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1. 发明授权

US06781121B1 Time-of-flight mass spectrometer 失效
标题翻译：飞行时间质谱仪
公开(公告)号：US06781121B1
公开(公告)日：2004-08-24
申请号：US09744043
申请日：2001-03-14
申请人： Stephen Charles Davis , Alexander Alekseevich Makarov , Andrew David Hoffman
发明人： Stephen Charles Davis , Alexander Alekseevich Makarov , Andrew David Hoffman
IPC分类号： B01D5944
CPC分类号： H01J49/025 , H01J49/40
摘要： A time-of-flight mass spectrometer, for example, a MALDI-TOF spectrometer, measures the characteristics of the charge to mass ratio of ionized particles by measuring the time taken for the particles to travel a pre-determined distance. The spectrometer comprises an accelerator (14) which accelerates the particles along at least two paths, which may be contained in a single beam of charged particles. Two detectors (26 and 30) mark the ends of the paths and are operable to detect the particles travelling therealong. The length of the path leading to the first detector (26) differs from that of the path leading to the second detector (30) to a sufficient extent to enable the difference in detection times of corresponding particles at the two detectors to be used to provide a measurement of said characteristics. Variations in initial velocities and/or ionization times of the particles will have similar effect on the outputs of both detectors so that one detector can, in effect, be used to calibrate or correct the output of the other detector.
摘要翻译：飞行时间质谱仪，例如MALDI-TOF光谱仪，通过测量颗粒行进预定距离所需的时间来测量电离颗粒的电荷与质量比的特性。光谱仪包括加速器（14），该加速器沿至少两个路径加速颗粒，该路径可以包含在单个带电粒子束中。两个检测器（26和30）标记路径的末端并且可操作以检测沿着其行进的颗粒。通向第一检测器（26）的路径的长度与通向第二检测器（30）的路径的长度不同，足以使得两个检测器处的相应颗粒的检测时间差可用于提供所述特性的测量。颗粒的初始速度和/或电离时间的变化将对两个检测器的输出具有相似的影响，使得实际上可以使用一个检测器来校准或校正另一检测器的输出。

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