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1. 发明授权

US5227412A Biodegradable and resorbable surgical material and process for preparation of the same 失效
标题翻译：可生物降解和可吸收的手术材料及其制备方法
公开(公告)号：US5227412A
公开(公告)日：1993-07-13
申请号：US944019
申请日：1992-09-14
申请人： Suong-Hyu Hyon , Yoshito Ikada , Yasuo Shikinami , Kaoru Tsuta , Hidekazu Boutani
发明人： Suong-Hyu Hyon , Yoshito Ikada , Yasuo Shikinami , Kaoru Tsuta , Hidekazu Boutani
IPC分类号： A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61L31/06 , A61L31/14
摘要： Biodegradable and resorbable surgical materials of molded articles of poly(lactic acid) or copolymers of lactic acid and glycolic acid, characterized in that the articles are molecular-orientated, and having a bending strength of 1.6.times.10.sup.33 to 2.5.times.10.sup.3 kg/cm.sup.2, a bending modulus of 5.5.times.10.sup.2 to 24.0.times.10.sup.2 kg/cm.sup.2, a crystallinity, determined by density measurement, of 10 to 60%, and a viscosity average molecular weight measured after melt processing of not less than 200,000, and in that at least 80% of initial strength of the articles is maintained after dipping in a saline at 37.degree. C. for three months.
摘要翻译：聚（乳酸）或乳酸和乙醇酸共聚物的可生物降解和可再吸收的外科材料，其特征在于制品是分子取向的，并且具有1.6×1033至2.5×10 3 kg / cm 2的弯曲强度， 5.5×102〜24.0×102kg / cm2的模量，通过密度测定确定的结晶度为10〜60％，熔融加工后测定的粘均分子量为20万以上，初始值为80％以上在37℃的盐水中浸渍3个月后，保持制品的强度。

2. 发明授权

US4966924A Soft contact lens and method of manufacturing the same 失效
标题翻译：软隐形眼镜及其制造方法
公开(公告)号：US4966924A
公开(公告)日：1990-10-30
申请号：US351348
申请日：1989-05-15
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： B29C39/02 , B29C39/38 , B29D11/00 , B29K29/00 , B29L11/00 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , B29D11/00076 , G02B1/043
摘要： A soft contact lens of PVA having a tensile strength of not less than 10 kg/cm.sup.2, a water content ranging from 40 to 95% by weight, a visible light transparency of not less than 90%, and an oxygen permeability of not less than 30.times.10.sup.-11 cm.sup.3 .multidot.(STP).multidot.cm/cm.sup.2 .multidot.sec.multidot.mmHg. This soft contact lens can be prepared by forming a solution of PVA in a mixed solvent of water and an organic solvent, pouring the PVA solution in a mold having a shape of contact lens, and crystallizing at a temperature of not more than ordinary temperature. The soft contact lens has a high mechanical strength, high water content, high transparency and high oxygen permeability.

3. 发明授权

US4727030A Preparation of porous polyvinyl alcohol gel containing an immobilized enzyme 失效
标题翻译：制备含有固定化酶的多孔聚乙烯醇凝胶
公开(公告)号：US4727030A
公开(公告)日：1988-02-23
申请号：US791274
申请日：1985-10-25
申请人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
发明人： Fumihiro Ishimura , Koji Murata , Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： C12N11/08 , C12N11/04 , C12N11/02 , C12N11/14
CPC分类号： C12N11/04
摘要： A porous gel containing an immobilized enzyme is prepared by mixing an aqueous solution of polyvinyl alcohol having a saponification degree of not lower than 95 mol% and an average polymerization degree of not lower than 1,000, with an enzyme or enzyme-producing cell, and activated carbon powder, pouring the mixture into a container of any desired form, gelating and molding the mixture by dehydrating it up to a dehydration ratio of not lower than 50%, immersing the resulting molding in water, and drying the immersed molding. Preferably, dehydrating is by leaving the mixture to stand at room temperature or a temperature of from 30.degree. C. to 40.degree. C. The enzyme or enzyme-producing cell may be mixed with or adsorbed on an inorganic or organic carrier. The dried molding may be granulated.
摘要翻译：通过将皂化度不低于95摩尔％且平均聚合度不低于1,000的聚乙烯醇水溶液与酶或酶产生细胞混合并制备含有固定化酶的多孔凝胶，并将其活化碳粉，将混合物倒入任何所需形式的容器中，通过将其脱水至脱水率不低于50％，将混合物凝胶化和模塑，将所得模制品浸入水中，并干燥浸渍的模制品。优选地，脱水是通过在室温或30℃至40℃的温度下使混合物静置。酶或酶产生细胞可以与无机或有机载体混合或吸附在无机或有机载体上。干燥的成型品可以造粒。

4. 发明授权

US4663358A Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the same 失效
标题翻译：多孔透明聚（乙烯醇）凝胶及其制造方法
公开(公告)号：US4663358A
公开(公告)日：1987-05-05
申请号：US855929
申请日：1986-04-25
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： C08L29/04 , B01J13/00 , C08J3/03 , C08J9/28 , C08L29/00 , C08L29/02
CPC分类号： C08J9/28 , C08J3/075 , C08J2329/04
摘要： A porous and transparent hydrated gel is prepared from a poly(vinyl alcohol) solution in a mixed solvent consisting of water and an water-miscible organic solvent. Upon cooling the poly(vinyl alcohol) solution below room temperature, a gel is formed as a consequence of crystallization of poly(vinyl alcohol) molecules. Exchange of the organic solvent included in the gel with water produces a hydrated gel of poly(vinyl alcohol) which has a high tensile strength, a high water content, and a high light transmittance.
摘要翻译：由聚（乙烯醇）溶液在由水和水混溶性有机溶剂组成的混合溶剂中制备多孔和透明的水合凝胶。在将聚（乙烯醇）溶液冷却至室温以下时，由于聚（乙烯醇）分子的结晶而形成凝胶。将凝胶中包含的有机溶剂与水的交换产生具有高拉伸强度，高含水量和高透光率的聚（乙烯醇）的水合凝胶。

5. 发明授权

US4765937A Method of preparing high strength and modulus poly(vinyl alcohol) fibers 失效
标题翻译：制备高强度和模量的聚（乙烯醇）纤维的方法
公开(公告)号：US4765937A
公开(公告)日：1988-08-23
申请号：US28943
申请日：1987-03-23
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： D01D5/00 , D01F6/14
CPC分类号： D01F6/14 , D07B2501/2061
摘要： High strength and modulus fibers are prepared from a poly(vinyl alcohol) solution in a mixed solvent consisting of water and water-miscible organic solvent. Upon extruding the poly(vinyl alcohol) solution into a coagulation bath, gel fibers are formed as a consequence of favorable gel structure with homogeneous net-works. Drawing the gel fibers to an exceedingly high degree leads to formation of poly(vinyl alcohol) fibers which have a superhigh tensile strength and a superhigh modulus.
摘要翻译：由聚（乙烯醇）溶液在由水和水混溶性有机溶剂组成的混合溶剂中制备高强度和模量的纤维。在将聚（乙烯醇）溶液挤出到凝固浴中时，由于具有均匀网状物的良好凝胶结构，形成凝胶纤维。将凝胶纤维拉伸到非常高的程度导致形成具有超高拉伸强度和超高模量的聚（乙烯醇）纤维。

6. 发明授权

US4874562A Method of molding a polyvinyl alcohol contact lens 失效
标题翻译：聚乙烯醇隐形眼镜的成型方法
公开(公告)号：US4874562A
公开(公告)日：1989-10-17
申请号：US117171
申请日：1987-09-30
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： B29C39/02 , B29C39/38 , B29D11/00 , B29K29/00 , B29L11/00 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , B29D11/00076 , G02B1/043
摘要： A soft contact lens of PVA having a tensile strength of not less than 10 kg/cm.sup.2, a water content ranging from 40 to 95% by weight, a visible light transparency of not less than 90%, and an oxygen permeability of not less than 30.times.10.sup.-11 cm.sup.3.(STP).cm/cm.sup.2.sec.mmHg. This soft contact lens can be prepared by forming a solution of PVA in a mixed solvent of water and an organic solvent, pouring the PVA solution in a mold having a shape of contact lens, and crystallizing at a temperature of not more than ordinary temperature. The soft contact lens has a high mechanical strength, high water content, high transparency and high oxygen permeability.
摘要翻译： PCT No.PCT / JP87 / 00082 Sec。 371日期1987年9月30日 102（e）1987年9月30日PCT PCT。1987年2月9日PCT公布。出版物WO87 / 日本1987年8月27日。拉伸强度为10kg / cm 2以上，PVA含量为40〜95重量％，可见光透明度为90％以上的PVA的软性隐形眼镜，透氧度不小于30×10-11 cm3。（STP）.cm / cm2.sec.mmHg。该软性隐形眼镜可以通过在水和有机溶剂的混合溶剂中形成PVA溶液，将PVA溶液倒入具有隐形眼镜形状的模具中，并在不高于常温的温度下结晶来制备。软性隐形眼镜具有高机械强度，高含水量，高透明度和高透氧性。

7. 发明授权

US4781926A Transdermal therapeutic composition 失效
标题翻译：透皮治疗组合物
公开(公告)号：US4781926A
公开(公告)日：1988-11-01
申请号：US842187
申请日：1986-03-21
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： A61K9/70 , A61K47/32 , A61L15/00
CPC分类号： A61K9/7084 , A61K47/32
摘要： Transdermal dosage compositions are prepared from hydrated poly(vinyl alcohol) gels and pharmacologically active substances without any chemicals such as crosslinking agents and catalysts. Heating process is not involved in the gel preparation. High water contents of the gels enable the stratum corneum to be swollen, resulting in high permeation of drugs through the skin.
摘要翻译：透皮剂量组合物由不含任何化学物质如交联剂和催化剂的水合聚（乙烯醇）凝胶和药理活性物质制备。加热过程不参与凝胶制备。凝胶含水量高使得角质层肿胀，导致药物通过皮肤的高渗透。

8. 发明授权

US07323211B2 Bone-adherent implant with shock-absorbing property and manufacturing method thereof 失效
标题翻译：具有减震性的骨粘连植入物及其制造方法
公开(公告)号：US07323211B2
公开(公告)日：2008-01-29
申请号：US10844734
申请日：2004-05-13
申请人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
发明人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
IPC分类号： B05D1/36
CPC分类号： A61L27/34 , A61L27/50 , Y10T428/31692 , Y10T428/31855
摘要： It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant.The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.
摘要翻译：本发明提供能够牢固地固定在生物体中的具有减震性的植入物以及这种植入物的制造方法。植入物包括：基底; 在基材上的第一膜，其由聚合物组成并具有能够吸附钙离子的官能团; 以及形成在第一膜上并由磷酸钙构成的第二膜。所述植入物的制造方法包括：在基底上形成所述第一膜; 然后交替地将基板浸入钙离子溶液和磷酸盐离子溶液中以形成第二膜。

9. 发明授权

US5100669A Polylactic acid type microspheres containing physiologically active substance and process for preparing the same 失效
标题翻译：含有生理活性物质的聚乳酸型微生物及其制备方法
公开(公告)号：US5100669A
公开(公告)日：1992-03-31
申请号：US315167
申请日：1989-02-24
申请人： Suong-Hyu Hyon , Yoshita Ikada
发明人： Suong-Hyu Hyon , Yoshita Ikada
IPC分类号： A61K9/58 , A61K9/16 , A61K9/51 , A61K9/52 , A61K47/00 , A61K47/34
CPC分类号： A61K9/5153 , A61K9/1647 , Y10S514/963 , Y10S977/773 , Y10S977/915 , Y10T428/2989
摘要： Microspheres comprising polylactic acid and a water soluble physiologically active substance and having a mean particle size of from about 0.01 .mu.m to 300 .mu.m, which show not more than 30% of an eluted amount of said physiologically active substance based on the content of said physiologically active substance in the polylactic acid type microspheres after 24 hours in in vitro elution test in phosphate buffer of pH 7.4 at 37.degree. C., and a process for preparing the same. The polylactic acid type microspheres of this invention is advantageous in that the active substance can be uniformly incorporated into the microspheres without loss of the activity, can gradually release the active substance for a long time of period of more than one week.

10. 发明授权

US07683106B2 Primer for dental materials and pulp capping agent for dentin regeneration 有权
标题翻译：用于牙科材料的底漆和牙本质再生的纸浆封端剂
公开(公告)号：US07683106B2
公开(公告)日：2010-03-23
申请号：US10548374
申请日：2004-03-05
申请人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
发明人： Masahiro Yoshiyama , Yoshihiro Nishitani , Sadami Tsutsumi , Suong-Hyu Hyon
IPC分类号： A61K6/08 , C08K3/38
CPC分类号： C09J129/04 , A61K6/0029 , A61L24/102 , C08L31/04
摘要： A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.
摘要翻译：公开了牙科材料底漆和表现出优异牙本质再生作用的牙本质再生浆果覆盖剂。牙科材料底漆包括其中固定有胶原的水解乙烯 - 乙酸乙烯酯共聚物，牙本质再生的纸浆覆盖剂包括其中固定有胶原的水解乙烯 - 乙酸乙烯酯共聚物和粘合剂。

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