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    • 5. 发明授权
    • Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample
    • 减少死体积的流体样品输送装置用于处理,控制和/或检测流体样品
    • US07892493B2
    • 2011-02-22
    • US12298951
    • 2007-04-23
    • Johannes Wilhelmus Weekamp
    • Johannes Wilhelmus Weekamp
    • G01N33/00
    • B01L3/50273B01L3/502707B01L3/502738B01L7/52B01L2200/143B01L2300/0627B01L2300/0645B01L2300/0816B01L2300/1822B01L2300/1827B01L2400/0478B01L2400/0481B01L2400/0655Y10T436/25Y10T436/2575
    • A fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample, includes a substrate having an upper surface with at least one processing, controlling and/or detecting element. At least one flexible membrane is arranged on the upper surface of the substrate. The fluid sample transport device further includes at least one plunger and/or actuating element for actuating an up and/or down movement of the flexible membrane to cause a fluid flow and/or to stop a fluid flow. A cover plate is arranged on the upper outer surface or lower outer surface of the flexible membrane. The cover plate includes at least one through going hole and/or cut-out for receiving a plunger and/or actuating element, so that movement of the plunger and/or actuating element causes a pump and/or valve action of the adjacent arranged flexible membrane area to cause a fluid flow in a channel temporally formed by expansion of the flexible membrane. The temporally formed channel is between the upper surface of the substrate and the lower surface of the flexible membrane.
    • 用于处理,控制和/或检测流体样品的死体积减小的流体样品输送装置包括具有至少一个处理,控制和/或检测元件的上表面的基底。 至少一个柔性膜布置在基板的上表面上。 流体样品输送装置还包括至少一个柱塞和/或致动元件,用于致动柔性膜的向上和/或向下运动以引起流体流动和/或停止流体流动。 盖板设置在柔性膜的上外表面或下外表面上。 盖板包括用于接收柱塞和/或致动元件的至少一个穿孔和/或切口,使得柱塞和/或致动元件的运动导致相邻布置的柔性的泵和/或阀动作 膜区域,以在由柔性膜的膨胀暂时形成的通道中引起流体流动。 时间上形成的通道位于基板的上表面和柔性膜的下表面之间。
    • 8. 发明申请
    • MICROELECTRONIC DEVICE WITH MAGNETIC MANIPULATOR
    • 具有磁力操纵器的微电子装置
    • US20090280571A1
    • 2009-11-12
    • US12305395
    • 2007-06-19
    • Jeroen Hans NieuwenhuisJohannes Wilhelmus Weekamp
    • Jeroen Hans NieuwenhuisJohannes Wilhelmus Weekamp
    • G01N27/72B03C5/02
    • G01R33/12B01L3/5027B82Y25/00G01R33/093G01R33/1269
    • The invention relates to a microelectronic device, particularly to a magnetic biosensor (10) which comprises a magnetic field generator, e.g. a bonding wire (16), extending in a sample chamber (5) a distance (d) away from a reaction surface (14) of a substrate (15). In a preferred embodiment, the device comprises a magnetic sensor element, e.g. a GMR sensor (12), for detecting magnetized particles (2) bound to specific binding sites (3) at the reaction surface (14). Moreover, it may comprise integrated magnetic excitation wires (11, 13) for generating a magnetic excitation field (B) at the reaction surface (14). In a particular application of the device (10), the stringency of the binding of magnetic particles can be tested by generating an inhomogeneous magnetic manipulation field (Bman) with the magnetic field generator (16) in the sample chamber (5).
    • 本发明涉及一种微电子器件,特别涉及一种磁性生物传感器(10),其包括一个磁场发生器, 接合线(16),其在离开基板(15)的反应表面(14)的距离(d)的样品室(5)中延伸。 在优选实施例中,该装置包括磁传感器元件,例如 用于检测在反应表面(14)处与特定结合位点(3)结合的磁化颗粒(2)的GMR传感器(12)。 此外,它可以包括用于在反应表面(14)处产生磁激励场(B)的集成磁激励线(11,13)。 在设备(10)的特定应用中,可以通过在样品室(5)中与磁场发生器(16)产生不均匀的磁操作场(Bman)来测试磁性颗粒的结合的严格性。