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1. 发明授权

US09675417B2 Safe ablation 有权
公开(公告)号：US09675417B2
公开(公告)日：2017-06-13
申请号：US13003022
申请日：2009-07-10
申请人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
发明人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
IPC分类号： A61B18/24 , A61B18/20 , A61B18/14 , A61B18/28 , A61B17/00 , A61B18/00
CPC分类号： A61B18/24 , A61B18/1492 , A61B18/28 , A61B2017/00057 , A61B2017/00084 , A61B2018/00023 , A61B2018/00666 , A61B2018/00791
摘要： The present invention relates to a device comprising a supply unit (2) for supplying ablation energy to a material (4), and a stimuli-responsive substance (3′) for controlling a level of the ablation energy deposited into the material (4). The device allows to limit a temperature of the material (4), so that risks associated to ablation at too high temperatures can be eliminated. The device may comprise at least one illumination unit (7) for illuminating the material (4), and at least one reception unit (8a, 8b) for receiving reflected light in order to obtain information about a state of the material (4). The obtained information can be used to regulate the supplied ablation energy.

2. 发明申请

US20110118714A1 SAFE ABLATION 有权
标题翻译：安全消除
公开(公告)号：US20110118714A1
公开(公告)日：2011-05-19
申请号：US13003022
申请日：2009-07-10
申请人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
发明人： Szabolcs Deladi , Nenad Mihajlovic , Ralph Kurt
IPC分类号： A61B18/24 , A61B18/20
CPC分类号： A61B18/24 , A61B18/1492 , A61B18/28 , A61B2017/00057 , A61B2017/00084 , A61B2018/00023 , A61B2018/00666 , A61B2018/00791
摘要： The present invention relates to a device comprising a supply unit (2) for supplying ablation energy to a material (4), and a stimuli-responsive substance (3′) for controlling a level of the ablation energy deposited into the material (4). The device allows to limit a temperature of the material (4), so that risks associated to ablation at too high temperatures can be eliminated. The device may comprise at least one illumination unit (7) for illuminating the material (4), and at least one reception unit (8a, 8b) for receiving reflected light in order to obtain information about a state of the material (4). The obtained information can be used to regulate the supplied ablation energy.
摘要翻译：本发明涉及一种包括用于向材料（4）提供消融能量的供应单元（2）和用于控制沉积到材料（4）中的消融能级的刺激响应物质（3'）的装置，。该装置允许限制材料（4）的温度，从而可以消除在过高温度下与消融相关的风险。装置可以包括用于照射材料（4）的至少一个照明单元（7）和用于接收反射光的至少一个接收单元（8a，8b），以便获得关于材料（4）的状态的信息。获得的信息可用于调节所提供的消融能量。

3. 发明申请

US20100094163A1 MEDICAL APPARATUS WITH A SENSOR FOR DETECTING A FORCE 审中-公开
标题翻译：具有用于检测力的传感器的医疗装置
公开(公告)号：US20100094163A1
公开(公告)日：2010-04-15
申请号：US12529372
申请日：2008-03-04
申请人： Szabolcs Deladi , Nenad Mihajlovic , Joachim Kahlert
发明人： Szabolcs Deladi , Nenad Mihajlovic , Joachim Kahlert
IPC分类号： A61B5/00 , H05K13/00
CPC分类号： A61B18/22 , A61B5/02154 , A61B5/6843 , A61B5/6885 , A61B18/1492 , A61B90/06 , A61B2090/064 , A61B2090/065 , A61N7/022 , G01L1/25 , G01L9/0077 , Y10T29/49002
摘要： The invention relates to a medical apparatus (120,130) having a sensor (100,110) for detecting a force acting on the medical apparatus (120,130) in a longitudinal direction. The medical apparatus (120,130) comprises an opto-mechanical force transducer having a flexible part (22,42) for receiving the force, an optical guide (1) having an outcoupling surface (11) that faces the flexible part (22,42) of the opto-mechanical force transducer, and a photodetector which detects an interference pattern composed of light (32) in the optical guide (1) that is reflected from the outcoupling surface (11) of the optical guide (1) and of light (33) in the optical guide (1) that is reflected from the flexible part (11) of the opto-mechanical force transducer. The use of the interference pattern composed of the light reflected from the out-coupling surface of the optical guide and the light reflected from the flexible part of the opto-mechanical force transducer results in a more accurate measurement of the force acting on the medical apparatus.
摘要翻译：本发明涉及一种具有传感器（100,110）的医疗设备（120,130），用于在纵向上检测作用在医疗设备（120,130）上的力。医疗设备（120,130）包括具有用于接收力的柔性部分（22,42）的光机力传感器，具有面向柔性部分（22,42）的外耦合表面（11）的光导（1）以及光检测器，其检测由所述光导（1）中的光（32）构成的干涉图案，所述干涉图案是从所述光导（1）的输出耦合表面（11）反射的，以及光（（1）中的从光学机械力传感器的柔性部分（11）反射的光纤（33）。使用由从光导的外耦合表面反射的光组成的干涉图案和从光机械力传感器的柔性部分反射的光导致对作用在医疗设备上的力的更准确的测量。

4. 发明授权

US08842953B2 Apparatus, method and computer program for applying energy to an object 有权
标题翻译：用于向物体施加能量的装置，方法和计算机程序
公开(公告)号：US08842953B2
公开(公告)日：2014-09-23
申请号：US12746187
申请日：2008-12-02
申请人： Nenad Mihajlovic , Szabolcs Deladi , Joachim Kahlert
发明人： Nenad Mihajlovic , Szabolcs Deladi , Joachim Kahlert
IPC分类号： G02B6/44 , G02B6/06 , A61B5/00 , A61B5/04 , A61B6/00 , A61N1/00 , A61B18/14 , A61B18/24 , A61B18/22 , A61B17/00 , A61B5/042 , A61B18/00 , A61B18/18
CPC分类号： A61B18/24 , A61B5/0084 , A61B5/042 , A61B5/6858 , A61B5/6885 , A61B5/6886 , A61B18/1492 , A61B18/1815 , A61B2017/00022 , A61B2017/00026 , A61B2017/00057 , A61B2017/003 , A61B2017/00867 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/2216 , A61B2018/2244 , G02B6/4416 , Y10T29/49117
摘要： An apparatus for applying energy to an object and/or sensing the object. The apparatus includes an optical device for applying and/or sensing light energy and an electrical device for applying and/or sensing electrical energy. At least one optical fiber is provided for applying light energy to the object and/or sensing the object. The at least one optical fiber is connected to the optical device and includes a conductive coating forming an electrical conductor for applying electrical energy to the object and/or sensing the object. The electrical conductor is connected to the electrical device.
摘要翻译：一种用于向物体施加能量和/或感测物体的装置。该装置包括用于施加和/或感测光能的光学装置和用于施加和/或感测电能的电气装置。提供至少一个光纤用于向物体施加光能和/或感测物体。所述至少一个光纤连接到所述光学装置，并且包括形成用于向所述物体施加电能和/或感测所述物体的电导体的导电涂层。电导体连接到电气设备。

5. 发明授权

US10335192B2 Apparatus for determining a property of an object using ultrasound scatter 有权
公开(公告)号：US10335192B2
公开(公告)日：2019-07-02
申请号：US13643116
申请日：2011-04-15
申请人： Godefridus Antonius Harks , Fei Zuo , Szabolcs Deladi , Steven Antonie Willem Fokkenrood , Nenad Mihajlovic
发明人： Godefridus Antonius Harks , Fei Zuo , Szabolcs Deladi , Steven Antonie Willem Fokkenrood , Nenad Mihajlovic
IPC分类号： A61B8/00 , A61B8/08 , A61B8/12 , A61B6/00 , A61B17/00 , A61B17/34 , A61B34/00 , A61B90/00 , A61B18/02 , A61B18/14 , A61B18/00 , A61B18/18 , A61B34/30 , A61B34/20
摘要： A monitoring apparatus for monitoring an ablation procedure applied to an object comprises an ultrasound signal providing unit for providing an ultrasound signal. The ultrasound signal is produced by sending ultrasound pulses out to the object, by subsequently receiving dynamic echo series after the ultrasound pulses have been reflected by the object, and finally by generating the ultrasound signal depending on the received dynamic echo series, whereby ultrasound scattering properties of the object are determined that represent blood perfusion. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal.

6. 发明申请

US20130041259A1 PROPERTY DETERMINING APPARATUS FOR DETERMINING A PROPERTY OF AN OBJECT 审中-公开
标题翻译：用于确定物体属性的物业确定装置
公开(公告)号：US20130041259A1
公开(公告)日：2013-02-14
申请号：US13643116
申请日：2011-04-15
申请人： Godefridus Antonius Harks , Fei Zuo , Szabolcs Deladi , Steven Antonie Willem Fokkenrood , Nenad Mihajlovic
发明人： Godefridus Antonius Harks , Fei Zuo , Szabolcs Deladi , Steven Antonie Willem Fokkenrood , Nenad Mihajlovic
IPC分类号： A61B8/06 , A61B8/12
CPC分类号： A61B17/3403 , A61B6/503 , A61B6/504 , A61B8/0833 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/4472 , A61B8/486 , A61B18/0206 , A61B18/1492 , A61B34/71 , A61B90/37 , A61B2017/00053 , A61B2017/00106 , A61B2017/3413 , A61B2018/00577 , A61B2018/0212 , A61B2018/1861 , A61B2034/2051 , A61B2034/2065 , A61B2034/301 , A61B2090/374 , A61B2090/376 , A61B2090/3762 , A61B2090/3784 , A61B2217/007
摘要： A monitoring apparatus for monitoring an ablation procedure applied to an object comprises an ultrasound signal providing unit for providing an ultrasound signal. The ultrasound signal is produced by sending ultrasound pulses out to the object, by subsequently receiving dynamic echo series after the ultrasound pulses have been reflected by the object, and finally by generating the ultrasound signal depending on the received dynamic echo series, whereby ultrasound scattering properties of the object are determined that represent blood perfusion. The monitoring apparatus further comprises an ablation depth determination unit for determining an ablation depth from the provided ultrasound signal.
摘要翻译：用于监视施加于物体的消融程序的监视装置包括用于提供超声信号的超声信号提供单元。超声波信号是通过将超声脉冲发送到对象而产生的，随后在物体反射了超声脉冲之后接收动态回波序列，最后根据接收到的动态回波序列产生超声波信号，由此超声散射特性确定对象的血液灌注。所述监测装置还包括消融深度确定单元，用于根据所提供的超声信号确定消融深度。

7. 发明申请

US20120287750A1 IMAGING APPARATUS 审中-公开
标题翻译：成像设备
公开(公告)号：US20120287750A1
公开(公告)日：2012-11-15
申请号：US13522789
申请日：2011-01-12
申请人： Szabolcs Deladi , Nenad Mihajlovic , Drazenko Babic , Jan Suijver , Yan Shi
发明人： Szabolcs Deladi , Nenad Mihajlovic , Drazenko Babic , Jan Suijver , Yan Shi
IPC分类号： G01S15/89 , A61B8/12
CPC分类号： A61B8/12 , A61B5/0084 , A61B6/032 , A61B6/12 , A61B6/5247 , A61B8/445 , A61B8/4483 , A61B8/5238 , A61B10/0233 , G01S15/8952
摘要： The invention relates to an imaging apparatus (1) for imaging an interior of an object (2). The imaging apparatus (1) comprises a first ultrasound sensor and a second ultrasound sensor for sensing the interior of the object at different frequencies, wherein the ultrasound sensing signals from the first ultrasound sensor are used for generating a first ultrasound image and a the ultrasound sensing signals from the second ultrasound sensor are used for generating a second ultrasound image. A larger frequency generally provides a smaller depth of penetrating the interior of the object and a larger spatial resolution than a smaller frequency. The imaging apparatus (1) can therefore provide the capability of simultaneously imaging the interior of the object with different spatial resolutions and at different penetration depths. This allows the imaging apparatus to improve the quality of imaging the interior of the object.
摘要翻译：本发明涉及一种用于对物体（2）的内部进行成像的成像装置（1）。成像装置（1）包括第一超声波传感器和用于感测不同频率的物体内部的第二超声波传感器，其中来自第一超声波传感器的超声波感测信号用于产生第一超声波图像和超声波感测来自第二超声波传感器的信号用于产生第二超声波图像。较大的频率通常提供穿透物体内部的较小深度和比较小频率更大的空间分辨率。因此，成像装置（1）能够提供以不同的空间分辨率和不同穿透深度同时对物体内部成像的能力。这允许成像装置提高对象内部的成像质量。

8. 发明申请

US20100272398A1 APPARATUS, METHOD AND COMPUTER PROGRAM FOR APPLYING ENERGY TO AN OBJECT 有权
标题翻译：用于将能量应用于对象的装置，方法和计算机程序
公开(公告)号：US20100272398A1
公开(公告)日：2010-10-28
申请号：US12746187
申请日：2008-12-02
申请人： Nenad Mihajlovic , Szabolcs Deladi , Joachim Kahlert
发明人： Nenad Mihajlovic , Szabolcs Deladi , Joachim Kahlert
IPC分类号： G02B6/38 , H02G3/00 , H01R43/00
CPC分类号： A61B18/24 , A61B5/0084 , A61B5/042 , A61B5/6858 , A61B5/6885 , A61B5/6886 , A61B18/1492 , A61B18/1815 , A61B2017/00022 , A61B2017/00026 , A61B2017/00057 , A61B2017/003 , A61B2017/00867 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/2216 , A61B2018/2244 , G02B6/4416 , Y10T29/49117
摘要： The present invention relates to an apparatus for applying energy to an object (2) and/or sensing the object (2). The apparatus comprises an optical device (8) for applying and/or sensing light energy and an electrical device (13) for applying and/or sensing electrical energy. At least one optical fiber is provided for applying light energy to the object (2) and/or sensing the object (2), wherein the at least one optical fiber is connected to the optical device (8), wherein the at least one optical fiber comprises a conductive coating forming an electrical conductor for applying electrical energy to the object and/or sensing the object and wherein the electrical conductor is connected to the electrical device (13).
摘要翻译：本发明涉及一种用于向物体（2）施加能量和/或感测物体（2）的装置。该装置包括用于施加和/或感测光能的光学装置（8）和用于施加和/或感测电能的电气装置（13）。提供至少一个光纤用于向物体（2）施加光能和/或感测物体（2），其中至少一个光纤连接到光学装置（8），其中至少一个光学纤维包括形成用于向物体施加电能和/或感测物体的电导体的导电涂层，并且其中电导体连接到电气装置（13）。

9. 发明申请

US20100162834A1 HYDROGEL BASED SENSOR PROBE FOR DETECTING AN ENVIRONMENTAL STATE 失效
标题翻译：用于检测环境状态的基于HYDROGEL的传感器探测器
公开(公告)号：US20100162834A1
公开(公告)日：2010-07-01
申请号：US12600881
申请日：2008-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
IPC分类号： G01D21/00 , G01B11/22
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： The invention relates to a sensor probe (100,110,120,130,140,150) for detecting an environmental state within a bodily lumen. The sensor probe (100,110,120,130,140,150) having an elongated body (9) comprises an optical guide (1) having an outcoupling surface (11), which is part of an end surface (3) of the elongated body (9), facing a reflective surface of an overhanging part (22,42,52,62), a photodetector which detects a property of light which is composed of light (32) in the optical guide (1) that is reflected from the outcoupling surface (11) of the optical guide (1) and of light (33) in the optical guide (1) that is reflected from the overhanging part (22,42,52,62), and a hydrogel material (2) of which a property changes when getting into contact with an environmental material and/or when detecting an environmental change, and which is provided between the end surface (3) of the elongated body (9) and the overhanging part (22,42,52,62). In this way a sensor probe (100,110,120,130,140,150) is provided that, because of its compactness, can be applied inside the bodily lumen for detecting and characterizing parameters that are vital indicators for the state of the human or animal body, and to which the hydrogel material (2) is responsive.
摘要翻译：本发明涉及一种用于检测体腔内的环境状态的传感器探针（100,110,120,130,140,150）。具有细长主体（9）的传感器探针（100,110,130,140,150）包括具有外耦合表面（11）的光导（1），该外耦合表面（11）是细长主体（9）的端表面（3）的一部分，面向反射表面突出部分（22,42,52,62）的光检测器，其检测由光导（1）中的光（32）组成的光的属性，所述光从光耦合表面（11）反射在导光体（1）中从突出部分（22,42,52,62）反射的导光体（1）和光（33）以及在接触时性质发生变化的水凝胶材料（2）和环境材料和/或当检测到环境变化时，并且设置在细长体（9）的端面（3）与伸出部分（22,42,52,62）之间。以这种方式，提供传感器探针（100,110,120,130,140,150），由于其紧凑性，可以在身体内部施加以检测和表征作为人体或动物体状态的重要指标的参数，并且将水凝胶材料（2）有反应。

10. 发明授权

US08244078B2 Hydrogel based sensor probe for detecting an environmental state 失效
标题翻译：用于检测环境状态的基于水凝胶的传感器探头
公开(公告)号：US08244078B2
公开(公告)日：2012-08-14
申请号：US12600881
申请日：2008-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： A sensor probe for detecting an environmental state within a bodily lumen includes an elongated body having an optical guide with an outcoupling surface, which is part of an end surface of the elongated body, facing a reflective surface of an overhanging part. The sensor probe further includes a photodetector which detects a property of light which is composed of light in the optical guide that is reflected from the outcoupling surface of the optical guide and of light in the optical guide that is reflected from the overhanging part. The sensor probe also includes a hydrogel material having a property that changes when getting into contact with an environmental material and/or when detecting an environmental change. The hydrogel material is provided between the end surface of the elongated body and the overhanging part.
摘要翻译：用于检测身体腔内的环境状态的传感器探针包括细长体，其具有带有外耦合表面的光导，所述光耦合器是细长体的端表面的一部分，面向突出部分的反射表面。传感器探头还包括光电检测器，其检测由光导中的光构成的光的特性，所述光从光导的输出耦合表面反射，以及从突出部反射的光导中的光。传感器探头还包括具有在与环境材料接触和/或当检测到环境变化时变化的性质的水凝胶材料。水凝胶材料设置在细长体的端面与突出部之间。

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