用于作为骨替代物植入人体的工程再生生物结构（erb），其包括内部微观结构，介观结构和/或宏观结构以提供改善的骨生长，以及用于制备所述erb的方法。在本发明的一个方面，生物结构具有可再吸收和不可再吸收的区域。在本发明的另一方面，生物结构由羟基磷灰石，磷酸三钙和/或脱矿质骨构成。在本发明的另一方面，多孔生物结构部分或全部注入可再吸收的，不可再吸收或可溶解的材料。

3. 发明授权

US08104614B2 Autoclavable medical instrument case for reduced instrument corrosion 有权
标题翻译：用于减少仪器腐蚀的高压灭菌医疗仪器箱
公开(公告)号：US08104614B2
公开(公告)日：2012-01-31
申请号：US12771782
申请日：2010-04-30
申请人： Frank Pinal , Alfred Anthony Litwak , Brian Umbach , Akhil Kumar Singh
发明人： Frank Pinal , Alfred Anthony Litwak , Brian Umbach , Akhil Kumar Singh
IPC分类号： B65D83/10
CPC分类号： A61L2/26 , A61B50/00 , A61B50/20 , A61B50/33 , A61B2050/0056 , A61L2202/182
摘要： A case for storing medical instruments contains a rotating bracket for holding the instruments. The bracket is connected to the tray and hinged lid of the case via a movable frame, and the bracket movement is controlled by opening and closing of the lid. When the lid is closed, the bracket points the tips of the instruments downward to minimize water collection; and when the lid is opened, the instrument holding bracket rotates so that the instruments it holds are moved to a vertical position, facilitating instrument selection.
摘要翻译：用于存储医疗器械的壳体包含用于保持器械的旋转支架。支架通过可动框架连接到外壳的托盘和铰链盖，支架的移动通过打开和关闭盖来控制。当盖子关闭时，支架向下指示仪器的尖端，以尽量减少收集水量; 并且当盖打开时，仪器夹持托架旋转，使其保持的仪器移动到垂直位置，便于仪器选择。

4. 发明申请

US20100256646A1 ORTHOBIOLOGICS DELIVERY TOOL 审中-公开
标题翻译： ORTHOBIOLOGICS交付工具
公开(公告)号：US20100256646A1
公开(公告)日：2010-10-07
申请号：US12416704
申请日：2009-04-01
申请人： Frank Pinal , Alfred Anthony Litwak , Brian Umbach , Akhil Kumar Singh
发明人： Frank Pinal , Alfred Anthony Litwak , Brian Umbach , Akhil Kumar Singh
IPC分类号： A61B17/56
CPC分类号： A61F2/4601 , A61B17/00491 , A61B17/8825 , A61B2050/005
摘要： A tool for delivering bio-compatible solid, fluid or mixed solid and fluid substances to an operating site within a patient. The tool has a tubular body or barrel with a central longitudinal through hole and a flow control valve for selectively allowing material to flow from a holding chamber within the barrel through an extender tip to a dispensing end of the tool. A plunger having a piston at one end may be inserted through the dispensing end of the barrel and drawn distally to aspirate material into the holding chamber using a syringe attached to the proximal end of the barrel, after which the valve is closed to retain the material in the chamber. The plunger, which fits into the through hole from either end of the barrel, is then removed and re-inserted into the proximal end of the barrel, the barrel valve is opened, and the plunger is pushed to move the material in the holding chamber through the extender tip and out the distal end of the barrel. An optional rod and multi-pronged blade mixing assembly may be inserted into the proximal end of the barrel to mix stored material after it is aspirated into the holding chamber and before it is dispensed.
摘要翻译：用于将生物相容的固体，流体或混合固体和流体物质输送到患者体内的操作部位的工具。该工具具有带有中心纵向通孔的管状主体或筒体，以及流量控制阀，用于选择性地允许材料从筒体内的保持室通过扩张器尖端流到工具的分配端。具有在一端具有活塞的柱塞可以插入通过筒的分配端并向远侧方向拉伸，以使用连接到筒的近端的注射器将材料吸入保持室中，之后关闭阀门以保持材料在房间里然后从柱塞的任一端装配到通孔中的柱塞被移除并重新插入到筒的近端中，筒形阀被打开，柱塞被推动以移动保持室中的材料通过扩展器尖端并且从筒的远端出来。可选的杆和多管叶片混合组件可以插入到筒的近端中，以将储存的材料吸入储存室中并在分配之前混合储存的材料。

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