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1. 发明申请

US20140163372A1 ABLATION APPARATUS 审中-公开
标题翻译：排除装置
公开(公告)号：US20140163372A1
公开(公告)日：2014-06-12
申请号：US14233897
申请日：2012-07-19
申请人： Szabolcs Deladi , Godefridus Antoniius Harks
发明人： Szabolcs Deladi , Godefridus Antoniius Harks
IPC分类号： A61B18/04 , A61B5/00
CPC分类号： A61B18/04 , A61B5/062 , A61B5/068 , A61B5/4836 , A61B5/4893 , A61B6/12 , A61B8/08 , A61B8/12 , A61B8/4245 , A61B8/445 , A61B8/463 , A61B8/466 , A61B8/483 , A61B8/486 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511
摘要： The invention relates to an ablation apparatus for ablating a structure (14) within tissue of a living being. An ultrasound visualization unit (15) generates a two-dimensional or a three-dimensional ultrasound image for finding the structure to be ablated within the tissue. Ablation energy provided by an ablation unit (19) can then accurately be directed to the found structure. Moreover, the ultrasound visualization unit is adapted to generate during the provision of the ablation energy an M-mode ultrasound image by sending and receiving ultrasound waves in the direction, in which the structure is located, as found by using the two-dimensional or three-dimensional ultrasound image, thereby monitoring the ablation procedure. This allows for an improved control of the ablation procedure and, thus, for an improved quality of this procedure.
摘要翻译：本发明涉及一种用于消融生物体内组织内的结构（14）的消融装置。超声可视化单元（15）产生二维或三维超声图像，以找到要在组织内消融的结构。然后由消融单元（19）提供的消融能量可以精确地指向所发现的结构。此外，超声可视化单元适于在提供消融能量期间通过在结构所在的方向上发送和接收超声波来产生M模式超声波图像，如通过使用二维或三维从而监测消融过程。这允许改善对消融程序的控制，从而改善该程序的质量。

2. 发明授权

US09901321B2 Monitoring apparatus for monitoring an ablation procedure 有权
公开(公告)号：US09901321B2
公开(公告)日：2018-02-27
申请号：US13142299
申请日：2010-01-08
申请人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
发明人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
IPC分类号： A61B8/08 , A61B8/12 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B17/00 , A61B18/00 , A61B8/00 , A61B90/00
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

3. 发明授权

US09681923B2 Medical ultrasound device with force detection 有权
公开(公告)号：US09681923B2
公开(公告)日：2017-06-20
申请号：US13393244
申请日：2010-09-08
申请人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
发明人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
IPC分类号： A61B90/00 , A61B5/00 , A61B8/12 , A61B18/02 , A61B18/12 , A61B18/14 , A61B17/00 , A61B8/00
CPC分类号： A61B90/06 , A61B5/6885 , A61B8/12 , A61B8/445 , A61B18/0206 , A61B18/12 , A61B18/1492 , A61B2017/00106 , A61B2090/065
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The transmission element and the one or more ultrasound transducers are mounted so that an acoustic path length (8) between the transmission element (5) and the ultrasound transducer (4) varies with contact force (10) imposed to the distal end region. The controller unit detects the acoustic path length between the ultrasound transducer and the transmission element and determines the contact force from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.

4. 发明申请

US20130150732A1 MAPPING SYSTEM AND METHOD FOR MEDICAL PROCEDURES 审中-公开
标题翻译：医疗程序的绘图系统和方法
公开(公告)号：US20130150732A1
公开(公告)日：2013-06-13
申请号：US13817263
申请日：2011-08-17
申请人： Robert Manzke , Raymond Emmanuel Chan , Adrien Desjardins , Gert Wim 'T Hooft , Szabolcs Deladi
发明人： Robert Manzke , Raymond Emmanuel Chan , Adrien Desjardins , Gert Wim 'T Hooft , Szabolcs Deladi
IPC分类号： A61B5/00 , A61B1/04 , A61B1/05 , A61B1/018 , A61B1/06 , A61B5/055 , A61B8/12 , A61B18/14 , A61M25/00 , A61B8/08 , A61B8/00 , A61B6/03 , A61B1/00 , A61B1/07
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/00045 , A61B1/00087 , A61B1/00094 , A61B1/0017 , A61B1/018 , A61B1/042 , A61B1/051 , A61B1/0676 , A61B1/07 , A61B5/0037 , A61B5/0044 , A61B5/055 , A61B5/4836 , A61B5/6856 , A61B5/6857 , A61B5/72 , A61B5/742 , A61B6/032 , A61B8/0883 , A61B8/12 , A61B8/461 , A61B8/5238 , A61B17/00234 , A61B18/1492 , A61B34/20 , A61B2017/00053 , A61B2017/00247 , A61B2017/003 , A61B2018/00392 , A61B2034/2061 , A61B2090/306 , A61B2090/374 , A61B2090/376 , A61B2090/3762 , A61M25/0082
摘要： A system and method for mapping interluminal structures includes an elongated flexible instrument (102). An optical shape sensing device (152, 154) is disposed within the flexible instrument and is configured to determine a shape of the flexible instrument relative to a reference. The shape sensing device is configured to collect information based on its configuration to map an interluminal structure during a procedure. An imaging enabled ablation device (117) is mounted at or near a distal end portion of the flexible instrument.
摘要翻译：用于映射椎间结构的系统和方法包括细长的柔性仪器（102）。光学形状感测装置（152,154）设置在柔性仪器内，并被配置成确定柔性仪器相对于参考物的形状。形状检测装置被配置为基于其配置收集信息以在过程期间映射连续结构。可成像使能的消融装置（117）安装在柔性仪器的远端部分处或附近。

5. 发明申请

US20120165669A1 MEDICAL ULTRASOUND DEVICE WITH FORCE DETECTION 有权
标题翻译：具有强力检测功能的医用超声波装置
公开(公告)号：US20120165669A1
公开(公告)日：2012-06-28
申请号：US13393244
申请日：2010-09-08
申请人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
发明人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
IPC分类号： A61B8/12 , A61B18/14 , A61N7/00
CPC分类号： A61B90/06 , A61B5/6885 , A61B8/12 , A61B8/445 , A61B18/0206 , A61B18/12 , A61B18/1492 , A61B2017/00106 , A61B2090/065
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The transmission element and the one or more ultrasound transducers are mounted so that an acoustic path length (8) between the transmission element (5) and the ultrasound transducer (4) varies with contact force (10) imposed to the distal end region. The controller unit detects the acoustic path length between the ultrasound transducer and the transmission element and determines the contact force from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.
摘要翻译：公开了一种医用超声波装置。该装置包括具有近端和远端区域（1）的细长主体。用于产生声辐射的一个或多个超声换能器（4）位于细长体内的远端区域。对声辐射基本透明的传输元件（5）位于声辐射的辐射路径中，并且控制器单元可操作地连接到超声换能器。传输元件和一个或多个超声波换能器被安装成使得传输元件（5）和超声换能器（4）之间的声学路径长度（8）随施加到远端区域的接触力（10）而变化。控制器单元检测超声换能器和传动元件之间的声路长度，并根据检测到的声道长度确定接触力。在一个实施例中，医疗装置是超声RF消融导管。

6. 发明申请

US20110275962A1 ACOUSTICAL SWITCH AND CATHETER COMPRISING ACOUSTICAL SWITCH 审中-公开
标题翻译：声学开关和导管包括声学开关
公开(公告)号：US20110275962A1
公开(公告)日：2011-11-10
申请号：US13127089
申请日：2009-11-05
申请人： Szabolcs Deladi , Jan F. Suijver , Godefridus Antonius Harks , Johannes Wilhelmus Weekamp , Antonius J.J. Rademakers , Maya Ella Barley
发明人： Szabolcs Deladi , Jan F. Suijver , Godefridus Antonius Harks , Johannes Wilhelmus Weekamp , Antonius J.J. Rademakers , Maya Ella Barley
IPC分类号： A61N7/00
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445 , A61B18/1492 , G10K11/28
摘要： The invention relates to an acoustical switch wherein the idea to the ultrasound propagation direction may be changes without moving the switch. The switch device comprises two sheets of acoustically transparent material. The sheets constitute opposite walls of a housing. The switch device further comprises one or more orifices for allowing conduction of fluid into and/or out of said housing. The switch device may be made reflective by filling the housing with a gas via the one or more orifices. Moreover, the switch device may be made transmissive to ultrasound by filling the housing with a liquid via the one or more orifices and/or by subjecting the housing to underpressure via the one or more orifices. The acoustical switch device fits well within a catheter, which has severe dimensional limitations.
摘要翻译：本发明涉及一种声学开关，其中超声波传播方向的想法可以是不改变开关而改变的。开关装置包括两片声透明材料。纸张构成外壳的相对壁。开关装置还包括用于允许流体进入和/或离开所述壳体的一个或多个孔。开关装置可以通过经由一个或多个孔口用气体填充壳体来制成反射性的。此外，开关装置可以通过经由一个或多个孔口填充液体的壳体和/或经由一个或多个孔口对壳体进行负压来对超声波进行透射。声学开关装置很好地配合在具有严格尺寸限制的导管内。

7. 发明申请

US20090002714A1 Optical Device Comprising a Cantilever and Method of Fabrication and Use Thereof 有权
标题翻译：包括悬臂的光学装置及其制造和使用方法
公开(公告)号：US20090002714A1
公开(公告)日：2009-01-01
申请号：US12094352
申请日：2005-11-28
申请人： Davide Iannuzzi , Szabolcs Deladi , Michael Curt Elwenspoek
发明人： Davide Iannuzzi , Szabolcs Deladi , Michael Curt Elwenspoek
IPC分类号： G01B9/02
CPC分类号： G01Q20/02 , G01Q60/38
摘要： The present invention provides an optical device, comprising an optical fiber and a cantilever that is arranged on an end of the optical fiber; The cantilever may be an integral part of the optical fiber, and may have a length that is substantially equal to a diameter of the optical fiber. Measurement means for measuring a displacement of the cantilever are connected to an opposite end of the, optical fiber. A method of measuring a displacement using the optical device comprises the steps of: —arranging measurement means, comprising a light source, on an opposite end of the optical fiber; —using the light source to send a beam of light into the optical fiber; —measuring the interference of light that is reflected on the end op the optical fiber and light that is reflected on the cantilever; and determining the displacement of the cantilever relative to an intermediate position dependent on the measured interference.
摘要翻译：本发明提供了一种光学装置，包括布置在光纤端部的光纤和悬臂; 悬臂可以是光纤的组成部分，并且可以具有基本上等于光纤直径的长度。用于测量悬臂的位移的测量装置连接到光纤的相对端。使用光学装置测量位移的方法包括以下步骤：在光纤的相对端上安置包括光源的测量装置; - 使用光源将光束发射到光纤中; - 测量反射在光纤上的光的干涉和反射在悬臂上的光; 并且根据所测量的干涉来确定悬臂相对于中间位置的位移。

8. 发明授权

US10383687B2 Combined ablation and ultrasound imaging 有权
公开(公告)号：US10383687B2
公开(公告)日：2019-08-20
申请号：US13576022
申请日：2011-02-03
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
IPC分类号： A61B18/18 , A61B18/04 , A61B18/14 , A61B17/34 , A61B18/12 , A61B18/20 , A61B18/24 , A61B17/00 , A61B18/00 , A61B90/00
摘要： The present invention relates to a system (100) for combined ablation and ultrasound imaging of associated tissue (40), which is particularly useful for use in an ablation process. The system comprises an interventional device (20) with an ultrasound transducer and an ablation unit. During an ablation process, the interventional device (20) can be applied for both ablation and imaging of the tissue (40) subject to the ablation. A controlling unit (CTRL) is further comprised within the system, and arranged to calculate a predictor value based on one or more signals from the ultrasound transducer, where the predictor value relates to a risk of impending tissue damage due to a rapid release of bubble energy. According to a specific embodiment, a primary signal is sent if the predictor value exceeds a threshold value, so that proper measures can be taken.

9. 发明授权

US09675417B2 Safe ablation 有权
公开(公告)号：US09675417B2
公开(公告)日：2017-06-13
申请号：US13003022
申请日：2009-07-10
申请人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
发明人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
IPC分类号： A61B18/24 , A61B18/20 , A61B18/14 , A61B18/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/24 , A61B18/1492 , A61B18/28 , A61B2017/00057 , A61B2017/00084 , A61B2018/00023 , A61B2018/00666 , A61B2018/00791
摘要： The present invention relates to a device comprising a supply unit (2) for supplying ablation energy to a material (4), and a stimuli-responsive substance (3′) for controlling a level of the ablation energy deposited into the material (4). The device allows to limit a temperature of the material (4), so that risks associated to ablation at too high temperatures can be eliminated. The device may comprise at least one illumination unit (7) for illuminating the material (4), and at least one reception unit (8a, 8b) for receiving reflected light in order to obtain information about a state of the material (4). The obtained information can be used to regulate the supplied ablation energy.

10. 发明授权

US08945015B2 Ablation probe with fluid-based acoustic coupling for ultrasonic tissue imaging and treatment 有权
标题翻译：消融探针与基于流体的声耦合用于超声波组织成像和治疗
公开(公告)号：US08945015B2
公开(公告)日：2015-02-03
申请号：US13735358
申请日：2013-01-07
申请人： Darrell L. Rankin , Josef V. Koblish , Szabolcs Deladi
发明人： Darrell L. Rankin , Josef V. Koblish , Szabolcs Deladi
IPC分类号： A61B8/00 , A61B18/14 , A61B8/08 , A61B18/12 , A61M5/00 , A61B8/12 , A61N7/00 , A61B17/32 , A61B5/00 , A61B17/00 , A61H23/02 , A61B19/00 , A61B17/02 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/0044 , A61B5/0084 , A61B5/6852 , A61B5/6869 , A61B8/0883 , A61B8/12 , A61B8/4254 , A61B8/4281 , A61B8/445 , A61B8/4477 , A61B8/5207 , A61B8/54 , A61B17/320068 , A61B18/1206 , A61B2017/00243 , A61B2017/0237 , A61B2018/00029 , A61B2090/378 , A61B2090/3782 , A61H23/0245 , A61M5/00 , A61N7/00 , A61N2007/0004 , A61N2007/0043 , A61N2007/0078 , A61N2007/0082
摘要： Devices and systems for ultrasonically imaging tissue and performing ablation therapy are disclosed. An ablation probe for treating and imaging body tissue includes an ablation electrode tip with a number of acoustic openings and a plurality of ultrasonic imaging sensors disposed within an interior lumen of the tip. The ultrasonic imaging sensors are supported within the interior lumen via an insert equipped with a number of recesses that receive the ultrasonic imaging sensors. An acoustically transparent shell disposed between the ultrasonic imaging sensors and the acoustic openings forms a fluid channel in the acoustic pathway of the sensors. During an ablation procedure, cooling fluid from an external fluid source is delivered through the fluid channel, providing an acoustic coupling effect between the ultrasonic imaging sensors and the surrounding body tissue.
摘要翻译：公开了用于组织超声成像和进行消融治疗的装置和系统。用于治疗和成像身体组织的消融探针包括具有多个声学开口的消融电极末端和设置在尖端的内腔内的多个超声成像传感器。超声波成像传感器经由插入件配备有多个容纳超声波成像传感器的凹部的内腔内支撑。设置在超声波成像传感器和声学开口之间的声透明壳体在传感器的声学通路中形成流体通道。在消融过程中，来自外部流体源的冷却流体通过流体通道输送，从而在超声波成像传感器和周围的身体组织之间提供声学耦合效应。

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