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1. 发明申请

US20060105963A1 Therapeutic agents for inhibiting and/or treating vaginal infection 失效
标题翻译：用于抑制和/或治疗阴道感染的治疗剂
公开(公告)号：US20060105963A1
公开(公告)日：2006-05-18
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K31/70 , A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译：提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），假丝酵母（例如白色假丝酵母）和/或毛滴虫（例如阴道毛滴虫）病原体。理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。在一个具体实施方案中，D-木糖醇用作治疗剂。

2. 发明申请

US20070026074A1 Vaginal treatment composition 有权
标题翻译：阴道治疗组合物
公开(公告)号：US20070026074A1
公开(公告)日：2007-02-01
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K9/14 , A61K31/70 , A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子提供阴道粘膜。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

3. 发明申请

US20070100304A1 Absorbent articles with improved odor control 有权
标题翻译：具有改善气味控制的吸收制品
公开(公告)号：US20070100304A1
公开(公告)日：2007-05-03
申请号：US11263598
申请日：2005-10-31
申请人： David Fell , Megan Lan , William Georger , Kelly Arehart , Bao Do , Stephanie Martin
发明人： David Fell , Megan Lan , William Georger , Kelly Arehart , Bao Do , Stephanie Martin
IPC分类号： A61F13/15
CPC分类号： A61L15/46 , A61F13/15658 , A61F13/53 , A61F13/8405 , A61F2013/15943 , A61F2013/530489 , A61F2013/530671 , A61F2013/8408 , A61F2013/8426 , A61F2013/8435 , A61F2013/8447 , A61F2013/8461 , A61L9/014 , A61L15/18 , A61L2300/10 , A61L2300/216 , A61L2300/606 , Y10T156/1084 , Y10T442/2525
摘要： A technique for incorporating odor control agent particles into an absorbent article is provided. More specifically, the odor control particles are “homogenously” distributed (e.g., in a substantially uniform manner) within an airformed fiber matrix of an absorbent core of an absorbent article. An absorbent core containing such a homogeneously distributed odor control particles may possess a greater surface area for contacting malodorous compounds, thereby increasing the likelihood of odor reduction.
摘要翻译：提供了将气味控制剂颗粒结合到吸收制品中的技术。更具体地，气味控制颗粒在吸收制品的吸收芯的气流形成的纤维基质内“均匀地”分布（例如基本均匀的方式）。含有这种均匀分布的气味控制颗粒的吸收芯可以具有更大的用于接触恶臭化合物的表面积，从而增加气味降低的可能性。

4. 发明申请

US20060134613A1 Detection of microbe contamination on elastomeric articles 有权
标题翻译：检测弹性制品上的微生物污染
公开(公告)号：US20060134613A1
公开(公告)日：2006-06-22
申请号：US11117635
申请日：2005-04-28
申请人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
发明人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
IPC分类号： C12Q1/70 , C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , G01N33/528
摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
摘要翻译：提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。

5. 发明申请

US20080145316A1 Skin coating with microbial indicator 审中-公开
标题翻译：皮肤涂层微生物指示剂
公开(公告)号：US20080145316A1
公开(公告)日：2008-06-19
申请号：US11639833
申请日：2006-12-14
申请人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
发明人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04 , C12Q1/70
CPC分类号： A61L26/0061 , A61L24/001
摘要： Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
摘要翻译：皮肤密封剂通常用于皮肤制服上以密封皮肤，并且在手术切口之前将任何残留的细菌保持在适当位置。这种密封剂通常在手术后留在皮肤上。提供皮肤涂层，其具有指示剂，其在与微生物或微生物副产物接触时产生可见的颜色变化，因此提供感染的早期预警。该涂层是可固化的涂料组合物，其也可以不使用皮肤制剂使用，并且可以用于保护皮肤中的其它中断，例如伤口，瘀伤，擦伤，烧伤，痤疮，水疱，叮咬，叮咬，刺穿和切口。它还可以用于闭合伤口或提供对皮肤其他部分（例如指甲和粘膜）的额外屏障。

6. 发明申请

US20060134728A1 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20060134728A1
公开(公告)日：2006-06-22
申请号：US11117651
申请日：2005-04-28
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/06 , C12Q1/04 , Y10T442/2566
摘要： A method for semi-quantitatively or quantitatively detecting the presence of a microbe in a sample is provided. The method utilizes a test dye that undergoes a detectable color change in the presence of one or more microbes. For example, in one embodiment, the test dye is a solvatochromic dye (e.g., Reichardt's dye) that responds to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth. Regardless, the color of the test dye may be compared to the color of a control dye, wherein the color of the control dye corresponds to a known microbe concentration.
摘要翻译：提供了一种半定量或定量检测样品中微生物存在的方法。该方法利用在一种或多种微生物存在下经历可检测的颜色变化的测试染料。例如，在一个实施方案中，测试染料是响应于微生物组分（例如细胞膜，细胞质等）与细胞外的环境的极性差异的溶剂化色素染料（例如，Reichardt's染料）。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。无论如何，可以将测试染料的颜色与对照染料的颜色进行比较，其中对照染料的颜色对应于已知的微生物浓度。

7. 发明申请

US20070048503A1 Solvatochromic visual indicator and the use of the same 有权
标题翻译：溶色变色视觉指示剂和使用相同
公开(公告)号：US20070048503A1
公开(公告)日：2007-03-01
申请号：US11216731
申请日：2005-08-31
申请人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
发明人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
IPC分类号： B41M5/00
CPC分类号： A61F13/42 , Y10S428/913 , Y10T428/24802 , Y10T428/24868
摘要： A graphic and/or message display system is described. The graphic and/or message display system functions to develop over a period of time a hidden graphic or message on an indicator panel or display area. The hidden graphic or message is revealed when an obscuring graphic reacts with a solvent to change color become at least substantially transparent. The graphic and/or message display system may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as a positive reinforcement or a reminder to perform a task. Methods for using the graphic and/or message display system are also described.
摘要翻译：描述图形和/或消息显示系统。图形和/或消息显示系统用于在一段时间内在指示器面板或显示区域上开发隐藏的图形或消息。隐藏的图形或消息被揭示，当模糊的图形与溶剂反应以改变颜色变得至少基本上是透明的。图形和/或消息显示系统可以用作独立设备，或者可以作为各种物品或产品的一部分而被并入，例如作为正的强化或提醒来执行任务。还描述了使用图形和/或消息显示系统的方法。

8. 发明申请

US20080057532A1 Method for detecting Candida on skin 有权
标题翻译：检测皮肤上假丝酵母的方法
公开(公告)号：US20080057532A1
公开(公告)日：2008-03-06
申请号：US11513500
申请日：2006-08-31
申请人： Stephanie Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
发明人： Stephanie Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
IPC分类号： C12Q1/04
CPC分类号： A61L15/56 , G01N2333/245 , G01N2333/31 , G01N2333/40
摘要： A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
摘要翻译：提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统，例如具有尿布疹的婴儿。该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应（例如颜色变化）的着色剂接触。例如，着色剂可以从第一颜色变为第二颜色，从无色到颜色，或从颜色变为无色。着色剂通常能够区分假丝酵母（例如白色念珠菌）和通常与尿布疹相关的其它微生物，例如金黄色葡萄球菌和大肠杆菌。因此，当真皮样品与着色剂接触时，可以简单地观察颜色变化以确定感染是否由念珠菌引起。如果颜色变化发生一定程度（例如，从黄色到鲜红色），则可以确定测试样品含有念珠菌。同样地，如果在较小程度上发生颜色变化（例如，从黄色到微弱橙色），或根本不发生变色，则可以确定真皮样品含有其他微生物（例如金黄色葡萄球菌或大肠杆菌），无感染存在，或感染仅仅是由于其他原因。无论是否需要对念珠菌的治疗，将变得显而易见。

9. 发明申请

US20070249958A1 Method for detecting the onset of ovulation 有权
标题翻译：检测排卵发作的方法
公开(公告)号：US20070249958A1
公开(公告)日：2007-10-25
申请号：US11408154
申请日：2006-04-20
申请人： Stephanie Martin , RameshBabu Boga , John MacDonald
发明人： Stephanie Martin , RameshBabu Boga , John MacDonald
IPC分类号： A61B10/00
CPC分类号： A61B10/0012 , A61B2010/0006 , A61B2010/0087 , A61D17/002 , G01N31/223 , Y10T436/18 , Y10T436/182 , Y10T436/25875
摘要： A method for detecting the onset of ovulation in a female mammal is provided. The method comprises contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.
摘要翻译：提供了一种用于检测雌性哺乳动物排卵发作的方法。该方法包括使一种或多种挥发性硫化合物存在下有效地经历快速和可检测的颜色变化的量使该雌性哺乳动物的口腔空气与芳基甲烷测试的色原体接触。将测试色原体的颜色与对应于排卵前的硫含量的对照颜色进行比较。测试色原体和对照色之间的颜色差异与排卵的发生相关。

10. 发明申请

US20070048247A1 Deodorizing tablets 审中-公开
标题翻译：除臭片
公开(公告)号：US20070048247A1
公开(公告)日：2007-03-01
申请号：US11217098
申请日：2005-08-31
申请人： Stephanie Martin , John MacDonald , Jaeho Kim
发明人： Stephanie Martin , John MacDonald , Jaeho Kim
IPC分类号： A61K31/12 , A61L9/00
CPC分类号： A61L9/01
摘要： A tablet that is capable of reducing odor when added to a liquid is provided. The deodorizing tablet may be used in a wide variety of applications in which odor control is desired, such as in toilets, water treatment/sewage systems, well water, bedpans, and so forth. In addition to providing odor control, the tablet is generally soluble in the liquid so that its components are better able to contact malodorous compounds contained within the liquid. In this regard, the present inventors have discovered that certain quinone compounds are both odor inhibiting and also soluble in liquids (e.g., urine), and thus particularly useful in forming the deodorizing tablet of the present invention.
摘要翻译：提供了当添加到液体中时能够减少气味的片剂。除臭片剂可用于需要气味控制的各种应用中，例如在厕所，水处理/污水系统，井水，卧床等中。除了提供气味控制之外，片剂通常可溶于液体，使得其组分更好地接触包含在液体中的恶臭化合物。在这方面，本发明人已经发现某些醌化合物既气味抑制又可溶于液体（例如尿液），因此特别可用于形成本发明的除臭片剂。

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