专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06781121B1 Time-of-flight mass spectrometer 失效
标题翻译：飞行时间质谱仪
公开(公告)号：US06781121B1
公开(公告)日：2004-08-24
申请号：US09744043
申请日：2001-03-14
申请人： Stephen Charles Davis , Alexander Alekseevich Makarov , Andrew David Hoffman
发明人： Stephen Charles Davis , Alexander Alekseevich Makarov , Andrew David Hoffman
IPC分类号： B01D5944
CPC分类号： H01J49/025 , H01J49/40
摘要： A time-of-flight mass spectrometer, for example, a MALDI-TOF spectrometer, measures the characteristics of the charge to mass ratio of ionized particles by measuring the time taken for the particles to travel a pre-determined distance. The spectrometer comprises an accelerator (14) which accelerates the particles along at least two paths, which may be contained in a single beam of charged particles. Two detectors (26 and 30) mark the ends of the paths and are operable to detect the particles travelling therealong. The length of the path leading to the first detector (26) differs from that of the path leading to the second detector (30) to a sufficient extent to enable the difference in detection times of corresponding particles at the two detectors to be used to provide a measurement of said characteristics. Variations in initial velocities and/or ionization times of the particles will have similar effect on the outputs of both detectors so that one detector can, in effect, be used to calibrate or correct the output of the other detector.
摘要翻译：飞行时间质谱仪，例如MALDI-TOF光谱仪，通过测量颗粒行进预定距离所需的时间来测量电离颗粒的电荷与质量比的特性。光谱仪包括加速器（14），该加速器沿至少两个路径加速颗粒，该路径可以包含在单个带电粒子束中。两个检测器（26和30）标记路径的末端并且可操作以检测沿着其行进的颗粒。通向第一检测器（26）的路径的长度与通向第二检测器（30）的路径的长度不同，足以使得两个检测器处的相应颗粒的检测时间差可用于提供所述特性的测量。颗粒的初始速度和/或电离时间的变化将对两个检测器的输出具有相似的影响，使得实际上可以使用一个检测器来校准或校正另一检测器的输出。

2. 发明授权

US06940066B2 Time of flight mass spectrometer and multiple detector therefor 有权
标题翻译：飞行时间质谱仪和多个检测器
公开(公告)号：US06940066B2
公开(公告)日：2005-09-06
申请号：US10478927
申请日：2002-05-28
申请人： Alexander Alekseevich Makarov , Stephen Charles Davis , Richard Whitney Stresau , Kevin Lionel Hunter , Wayne Leslie Sheils
发明人： Alexander Alekseevich Makarov , Stephen Charles Davis , Richard Whitney Stresau , Kevin Lionel Hunter , Wayne Leslie Sheils
IPC分类号： H01J49/40 , B01D59/44
CPC分类号： H01J49/025 , H01J49/40
摘要： An ion detection arrangement 140 for a time-of-flight (TOF) mass spectrometer 10 includes a beam splitter formed as a mesh 150 at the end of the TOF acceleration and detection chamber 110. Ions enter the detection arrangement through a common entrance window and are then divided by the beam splitter. Those ions striking the mesh 150 generate secondary electrons 160 which are detected by a microchannel plate forming a first detector 170. Those ions passing through the ion beam splitter are detected directly by a second detector 190 also formed from a microchannel plate.The two detectors are each connected to a corresponding data acquisition system 180, 200 and the data obtained by each are combined to generate a mass spectrum. The problems of detector saturation are thus avoided.
摘要翻译：时间飞行（TOF）质谱仪10的离子检测装置140包括在TOF加速和检测室110的端部处形成为网孔150的分束器。离子通过公共入口窗进入检测装置，然后由分束器分开。撞击网格150的那些离子产生二次电子160，其由形成第一检测器170的微通道板检测。通过离子束分离器的那些离子直接由也由微通道板形成的第二检测器190检测。两个检测器各自连接到对应的数据采集系统180,200，并且由每个检测器获得的数据被组合以产生质谱。因此避免了检测器饱和的问题。

3. 发明授权

US09012839B2 Mass spectrometer vacuum interface method and apparatus 有权
标题翻译：质谱仪真空接口方法及仪器
公开(公告)号：US09012839B2
公开(公告)日：2015-04-21
申请号：US14364616
申请日：2012-12-12
申请人： Alexander Alekseevich Makarov , Lothar Rottmann
发明人： Alexander Alekseevich Makarov , Lothar Rottmann
IPC分类号： H01J49/06 , H01J49/04 , H01J49/26
CPC分类号： H01J49/06 , H01J49/0495 , H01J49/067 , H01J49/105 , H01J49/24
摘要： A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture. Within the skimmer apparatus, a portion of the skimmed plasma adjacent the skimmer apparatus is separated from the remainder of the skimmed plasma by providing means to prevent, inhibit or impede, the separated portion from reaching the extraction optics while allowing the remainder to expand towards the extraction optics. This allows removal of ions liberated from deposition matter on the skimmer apparatus surface, thereby discriminating against such ions, and offering reduced memory effects. The remainder of the plasma can expand towards the extraction optics, so interaction and mixing between the boundary layer and the remainder of the plasma can be reduced or minimized.
摘要翻译：一种操作质谱仪真空界面的方法，其包括具有撇渣器孔径和下游离子提取光学器件的分离器装置。一个膨胀的等离子体通过撇渣器孔径被撇去。在撇渣器装置内，通过提供用于防止，抑制或妨碍分离的部分到达提取光学器件的装置将与分离器装置相邻的脱脂等离子体的一部分与剩余的等离子体分离，同时允许其余部分向着提取光学。这允许从分离器装置表面上的沉积物质释放的离子去除，从而区分这些离子，并提供减少的记忆效应。等离子体的其余部分可以朝向提取光学器件扩展，因此边界层和等离子体的其余部分之间的相互作用和混合可以被减小或最小化。

4. 发明授权

US07759638B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07759638B2
公开(公告)日：2010-07-20
申请号：US11909855
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/004 , H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包含反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

5. 发明申请

US20090179150A1 MASS SPECTROMETER WITH LOOPED ION PATH 有权
标题翻译：带循环离子通道的质谱仪
公开(公告)号：US20090179150A1
公开(公告)日：2009-07-16
申请号：US12013352
申请日：2008-01-11
申请人： Viatcheslav V. Kovtoun , Alexander Alekseevich Makarov
发明人： Viatcheslav V. Kovtoun , Alexander Alekseevich Makarov
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , H01J49/062
摘要： A mass spectrometer includes at least one ion selector, at least one collision cell, and an ion path switching device arranged to define a looped ion path around which ions derived from a sample may be sent multiple times (without reversal of ion travel) in order to effect a desired number of isolation/fragmentation cycles for MSn analysis. When the desired number of isolation/fragmentation cycles have been completed, the ion path switching device directs the ions to a detector or a separate mass analyzer for acquisition of a mass spectrum.
摘要翻译：质谱仪包括至少一个离子选择器，至少一个碰撞池和离子路径切换装置，该离子路径切换装置被设置成限定循环的离子路径，围绕该离子路径从样品衍生的离子可以顺次多次发射（不反转离子行程）以实现MSn分析所需数量的分离/分段循环。当所需数量的隔离/破碎循环已经完成时，离子路径切换装置将离子引导到检测器或用于采集质谱的单独的质量分析器。

6. 发明申请

US20080224033A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20080224033A1
公开(公告)日：2008-09-18
申请号：US11909855
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/40 , B01D59/44
CPC分类号： H01J49/004 , H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包含反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

7. 发明授权

US08153963B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US08153963B2
公开(公告)日：2012-04-10
申请号：US12796580
申请日：2010-06-08
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包含反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

8. 发明授权

US08030613B2 RF power supply for a mass spectrometer 有权
标题翻译：用于质谱仪的RF电源
公开(公告)号：US08030613B2
公开(公告)日：2011-10-04
申请号：US12356973
申请日：2009-01-21
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Alexander Kholomeev
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Alexander Kholomeev
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/36 , H01J49/423 , H01J49/427
摘要： The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.
摘要翻译：本发明提供质谱仪中的射频（RF）电源。电源向存储设备的电极提供RF信号以产生捕获场。射频场通常在离子喷射之前倒塌。在说明性实施例中，RF电源包括RF信号电源; 布置成接收由RF信号电源提供的信号并提供用于向离子存储装置的电极供应的输出RF信号的线圈; 以及分流器，其包括可操作以在第一打开位置和第二关闭位置之间切换的开关，其中分流器使线圈输出短路。

9. 发明申请

US20100051799A1 MULTI-CHANNEL DETECTION 有权
标题翻译：多通道检测
公开(公告)号：US20100051799A1
公开(公告)日：2010-03-04
申请号：US12444838
申请日：2007-10-17
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/26
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has travelled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出来调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

10. 发明申请

US20140339418A1 Mass Spectrometer Vacuum Interface Method and Apparatus 有权
标题翻译：质谱仪真空界面方法及仪器
公开(公告)号：US20140339418A1
公开(公告)日：2014-11-20
申请号：US14364616
申请日：2012-12-12
申请人： Alexander Alekseevich Makarov , Lothar Rottmann
发明人： Alexander Alekseevich Makarov , Lothar Rottmann
IPC分类号： H01J49/06 , H01J49/04
CPC分类号： H01J49/06 , H01J49/0495 , H01J49/067 , H01J49/105 , H01J49/24
摘要： A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture. Within the skimmer apparatus, a portion of the skimmed plasma adjacent the skimmer apparatus is separated from the remainder of the skimmed plasma by providing means to prevent, inhibit or impede, the separated portion from reaching the extraction optics while allowing the remainder to expand towards the extraction optics. This allows removal of ions liberated from deposition matter on the skimmer apparatus surface, thereby discriminating against such ions, and offering reduced memory effects. The remainder of the plasma can expand towards the extraction optics, so interaction and mixing between the boundary layer and the remainder of the plasma can be reduced or minimized.
摘要翻译：一种操作质谱仪真空界面的方法，其包括具有撇渣器孔径和下游离子提取光学器件的分离器装置。一个膨胀的等离子体通过撇渣器孔径被撇去。在撇渣器装置内，通过提供用于防止，抑制或妨碍分离的部分到达提取光学器件的装置将与分离器装置相邻的脱脂等离子体的一部分与剩余的等离子体分离，同时允许其余部分向着提取光学。这允许从分离器装置表面上的沉积物质释放的离子去除，从而区分这些离子，并提供减少的记忆效应。等离子体的其余部分可以朝向提取光学器件扩展，因此边界层和等离子体的其余部分之间的相互作用和混合可以被减小或最小化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式