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1. 发明授权

US10383687B2 Combined ablation and ultrasound imaging 有权
公开(公告)号：US10383687B2
公开(公告)日：2019-08-20
申请号：US13576022
申请日：2011-02-03
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
IPC分类号： A61B18/18 , A61B18/04 , A61B18/14 , A61B17/34 , A61B18/12 , A61B18/20 , A61B18/24 , A61B17/00 , A61B18/00 , A61B90/00
摘要： The present invention relates to a system (100) for combined ablation and ultrasound imaging of associated tissue (40), which is particularly useful for use in an ablation process. The system comprises an interventional device (20) with an ultrasound transducer and an ablation unit. During an ablation process, the interventional device (20) can be applied for both ablation and imaging of the tissue (40) subject to the ablation. A controlling unit (CTRL) is further comprised within the system, and arranged to calculate a predictor value based on one or more signals from the ultrasound transducer, where the predictor value relates to a risk of impending tissue damage due to a rapid release of bubble energy. According to a specific embodiment, a primary signal is sent if the predictor value exceeds a threshold value, so that proper measures can be taken.

2. 发明申请

US20120302877A1 COMBINED ABLATION AND ULTRASOUND IMAGING 审中-公开
标题翻译：组合吸收和超声成像
公开(公告)号：US20120302877A1
公开(公告)日：2012-11-29
申请号：US13576022
申请日：2011-02-03
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
IPC分类号： A61B8/12 , A61M25/095 , A61B5/01 , A61B5/053 , A61B5/103
CPC分类号： A61B18/18 , A61B17/3478 , A61B18/04 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B18/24 , A61B2017/00106 , A61B2018/00029 , A61B2018/00351 , A61B2018/00642 , A61B2018/00666 , A61B2018/00875 , A61B2018/1425 , A61B2018/1861 , A61B2018/1869 , A61B2090/064 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a system (100) for combined ablation and ultrasound imaging of associated tissue (40), which is particularly useful for use in an ablation process. The system comprises an interventional device (20) with an ultrasouond transducer and an ablation unit. During an ablation process, the interventional device (20) can be applied for both ablation and imaging of the tissue (40) subject to the ablation. A controlling unit (CTRL) is further comprised within the system, and arranged to calculate a predictor value based on one or more signals from the ultrasound transducer, where the predictor value relates to a risk of impending tissue damage due to a rapid release of bubble energy. According to a specific embodiment, a primary signal is sent if the predictor value exceeds a threshold value, so that proper measures can be taken.
摘要翻译：本发明涉及一种用于相关组织（40）的组合消融和超声成像的系统（100），其特别适用于消融过程。该系统包括具有超级换能器和消融单元的介入装置（20）。在消融过程期间，介入装置（20）可以应用于经受消融的组织（40）的消融和成像。控制单元（CTRL）还包括在系统内，并被布置成基于来自超声换能器的一个或多个信号来计算预测值，其中预测值与由于气泡的快速释放引起的组织损伤的风险相关能源。根据具体实施例，如果预测值超过阈值，则发送主信号，从而可以采取适当的措施。

3. 发明申请

US20120116237A1 APPARATUS, METHOD AND COMPUTER PROGRAM FOR DETERMINING A PROPERTY OF A HEART 有权
标题翻译：用于确定心脏属性的装置，方法和计算机程序
公开(公告)号：US20120116237A1
公开(公告)日：2012-05-10
申请号：US13319849
申请日：2010-05-10
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0073 , A61B5/0084 , A61B5/0507 , A61B5/053 , A61B5/061 , A61B5/062 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B90/39 , A61B2017/00106 , A61B2218/002 , A61B2562/0209
摘要： The present invention relates to an apparatus for determining a property of a heart. The apparatus comprises a catheter (5), which comprises a first property sensing unit for sensing a contraction signal indicative of a reoccurring local contraction of the heart (2) at a sensing site of the heart (2). The apparatus further comprises a first property determining unit (8) for determining the reoccurring local contraction of the heart (2) at the sensing site from the sensed contraction signal as a first property of the heart (2). The reoccurring local contraction provides information about the heart (2), which can be used for a better and/or more reliable characterization of the heart (2).
摘要翻译：本发明涉及一种用于确定心脏特性的装置。该装置包括导管（5），其包括第一特性感测单元，用于感测指示在心脏（2）的感测位置处心脏（2）的再次出现的局部收缩的收缩信号。该装置还包括第一属性确定单元（8），用于根据感测到的收缩信号确定心脏（2）在感测位置处的再次出现的局部收缩，作为心脏（2）的第一属性。复发的局部收缩提供了关于心脏（2）的信息，其可以用于更好和/或更可靠地表征心脏（2）。

4. 发明授权

US08774906B2 Apparatus, method and computer program for determining a property of a heart 有权
标题翻译：用于确定心脏特性的装置，方法和计算机程序
公开(公告)号：US08774906B2
公开(公告)日：2014-07-08
申请号：US13319849
申请日：2010-05-10
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
IPC分类号： A61B5/0452
CPC分类号： A61B5/1107 , A61B5/0073 , A61B5/0084 , A61B5/0507 , A61B5/053 , A61B5/061 , A61B5/062 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B90/39 , A61B2017/00106 , A61B2218/002 , A61B2562/0209
摘要： The present invention relates to an apparatus for determining a property of a heart. The apparatus comprises a catheter (5), which comprises a first property sensing unit for sensing a contraction signal indicative of a reoccurring local contraction of the heart (2) at a sensing site of the heart (2). The apparatus further comprises a first property determining unit (8) for determining the reoccurring local contraction of the heart (2) at the sensing site from the sensed contraction signal as a first property of the heart (2). The reoccurring local contraction provides information about the heart (2), which can be used for a better and/or more reliable characterization of the heart (2).
摘要翻译：本发明涉及一种用于确定心脏特性的装置。该装置包括导管（5），其包括第一特性感测单元，用于感测指示在心脏（2）的感测位置处心脏（2）的再次出现的局部收缩的收缩信号。该装置还包括第一属性确定单元（8），用于根据感测到的收缩信号确定心脏（2）在感测位置处的再次出现的局部收缩，作为心脏（2）的第一属性。复发的局部收缩提供了关于心脏（2）的信息，其可以用于更好和/或更可靠地表征心脏（2）。

5. 发明授权

US09681923B2 Medical ultrasound device with force detection 有权
公开(公告)号：US09681923B2
公开(公告)日：2017-06-20
申请号：US13393244
申请日：2010-09-08
申请人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
发明人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
IPC分类号： A61B90/00 , A61B5/00 , A61B8/12 , A61B18/02 , A61B18/12 , A61B18/14 , A61B17/00 , A61B8/00
CPC分类号： A61B90/06 , A61B5/6885 , A61B8/12 , A61B8/445 , A61B18/0206 , A61B18/12 , A61B18/1492 , A61B2017/00106 , A61B2090/065
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The transmission element and the one or more ultrasound transducers are mounted so that an acoustic path length (8) between the transmission element (5) and the ultrasound transducer (4) varies with contact force (10) imposed to the distal end region. The controller unit detects the acoustic path length between the ultrasound transducer and the transmission element and determines the contact force from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.

6. 发明申请

US20120165669A1 MEDICAL ULTRASOUND DEVICE WITH FORCE DETECTION 有权
标题翻译：具有强力检测功能的医用超声波装置
公开(公告)号：US20120165669A1
公开(公告)日：2012-06-28
申请号：US13393244
申请日：2010-09-08
申请人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
发明人： Maya Ella Barley , Godefridus Antonius Harks , Szabolcs Deladi
IPC分类号： A61B8/12 , A61B18/14 , A61N7/00
CPC分类号： A61B90/06 , A61B5/6885 , A61B8/12 , A61B8/445 , A61B18/0206 , A61B18/12 , A61B18/1492 , A61B2017/00106 , A61B2090/065
摘要： A medical ultrasound device is disclosed. The device comprises an elongated body having a proximal end and a distal end region (1). One or more ultrasound transducers (4) for generating acoustic radiation are positioned in the distal end region, inside the elongated body. A transmission element (5) which is substantially transparent to acoustic radiation is positioned in the radiation path of the acoustic radiation, and a controller unit is operatively connected to the ultrasound transducer. The transmission element and the one or more ultrasound transducers are mounted so that an acoustic path length (8) between the transmission element (5) and the ultrasound transducer (4) varies with contact force (10) imposed to the distal end region. The controller unit detects the acoustic path length between the ultrasound transducer and the transmission element and determines the contact force from the detected acoustic path length. In an embodiment, the medical device is an ultrasound RF ablation catheter.
摘要翻译：公开了一种医用超声波装置。该装置包括具有近端和远端区域（1）的细长主体。用于产生声辐射的一个或多个超声换能器（4）位于细长体内的远端区域。对声辐射基本透明的传输元件（5）位于声辐射的辐射路径中，并且控制器单元可操作地连接到超声换能器。传输元件和一个或多个超声波换能器被安装成使得传输元件（5）和超声换能器（4）之间的声学路径长度（8）随施加到远端区域的接触力（10）而变化。控制器单元检测超声换能器和传动元件之间的声路长度，并根据检测到的声道长度确定接触力。在一个实施例中，医疗装置是超声RF消融导管。

7. 发明申请

US20110275962A1 ACOUSTICAL SWITCH AND CATHETER COMPRISING ACOUSTICAL SWITCH 审中-公开
标题翻译：声学开关和导管包括声学开关
公开(公告)号：US20110275962A1
公开(公告)日：2011-11-10
申请号：US13127089
申请日：2009-11-05
申请人： Szabolcs Deladi , Jan F. Suijver , Godefridus Antonius Harks , Johannes Wilhelmus Weekamp , Antonius J.J. Rademakers , Maya Ella Barley
发明人： Szabolcs Deladi , Jan F. Suijver , Godefridus Antonius Harks , Johannes Wilhelmus Weekamp , Antonius J.J. Rademakers , Maya Ella Barley
IPC分类号： A61N7/00
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445 , A61B18/1492 , G10K11/28
摘要： The invention relates to an acoustical switch wherein the idea to the ultrasound propagation direction may be changes without moving the switch. The switch device comprises two sheets of acoustically transparent material. The sheets constitute opposite walls of a housing. The switch device further comprises one or more orifices for allowing conduction of fluid into and/or out of said housing. The switch device may be made reflective by filling the housing with a gas via the one or more orifices. Moreover, the switch device may be made transmissive to ultrasound by filling the housing with a liquid via the one or more orifices and/or by subjecting the housing to underpressure via the one or more orifices. The acoustical switch device fits well within a catheter, which has severe dimensional limitations.
摘要翻译：本发明涉及一种声学开关，其中超声波传播方向的想法可以是不改变开关而改变的。开关装置包括两片声透明材料。纸张构成外壳的相对壁。开关装置还包括用于允许流体进入和/或离开所述壳体的一个或多个孔。开关装置可以通过经由一个或多个孔口用气体填充壳体来制成反射性的。此外，开关装置可以通过经由一个或多个孔口填充液体的壳体和/或经由一个或多个孔口对壳体进行负压来对超声波进行透射。声学开关装置很好地配合在具有严格尺寸限制的导管内。

8. 发明申请

US20120136351A1 CATHETER FOR OPEN-LOOP IRRIGATED ABLATION OF TISSUE 有权
标题翻译：用于组织开放循环灌注的导管
公开(公告)号：US20120136351A1
公开(公告)日：2012-05-31
申请号：US13388998
申请日：2010-08-26
申请人： Johannes Wilhelmus Weekamp , Jan Frederik Suijver , Waltherus Cornelis Jozef Bierhoff , Szabolcs Deladi , Godefridus Antonius Harks
发明人： Johannes Wilhelmus Weekamp , Jan Frederik Suijver , Waltherus Cornelis Jozef Bierhoff , Szabolcs Deladi , Godefridus Antonius Harks
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B8/12 , A61B8/445 , A61B18/1815 , A61B18/20 , A61B2017/003 , A61B2018/00029 , A61B2018/00351 , A61B2018/00357 , A61B2018/1472 , A61B2018/1497 , A61B2090/3782 , A61B2090/3784 , A61N7/022 , A61N2007/0078
摘要： The present invention relates to a catheter (20) adapted for open-loop irrigated ablation, such as RF ablation, of a tissue (40). Said catheter has a distal tip (22) with an ablation entity (15) adapted for performing ablation of the tissue, an irrigation hole (21) and an ultrasound transducer (5) adapted for transmitting and/or receiving ultrasonic waves. The ultrasound transducer is disposed behind or in the irrigation hole of the catheter, so as to allow an irrigation fluid to flow out of the irrigation hole, and so as to allow transmitting and/or receiving the ultrasonic waves through the irrigation hole. The invention also relates to an imaging system and to a corresponding method for operating a catheter.
摘要翻译：本发明涉及适用于组织（40）的开环灌洗消融（例如RF消融）的导管（20）。所述导管具有远侧末端（22），其具有适于进行组织消融的消融实体（15），适于发射和/或接收超声波的冲洗孔（21）和超声换能器（5）。超声波换能器设置在导管的后面或其中的冲洗孔中，以便使冲洗流体从冲洗孔流出，并且允许通过冲洗孔传输和/或接收超声波。本发明还涉及一种用于操作导管的成像系统和相应的方法。

9. 发明授权

US10792099B2 Energy application apparatus for applying energy to an object 有权
公开(公告)号：US10792099B2
公开(公告)日：2020-10-06
申请号：US13704005
申请日：2011-06-24
申请人： Szabolcs Deladi , Godefridus Antonius Harks , Gerardus Henricus Maria Gijsbers , Jan Frederik Suijver
发明人： Szabolcs Deladi , Godefridus Antonius Harks , Gerardus Henricus Maria Gijsbers , Jan Frederik Suijver
IPC分类号： A61B18/18 , A61B18/12 , A61B18/14 , A61B18/00 , A61B17/00 , A61B90/00 , A61B34/20
摘要： The invention relates to an energy application apparatus for applying energy to an object. A plurality of energy application elements (4) applies energy to the object at different locations and at least one ultrasound element (18) generates an ultrasound signal being indicative of a property of the object at the different locations, wherein at least one energy application element is individually controlled depending on an energy application influence, in particular, an ablation depth, determined for the location at which the at least one energy application element applies energy from the ultrasound signal. Thus, at least one local control point for applying energy to the object is provided, thereby improving the control of applying energy to the object.

10. 发明授权

US09808323B2 Visualization apparatus 有权
公开(公告)号：US09808323B2
公开(公告)日：2017-11-07
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
IPC分类号： G09G5/00 , A61B90/00 , A61B18/14 , A61B17/00 , A61B34/20
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display (10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.

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