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1. 发明授权

US06740215B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06740215B1
公开(公告)日：2004-05-25
申请号：US09959571
申请日：2001-10-30
申请人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
摘要翻译：一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

2. 再颁专利

USRE39390E1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：USRE39390E1
公开(公告)日：2006-11-14
申请号：US10924334
申请日：2002-05-17
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with which is obtained by filtering out hemocytes therein filtered in blood can rapidly reach an electrode system. In a biosensor where plasma with which is obtained by filtering out hemocytes therein filtered with by a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其测量对象为全血，等离子体<？delete-start id =“DEL-S-00001”date =“20061114”？>与<？delete -end id =“DEL-S-00001”？> <？insert-start id =“INS-S-00001”date =“20061114”？>通过过滤出<？insert-end id =“INS- S-00001“？>血细胞<？delete-start id =”DEL-S-00002“date =”20061114“？>其中过滤的<？delete-end id =”DEL-S-00002“？> 在血液中开始id =“INS-S-00002”date =“20061114”？> <？insert-end id =“INS-S-00002”？>可以快速到达电极系统。在等离子体<？delete-start id =“DEL-S-00003”date =“20061114”？>与<？delete-end id =“DEL-S-00003”？> <？insert-start id = 通过滤出<？insert-end id =“INS-S-00003”？>血细胞<？delete-start id =“DEL-S-00004”获得的“INS-S-00003”date =“20061114”？ “date =”20061114“？>用<？delete-end id =”DEL-S-00004“？> <？insert-start id =”INS-S-00004“date =”20061114“？> ？insert-end id =“INS-S-00004”？>由于毛细作用，将过滤器吸入样品溶液供给路径，形成有：从底部保持过滤器的初级侧部的第一按压部，用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

3. 发明授权

US07235170B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07235170B2
公开(公告)日：2007-06-26
申请号：US10344671
申请日：2002-05-13
申请人： Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Shiro Nankai
发明人： Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/26
CPC分类号： C12Q1/006 , C12Q1/001 , C12Q1/54
摘要： A biosensor that is highly responsive and capable of rapid and highly sensitive quantification of a specific component contained in a sample is provided. The biosensor of this invention comprises: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode disposed on the base plate; and a reagent system comprising an oxidoreductase which catalyzes the oxidation reaction of glucose, gluconolactonase and a buffer. The buffer is selected from the group consisting of phthalic acid and its salts, maleic acid and its salts, succinic acid and its salts, phospholic acid and its salts, acetic acid and its salts, boric acid and its salts, citric acid and its salts, glycine, tris(hydroxymethyl)aminomethane, piperazine-N,N′-bis(2-ethane sulfonic acid) and the like.
摘要翻译：提供了一种生物传感器，其具有高响应性并且能够对包含在样品中的特定成分进行快速和高灵敏度的定量。本发明的生物传感器包括：电绝缘基板; 电极系统，包括设置在所述基板上的工作电极和对置电极; 以及包含催化葡萄糖，葡糖酸内切酶和缓冲液的氧化反应的氧化还原酶的试剂体系。缓冲剂选自邻苯二甲酸及其盐，马来酸及其盐，琥珀酸及其盐，磷酸及其盐，乙酸及其盐，硼酸及其盐，柠檬酸及其盐，甘氨酸，三（羟甲基）氨基甲烷，哌嗪-N，N'-双（2-乙磺酸）等。

4. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

5. 发明授权

US06706232B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06706232B2
公开(公告)日：2004-03-16
申请号：US10363589
申请日：2003-03-04
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with hemocytes therein filtered can rapidly reach an electrode system. In a biosensor where plasma with hemocytes therein filtered with a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其被测量对象是全血，其中血细胞在其中被过滤的血浆可以快速地达到电极系统。在生物传感器中，其中用过滤器过滤血细胞的血浆由于毛细作用而被吸入样品溶液供应通道中，形成有：从底部保持过滤器的初级侧部分的第一按压部分; 用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

6. 发明授权

US06776888B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06776888B2
公开(公告)日：2004-08-17
申请号：US10089289
申请日：2002-03-26
申请人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： The present invention provides a biosensor that enables highly-accurate measurement of a sample solution including a solid component like hemocytes and has a little variation in response. The biosensor includes: an insulating base plate, an electrode system having at least a working electrode and a counter electrode provided on the base plate, a cover member that is combined with the base plate to define a sample solution supply pathway for leading a sample solution from a sample supply unit to the electrode system, a reaction reagent system including at least an oxidation-reduction enzyme and an electron mediator, and a filter disposed between the electrode system and the sample supply unit in the sample solution supply pathway. The biosensor has a space that encircles surface of the filter in an area from one end of the filter close to the sample supply unit to the other end of the filter close to the electrode system. This arrangement effectively prevents the solid component like hemocytes from flowing into the electrode system without being filtered out by the filter.
摘要翻译：本发明提供一种生物传感器，其能够高精度地测量包含像血细胞这样的固体成分的样品溶液，并且响应性变化很小。生物传感器包括：绝缘基板，至少具有工作电极和设置在基板上的对电极的电极系统，与基板结合以限定用于引导样品溶液的样品溶液供给路径的盖构件从样品供给单元到电极系统，至少包含氧化还原酶和电子介体的反应试剂系统，以及设置在样品溶液供给路径中的电极系统和样品供给单元之间的过滤器。生物传感器具有在过滤器的一端靠近样品供给单元的一个区域中的过滤器的表面周围到靠近电极系统的过滤器的另一端的空间。这种布置有效地防止诸如血细胞的固体组分流入电极系统而不被过滤器过滤掉。

7. 发明授权

US06451372B2 Biosensor and method of producing the same 失效
标题翻译：生物传感器及其生产方法
公开(公告)号：US06451372B2
公开(公告)日：2002-09-17
申请号：US09770946
申请日：2001-01-26
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： B05D300
CPC分类号： C12Q1/002
摘要： The present invention provides a biosensor that has a reaction reagent system easily dissolved even in a sample solution containing a high concentration of a substrate and ensures rapid and highly accurate measurement. The method of forming a target reaction layer according to the present invention dissolves a material constituting the target reaction layer in a solvent of a sublimable substance to prepare a solution, applies the solution in a desired area to form the target reaction layer, freezes the applied solution, and sublimates the solvent included in a solid matter of the frozen solution under reduced pressure for removal. The resultant reaction layer has a large surface area and is easily dissolved in the sample solution to enable rapid measurement.
摘要翻译：本发明提供了一种生物传感器，其具有即使在含有高浓度基板的样品溶液中也容易溶解的反应试剂体系，并且确保快速且高精度的测量。根据本发明的形成目标反应层的方法将构成目标反应层的材料溶解在可升华物质的溶剂中以制备溶液，将溶液施加到所需区域以形成目标反应层，冻结所施加的溶液，并在减压下升华包含在冷冻溶液的固体物质中的溶剂以除去。所得反应层的表面积大，容易溶解在样品溶液中，能够快速测定。

8. 发明授权

US6051392A Method for quantitating a substrate and measurement device used therefor 有权
标题翻译：用于定量基板的方法和用于其的测量装置
公开(公告)号：US6051392A
公开(公告)日：2000-04-18
申请号：US328510
申请日：1999-06-09
申请人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27/327 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1486 , A61B5/15 , A61B5/155 , A61B5/157 , G01N27/28 , G01N27/30 , G01N33/487 , C12Q1/26 , C12Q1/54
CPC分类号： A61B5/1486 , A61B5/150022 , A61B5/150435 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/15142 , A61B5/15151 , A61B5/15171 , A61B5/6848 , A61B5/14532 , Y10S435/817
摘要： The present invention provides a measurement device facilitating accurate quantitation of a substrate from a trace amount of sample and a highly reliable quantitating method of a substrate. The method uses an analysis element comprising a pair of electrodes for electrochemically quantitating reaction between a substrate in a sample and an oxidoreductase. One of the electrodes of the analysis element is a membrane formed on an inner wall of a cylindrical hollow space having an opening and the other is a needle. The needle electrode is projected temporarily external to the hollow space to puncture a subject and the resultant sample is collected from the subject.
摘要翻译：本发明提供了一种测量装置，其有助于从微量样品和基板的高可靠性定量方法对衬底的精确定量。该方法使用包括一对电极的分析元件，用于电化学定量样品中的底物与氧化还原酶之间的反应。分析元件的一个电极是形成在具有开口的圆柱形中空空间的内壁上的膜，另一个是针。针状电极暂时投射到中空空间的外部，以刺破被检体，并从被检体收集所得样品。

9. 发明授权

US07267750B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07267750B2
公开(公告)日：2007-09-11
申请号：US10466561
申请日：2002-01-10
申请人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
发明人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27/327
CPC分类号： C12Q1/005 , C12Q1/004
摘要： A biosensor comprising: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode formed on the base plate; a cover member which is joined to the base plate to form a sample solution supply pathway for supplying a sample solution to the electrode system between the cover member and the base plate; and a reagent system comprising at least an oxidoreductase and an electron mediator disposed in the sample solution supply pathway, wherein the electron mediator is provided on the base plate and the oxidoreductase is provided on the cover member such that the electron mediator and the oxidoreductase are not in contact with each other.
摘要翻译：一种生物传感器，包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 盖构件，其连接到所述基板，以形成用于将样品溶液供应到所述盖构件和所述基板之间的所述电极系统的样品溶液供给路径; 以及试剂系统，其至少包含设置在样品溶液供给路径中的氧化还原酶和电子介体，其中，所述电子介体设置在所述底板上，所述氧化还原酶设置在所述覆盖部件上，使得所述电子介体和所述氧化还原酶不是彼此接触。

10. 发明授权

US06436255B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06436255B2
公开(公告)日：2002-08-20
申请号：US09764142
申请日：2001-01-19
申请人： Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： The present invention provides a biosensor which enables prompt quantification by facilitating introduction of a sample solution even when the amount of the sample solution is small and improving dissolution of reagents. The biosensor comprises an insulating base plate; an electrode system including at least a measuring electrode and a counter electrode formed on the base plate; a cover member integrated into the base plate to form a sample solution supply pathway for supplying a sample solution to the electrode system between the cover member and the base plate; a reaction reagent system including at least an electron mediator and an oxidoreductase; and a carrier supporting at least the electron mediator or the oxidoreductase of the reaction reagent system, wherein the carrier is partially or wholly disposed outside the sample solution supply pathway.
摘要翻译：本发明提供一种生物传感器，其即使在样品溶液量少且改善试剂溶解的情况下也能够通过促进样品溶液的引入而迅速进行定量。生物传感器包括绝缘基板; 电极系统，其至少包括形成在所述基板上的测量电极和对电极; 集成到所述基板中以形成用于将样品溶液供应到所述盖构件和所述基板之间的所述电极系统的样品溶液供给路径的盖构件; 至少包括电子介体和氧化还原酶的反应试剂系统; 和至少支持反应试剂体系的电子介体或氧化还原酶的载体，其中载体被部分或全部置于样品溶液供给路径的外部。

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