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1. 发明授权

US07323211B2 Bone-adherent implant with shock-absorbing property and manufacturing method thereof 失效
标题翻译：具有减震性的骨粘连植入物及其制造方法
公开(公告)号：US07323211B2
公开(公告)日：2008-01-29
申请号：US10844734
申请日：2004-05-13
申请人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
发明人： Suong-Hyu Hyon , Kazuaki Matsumura , Sadami Tsutsumi
IPC分类号： B05D1/36
CPC分类号： A61L27/34 , A61L27/50 , Y10T428/31692 , Y10T428/31855
摘要： It is to provide an implant with shock-absorbing property that is able to be strongly secured in a living body as well as a manufacturing method of such implant.The implant comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. The manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately as to form the second film.
摘要翻译：本发明提供能够牢固地固定在生物体中的具有减震性的植入物以及这种植入物的制造方法。植入物包括：基底; 在基材上的第一膜，其由聚合物组成并具有能够吸附钙离子的官能团; 以及形成在第一膜上并由磷酸钙构成的第二膜。所述植入物的制造方法包括：在基底上形成所述第一膜; 然后交替地将基板浸入钙离子溶液和磷酸盐离子溶液中以形成第二膜。

2. 发明授权

US5100669A Polylactic acid type microspheres containing physiologically active substance and process for preparing the same 失效
标题翻译：含有生理活性物质的聚乳酸型微生物及其制备方法
公开(公告)号：US5100669A
公开(公告)日：1992-03-31
申请号：US315167
申请日：1989-02-24
申请人： Suong-Hyu Hyon , Yoshita Ikada
发明人： Suong-Hyu Hyon , Yoshita Ikada
IPC分类号： A61K9/58 , A61K9/16 , A61K9/51 , A61K9/52 , A61K47/00 , A61K47/34
CPC分类号： A61K9/5153 , A61K9/1647 , Y10S514/963 , Y10S977/773 , Y10S977/915 , Y10T428/2989
摘要： Microspheres comprising polylactic acid and a water soluble physiologically active substance and having a mean particle size of from about 0.01 .mu.m to 300 .mu.m, which show not more than 30% of an eluted amount of said physiologically active substance based on the content of said physiologically active substance in the polylactic acid type microspheres after 24 hours in in vitro elution test in phosphate buffer of pH 7.4 at 37.degree. C., and a process for preparing the same. The polylactic acid type microspheres of this invention is advantageous in that the active substance can be uniformly incorporated into the microspheres without loss of the activity, can gradually release the active substance for a long time of period of more than one week.

3. 发明授权

US4966924A Soft contact lens and method of manufacturing the same 失效
标题翻译：软隐形眼镜及其制造方法
公开(公告)号：US4966924A
公开(公告)日：1990-10-30
申请号：US351348
申请日：1989-05-15
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： B29C39/02 , B29C39/38 , B29D11/00 , B29K29/00 , B29L11/00 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , B29D11/00076 , G02B1/043
摘要： A soft contact lens of PVA having a tensile strength of not less than 10 kg/cm.sup.2, a water content ranging from 40 to 95% by weight, a visible light transparency of not less than 90%, and an oxygen permeability of not less than 30.times.10.sup.-11 cm.sup.3 .multidot.(STP).multidot.cm/cm.sup.2 .multidot.sec.multidot.mmHg. This soft contact lens can be prepared by forming a solution of PVA in a mixed solvent of water and an organic solvent, pouring the PVA solution in a mold having a shape of contact lens, and crystallizing at a temperature of not more than ordinary temperature. The soft contact lens has a high mechanical strength, high water content, high transparency and high oxygen permeability.

4. 再颁专利

USRE44762E1 Ultra high molecular weight polyethylene molded article for artificial joints and method of preparing the same 失效
标题翻译：用于人造关节的超高分子量聚乙烯模塑制品及其制备方法
公开(公告)号：USRE44762E1
公开(公告)日：2014-02-11
申请号：US13531232
申请日：2012-06-22
申请人： Suong-Hyu Hyon , Hiroki Takahashi
发明人： Suong-Hyu Hyon , Masanori Oka
IPC分类号： C08J3/28 , C08G61/04
摘要： An ultra high molecular weight polyethylene molded article for artificial joints has molecular orientation or crystal orientation in the molded article, and is low in friction and is superior in abrasion resistance, and therefore is available as components for artificial joints. Further, the ultra high molecular weight polyethylene molded article for artificial joints can be used as a component for artificial hip joints (artificial acetabular cup), a component for artificial knee joints (artificial tibial insert) and the socket for artificial elbow joints, and in addition to the medical use, it can be applied as materials for various industries by utilizing the characteristics such as low friction and superior abrasion resistance.
摘要翻译：用于人造关节的超高分子量聚乙烯模塑制品在模塑制品中具有分子取向或晶体取向，并且摩擦力低，耐磨性优异，因此可用作人造关节的组分。此外，用于人造关节的超高分子量聚乙烯模制品可用作人造髋关节（人造髋臼杯），人造膝关节（人造胫骨插入物）和人造肘关节插座的组分除了医疗用途，它可以通过利用低摩擦和优异的耐磨性等特点作为各行业的材料。

5. 发明授权

US07834065B2 Medical-use two part reactive adhesive and medical-use resin having self-degradation property 有权
标题翻译：医用两部分反应性粘合剂和具有自降解性能的医用树脂
公开(公告)号：US07834065B2
公开(公告)日：2010-11-16
申请号：US11881941
申请日：2007-07-30
申请人： Naoki Nakajima , Hajime Sugai , Masakazu Konda , Suong-Hyu Hyon
发明人： Naoki Nakajima , Hajime Sugai , Masakazu Konda , Suong-Hyu Hyon
IPC分类号： C08L15/00
CPC分类号： A61L24/0031 , A61L24/043 , C08L5/08
摘要： Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.
摘要翻译：医用两部分粘合剂包括：第一部分由水溶液或引入醛基的α-葡聚糖的粉末组成; 第二部分由含有氨基的单元的聚合物链形成的含有氨基的聚合物的水溶液或粉末，分子量在1000〜20000的范围内; 以及通过固化粘合剂获得的医用水凝胶树脂。第一部分和第二部分的混合物在混合它们以形成水凝胶时的pH为5.0-8.0。在优选的实施方案中，含氨基的聚合物是由微生物或酶产生的ε-聚-L-赖氨酸。

6. 发明申请

US20070259329A1 Anergy-inducing cellular composition 审中-公开
标题翻译：抗生素诱导细胞组成
公开(公告)号：US20070259329A1
公开(公告)日：2007-11-08
申请号：US11418422
申请日：2006-05-03
申请人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
发明人： Jong-Yoon Kim , Kazuaki Matsumura , Yasuhiro Iwanaga , Hajime Sugai , Suong-Hyu Hyon
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The invention is directed to an anergy-inducing cellular composition comprising: cells having antigenic determinants on the cell surface and an anergy-inducing compound [e.g., (−)-epigallocatechin-3-o-gallate (EGCG)] attached by its chemical affinity to the antigenic determinants. In one embodiment, the anergy-inducing compound blocks co-stimulatory molecules among the antigenic determinants of the cells, which upon encountering with T-cell renders the latter anergic, that is, unresponsive toward alloantigens. In another embodiment, EGCG is of high purity for its efficient attachment to the antigenic determinants. The anergy-inducing cellular composition is prepared by immersing the cells in a culture media solution (RPMI 1640) containing 50-500 ppm EGCG at low physiological temperatures for one to two hours to minimize the cells' mortality. A specific use of the resulting anergic cellular composition is suggested, which is the attenuation of two undesirable acute allogenic responses resulting from major histocompatibility disparity, namely, transplant rejection and GVHD.
摘要翻译：本发明涉及一种免疫诱导细胞组合物，其包含：在细胞表面具有抗原决定簇的细胞和通过其化学亲合力附着的无能力诱导化合物[例如（ - ） - 表没食子儿茶素-3-邻氯乙酸酯（EGCG）] 对抗原决定簇。在一个实施方案中，所述无反应诱导化合物阻断所述细胞的抗原决定簇之间的共刺激分子，其在与T细胞相遇时使得后者不敏感，即对同种异体抗原无反应。在另一个实施方案中，EGCG与抗原决定簇的有效连接具有高纯度。通过将细胞浸入含有50-500ppm EGCG的培养基溶液（RPMI 1640）中在低生理温度下浸泡1至2小时来制备无能诱导细胞组合物，以使细胞的死亡率最小化。提出了所得到的无菌细胞组合物的具体用途，其是由主要组织相容性差异（即移植排斥和GVHD）引起的两种不希望的急性同种异体反应的减弱。

7. 发明授权

US06232384B1 Bone fixation materials and methods for their preparation 失效
标题翻译：骨固定材料及其制备方法
公开(公告)号：US06232384B1
公开(公告)日：2001-05-15
申请号：US09154101
申请日：1998-09-16
申请人： Suong-Hyu Hyon
发明人： Suong-Hyu Hyon
IPC分类号： C08K310
CPC分类号： A61L31/127
摘要： A bone fixation material has an initial bending strength at break of more than 250 MPa, maintains its strength more than 3 months in a living body organism and has the characteristic of biodegrading and bioabsorbing into and disappearing from the organism within a range of 6 months to 3 years. The material comprises a polymer with the characteristic of biodegrading and bioabsorbing into the living body organism, a hydroxyapatite and an alkaline inorganic compound.
摘要翻译：骨固定材料具有大于250MPa的初始弯曲强度，在活体生物体中保持其强度超过3个月，并且在6个月至6个月的范围内具有生物降解和生物吸收和从生物体中消失的特征 3年。该材料包括具有生物降解和生物吸收生物体生物特征的聚合物，羟基磷灰石和碱性无机化合物。

8. 发明授权

US6103778A Adhesive composition for surgical use 失效
标题翻译：用于外科用途的粘合剂组合物
公开(公告)号：US6103778A
公开(公告)日：2000-08-15
申请号：US162491
申请日：1998-09-28
申请人： Suong-Hyu Hyon , Naoki Nakajima
发明人： Suong-Hyu Hyon , Naoki Nakajima
IPC分类号： A61L24/00 , A61L24/04 , C09J4/04 , C08L67/00 , A61K31/765
CPC分类号： A61L24/043
摘要： An adhesive composition for surgical use including an .alpha.-cyanoacrylate adhesive composition with a polymer characteristic for biodegrading and bioabsorbing the adhesive into the body of a living organism. It is preferred that the polymer is a co-polymer of DL-lactic acid and .epsilon.-caprolactone or a co-polymer of DL-lactic acid, ethylene glycol and .epsilon.-caprolactone, or a co-polymer of ethylene glycol and .epsilon.-caprolactone.
摘要翻译：一种用于外科用途的粘合剂组合物，包括具有聚合物特性的α-氰基丙烯酸酯粘合剂组合物，用于生物降解和将粘合剂生物吸收到生物体内。优选的是，聚合物是DL-乳酸和ε-己内酯的共聚物或DL-乳酸，乙二醇和ε-己内酯的共聚物，或乙二醇和ε-己内酯的共聚物。

9. 发明授权

US4874562A Method of molding a polyvinyl alcohol contact lens 失效
标题翻译：聚乙烯醇隐形眼镜的成型方法
公开(公告)号：US4874562A
公开(公告)日：1989-10-17
申请号：US117171
申请日：1987-09-30
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： B29C39/02 , B29C39/38 , B29D11/00 , B29K29/00 , B29L11/00 , G02B1/04 , G02C7/04
CPC分类号： G02C7/04 , B29D11/00076 , G02B1/043
摘要： A soft contact lens of PVA having a tensile strength of not less than 10 kg/cm.sup.2, a water content ranging from 40 to 95% by weight, a visible light transparency of not less than 90%, and an oxygen permeability of not less than 30.times.10.sup.-11 cm.sup.3.(STP).cm/cm.sup.2.sec.mmHg. This soft contact lens can be prepared by forming a solution of PVA in a mixed solvent of water and an organic solvent, pouring the PVA solution in a mold having a shape of contact lens, and crystallizing at a temperature of not more than ordinary temperature. The soft contact lens has a high mechanical strength, high water content, high transparency and high oxygen permeability.
摘要翻译： PCT No.PCT / JP87 / 00082 Sec。 371日期1987年9月30日 102（e）1987年9月30日PCT PCT。1987年2月9日PCT公布。出版物WO87 / 日本1987年8月27日。拉伸强度为10kg / cm 2以上，PVA含量为40〜95重量％，可见光透明度为90％以上的PVA的软性隐形眼镜，透氧度不小于30×10-11 cm3。（STP）.cm / cm2.sec.mmHg。该软性隐形眼镜可以通过在水和有机溶剂的混合溶剂中形成PVA溶液，将PVA溶液倒入具有隐形眼镜形状的模具中，并在不高于常温的温度下结晶来制备。软性隐形眼镜具有高机械强度，高含水量，高透明度和高透氧性。

10. 发明授权

US4781926A Transdermal therapeutic composition 失效
标题翻译：透皮治疗组合物
公开(公告)号：US4781926A
公开(公告)日：1988-11-01
申请号：US842187
申请日：1986-03-21
申请人： Suong-Hyu Hyon , Yoshito Ikada
发明人： Suong-Hyu Hyon , Yoshito Ikada
IPC分类号： A61K9/70 , A61K47/32 , A61L15/00
CPC分类号： A61K9/7084 , A61K47/32
摘要： Transdermal dosage compositions are prepared from hydrated poly(vinyl alcohol) gels and pharmacologically active substances without any chemicals such as crosslinking agents and catalysts. Heating process is not involved in the gel preparation. High water contents of the gels enable the stratum corneum to be swollen, resulting in high permeation of drugs through the skin.
摘要翻译：透皮剂量组合物由不含任何化学物质如交联剂和催化剂的水合聚（乙烯醇）凝胶和药理活性物质制备。加热过程不参与凝胶制备。凝胶含水量高使得角质层肿胀，导致药物通过皮肤的高渗透。

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