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1. 发明申请

US20110311615A1 NOVEL GP41 ANTIGENS 有权
标题翻译：新型GP41抗原
公开(公告)号：US20110311615A1
公开(公告)日：2011-12-22
申请号：US13144000
申请日：2010-02-08
申请人： Sylvain Fleury , Nicolas Mouz , Marie-Gaelle Roger
发明人： Sylvain Fleury , Nicolas Mouz , Marie-Gaelle Roger
IPC分类号： A61K9/133 , A61K39/21 , C07K17/02 , C07H21/04 , C12N5/10 , A61P37/04 , A61P31/18 , C12N1/21 , C12N1/19 , C07K14/16 , C12N15/63
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5258 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55555 , A61K2039/575 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： The present invention deals with a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N−L−C and comprising: a N-helix region of gp41 (N), a C-helix region of gp41 (C), and a connecting loop comprising a synthetic linker (L) between the N and C-helices, the linker replacing amino acids 593-617 of gp41, the numbering scheme being based upon the prototypic isolate HIV-1 HxB2 Clade B strain, said polypeptide comprising the calveolin-1 neutral izing and 98.6 D epitopes, but not 2F5 and 4E10 epitopes, not the fusion peptide, the polypeptide having a minimal immunogenic cross-reactivity with human interleukin 2 (IL2).
摘要翻译：本发明涉及包含由式N-L-C表示的三个连续片段N，L和C的修饰多肽，其包含：gp41（N）的N-螺旋区，gp41（C）的C-螺旋区，，以及连接环，其包含在N和C-螺旋之间的合成接头（L），所述接头代替gp41的氨基酸593-617，编号方案基于原型分离物HIV-1 HxB2进化枝B菌株，所述多肽包括犊牛素-1中和和98.6D表位，而不是2F5和4E10表位，而不是融合肽，所述多肽与人白介素2（IL2）具有最小的免疫原性交叉反应性。

2. 发明申请

US20080171077A1 Method and apparatus for making uniformly sized particles 有权
标题翻译：制造尺寸一致的颗粒的方法和装置
公开(公告)号：US20080171077A1
公开(公告)日：2008-07-17
申请号：US11653618
申请日：2007-01-12
申请人： Mark Gray
发明人： Mark Gray
IPC分类号： A61K9/127 , A61K9/133 , B28B1/54 , A61K31/7105 , A61K33/30
CPC分类号： A61K31/7105 , A61K33/26 , A61K49/1818 , B01F5/0475 , B01F5/0483 , B01F13/0059 , B82Y5/00
摘要： A method and apparatus for making substantially uniformly sized liposomes and other small particles are provided. Droplets of a first liquid are ejected into a laminar flow of a second liquid, each droplet having a volume of from 0.97V to 1.03V, where V is the mean droplet volume and 1 fL≦V≦50 nL, wherein the first and second liquids are no more than sparingly soluble in one another, and wherein the first liquid contains a solute dissolved, dispersed, or suspended therein; and the first liquid is then removed to form a plurality of substantially uniformly sized particles. In one embodiment, the apparatus includes liquid inlet and outlet channels, a plurality of transverse liquid channels extending from the liquid inlet to the liquid outlet channel, a plurality of nozzles in liquid flow communication with the plurality of transverse liquid channels, one or more nozzle actuators coupled to the plurality of nozzles, and an evaporator coupled to the liquid outlet channel.
摘要翻译：提供了制备基本均匀的脂质体和其它小颗粒的方法和装置。第一液体的液滴喷射到第二液体的层流中，每个液滴的体积为0.97V至1.03V，其中V为平均液滴体积，1fL <= V <= 50nL，其中第一液体并且第二液体彼此之间不能微溶，并且其中第一液体含有溶解，分散或悬浮在其中的溶质; 然后除去第一液体以形成多个基本均匀的颗粒。在一个实施例中，该装置包括液体入口和出口通道，从液体入口延伸到液体出口通道的多个横向液体通道，与多个横向液体通道液体流动连通的多个喷嘴，一个或多个喷嘴耦合到多个喷嘴的致动器和耦合到液体出口通道的蒸发器。

3. 发明申请

US20070243241A1 Silicone Vesicles Containing Actives 审中-公开
标题翻译：含有活性物质的硅胶囊
公开(公告)号：US20070243241A1
公开(公告)日：2007-10-18
申请号：US11578541
申请日：2005-04-19
申请人： Shaow Lin , Stephanie Postiaux
发明人： Shaow Lin , Stephanie Postiaux
IPC分类号： A61K9/133 , B01J13/00
CPC分类号： A61K8/14 , A61K8/34 , A61K8/585 , A61K8/671 , A61K8/894 , A61Q1/02 , A61Q1/06 , A61Q17/04 , A61Q19/00 , B01J13/02 , B01J13/12
摘要： A process for preparing a vesicle composition based upon mixing an organopolysiloxane having at least one hydrophilic substituent group, a water miscible volatile solvent, and water is disclosed. The vesicle compositions produced by the method are useful in various personal, household, and health care applications.
摘要翻译：公开了一种基于混合具有至少一个亲水取代基的有机聚硅氧烷，水混溶性挥发性溶剂和水来制备囊泡组合物的方法。通过该方法生产的囊泡组合物可用于各种个人，家庭和医疗保健应用。

4. 发明授权

US07081253B2 Use of nanodispersions in pharmaceutical end formulations 有权
标题翻译：在药物末端制剂中使用纳米分散体
公开(公告)号：US07081253B2
公开(公告)日：2006-07-25
申请号：US09306006
申请日：1999-05-06
申请人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
发明人： Andreas Werner Supersaxo , Hans Georg Weder , Dietmar Hüglin , Joachim Friedrich Röding
IPC分类号： A61K9/127 , A61K9/133 , A61K9/10
CPC分类号： A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要： A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译：给出了使用纳米分散体的描述，该纳米分散体包含（a）在药物末端制剂中的成膜分子，（b）共乳化剂和（c）亲脂性组分，纳米分散体可通过（α）混合组分（a），（b）和（c），直到获得均匀的透明液体，和（β）将步骤（α）中获得的液体加入到药物末端制剂的水相中，步骤（α）和）在没有任何额外的能量供应的情况下进行。根据本发明使用的纳米分散体适合用作药物活性剂的运输载体。

5. 发明申请

US20050013833A1 Composition based on lipid lamellar vesicles incorporating at least a dhea compound 审中-公开
标题翻译：基于掺入至少一种dhea化合物的脂质层状囊泡的组合物
公开(公告)号：US20050013833A1
公开(公告)日：2005-01-20
申请号：US10484000
申请日：2002-07-18
申请人： Jean-Thierry Simonnet
发明人： Jean-Thierry Simonnet
IPC分类号： A61K8/00 , A61K8/30 , A61K8/34 , A61K8/40 , A61K8/49 , A61K8/97 , A61K9/127 , A61K9/133 , A61Q19/00 , A61Q19/08 , A61K35/78 , A61K9/14 , A61K31/57
CPC分类号： A61K9/1272
摘要： The present invention relates to a composition comprising: a dispersion, in an outer aqueous phase, of vesicles formed by lipid lamellar phases comprising at least one amphiphilic lipid and encapsulating an inner hydrophilic phase, the said lamellar phases not comprising succinic and/or hemisuccinic derivatives, and at least one DHEA-based compound included in the said lamellar phases. The incorporation of the DHEA-based compound into the lamellar phases of vesicles makes it possible to avoid its recrystallization in the outer aqueous phase and to improve its bioavailability.
摘要翻译：本发明涉及一种组合物，其包含：在外部水相中的分散体，由包含至少一种两亲性脂质和包封内部亲水相的脂质层状相形成的囊泡，所述层状相不包含琥珀酸和/或半琥珀酸衍生物，以及包含在所述层状相中的至少一种基于DHEA的化合物。将DHEA基化合物掺入囊泡的层状相使得可以避免其在外部水相中的再结晶并提高其生物利用度。

6. 发明授权

US6156338A Method for preparing compositions for transferring nucleic acids 失效
标题翻译：制备转移核酸组合物的方法
公开(公告)号：US6156338A
公开(公告)日：2000-12-05
申请号：US269515
申请日：1999-04-02
申请人： Joel Vacus , Tsiala Bouknikachvili
发明人： Joel Vacus , Tsiala Bouknikachvili
IPC分类号： C12N15/09 , A61K9/127 , A61K9/133 , A61K47/24 , A61K47/48 , A61K48/00 , C12N15/87 , C12N15/88 , C12Q1/68
CPC分类号： A61K48/00 , A61K47/488 , A61K9/1272 , C12N15/87 , C12N15/88
摘要： The invention concerns a method for preparing a composition for transferring nucleic acids consisting in contacting a nucleic acid with a cationic lipid, whereby, previous to contacting, the cationic lipid is subjected to a heating step. The invention also concerns the resulting compositions and their use.
摘要翻译： PCT No.PCT / FR97 / 01747 Sec。一九九九年四月二日 102（e）1999年4月2日PCT PCT 1997年10月3日PCT公布。公开号WO98 / 15639 日期1998年4月16日本发明涉及一种制备用于转移核酸的组合物的方法，所述核酸在核酸与阳离子脂质接触中接触，由此，在接触之前，对阳离子脂质进行加热步骤。本发明还涉及所得组合物及其用途。

7. 发明授权

US6143321A Liposomes containing active agents 有权
标题翻译：含有活性剂的脂质体
公开(公告)号：US6143321A
公开(公告)日：2000-11-07
申请号：US174775
申请日：1998-10-19
申请人： David Needham , Ranjit S. Sarpal
发明人： David Needham , Ranjit S. Sarpal
IPC分类号： A61K9/107 , A61K9/127 , A61K9/133
CPC分类号： A61K9/1271 , A61K9/1075
摘要： Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
摘要翻译：脂质体制剂被设计为使可以由脂质体携带的难溶于水的活性剂的量最大化。描述了在胶束制剂中在脂质体的脂质双层中含有活性剂和/或包埋在脂质体内部空间内的脂质体。提出制备这种脂质体的方法。

8. 发明授权

US6099857A Cell membrane fusion composition and method 失效
标题翻译：细胞膜融合组合物及方法
公开(公告)号：US6099857A
公开(公告)日：2000-08-08
申请号：US92617
申请日：1998-06-05
申请人： Richard W. Gross
发明人： Richard W. Gross
IPC分类号： A61K9/127 , C12N9/02 , A61K9/133
CPC分类号： C12N9/0008 , A61K9/1271
摘要： A lipid vesicle composition for use in delivering a vesicle-encapsulated agent to a target cell is disclosed. The composition is formed of vesicle-forming lipids, including at least 10 mole percent plasmalogen phospholipid with a small-volume polar head group. The composition may also include a fusion protein for promoting fusion of the vesicles to the target cells. A novel fusion protein identified as an isoform of glyceraldehyde-3-phosphate dehydrogenase is also disclosed.
摘要翻译：公开了一种用于将囊泡包封的药物递送至靶细胞的脂质囊泡组合物。该组合物由囊泡形成脂质形成，包括至少10摩尔％的具有小体积极性头基的磷脂酰磷脂。组合物还可以包括用于促进囊泡融合到靶细胞的融合蛋白。还公开了鉴定为甘油醛-3-磷酸脱氢酶同工型的新型融合蛋白。

9. 发明授权

US6096335A Stable particulate complexes having a lamellar, rolled, and condensed structure 失效
标题翻译：具有层状，轧制和冷凝结构的稳定的颗粒复合物
公开(公告)号：US6096335A
公开(公告)日：2000-08-01
申请号：US126402
申请日：1998-07-30
申请人： Alain R. Thierry
发明人： Alain R. Thierry
IPC分类号： C12N15/09 , A61K9/127 , A61K9/133 , A61K31/7105 , A61K31/711 , A61K38/48 , A61K47/18 , A61K47/24 , A61K47/28 , A61K47/48 , A61K48/00 , B32B9/02 , C12N15/88
CPC分类号： A61K48/00 , A61K38/4846 , A61K47/48815 , A61K47/48846 , A61K9/1272 , Y10T428/2984 , Y10T428/2989
摘要： This invention concerns stable particulate complexes with a neutral or negative global charge of lamellar structure made consisting of at least one globally anionic biologically active substance and mixture of a cationic constituent and an anionic constituent. The invention also concerns unilamellar vesicles for preparation of these complexes as well as their preparation and utilisation.
摘要翻译：本发明涉及具有由至少一种全球阴离子生物活性物质和阳离子组分和阴离子组分的混合物组成的层状结构的中性或负性全局电荷的稳定的微粒复合物。本发明还涉及用于制备这些复合物的单层囊泡及其制备和利用。

10. 发明授权

US6030639A Treatment using prostoglandin and particulate formulations 失效
标题翻译：使用前列腺素和颗粒制剂进行治疗
公开(公告)号：US6030639A
公开(公告)日：2000-02-29
申请号：US652259
申请日：1996-05-23
申请人： Andrew S. Janoff , David F. Eierman
发明人： Andrew S. Janoff , David F. Eierman
IPC分类号： A61K9/127 , A61K31/557 , A61K9/133 , A61K9/16
CPC分类号： A61K9/127 , A61K31/557
摘要： Provided herein is a method of administering a free arachidonic acid metabolite to an animal, the method involving administration of the free metabolite and an endocytosable particle. This method can be used to treat animals afflicted with disorders characterized by cell activation and adhesion, inflammation or toxemia. Also provided is a method of treating a animal for such disorders by administration to the animals of a composition containing an anti-disorder effective amount of an endocytosable particle.
摘要翻译：本文提供了向动物施用游离花生四烯酸代谢物的方法，该方法涉及施用游离代谢物和可内吞颗粒。该方法可用于治疗以细胞活化和粘附，炎症或毒血症为特征的疾病。还提供了通过向动物施用含有抗障碍有效量的可内吞颗粒的组合物来治疗动物以治疗这种疾病的方法。

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