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1. 发明申请

US20070026074A1 Vaginal treatment composition 有权
标题翻译：阴道治疗组合物
公开(公告)号：US20070026074A1
公开(公告)日：2007-02-01
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K9/14 , A61K31/70 , A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子提供阴道粘膜。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

2. 发明申请

US20060105963A1 Therapeutic agents for inhibiting and/or treating vaginal infection 失效
标题翻译：用于抑制和/或治疗阴道感染的治疗剂
公开(公告)号：US20060105963A1
公开(公告)日：2006-05-18
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K31/70 , A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译：提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），假丝酵母（例如白色假丝酵母）和/或毛滴虫（例如阴道毛滴虫）病原体。理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。在一个具体实施方案中，D-木糖醇用作治疗剂。

3. 发明授权

US07786176B2 Vaginal treatment composition containing xylitol 有权
标题翻译：含有木糖醇的阴道治疗组合物
公开(公告)号：US07786176B2
公开(公告)日：2010-08-31
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

4. 发明授权

US07619008B2 Xylitol for treatment of vaginal infections 失效
标题翻译：木糖醇用于治疗阴道感染
公开(公告)号：US07619008B2
公开(公告)日：2009-11-17
申请号：US11194039
申请日：2005-07-29
申请人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Shu-Ping Yang , Lei Huang , Stephanie M. Martin , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K31/7004 , A61K9/0034 , A61K31/047
摘要： A vaginal treatment composition that employs a therapeutic agent to inhibit and/or treat vaginal infection is provided. The therapeutic agent is capable of inhibiting and/or killing Gardnerella (e.g., Gardnerella vaginalis), Candida (e.g., Candida albicans), and/or Trichomonas (e.g., Trichomonas vaginalis) pathogens. Desirably, such antimicrobial efficacy is achieved without substantially inhibiting the growth of Lactobacillus acidophilus. For instance, sugars and/or sugar alcohols may be employed in the present invention as a therapeutic agent for inhibiting and/or treating vaginal infection. In one particular embodiment, D-xylitol is used as the therapeutic agent.
摘要翻译：提供了使用治疗剂抑制和/或治疗阴道感染的阴道治疗组合物。治疗剂能够抑制和/或杀死加德纳（Gardnerella vaginalis），念珠菌（例如白色念珠菌）和/或滴虫（例如阴道毛滴虫）病原体。理想地，实现了这样的抗微生物效能，而基本上不抑制嗜酸乳杆菌的生长。例如，本发明中可以使用糖和/或糖醇作为抑制和/或治疗阴道感染的治疗剂。在一个具体实施方案中，D-木糖醇用作治疗剂。

5. 发明申请

US20070134337A1 Bacteria binding products 审中-公开
标题翻译：细菌结合产品
公开(公告)号：US20070134337A1
公开(公告)日：2007-06-14
申请号：US10583423
申请日：2004-12-22
申请人： Julie Villanueva , Curtis Sayre , Lei Huang , Kevin McGrath , Ning Wei
发明人： Julie Villanueva , Curtis Sayre , Lei Huang , Kevin McGrath , Ning Wei
IPC分类号： A61K9/14 , C12Q1/18 , B32B5/02
CPC分类号： D06M11/45 , A61L2/02 , A61L2/232 , D01F1/103 , D06M11/79 , D06M15/55 , D06M15/61 , D06M23/08 , Y10T442/2525
摘要： There is provided products for the removal of negatively charged particles like bacteria from surfaces. The products have a positive charge that may be developed through the use of cationic treatments. The product or substrate from which it is made may be dipped in an aqueous solution of a non-antimicrobial treatment having a positive charge and the excess solution squeezed out. Treatment of the resulting coated substrate with heat at a temperature and for a time sufficient adheres the coating to the substrate. Alternatively, a non-antimicrobial, cationically charged chemical may be imbedded in a substrate web such that it will bloom to the surface when the web is exposed to water. A suitable substrate web may be a pulp and synthetic fiber fabric made by coforming or hydroengling and may be a laminate including other layers. The treated substrate and product remove a substantial amount of the bacteria from a surface yet do not appreciably kill the bacteria. Harsh, oxidizing, chemicals are not used in the preparation of the products and so the products are mild in their effect on the user's skin. The removal of the bacteria, in contrast to killing the bacteria, does not encourage the bacteria to develop immunity to the treatment.
摘要翻译：提供了从表面除去带负电荷的颗粒如细菌的产品。这些产品具有通过使用阳离子处理可以开发的正电荷。可以将其制成的产品或基材浸渍在具有正电荷且过量溶液挤出的非抗微生物处理的水溶液中。在一段温度和一段时间内用热量处理所得的涂覆的基材足以将涂层粘附到基材上。或者，非抗微生物的带阳离子电荷的化学品可以嵌入在基材网中，使得当幅材暴露于水时，其将开花到表面。合适的基材纤维网可以是通过共成型或水化加工制成的纸浆和合成纤维织物，并且可以是包括其它层的层压体。经处理的底物和产物从表面除去大量的细菌，但不会明显杀死细菌。苛刻，氧化，化学品不用于制备产品，因此产品对用户皮肤的影响温和。与杀死细菌相反，细菌的去除不会鼓励细菌发挥对治疗的免疫力。

6. 发明申请

US20050137540A1 Bacteria removing wipe 审中-公开
标题翻译：细菌去除擦拭
公开(公告)号：US20050137540A1
公开(公告)日：2005-06-23
申请号：US10745266
申请日：2003-12-23
申请人： Julie Villanueva , Curtis Sayre , Lei Huang , Kevin McGrath , Ning Wei
发明人： Julie Villanueva , Curtis Sayre , Lei Huang , Kevin McGrath , Ning Wei
IPC分类号： A61L2/02 , A61L2/232 , D01F1/10 , D06M11/45 , D06M11/79 , D06M15/55 , D06M15/61 , D06M23/08 , A61F13/15
CPC分类号： D06M11/45 , A61L2/02 , A61L2/232 , D01F1/103 , D06M11/79 , D06M15/55 , D06M15/61 , D06M23/08 , Y10T442/2525
摘要： There is provided a wipe for the removal of bacteria from surfaces. The wipe has a positive charge that may be developed through the use of cationic treatments. The wipe may be dipped in an aqueous solution of a non-antimicrobial treatment having a positive charge and the excess solution squeezed out of the wipe. Treatment of the resulting coated wipe with heat at a temperature and for a time sufficient adheres the coating to the wipe. Alternatively, a non-antimicrobial, cationically charged chemical may be imbedded in the web such that it will bloom to the surface when the wipe is exposed to water. The web is desirably a pulp and synthetic fiber fabric made by coforming or hydroengling and may be a laminate including other layers. The treated web removes a substantial amount of the bacteria from a surface yet does not appreciably inhibit the growth of the bacteria. The web does not contain harsh chemicals and so is mild in its effect on the user's skin. The removal of the bacteria in contrast to killing the bacteria does not encourage it to develop immunity to the treatment.
摘要翻译：提供了从表面去除细菌的擦拭物。擦拭具有通过使用阳离子处理可以开发的正电荷。擦拭物可以浸渍在具有正电荷的非抗微生物处理的水溶液中，并且将过量的溶液从擦拭物中挤出。在一段温度和一段时间内用热量处理所得到的涂布擦拭物将涂层粘附到擦拭物上。或者，非抗微生物的带阳离子电荷的化学品可以嵌入在幅材中，使得当擦拭物暴露于水时，其将暴露于表面。纤维网理想地是通过共成型或水化加工而制成的纸浆和合成纤维织物，并且可以是包括其它层的层压体。经处理的纤维网从表面除去大量的细菌，但不明显地抑制细菌的生长。网不含刺激性化学物质，因此对使用者皮肤的影响温和。与杀死细菌相反的细菌的去除并不鼓励它发展出治疗的免疫力。

7. 发明授权

US07935538B2 Indicator immobilization on assay devices 有权
标题翻译：指示剂固定在测定装置上
公开(公告)号：US07935538B2
公开(公告)日：2011-05-03
申请号：US11640100
申请日：2006-12-15
申请人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
发明人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N21/78 , G01N33/558 , Y10S435/97 , Y10S436/81
摘要： A lateral flow assay device for detecting the presence or quantity of an analyte in a test sample is provided. The device comprises a chromatographic medium that defines a detection zone, wherein a crosslinked network is non-diffusively immobilized within the detection zone. The crosslinked network contains a small molecule indicator that is configured to undergo a detectable color change in the presence of the analyte.
摘要翻译：提供了用于检测测试样品中分析物的存在或数量的侧流测定装置。该装置包括限定检测区的色谱介质，其中交联网络非扩散地固定在检测区内。交联网络包含小分子指示剂，其被配置为在分析物存在下经历可检测的颜色变化。

8. 发明申请

US20070141130A1 Wound or surgical dressing 有权
标题翻译：伤口或手术敷料
公开(公告)号：US20070141130A1
公开(公告)日：2007-06-21
申请号：US11303011
申请日：2005-12-15
申请人： Julie Villanueva , Curtis Sayre
发明人： Julie Villanueva , Curtis Sayre
IPC分类号： A61L15/00 , A61K33/06
CPC分类号： A61L15/46 , A61L2300/102 , A61L2300/404 , A61L2300/80
摘要： A wound or surgical dressing is disclosed. The wound or surgical dressing is configured to cover or surround a wound, a surgical incision, or any type of skin irritation. In accordance with the present disclosure, the wound or surgical dressing is treated with a bacteriostatic composition that is capable of binding and trapping negatively charged matter, such as bacteria, pathogens, and the like. The bacteriostatic composition comprises a cationic polymer, a cationic oligomer, or particles coated with a cationic material. The bacteriostatic composition is bonded to the wound or surgical dressing in a manner such that the bacteriostatic composition is not substantially transferred to a patient being treated.
摘要翻译：披露伤口或手术敷料。伤口或手术敷料构造成覆盖或围绕伤口，手术切口或任何类型的皮肤刺激。根据本公开，伤口或外科敷料用能够结合并捕获带负电荷的物质如细菌，病原体等的抑菌组合物进行处理。抑菌组合物包含阳离子聚合物，阳离子低聚物或涂覆有阳离子材料的颗粒。抑菌组合物以使得抑菌组合物基本上不被转移到被治疗的患者的方式结合到伤口或外科敷料上。

9. 发明申请

US20050244402A1 Absorption of pain-causing agents 审中-公开
标题翻译：吸收致痛剂
公开(公告)号：US20050244402A1
公开(公告)日：2005-11-03
申请号：US10835886
申请日：2004-04-30
申请人： Julie Villanueva , Curtis Sayre , Robert Lyng
发明人： Julie Villanueva , Curtis Sayre , Robert Lyng
IPC分类号： A61F13/20 , A61K9/00 , A61L15/16 , A61L15/44 , A61L31/16 , A61K39/395
CPC分类号： A61K9/0036 , A61F13/2051 , A61F13/8405 , A61K31/785 , A61K47/34
摘要： There is provided a pain relieving substance made of an eicosanoid-absorbent substance and a carrier. The eicosanoid-absorbent substance may be an eicosanoid enzyme, antibody and/or acid moiety binder. The eicosanoids may be prostaglantins, thromboxanes, leukotrienes, lipoxins and hydroxyl and hydroperoxy fatty acids and mixtures thereof. The eicosanoid-absorbent substance may be delivered in a liquid carrier such as a gel or lotion or may be delivered by a solid carrier such as a tampon, sponge, etc.
摘要翻译：提供了由类花生酸吸收物质和载体制成的止痛物质。类花生酸吸收物质可以是类花生酸酶，抗体和/或酸部分粘合剂。类花生酸可以是前列腺素，血栓素，白细胞三烯，脂氧素和羟基和氢过氧脂肪酸及其混合物。类花生酸吸收物质可以在诸如凝胶或洗剂之类的液体载体中递送，或者可以通过固体载体如棉塞，海棉等递送。

10. 发明申请

US20080145949A1 Indicator immobilization on assay devices 有权
标题翻译：指示剂固定在测定装置上
公开(公告)号：US20080145949A1
公开(公告)日：2008-06-19
申请号：US11640100
申请日：2006-12-15
申请人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
发明人： Xuedong Song , Curtis Sayre , Shawn R. Feaster , Julie Villanueva
IPC分类号： G01N21/75 , G01N21/01
CPC分类号： G01N33/54393 , G01N21/78 , G01N33/558 , Y10S435/97 , Y10S436/81
摘要： A lateral flow assay device for detecting the presence or quantity of an analyte in a test sample is provided. The device comprises a chromatographic medium that defines a detection zone, wherein a crosslinked network is non-diffusively immobilized within the detection zone. The crosslinked network contains a small molecule indicator that is configured to undergo a detectable color change in the presence of the analyte.
摘要翻译：提供了用于检测测试样品中分析物的存在或数量的侧流测定装置。该装置包括限定检测区的色谱介质，其中交联网络非扩散地固定在检测区内。交联网络包含小分子指示剂，其被配置为在分析物存在下经历可检测的颜色变化。

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