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1. 发明授权

US07323211B2 Bone-adherent implant with shock-absorbing property and manufacturing method thereof 失效
标题翻译：具有减震性的骨粘连植入物及其制造方法
公开(公告)号：US07323211B2
公开(公告)日：2008-01-29
申请号：US10844734
申请日：2004-05-13
申请人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
发明人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
IPC分类号： B05D1/36
CPC分类号： A61L27/34 , A61L27/50 , Y10T428/31692 , Y10T428/31855
摘要： It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant.The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.
摘要翻译：本发明提供能够牢固地固定在生物体中的具有减震性的植入物以及这种植入物的制造方法。植入物包括：基底; 在基材上的第一膜，其由聚合物组成并具有能够吸附钙离子的官能团; 以及形成在第一膜上并由磷酸钙构成的第二膜。所述植入物的制造方法包括：在基底上形成所述第一膜; 然后交替地将基板浸入钙离子溶液和磷酸盐离子溶液中以形成第二膜。

2. 发明申请

US20080145440A1 Microparticle preparation and medical composition 审中-公开
标题翻译：微粒制备和医药成分
公开(公告)号：US20080145440A1
公开(公告)日：2008-06-19
申请号：US11812468
申请日：2007-06-19
申请人： Han Hee Cho , Long Hai Han , Kazuaki Matsumura , Sadami Tsutsumi , Suong Hyu Hyon , Masaji Matsunaga , Fumihito Yoshida
发明人： Han Hee Cho , Long Hai Han , Kazuaki Matsumura , Sadami Tsutsumi , Suong Hyu Hyon , Masaji Matsunaga , Fumihito Yoshida
IPC分类号： A61K33/24 , A61K31/282 , A61K47/30 , A61K9/14 , A61P35/00
CPC分类号： A61K45/06 , A61K9/0019 , A61K9/1629 , A61K9/1688 , A61K31/282 , A61K31/7088 , A61K33/24 , A61K2300/00
摘要： According to the present invention, an early-phase release amount of cisplatin (CCDP) is reduced and a release of cisplatin is maintained over a long period of time, such that an anticancer effect against cancer cells is enhanced while side effects are reduced. In this manner, a life prolongation effect for patients is enhanced. A microparticle preparation contains cisplatin that is intercalated into double-helical DNA. The microparticle preparation stably retains cisplatin and exhibits an excellent slow-release property. Accordingly, even when cisplatin containing severe toxicity is used, the side effects can be suppressed and an excellent anticancer effect can be provided over a long period of time.
摘要翻译：根据本发明，降低了顺铂（CCDP）的早期释放量，长时间维持顺铂的释放，从而增加抗癌细胞的抗癌作用，同时副作用降低。以这种方式，对患者的延长寿命的作用增强。微粒制剂含有插入双螺旋DNA的顺铂。微粒制剂稳定地保持顺铂并显示出优异的缓释性能。因此，即使使用含有严重毒性的顺铂，也可以抑制副作用，能够长时间地提供优异的抗癌作用。

3. 发明申请

US20070259329A1 Anergy-inducing cellular composition 审中-公开
标题翻译：抗生素诱导细胞组成
公开(公告)号：US20070259329A1
公开(公告)日：2007-11-08
申请号：US11418422
申请日：2006-05-03
申请人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
发明人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The invention is directed to an anergy-inducing cellular composition comprising: cells having antigenic determinants on the cell surface and an anergy-inducing compound [e.g., (−)-epigallocatechin-3-o-gallate (EGCG)] attached by its chemical affinity to the antigenic determinants. In one embodiment, the anergy-inducing compound blocks co-stimulatory molecules among the antigenic determinants of the cells, which upon encountering with T-cell renders the latter anergic, that is, unresponsive toward alloantigens. In another embodiment, EGCG is of high purity for its efficient attachment to the antigenic determinants. The anergy-inducing cellular composition is prepared by immersing the cells in a culture media solution (RPMI 1640) containing 50-500 ppm EGCG at low physiological temperatures for one to two hours to minimize the cells' mortality. A specific use of the resulting anergic cellular composition is suggested, which is the attenuation of two undesirable acute allogenic responses resulting from major histocompatibility disparity, namely, transplant rejection and GVHD.
摘要翻译：本发明涉及一种免疫诱导细胞组合物，其包含：在细胞表面具有抗原决定簇的细胞和通过其化学亲合力附着的无能力诱导化合物[例如（ - ） - 表没食子儿茶素-3-邻氯乙酸酯（EGCG）] 对抗原决定簇。在一个实施方案中，所述无反应诱导化合物阻断所述细胞的抗原决定簇之间的共刺激分子，其在与T细胞相遇时使得后者不敏感，即对同种异体抗原无反应。在另一个实施方案中，EGCG与抗原决定簇的有效连接具有高纯度。通过将细胞浸入含有50-500ppm EGCG的培养基溶液（RPMI 1640）中在低生理温度下浸泡1至2小时来制备无能诱导细胞组合物，以使细胞的死亡率最小化。提出了所得到的无菌细胞组合物的具体用途，其是由主要组织相容性差异（即移植排斥和GVHD）引起的两种不希望的急性同种异体反应的减弱。

4. 发明申请

US20070259327A1 Cryopreservation medium and cryopreservation method for tissues and cells 审中-公开
标题翻译：冷冻保存培养基和组织和细胞的低温保存方法
公开(公告)号：US20070259327A1
公开(公告)日：2007-11-08
申请号：US11418421
申请日：2006-05-03
申请人： Yasuhiro Iwanaga , Kazuaki Matsumura , Jong-Yoon Kim , Hajime Sugai , Suong-Hyu Hyon
发明人： Yasuhiro Iwanaga , Kazuaki Matsumura , Jong-Yoon Kim , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： C12N5/08 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0221
摘要： A cryopreservation medium and a cryopreservation method which make it possible to cryopreserve tissues and cells with high viability are provided. A cryopreservation medium contains polyphenol at a concentration of from 30 to 120 ppm. In an embodiment, a cryopreservation method for tissues and cells comprises: incubating tissues or cells for 2 hours in culture medium supplemented with polyphenol at concentrations of from 30 to 120 ppm; suspending tissues or cells in a cryopreservation medium; freezing the suspension of the tissues or cells in the cryopreservation medium; and storing the frozen suspension of tissues or cells in the cryopreservation medium.
摘要翻译：提供了一种冷冻保存培养基和一种低温保存方法，其可以以高活力冷冻保存组织和细胞。冷冻保存培养基含有浓度为30至120ppm的多酚。在一个实施方案中，用于组织和细胞的冷冻保存方法包括：在补充有30至120ppm浓度的多酚的培养基中孵育组织或细胞2小时; 将组织或细胞悬浮在冷冻保存培养基中; 冻结冷冻保存培养基中组织或细胞的悬浮液; 并将冷冻的组织或细胞悬浮液储存在冷冻保存培养基中。

5. 发明申请

US20110172315A1 COMPOSITION FOR CRYOPRESERVATION OF CELLS AND TISSUES 审中-公开
标题翻译：用于细胞和组织的组织的组合物
公开(公告)号：US20110172315A1
公开(公告)日：2011-07-14
申请号：US13001237
申请日：2009-06-26
申请人： Kazuaki Matsumura , Hajime Sugai , Suong-Hyu Hyon
发明人： Kazuaki Matsumura , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： A01N25/00 , C12N5/071 , A01P15/00 , C09K15/20 , C09K15/18 , A23L1/305 , H01M2/14 , B05D5/00
CPC分类号： A01N1/0221 , A23L3/375 , A23V2002/00 , A61K9/19 , A61K47/34 , C12N5/0602
摘要： A composition for cryopreservation of cells and tissues of human and other animals in a safe manner without using toxic substances such as DMSO, as well as for freeze preserving or freeze-drying of foods and pharmaceuticals. In examples, ε-poly-L-lysine is reacted with succinic anhydride so that 60% or more of amino groups are blocked; and, thus obtained polymer compound is added to Dulbecco-modified eagle MEM culture medium (DMEM) on market sale to form a cryopreservation liquid. In examples for foods or pharmaceuticals, the ε-poly-L-lysine derivative was added by 0.5-10 wt % to curb freeze concentration.
摘要翻译：用于以不安全的方式冷冻保存人和其他动物的细胞和组织的组合物，而不使用有毒物质如DMSO，以及用于食品和药物的冷冻保存或冷冻干燥。在实施例中，将聚-L-赖氨酸与琥珀酸酐反应，使得60％以上的氨基被封闭; 并将所获得的高分子化合物在市售上添加到Dulbecco改良的Eagle MEM培养基（DMEM）中以形成冷冻保存液。在食品或药物的实例中，加入0.5〜10重量％的α-聚-L-赖氨酸衍生物来抑制冷冻浓度。

6. 发明授权

US08360891B2 Game device, game processing method, information recording medium, and program 有权
标题翻译：游戏装置，游戏处理方法，信息记录介质和程序
公开(公告)号：US08360891B2
公开(公告)日：2013-01-29
申请号：US12809970
申请日：2008-12-17
申请人： Kazuaki Matsumura
发明人： Kazuaki Matsumura
IPC分类号： A63F13/00
CPC分类号： A63F13/67 , A63F13/10 , A63F13/56 , A63F13/822 , A63F2300/6027 , A63F2300/64 , A63F2300/807 , A63F2300/8076
摘要： In a game device (200), a memory unit (201) stores a position of a player character, a position of an enemy character, an elapsed time up to a present time after the enemy character has appeared, and candidates of a position where a new enemy character is to appear. A measuring unit (202) measures an elapsed time up to a present time after the enemy character has appeared, and stores the measured elapsed time in the memory unit (201). A calculating unit (203) calculates a reference distance which becomes a determination criterion for a position where a new enemy character appears based on the stored elapsed time. The reference distance monotonically increases relative to the increasing of the elapsed time. An appearance setting unit (204) selects a candidate having a distance to the player character closest to the reference distance among the candidates stored in the memory unit (201), and causes a new enemy character to appear at the selected candidate position.
摘要翻译：在游戏装置（200）中，存储单元（201）存储玩家角色的位置，敌人角色的位置，直到敌方角色出现之后的当前时间的经过时间，以及一个新的敌人角色出现。测量单元（202）测量出现敌人角色之后的当前时间的经过时间，并将所测量的经过时间存储在存储单元（201）中。计算单元（203）基于所存储的经过时间计算作为新的敌人角色出现位置的确定标准的参考距离。参考距离相对于经过时间的增加单调增加。外观设置单元（204）选择存储在存储单元（201）中的候选者中与候选人角色最接近参考距离的候选，并使新的敌人角色出现在所选候选位置。

7. 发明授权

US08485898B2 Game device, method for controlling game device, program, and information storage medium 有权
标题翻译：游戏装置，游戏装置控制方法，程序和信息存储介质
公开(公告)号：US08485898B2
公开(公告)日：2013-07-16
申请号：US13262173
申请日：2009-10-22
申请人： Hiroyuki Tomita , Kazuaki Matsumura , Tomomi Tsubakisawa
发明人： Hiroyuki Tomita , Kazuaki Matsumura , Tomomi Tsubakisawa
IPC分类号： G06F17/00
CPC分类号： A63F13/525 , A63F2300/6045 , A63F2300/8011
摘要： To provide a game device capable of allowing a user, when selecting any selected image candidate, to experience a real feeling of the relationship with another selected image candidate. A determination unit (70a) determines whether or not the designated area designated by a user is included in the determination area for a selected image candidate. When the designated area is included in the determination area, the designation unit (72a) designates the selected image candidate corresponding to the determination area as a selected image. A determination area control unit (68) changes the size of a determination area for another selection candidate image, based on a parameter stored so as to be correlated to a combination of the selected image candidate designated as a selected image and the other selected image candidate. A designated area control unit (82) changes the size of the designated area, based on a parameter stored so as to be correlated to a combination of the selected image candidate designated as the selected image and a selected image candidate located closest to the designated area.
摘要翻译：为了提供能够允许用户在选择任何选择的图像候选者时体验与另一个选择的图像候选者的关系的真实感觉的游戏装置。确定单元（70a）确定用户指定的指定区域是否包括在所选图像候选的确定区域中。当指定区域包括在确定区域中时，指定单元（72a）将与确定区域相对应的所选择的图像候选指定为所选择的图像。确定区域控制单元（68）基于存储的参数来改变另一选择候选图像的确定区域的大小，以便与被指定为所选图像的所选择的图像候选与另一个选择的图像候选者的组合相关联。指定区域控制单元（82）基于存储的参数来改变指定区域的大小，以便与被指定为所选择的图像的所选择的图像候选和最接近指定区域的选定图像候选者的组合相关联。

8. 发明授权

US10308386B2 Medicine dispensing apparatus 有权
公开(公告)号：US10308386B2
公开(公告)日：2019-06-04
申请号：US13485831
申请日：2012-05-31
申请人： Naoki Koike , Takafumi Imai , Kazuaki Matsumura , Takuya Tsugui , Kazunori Tsukamoto
发明人： Naoki Koike , Takafumi Imai , Kazuaki Matsumura , Takuya Tsugui , Kazunori Tsukamoto
IPC分类号： B65B43/46 , B65B43/52 , B65B5/10 , G07F17/00 , B65C1/04
摘要： A medicine dispensing apparatus fills a vial having a polygonal cross-sectional shape with medicines to dispense the medicines. The apparatus contains a stocker, a first vial transporting unit, a vial orienting unit, a labeling unit, a second vial transporting unit, a medicine filling unit, and a vial discharging window. The stocker stores the vial. The first vial transporting unit transports the vial from the stocker to the labeling unit. The vial orienting unit adjusts an orientation of the vial. The labeling unit labels the vial. The second vial transporting unit transports the vial from the labeling unit to the medicine filling unit. The medicine filling unit fills the vial with the medicines. The second vial transporting unit further transports the vial from the medicine filling unit to the vial discharging window, where the vial is discharged through the vial discharging window.

9. 发明申请

US20120304596A1 MEDICINE DISPENSING APPARATUS 审中-公开
标题翻译：医药配药设备
公开(公告)号：US20120304596A1
公开(公告)日：2012-12-06
申请号：US13485831
申请日：2012-05-31
申请人： Naoki KOIKE , Takafumi Imai , Kazuaki Matsumura , Takuya Tsugui , Kazunori Tsukamoto
发明人： Naoki KOIKE , Takafumi Imai , Kazuaki Matsumura , Takuya Tsugui , Kazunori Tsukamoto
IPC分类号： B65B61/26 , B65B43/46 , B65B61/28
CPC分类号： B65B43/46 , B65B5/103 , B65B43/52 , B65C1/045 , B65C1/047 , G07F17/0092
摘要： A medicine dispensing apparatus fills a vial having a polygonal cross-sectional shape with medicines to dispense the medicines. The apparatus contains a stocker, a first vial transporting unit, a vial orienting unit, a labeling unit, a second vial transporting unit, a medicine filling unit, and a vial discharging window. The stocker stores the vial. The first vial transporting unit transports the vial from the stocker to the labeling unit. The vial orienting unit adjusts an orientation of the vial. The labeling unit labels the vial. The second vial transporting unit transports the vial from the labeling unit to the medicine filling unit. The medicine filling unit fills the vial with the medicines. The second vial transporting unit further transports the vial from the medicine filling unit to the vial discharging window, where the vial is discharged through the vial discharging window.
摘要翻译：药物分注装置用药物填充具有多边形横截面形状的小瓶以分配药物。该装置包括储存器，第一小瓶输送单元，小瓶定向单元，标签单元，第二小瓶传送单元，药物填充单元和小瓶排出窗。储存器存放小瓶。第一个小瓶运输单元将小瓶从储料器运送到标签单元。小瓶定向单元调整小瓶的方向。标签单元标记小瓶。第二小瓶输送单元将小瓶从标签单元输送到药物填充单元。药物填充单元向药瓶填充药物。第二小瓶输送单元还将小瓶从药物填充单元运送到小瓶排出窗口，其中小瓶通过小瓶排出窗口排出。

10. 发明申请

US20120021830A1 GAME DEVICE, METHOD FOR CONTROLLING GAME DEVICE, PROGRAM, AND INFORMATION STORAGE MEDIUM 有权
标题翻译：游戏设备，用于控制游戏设备的方法，程序和信息存储介质
公开(公告)号：US20120021830A1
公开(公告)日：2012-01-26
申请号：US13262173
申请日：2009-10-22
申请人： Hiroyuki Tomita , Kazuaki Matsumura , Tomomi Tsubakisawa
发明人： Hiroyuki Tomita , Kazuaki Matsumura , Tomomi Tsubakisawa
IPC分类号： A63F13/00
CPC分类号： A63F13/525 , A63F2300/6045 , A63F2300/8011
摘要： To provide a game device capable of allowing a user, when selecting any selected image candidate, to experience a real feeling of the relationship with another selected image candidate. A determination unit (70a) determines whether or not the designated area designated by a user is included in the determination area for a selected image candidate. When the designated area is included in the determination area, the designation unit (72a) designates the selected image candidate corresponding to the determination area as a selected image. A determination area control unit (68) changes the size of a determination area for another selection candidate image, based on a parameter stored so as to be correlated to a combination of the selected image candidate designated as a selected image and the other selected image candidate. A designated area control unit (82) changes the size of the designated area, based on a parameter stored so as to be correlated to a combination of the selected image candidate designated as the selected image and a selected image candidate located closest to the designated area.
摘要翻译：为了提供能够允许用户在选择任何选择的图像候选者时体验与另一个选择的图像候选者的关系的真实感觉的游戏装置。确定单元（70a）确定用户指定的指定区域是否包括在所选图像候选的确定区域中。当指定区域包括在确定区域中时，指定单元（72a）将与确定区域相对应的所选择的图像候选指定为所选择的图像。确定区域控制单元（68）基于存储的参数来改变另一选择候选图像的确定区域的大小，以便与被指定为所选图像的所选择的图像候选与另一个选择的图像候选者的组合相关联。指定区域控制单元（82）基于存储的参数来改变指定区域的大小，以便与被指定为所选择的图像的所选择的图像候选和最接近指定区域的选定图像候选者的组合相关联。

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