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1. 发明授权

US07402171B2 Prosthetic valve that permits retrograde flow 有权
标题翻译：允许逆行流动的假体瓣膜
公开(公告)号：US07402171B2
公开(公告)日：2008-07-22
申请号：US10797449
申请日：2004-03-10
申请人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
发明人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration.
摘要翻译：提供了一种用于调节通过身体容器的流体流动的人造瓣膜。阀包括可膨胀的支撑框架和瓣膜小叶，并且包括至少一个开口，当阀处于关闭构型时允许通过阀的受控量的逆流流动。

2. 发明授权

US08021417B2 Prosthetic valve that permits retrograde flow 有权
标题翻译：允许逆行流动的假体瓣膜
公开(公告)号：US08021417B2
公开(公告)日：2011-09-20
申请号：US12139836
申请日：2008-06-16
申请人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
发明人： Thomas A. Osborne , Brian C. Case , Mark W. Bleyer , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： A prosthetic valve for regulating fluid flow through a body vessel is provided. The valve includes an expandable support frame and a valve leaflet, and includes at least one opening that permits a controlled amount of retrograde flow through the valve when the valve is in a closed configuration. A flap disposed adjacent the opening is able to temporarily and substantially close the opening to contribute to the regulation of retrograde flow proceeding through the valve.
摘要翻译：提供了一种用于调节通过身体容器的流体流动的人造瓣膜。阀包括可膨胀的支撑框架和瓣膜小叶，并且包括至少一个开口，当阀处于关闭构型时允许通过阀的受控量的逆行流动。邻近开口设置的翼片能够暂时且基本上关闭开口，以有助于调节通过阀门的逆行流。

3. 发明授权

US08382822B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

4. 发明申请

US20090216321A1 PROSTHETIC VALVE WITH SELECTIVELY POSITIONED BIOACTIVE AGENT 审中-公开
标题翻译：具有选择性定位的生物剂的前驱阀
公开(公告)号：US20090216321A1
公开(公告)日：2009-08-27
申请号：US12437731
申请日：2009-05-08
申请人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
发明人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： A prosthetic valve includes a support frame, a leaflet attached to the support frame, and a bioactive agent associated with the leaflet. A first free edge of the leaflet permits fluid flow through a body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction. A second free edge of the leaflet at least partially defines an opening for permitting a controlled amount of fluid flow through the body vessel.
摘要翻译：假体瓣膜包括支撑框架，附接到支撑框架的小叶以及与小叶相关联的生物活性剂。小叶的第一自由边允许流体沿着第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过身体血管。叶片的第二自由边缘至少部分地限定了允许受控量的流体流过身体容器的开口。

5. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

6. 发明授权

US07544207B2 Medical device with bioactive agent 有权
标题翻译：带有生物活性剂的医疗器械
公开(公告)号：US07544207B2
公开(公告)日：2009-06-09
申请号：US11244991
申请日：2005-10-06
申请人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
发明人： Thomas A. Osborne , Jacob A. Flagle , Brian C. Case , Joseph F. Obermiller , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2230/0026 , A61F2230/0067 , A61F2230/008 , A61F2230/0095 , A61F2250/0067
摘要： Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.
摘要翻译：提供具有一种或多种生物活性剂的医疗装置用于调节通过身体血管的流体流动。根据本发明的医疗装置可以包括包括生物活性剂的人造瓣膜。

7. 发明授权

US08128682B2 Medical device with tensionably attached remodelable material 有权
标题翻译：具有可张力连接的可重塑材料的医疗装置
公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

8. 发明授权

US07717952B2 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US07717952B2
公开(公告)日：2010-05-18
申请号：US11586285
申请日：2006-10-25
申请人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
发明人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

9. 发明申请

US20120296412A1 DELIVERY SYSTEM WITH MEDICAL DEVICE RELEASE BY EVERTABLE SLEEVE 有权
标题翻译：带有医疗器械的交付系统由可靠的套管释放
公开(公告)号：US20120296412A1
公开(公告)日：2012-11-22
申请号：US13562674
申请日：2012-07-31
申请人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
发明人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
IPC分类号： A61F2/84 , A61F2/06 , A61B17/22 , A61F2/24 , A61M29/00
CPC分类号： A61F2/95 , A61B17/12109 , A61B17/12131 , A61B2017/12054 , A61B2017/3435 , A61F2/966
摘要： A medical device delivery system has a tubular member defining a passageway and an inner member slideably disposed within the passageway. An expandable intraluminal medical device is disposed on a chamber of the inner member, and an evertable sleeve is attached to the inner member proximal to the chamber and to an inner surface of the tubular member. Relative movement between the tubular and outer members moves the evertable sleeve from a first position substantially overlying the expandable intraluminal medical device to a second position substantially proximal to the chamber.
摘要翻译：医疗装置输送系统具有限定通道的管状构件和可滑动地设置在通道内的内部构件。可扩展的管腔内医疗装置设置在内部构件的腔室上，并且可翻转套筒附接到靠近腔室的内部构件和管状构件的内表面。管状和外部构件之间的相对运动将可翻转套管从基本上覆盖可膨胀管腔内医疗装置的第一位置移动到基本上靠近腔室的第二位置。

10. 发明授权

US08066733B2 Inverting occlusion devices, methods, and systems 有权
公开(公告)号：US08066733B2
公开(公告)日：2011-11-29
申请号：US12338731
申请日：2008-12-18
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
IPC分类号： A61M29/00
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.

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