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    • 1. 发明授权
    • Analysis method using reporter (label) intermolecular interaction
    • 分析方法采用报告(标记)分子间相互作用
    • US07595202B2
    • 2009-09-29
    • US10475540
    • 2002-04-23
    • Teruyuki NagamuneHiroshi UedaYoshiyuki OhiroNorio Shibata
    • Teruyuki NagamuneHiroshi UedaYoshiyuki OhiroNorio Shibata
    • G01N33/541G01N21/76G01N33/533G01N33/566G01N33/53G01N33/542
    • G01N33/54306G01N33/533G01N33/542G01N33/582
    • The present invention provides a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good precision and high sensitivity, and a measurement system using the method. Two types of material having affinity for the subject material to be measured are respectively labeled with a combination of reporters that give rise to energy transfer; those that have been thus obtained by labeling these materials are each further labeled with materials that have weak affinity for each other to give reagents, which are then mixed with a sample to give the reaction complex. Each of the materials is brought into spatial proximity by binding based on the affinity among the materials having weak affinity for each other in the reaction complex, and since that condition is stably maintained, a more efficient energy transfer occurs.
    • 本发明提供了一种用于控制反应复合物中能量供体和能量受体的空间排列的方法,以便以高精度和高灵敏度进行测量,以及使用该方法的测量系统。 分别用引起能量转移的记者的组合来标示对被测量物质具有亲和性的两种类型的材料; 通过标记这些材料得到的那些物质每个进一步用彼此具有弱亲和力的材料进行标记,得到试剂,然后将其与样品混合以得到反应络合物。 通过基于在反应络合物中彼此之间具有弱亲和力的材料之间的亲和力,通过结合使每种材料变得空间接近,并且由于稳定地保持该条件,因此发生更有效的能量转移。
    • 2. 发明申请
    • 2-FLUORO-1,3-BENZODITHIOL 1,1,3,3-TETRAOXIDE DERIVATIVE, PRODUCTION METHOD THEREOF, AND PRODUCTION METHOD OF MONOFLUOROMETHYL GROUP-CONTAINING COMPOUND USING THE SAME
    • 二氟-1,3-二苯并咪唑1,1,3,3-四氧化硫衍生物及其制备方法,以及使用该单体的含氟单体组的化合物的制造方法
    • US20110319637A1
    • 2011-12-29
    • US13254260
    • 2010-02-12
    • Norio Shibata
    • Norio Shibata
    • C07D339/06C07C29/147C07C29/132
    • C07B53/00C07B2200/07C07C29/32C07D339/06C07C33/48
    • A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production method of a monofluoromethyl group-containing compound using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative are provided. The 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative represented by the following general formula (1) (wherein R1, R2, R3, and R4 each independently represent a hydrogen atom, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a straight-chain or branched alkyloxy group having 1 to 4 carbon atoms, a halogen atom, a nitro group, or a cyano group), the production method thereof, and various monofluoromethyl group-containing compounds are manufactured using this 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethylating agent.
    • 作为药物和农药合成中的中间体的作为单氟甲基导入剂的2-氟-1,3-苯并二硫醇1,1,3,3-四氧化物衍生物,其制造方法和单氟甲基的制造方法 提供了使用该2-氟-1,3-苯并二硫醇1,1,3,3-四氧化物衍生物的含有基团的化合物。 由以下通式(1)表示的2-氟-1,3-苯并二硫醇1,1,3,3-四氧化物衍生物(其中R 1,R 2,R 3和R 4各自独立地表示氢原子,直链 或具有1〜4个碳原子的支链烷基,具有1〜4个碳原子的直链或支链烷氧基,卤原子,硝基或氰基),其制备方法和各种单氟甲基 - 使用该2-氟-1,3-苯并二硫醇1,1,3,3-四氧化物衍生物作为单氟甲基化剂制造含氟化合物。
    • 8. 发明授权
    • Method for applying a coating liquid to a web
    • 将涂布液施加到网上的方法
    • US5209954A
    • 1993-05-11
    • US899592
    • 1992-06-18
    • Shinsuke TakahashiNorio Shibata
    • Shinsuke TakahashiNorio Shibata
    • B05C5/02G03C1/74G11B5/842
    • G11B5/842B05C5/0254G03C1/74G03C2001/7459G03C2001/7466
    • A method for applying a coating liquid and a method for forming a coating liquid application device are taught. According to the method, a portion of an applied liquid supplied into a liquid reservoir is drained from one end thereof, and the other portion of the liquid is continuously discharged from the outlet portion of a slot which faces the surface of a flexible band-like carrier moving continuously so as to form a thin film of liquid on the surface. In this liquid application device, the diameter D of the reservoir, the width d of the slot, the depth L.sub.1 of the slot from the reservoir to the outlet portion at the applied liquid supply end of the reservoir, the depth L.sub.2 of the slot from the reservoir to the outlet portion at the applied liquid drain end of the reservoir, the length W of the outlet portion, the viscosity .eta..sub.p of the liquid in the reservoir, the viscosity .eta..sub.s of the liquid in the slot, the supplied quantity Q.sub.1 of the liquid and the drained quantity Q.sub.2 of the liquid are selected to comply with: ##EQU1##
    • 教导涂布液的涂布方法和涂布液涂布装置的形成方法。 根据该方法,供给液体储存器的被涂液的一部分从其一端排出,液体的另一部分从面向柔性带状表面的槽的出口部分连续排出 载体连续移动,以在表面上形成液体薄膜。 在这种液体施加装置中,储存器的直径D,槽的宽度d,槽中从储存器到出口部分的槽的深度L1在储存器的施加的液体供应端处,槽的深度L2从 在储存器的施加的液体排放端处的出口部分的储存器,出口部分的长度W,储存器中的液体的粘度等级,槽中的液体的粘度等级,供给量Q1 的液体和液体的排出量Q2被选择为符合:
    • 9. 发明授权
    • Method of application and device for application
    • 应用方法和应用设备
    • US5206056A
    • 1993-04-27
    • US770005
    • 1991-10-02
    • Norio ShibataNaoyoshi Chino
    • Norio ShibataNaoyoshi Chino
    • B05C5/02B05D1/26D21H23/46G03C1/74G11B5/842
    • G11B5/842B05C5/0254D21H23/46G03C1/74G03C2001/7459G03C2001/7466
    • An application device capable of very rapidly applying a liquid in the form of a thin film to a continuously moving flexible carrier in such a manner as to avoid corrosion and wear to the surface of the doctor edge portion of the application device to thus avoid the formation of streaks on the surface of the applied liquid. A clearance between the surface of the carrier and the surface of the doctor edge portion is made larger at the downstream end of the surface of the doctor edge portion than at the upstream part thereof. For this purpose, a support roller is provided near the downstream end of the surface of the doctor edge portion so that the clearance between the surface of the doctor edge portion and the surface of the carrier can be appropriately controlled along substantially the entire width of the doctor edge portion by adjustably displacing the roller. Application is performed while the clearance between the surface of the carrier and the doctor edge portion is set larger at the downstream end of the surface of the doctor edge portion than at the upstream part of the surface thereof.
    • 一种能够非常快速地将薄膜形式的液体施加到连续移动的柔性载体的应用装置,以避免腐蚀和磨损到施加装置的刮刀边缘部分的表面,从而避免形成 在所施加的液体的表面上的条纹。 在刮刀边缘部分的表面的下游端比在其上游部分处使载体表面与刮刀边缘部分表面之间的间隙更大。 为此,在刮刀边缘部分的表面的下游端附近设置有支撑辊,使得刮刀边缘部分的表面与载体表面之间的间隙可以基本上沿着 刮刀边缘部分通过可调地移动辊子。 当在刮刀边缘部分的表面的下游端比在其表面的上游部分处设置载体表面和刮刀边缘部分之间的间隙更大的应用。