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1. 发明授权

US07816145B2 Method, device and apparatus for measuring the concentration of creatinine, and method, device and apparatus for measuring the amount of salt using the same 有权
标题翻译：用于测量肌酸酐浓度的方法，装置和装置，以及用于测量其使用量的盐的量的方法，装置和装置
公开(公告)号：US07816145B2
公开(公告)日：2010-10-19
申请号：US12717493
申请日：2010-03-04
申请人： Takahiro Nakaminami , Kouji Kashiwada , Atsushi Fukunaga
发明人： Takahiro Nakaminami , Kouji Kashiwada , Atsushi Fukunaga
IPC分类号： G01N33/00
CPC分类号： G01N33/70 , C12Q1/34 , G01N21/80 , G01N33/5302 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method for measuring a concentration of creatinine includes the steps of: (A) mixing a sample containing creatinine with a creatinine quantitative reagent containing a metal complex of at least one of hexacyanoferrate and hexacyanoruthenate in the absence of picric acid and any enzyme responsive to creatinine, to cause the creatinine to reduce the metal complex; (B) electrochemically or optically measuring the amount of the metal complex reduced in the step (A); and (C) determining the concentration of the creatinine contained in the sample from the amount of the reduced metal complex measured in the step (B).
摘要翻译：用于测量肌酸酐浓度的方法包括以下步骤：（A）在不存在苦味酸和任何对肌酸酐敏感的酶的情况下，将含有肌酸酐的样品与含有六氰基铁酸盐和六氰基钌酸盐中的至少一种的金属络合物的肌酸定量试剂混合，使肌酸酐减少金属络合物; （B）电化学或光学测量步骤（A）中还原的金属络合物的量; 和（C）从步骤（B）中测量的还原金属络合物的量确定样品中所含的肌酸酐的浓度。

2. 发明授权

US07611672B1 Measurement cell 有权
标题翻译：测量单元
公开(公告)号：US07611672B1
公开(公告)日：2009-11-03
申请号：US12092212
申请日：2006-11-27
申请人： Atsushi Fukunaga , Eiji Noguchi , Takahiro Nakaminami
发明人： Atsushi Fukunaga , Eiji Noguchi , Takahiro Nakaminami
IPC分类号： B01L3/00 , G01N1/10
CPC分类号： G01N21/11 , G01N21/03 , G01N21/15 , G01N2021/0325 , G01N2021/036 , G01N2021/152
摘要： A measurement cell 1 includes: an opening part 106 for supplying a sample into a sample holding part 105 for holding a sample; an optical window portion for allowing light to enter the sample holding part 105 and allowing light to exit the sample holding part 105; a protection cover 101 for protecting the optical window portion, provided along the circumference of the sample holding part 105; and a first protection-cover-holding part 102 for holding the protection cover 101 at the position where the optical window portion is covered.
摘要翻译：测量单元1包括：用于将样品供给到用于保持样品的样品保持部105中的开口部106; 用于允许光进入样品保持部分105并允许光离开样品保持部分105的光学窗口部分; 保护盖101，用于保护沿着样品保持部105的圆周设置的光学窗口部; 以及用于将保护盖101保持在光学窗口部分被覆盖的位置处的第一保护盖保持部分102。

3. 发明申请

US20090170210A1 MEASURING DEVICE, MEASURING APPARATUS AND METHOD OF MEASURING 审中-公开
标题翻译：测量装置，测量装置和测量方法
公开(公告)号：US20090170210A1
公开(公告)日：2009-07-02
申请号：US11995164
申请日：2006-10-24
申请人： Atsushi Fukunaga , Takahiro Nakaminami , Akihito Kamei
发明人： Atsushi Fukunaga , Takahiro Nakaminami , Akihito Kamei
IPC分类号： G01N27/27 , G01N21/00 , C12M1/40
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and at least one electrode. The second container has a second sample supply inlet for supplying the sample to the second container and a reagent holding part for holding a reagent for the optical measurement.
摘要翻译：本发明的测量装置包括：第一容器和用于保持样品的第二容器; 以及用于进行光学测量的光学测量部件。第一容器具有用于将含有分析物的样品供应到第一容器和至少一个电极的第一样品供应入口。第二容器具有用于将样品供应到第二容器的第二样品供给入口和用于保持用于光学测量的试剂的试剂保持部。

4. 发明申请

US20090263283A1 MEASUREMENT CELL 有权
标题翻译：测量单元
公开(公告)号：US20090263283A1
公开(公告)日：2009-10-22
申请号：US12092212
申请日：2006-11-27
申请人： Atsushi Fukunaga , Eiji Noguchi , Takahiro Nakaminami
发明人： Atsushi Fukunaga , Eiji Noguchi , Takahiro Nakaminami
IPC分类号： G01N21/00
CPC分类号： G01N21/11 , G01N21/03 , G01N21/15 , G01N2021/0325 , G01N2021/036 , G01N2021/152
摘要： A measurement cell 1 includes: an opening part 106 for supplying a sample into a sample holding part 105 for holding a sample; an optical window portion for allowing light to enter the sample holding part 105 and allowing light to exit the sample holding part 105; a protection cover 101 for protecting the optical window portion, provided along the circumference of the sample holding part 105; and a first protection-cover-holding part 102 for holding the protection cover 101 at the position where the optical window portion is covered.
摘要翻译：测量单元1包括：用于将样品供给到用于保持样品的样品保持部105中的开口部106; 用于允许光进入样品保持部分105并允许光离开样品保持部分105的光学窗口部分; 保护盖101，用于保护沿着样品保持部105的圆周设置的光学窗口部; 以及用于将保护盖101保持在光学窗口部分被覆盖的位置处的第一保护盖保持部分102。

5. 发明授权

US08399259B2 Measuring device, measuring apparatus and method of measuring 有权
标题翻译：测量装置，测量装置和测量方法
公开(公告)号：US08399259B2
公开(公告)日：2013-03-19
申请号：US12769372
申请日：2010-04-28
申请人： Atsushi Fukunaga , Takahiro Nakaminami , Akihito Kamei
发明人： Atsushi Fukunaga , Takahiro Nakaminami , Akihito Kamei
IPC分类号： G01N27/00 , G01N27/26
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and at least one electrode. The second container has a second sample supply inlet for supplying the sample to the second container and a reagent holding part for holding a reagent for the optical measurement.
摘要翻译：本发明的测量装置包括：第一容器和用于保持样品的第二容器; 以及用于进行光学测量的光学测量部件。第一容器具有用于将含有分析物的样品供应到第一容器和至少一个电极的第一样品供应入口。第二容器具有用于将样品供应到第二容器的第二样品供给入口和用于保持用于光学测量的试剂的试剂保持部。

6. 发明申请

US20090219514A1 MEASURING DEVICE, MEASURING APPARATUS AND METHOD OF MEASURING 有权
标题翻译：测量装置，测量装置和测量方法
公开(公告)号：US20090219514A1
公开(公告)日：2009-09-03
申请号：US11995473
申请日：2006-10-24
申请人： Takahiro Nakaminami , Akihito Kamei , Atsushi Fukunaga
发明人： Takahiro Nakaminami , Akihito Kamei , Atsushi Fukunaga
IPC分类号： G01N21/00 , G01N27/416
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： A measuring device for analyzing an analyte contained in a sample. The device includes a hollow housing, a sample holding part provided inside the housing for holding the sample, a sample supply inlet provided for the housing so as to communicate with the sample holding part, an optical measurement part provided for the sample holding part for making an optical measurement, a reagent holding part provided for the sample holding part for holding a reagent for the optical measurement, and at least one electrode provided on an outer surface of the housing.
摘要翻译：用于分析样品中所含分析物的测量装置。该装置包括中空壳体，设置在壳体内用于保持样品的样品保持部分，设置用于壳体以便与样品保持部分连通的样品供应入口，设置用于制备样品保持部分的光学测量部件光学测量装置，用于保持用于光学测量的试剂的样品保持部件的试剂保持部件和设置在壳体的外表面上的至少一个电极。

7. 发明授权

US07646474B2 Measuring device, measuring apparatus and method of measuring 有权
标题翻译：测量装置，测量装置和测量方法
公开(公告)号：US07646474B2
公开(公告)日：2010-01-12
申请号：US11995473
申请日：2006-10-24
申请人： Takahiro Nakaminami , Akihito Kamei , Atsushi Fukunaga
发明人： Takahiro Nakaminami , Akihito Kamei , Atsushi Fukunaga
IPC分类号： G01N21/00
CPC分类号： G01N21/255 , G01N21/03 , G01N21/59 , G01N2035/1062
摘要： A measuring device for analyzing an analyte contained in a sample. The device includes a hollow housing, a sample holding part provided inside the housing for holding the sample, a sample supply inlet provided for the housing so as to communicate with the sample holding part, an optical measurement part provided for the sample holding part for making an optical measurement, a reagent holding part provided for the sample holding part for holding a reagent for the optical measurement, and at least one electrode provided on an outer surface of the housing.
摘要翻译：用于分析样品中所含分析物的测量装置。该装置包括中空壳体，设置在壳体内用于保持样品的样品保持部分，设置用于壳体以便与样品保持部分连通的样品供应入口，设置用于制备样品保持部件的光学测量部件光学测量装置，用于保持用于光学测量的试剂的样品保持部件的试剂保持部件和设置在壳体的外表面上的至少一个电极。

8. 发明申请

US20050164328A1 Substrate determining method 审中-公开
标题翻译：基板测定方法
公开(公告)号：US20050164328A1
公开(公告)日：2005-07-28
申请号：US10507010
申请日：2003-03-05
申请人： Susumu Kuwabata , Takahiro Nakaminami
发明人： Susumu Kuwabata , Takahiro Nakaminami
IPC分类号： C12Q1/00 , C12Q1/26 , C12Q1/32
CPC分类号： C12Q1/001 , C12Q1/26 , C12Q1/32 , G01N27/3273
摘要： There is provided a method for precisely quantitating a substrate by means of a measurement system with a simple structure without occurrence of a measurement error due to an interfering substance. In a method for quantitating a substrate in a sample solution which contains a dissolved interfering substance and the substrate, by the use of an electrode system and a reagent system, (a) a sample solution which contains a dissolved interfering substance and a substrate is supplied to an electrode system comprising a working electrode and a counter electrode under the existence of a reagent system comprising oxidoreductase and an electron mediator; (b) an AC potential is applied to the working electrode, to cause a redox reaction of the electron mediator: (c) an electric signal produced on the basis of the redox reaction is measured by means of the electrode system; and (d) the substrate is quantitated on the basis of the electric signal.
摘要翻译：提供了通过具有简单结构的测量系统精确定量基板的方法，而不会由于干扰物质而出现测量误差。在通过使用电极系统和试剂系统对含有溶解的干扰物质和基板的样品溶液中的基板进行定量的方法中，（a）供给含有溶解的干燥物质和基材的样品溶液涉及在存在包含氧化还原酶和电子介体的试剂体系的情况下包括工作电极和对电极的电极系统; （b）对工作电极施加AC电位，引起电子介体的氧化还原反应：（c）利用电极系统测定基于氧化还原反应产生的电信号; 和（d）基于电信号定量衬底。

9. 发明授权

US06740215B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06740215B1
公开(公告)日：2004-05-25
申请号：US09959571
申请日：2001-10-30
申请人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
摘要翻译：一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

10. 发明授权

US08673127B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08673127B2
公开(公告)日：2014-03-18
申请号：US12928841
申请日：2010-12-21
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
IPC分类号： G01N27/327
CPC分类号： C12Q1/003
摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
摘要翻译：在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器浓度。

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