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1. 发明授权

US09901321B2 Monitoring apparatus for monitoring an ablation procedure 有权
公开(公告)号：US09901321B2
公开(公告)日：2018-02-27
申请号：US13142299
申请日：2010-01-08
申请人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
发明人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
IPC分类号： A61B8/08 , A61B8/12 , A61B18/02 , A61B18/14 , A61B18/18 , A61B18/20 , A61B17/00 , A61B18/00 , A61B8/00 , A61B90/00
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.

2. 发明申请

US20120004547A1 MONITORING APPARATUS FOR MONITORING AN ABLATION PROCEDURE 有权
标题翻译：监测装置的监测程序
公开(公告)号：US20120004547A1
公开(公告)日：2012-01-05
申请号：US13142299
申请日：2010-01-08
申请人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
发明人： Erik Harks , Szabolcs Deladi , Jan Frederik Suijver , Ladislav Jankovic , Yan Shi , Wouter Harry Jacinth Rensen , Maya Barley , Nijs Cornelis Van Der Vaart
IPC分类号： A61B8/00 , A61B18/12 , A61B8/12
CPC分类号： A61B8/0858 , A61B8/12 , A61B8/445 , A61B8/486 , A61B18/02 , A61B18/1442 , A61B18/1492 , A61B18/18 , A61B18/20 , A61B2017/00106 , A61B2018/00577 , A61B2018/00738 , A61B2090/376 , A61B2090/3784 , A61B2218/002
摘要： The present invention relates to a monitoring apparatus (101) for monitoring an ablation procedure. The monitoring apparatus (101) comprises an ultrasound signal providing unit for providing an ultrasound signal that depends on received echo series of an object (4) that is ablated. The monitoring apparatus (101) further comprises an ablation depth determination unit (103) for determining an ablation depth from the provided ultrasound signal. The ablation depth can be determined directly from the ultrasound signal and is an important parameter while performing an ablation procedure. For example, it can be used for determining the progress of ablation within the object (4) and for determining when the ablation has reached a desired progression.
摘要翻译：本发明涉及一种用于监测消融程序的监测装置（101）。监视装置（101）包括：超声信号提供单元，用于提供取决于被消融的对象（4）的接收到的回波序列的超声信号。监测装置（101）还包括用于根据所提供的超声信号确定消融深度的消融深度确定单元（103）。消融深度可以直接从超声信号确定，并且是执行消融过程的重要参数。例如，它可以用于确定对象（4）内的消融进展并确定消融何时达到期望的进程。

3. 发明授权

US09808323B2 Visualization apparatus 有权
公开(公告)号：US09808323B2
公开(公告)日：2017-11-07
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
IPC分类号： G09G5/00 , A61B90/00 , A61B18/14 , A61B17/00 , A61B34/20
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display (10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.

4. 发明申请

US20120105480A1 VISUALIZATION APPARATUS 有权
标题翻译：可视化装置
公开(公告)号：US20120105480A1
公开(公告)日：2012-05-03
申请号：US13321580
申请日：2010-05-03
申请人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
发明人： Maya Barley , Szabolcs Deladi , Godefridus Antonius Harks , Jan Frederik Suijver , Mischa Megens
IPC分类号： G09G5/00
CPC分类号： A61B90/36 , A61B18/1492 , A61B34/20 , A61B2017/00106 , A61B2090/062 , A61B2090/065 , A61B2090/376 , G06F19/00
摘要： The invention relates to a visualization apparatus for visualizing quality of applying energy to an object. The quality of applying energy at a location on the object (3) is visualized based on a) a provided image of the object and b) a provided quality value representing the quality of applying energy to the object at the location on the object (3), wherein a visual property assigning unit (9) assigns a visual property to the location depending on the quality value and a display(10) displays the provided image and the assigned visual property at the location on the object shown in the image. In general a person who applies energy to the object is focused on the location at which energy is applied. Since quality information is shown at the location on which the person is already focused, the quality dependent information can easily be absorbed by the person.
摘要翻译：本发明涉及一种可视化装置，用于将能量施加到物体的质量。基于a）所提供的对象图像和b）提供的质量值，表示在物体上的位置处对物体施加能量的质量（3），可视化对象（3）上的位置处的能量的质量），其中，视觉特性分配单元（9）根据所述质量值向所述位置分配视觉特性，并且显示器（10）在所述图像中所示的对象的位置处显示所提供的图像和所分配的视觉特性。通常，将能量施加到物体的人集中在施加能量的位置上。由于质量信息显示在人已经聚焦的位置，所以质量依赖信息可以容易地被人吸收。

5. 发明授权

US10383687B2 Combined ablation and ultrasound imaging 有权
公开(公告)号：US10383687B2
公开(公告)日：2019-08-20
申请号：US13576022
申请日：2011-02-03
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Jan Frederik Suijver , Maya Ella Barley , Edwin Gerardus Johannus Maria Bongers
IPC分类号： A61B18/18 , A61B18/04 , A61B18/14 , A61B17/34 , A61B18/12 , A61B18/20 , A61B18/24 , A61B17/00 , A61B18/00 , A61B90/00
摘要： The present invention relates to a system (100) for combined ablation and ultrasound imaging of associated tissue (40), which is particularly useful for use in an ablation process. The system comprises an interventional device (20) with an ultrasound transducer and an ablation unit. During an ablation process, the interventional device (20) can be applied for both ablation and imaging of the tissue (40) subject to the ablation. A controlling unit (CTRL) is further comprised within the system, and arranged to calculate a predictor value based on one or more signals from the ultrasound transducer, where the predictor value relates to a risk of impending tissue damage due to a rapid release of bubble energy. According to a specific embodiment, a primary signal is sent if the predictor value exceeds a threshold value, so that proper measures can be taken.

6. 发明授权

US08774906B2 Apparatus, method and computer program for determining a property of a heart 有权
标题翻译：用于确定心脏特性的装置，方法和计算机程序
公开(公告)号：US08774906B2
公开(公告)日：2014-07-08
申请号：US13319849
申请日：2010-05-10
申请人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
发明人： Godefridus Antonius Harks , Szabolcs Deladi , Bart Michiel De Boer , Maya Ella Barley , Jan Frederik Suijver
IPC分类号： A61B5/0452
CPC分类号： A61B5/1107 , A61B5/0073 , A61B5/0084 , A61B5/0507 , A61B5/053 , A61B5/061 , A61B5/062 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B18/02 , A61B18/1492 , A61B18/18 , A61B90/39 , A61B2017/00106 , A61B2218/002 , A61B2562/0209
摘要： The present invention relates to an apparatus for determining a property of a heart. The apparatus comprises a catheter (5), which comprises a first property sensing unit for sensing a contraction signal indicative of a reoccurring local contraction of the heart (2) at a sensing site of the heart (2). The apparatus further comprises a first property determining unit (8) for determining the reoccurring local contraction of the heart (2) at the sensing site from the sensed contraction signal as a first property of the heart (2). The reoccurring local contraction provides information about the heart (2), which can be used for a better and/or more reliable characterization of the heart (2).
摘要翻译：本发明涉及一种用于确定心脏特性的装置。该装置包括导管（5），其包括第一特性感测单元，用于感测指示在心脏（2）的感测位置处心脏（2）的再次出现的局部收缩的收缩信号。该装置还包括第一属性确定单元（8），用于根据感测到的收缩信号确定心脏（2）在感测位置处的再次出现的局部收缩，作为心脏（2）的第一属性。复发的局部收缩提供了关于心脏（2）的信息，其可以用于更好和/或更可靠地表征心脏（2）。

7. 发明申请

US20120022375A1 ACOUSTIC DEVICE FOR ULTRASONIC IMAGING 审中-公开
标题翻译：用于超声波成像的声学设备
公开(公告)号：US20120022375A1
公开(公告)日：2012-01-26
申请号：US13146066
申请日：2010-01-25
申请人： Szabolcs Deladi , Jan Frederik Suijver , David Maresca
发明人： Szabolcs Deladi , Jan Frederik Suijver , David Maresca
IPC分类号： A61B8/12 , A61B8/13 , A61B8/00
CPC分类号： G10K11/30
摘要： The present invention relates to an acoustic device for ultrasonic imaging of an object (21). The device comprises an acoustic transducer (10 and an acoustic lens (20) arranged to variably refract the said acoustic pulse to and/or from the acoustic transducer. The acoustic lens comprising a first (L1) and a second fluid (L2) being separated by an acoustic interface (7), the normal of the said acoustic interface forming a relative angle of incidence (AI) with the said acoustic pulse, e.g. an electrowetting lens. The first and the second fluid of the acoustic lens (20) are specifically chosen so that the acoustic interface (7) has a reflection minima at a non-zero relative angle of incidence (AI). The invention is advantageous for obtaining an improved acoustic device having a substantially lower reflection in a broader interval of incidence angles as compared to hitherto seen ultrasonic imaging utilising acoustic lenses with two or more fluids as the active acoustic refracting entities.
摘要翻译：本发明涉及一种用于物体（21）的超声波成像的声学装置。该装置包括声换能器（10和声透镜），该声透镜被布置成可将声脉冲可变地折射到声换能器和/或从该声换能器。声学透镜包括分离的第一液体（L1）和第二流体（L2）通过声学接口（7），所述声学接口的法线形成与所述声学脉冲（例如电润湿透镜）的相对入射角（AI），声透镜的第一和第二流体被选择使得声学接口（7）具有非零相对入射角（AI）的反射最小值。本发明有利于获得具有较大入射角的基本上较低的反射的改进的声学装置，到目前为止，使用具有两种或多种流体的声透镜作为主动声学折射实体的超声波成像。

8. 发明申请

US20100277809A1 FLUID LENS WITH PRESSURE RELEASE SYSTEM 有权
标题翻译：带压力释放系统的流体镜
公开(公告)号：US20100277809A1
公开(公告)日：2010-11-04
申请号：US12811831
申请日：2009-01-12
申请人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
发明人： Jan Frederik Suijver , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Antonius Johannes Josephus Rademakers , Cornelius Antonius Micolaas Maria Van Der Vleuten , Johannes Wilhelmus Weekamp , Waltherus Cornelis Jozef Bierhoff
IPC分类号： G02B3/14 , A61B1/06
CPC分类号： G02B7/008 , A61B1/0019 , G02B3/14 , G02B23/2407
摘要： Fluid lens system, e.g. for medical imaging or medical treatment, with a container enclosing a fluid arranged to refract incoming waves. A pressure release mechanism is in contact with the fluid so as to compensate changes in its volume due to thermal variations, e.g. during high temperature medical cleaning. This pressure release mechanism is positioned within a pathway of incoming waves. In preferred embodiments a fluid container connected via a tube to the fluid as a reservoir, is arranged within or outside the container, e.g. beyond an image sensor. Alternatively, an easily compressible body, e.g. a small closed metal bellows enclosing a gas, is positioned inside the fluid to absorb volume changes by compression. In both embodiments, the pressure release elements are preferably positioned in a peripheral part of the pathway of incoming waves to not affect performance of the lens. In another aspect, a fluid lens includes a container with an inner container part that fits inside an outer container part, wherein the inner container part is in rigid connection to at least a one boundary arranged for penetration of incoming waves. The pressure release mechanism is positioned within the outer container part, and it is in contact with the fluid so as to compensate changes in volume of the fluid due to thermal variations. In one embodiment the inner and outer container parts are arranged for relative one-dimensional movement and fluid tight interconnected. In another embodiment, a fluid filled cavity is formed between the inner and outer container parts, and this cavity houses a compressible body. The lens systems are suited for applications such as medical endoscopes, catheters and needles, optically as well as acoustically based.
摘要翻译：流体透镜系统，例如用于医疗成像或医疗处理，容器包围布置成折射入射波的流体。压力释放机构与流体接触，以便补偿由于热变化引起的体积变化，例如，在高温医疗清洗过程中。该压力释放机构位于入射波的通路内。在优选实施例中，经由管连接到作为储存器的流体的流体容器设置在容器内或外部，例如，超越图像传感器。或者，容易压缩的主体，例如，围绕气体的小封闭金属波纹管位于流体内部以通过压缩吸收体积变化。在两个实施例中，压力释放元件优选地定位在入射波通路的周边部分中，从而不影响透镜的性能。在另一方面，一种流体透镜包括具有内部容器部分的容器，该内部容器部分装配在外部容器部分内部，其中内部容器部分刚好连接至布置成用于穿透入射波的至少一个边界。压力释放机构定位在外部容器部分内，并且与流体接触，以补偿由于热变化引起的流体体积的变化。在一个实施例中，内部和外部容器部件布置用于相对一维运动并且流体密封互连。在另一个实施例中，在内部和外部容器部分之间形成流体填充空腔，并且该空腔容纳可压缩体。透镜系统适用于诸如医用内窥镜，导管和针的应用，光学和声学基础。

9. 发明申请

US20100162834A1 HYDROGEL BASED SENSOR PROBE FOR DETECTING AN ENVIRONMENTAL STATE 失效
标题翻译：用于检测环境状态的基于HYDROGEL的传感器探测器
公开(公告)号：US20100162834A1
公开(公告)日：2010-07-01
申请号：US12600881
申请日：2008-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
IPC分类号： G01D21/00 , G01B11/22
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： The invention relates to a sensor probe (100,110,120,130,140,150) for detecting an environmental state within a bodily lumen. The sensor probe (100,110,120,130,140,150) having an elongated body (9) comprises an optical guide (1) having an outcoupling surface (11), which is part of an end surface (3) of the elongated body (9), facing a reflective surface of an overhanging part (22,42,52,62), a photodetector which detects a property of light which is composed of light (32) in the optical guide (1) that is reflected from the outcoupling surface (11) of the optical guide (1) and of light (33) in the optical guide (1) that is reflected from the overhanging part (22,42,52,62), and a hydrogel material (2) of which a property changes when getting into contact with an environmental material and/or when detecting an environmental change, and which is provided between the end surface (3) of the elongated body (9) and the overhanging part (22,42,52,62). In this way a sensor probe (100,110,120,130,140,150) is provided that, because of its compactness, can be applied inside the bodily lumen for detecting and characterizing parameters that are vital indicators for the state of the human or animal body, and to which the hydrogel material (2) is responsive.
摘要翻译：本发明涉及一种用于检测体腔内的环境状态的传感器探针（100,110,120,130,140,150）。具有细长主体（9）的传感器探针（100,110,130,140,150）包括具有外耦合表面（11）的光导（1），该外耦合表面（11）是细长主体（9）的端表面（3）的一部分，面向反射表面突出部分（22,42,52,62）的光检测器，其检测由光导（1）中的光（32）组成的光的属性，所述光从光耦合表面（11）反射在导光体（1）中从突出部分（22,42,52,62）反射的导光体（1）和光（33）以及在接触时性质发生变化的水凝胶材料（2）和环境材料和/或当检测到环境变化时，并且设置在细长体（9）的端面（3）与伸出部分（22,42,52,62）之间。以这种方式，提供传感器探针（100,110,120,130,140,150），由于其紧凑性，可以在身体内部施加以检测和表征作为人体或动物体状态的重要指标的参数，并且将水凝胶材料（2）有反应。

10. 发明授权

US08244078B2 Hydrogel based sensor probe for detecting an environmental state 失效
标题翻译：用于检测环境状态的基于水凝胶的传感器探头
公开(公告)号：US08244078B2
公开(公告)日：2012-08-14
申请号：US12600881
申请日：2008-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： A sensor probe for detecting an environmental state within a bodily lumen includes an elongated body having an optical guide with an outcoupling surface, which is part of an end surface of the elongated body, facing a reflective surface of an overhanging part. The sensor probe further includes a photodetector which detects a property of light which is composed of light in the optical guide that is reflected from the outcoupling surface of the optical guide and of light in the optical guide that is reflected from the overhanging part. The sensor probe also includes a hydrogel material having a property that changes when getting into contact with an environmental material and/or when detecting an environmental change. The hydrogel material is provided between the end surface of the elongated body and the overhanging part.
摘要翻译：用于检测身体腔内的环境状态的传感器探针包括细长体，其具有带有外耦合表面的光导，所述光耦合器是细长体的端表面的一部分，面向突出部分的反射表面。传感器探头还包括光电检测器，其检测由光导中的光构成的光的特性，所述光从光导的输出耦合表面反射，以及从突出部反射的光导中的光。传感器探头还包括具有在与环境材料接触和/或当检测到环境变化时变化的性质的水凝胶材料。水凝胶材料设置在细长体的端面与突出部之间。

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