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1. 发明授权

US07217794B2 Compounds and methods for treatment of thrombosis 有权
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：US07217794B2
公开(公告)日：2007-05-15
申请号：US10817248
申请日：2004-04-02
申请人： Sherin S. Abdel-Meguid , Robert E. Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott R. Magee , Harold V. Meyers , Pramod Pandey , Michael J. Rynkiewicz , David T. Weaver , Zihong Gho , Thomas D. Bannister
发明人： Sherin S. Abdel-Meguid , Robert E. Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott R. Magee , Harold V. Meyers , Pramod Pandey , Michael J. Rynkiewicz , David T. Weaver , Zihong Gho , Thomas D. Bannister
IPC分类号： C07K14/745 , C07K1/00 , C07K14/00
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.
摘要翻译：本发明提供了通过向哺乳动物施用本发明的化合物来抑制因子XIa的化合物和预防或治疗不期望的血栓形成的方法。本发明还提供了因子XIa的三维结构以及使用这些结构设计或选择另外的因子XIa抑制剂的方法。

2. 发明申请

US20080146811A1 Compounds and Methods For Treatment of Thrombosis 审中-公开
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：US20080146811A1
公开(公告)日：2008-06-19
申请号：US11658121
申请日：2005-07-22
申请人： Hongfeng Deng , Jian Lin , Zihong Guo , Harold V. Meyers , Sherin S. Abdel-Meguid , Robert E. Babine
发明人： Hongfeng Deng , Jian Lin , Zihong Guo , Harold V. Meyers , Sherin S. Abdel-Meguid , Robert E. Babine
IPC分类号： C07D401/12 , C07D209/14
CPC分类号： C07D471/04 , C07D209/42 , C07D401/14 , C07D405/12
摘要： The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.
摘要翻译：本发明提供了用于治疗血栓栓塞障碍的化合物，药物组合物和方法，例如动脉血管栓塞性疾病，静脉心血管血栓栓塞障碍或心脏腔室中的血栓栓塞性疾病。

3. 发明申请

US20050143317A1 Compounds and methods for treatment of thrombosis 有权
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：US20050143317A1
公开(公告)日：2005-06-30
申请号：US10817248
申请日：2004-04-02
申请人： Sherin Abdel-Meguid , Robert Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott Magee , Harold Meyers , Pramod Pandey , Michael Rynkiewicz , David Weaver , Zihong Gho , Thomas Bannister
发明人： Sherin Abdel-Meguid , Robert Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott Magee , Harold Meyers , Pramod Pandey , Michael Rynkiewicz , David Weaver , Zihong Gho , Thomas Bannister
IPC分类号： A61K20060101 , A61K38/00 , A61K38/04 , C07K2/00 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/078
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.
摘要翻译：本发明提供了通过向哺乳动物施用本发明的化合物来抑制因子XIa的化合物和预防或治疗不期望的血栓形成的方法。本发明还提供了因子XIa的三维结构以及使用这些结构设计或选择另外的因子XIa抑制剂的方法。

4. 发明申请

US20090143351A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20090143351A1
公开(公告)日：2009-06-04
申请号：US12359490
申请日：2009-01-26
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D401/06 , C07D205/08 , A61P7/00 , C07D401/04 , A61K31/4427
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

5. 发明申请

US20100144698A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20100144698A1
公开(公告)日：2010-06-10
申请号：US12703610
申请日：2010-02-10
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D205/04 , A61P9/00 , A61P7/00
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

6. 发明授权

US07501404B2 Substituted azetidinones 有权
标题翻译：取代的氮杂环丁酮
公开(公告)号：US07501404B2
公开(公告)日：2009-03-10
申请号：US11398438
申请日：2006-04-04
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： C07D205/08 , C07D205/085 , C07D401/14 , C07D401/12 , C07D401/06 , C07D403/12 , C07D403/14 , C07D403/04 , A61K31/397 , A61K31/506 , A61K31/4427 , A61K31/41
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

7. 发明申请

US20070105832A1 Substituted azetidinones 有权
标题翻译：取代的氮杂环丁酮
公开(公告)号：US20070105832A1
公开(公告)日：2007-05-10
申请号：US11398438
申请日：2006-04-04
申请人： Thomas Bannister , Cassandra Celatka , Nizal Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael Rynkiewicz , Kerry Spear , James Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael Rynkiewicz , Kerry Spear , James Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D205/08
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

8. 发明授权

US09455094B2 Graphene-carbon nanotube hybrid materials and use as electrodes 有权
标题翻译：石墨烯碳纳米管混合材料，用作电极
公开(公告)号：US09455094B2
公开(公告)日：2016-09-27
申请号：US14358864
申请日：2012-11-19
申请人： James M. Tour , Yu Zhu , Lei Li , Zheng Yan , Jian Lin
发明人： James M. Tour , Yu Zhu , Lei Li , Zheng Yan , Jian Lin
IPC分类号： H01G11/36 , C01B31/04 , C01B31/02 , H01G11/72 , B82Y30/00 , B82Y40/00
CPC分类号： H01G11/36 , B82Y30/00 , B82Y40/00 , C01B32/158 , C01B32/16 , C01B32/182 , C01B32/194 , H01G11/72 , Y02E60/13 , Y10T428/24893 , Y10T428/30
摘要： Provided are methods of making graphene-carbon nanotube hybrid materials. Such methods generally include: (1) associating a graphene film with a substrate; (2) applying a catalyst and a carbon source to the graphene film; and (3) growing carbon nanotubes on the graphene film. The grown carbon nanotubes become covalently linked to the graphene film through carbon-carbon bonds that are located at one or more junctions between the carbon nanotubes and the graphene film. In addition, the grown carbon nanotubes are in ohmic contact with the graphene film through the carbon-carbon bonds at the one or more junctions. The one or more junctions may include seven-membered carbon rings. Also provided are the formed graphene-carbon nanotube hybrid materials.
摘要翻译：提供制造石墨烯 - 碳纳米管混合材料的方法。这些方法通常包括：（1）将石墨烯膜与基底缔合; （2）向石墨烯膜施加催化剂和碳源; 和（3）在石墨烯膜上生长碳纳米管。生长的碳纳米管通过位于碳纳米管和石墨烯膜之间的一个或多个结处的碳 - 碳键共价连接到石墨烯膜上。此外，生长的碳纳米管通过在一个或多个结处的碳 - 碳键与石墨烯膜欧姆接触。一个或多个连接点可以包括七元碳环。还提供了形成的石墨烯 - 碳纳米管混合材料。

9. 发明申请

US20160054390A1 TECHNIQUES FOR ROBUST BATTERY STATE ESTIMATION 审中-公开
标题翻译：用于稳健电池状态估计的技术
公开(公告)号：US20160054390A1
公开(公告)日：2016-02-25
申请号：US14463016
申请日：2014-08-19
申请人： Jian Lin , Hong Yang , Pawel Malysz , Jin Ye , Ran Gu , Ali Emadi
发明人： Jian Lin , Hong Yang , Pawel Malysz , Jin Ye , Ran Gu , Ali Emadi
IPC分类号： G01R31/36
CPC分类号： G01R31/367 , B60L58/10 , G01R31/3842 , G01R31/392 , Y02T10/7005 , Y02T10/705
摘要： More accurate and robust battery state estimation (BSE) techniques for a battery system of an electrified vehicle include estimating a current bias or offset generated by a current sensor and then adjusting the measured current to compensate for the estimated current bias. The techniques obtain nominal parameters for a battery model of the battery system based on a measured temperature and an estimated open circuit voltage (OCV). The techniques use these nominal parameters and the corrected measured current to estimate the OCV, a capacity, and an impedance of the battery system. The techniques utilize the OCV to estimate a state of charge (SOC) of the battery system. The techniques also estimate a state of health (SOH) of the battery system based on its estimated capacity and impedance. The techniques then control the electrified vehicle based on the SOC and/or the SOH.
摘要翻译：用于电气化车辆的电池系统的更精确和鲁棒的电池状态估计（BSE）技术包括估计由电流传感器产生的电流偏差或偏移，然后调整测量的电流以补偿估计的电流偏差。该技术基于测量的温度和估计的开路电压（OCV）获得电池系统的电池模型的标称参数。这些技术使用这些标称参数和校正的测量电流来估计电池系统的OCV，容量和阻抗。该技术利用OCV来估计电池系统的充电状态（SOC）。这些技术还基于其估计的容量和阻抗来估计电池系统的健康状况（SOH）。然后，这些技术基于SOC和/或SOH控制电气化车辆。

10. 发明授权

US08552687B2 Method and system for characterizing a battery 有权
标题翻译：表征电池的方法和系统
公开(公告)号：US08552687B2
公开(公告)日：2013-10-08
申请号：US12134032
申请日：2008-06-05
申请人： Jian Lin , Xidong Tang , Xiaodong Zhang , Brian J. Koch , Damon R. Frisch , Wei Liu , Michael J. Gielniak
发明人： Jian Lin , Xidong Tang , Xiaodong Zhang , Brian J. Koch , Damon R. Frisch , Wei Liu , Michael J. Gielniak
IPC分类号： H02J7/00
CPC分类号： G01R31/3651 , B60L11/1851 , Y02T10/7011 , Y02T10/705
摘要： Methods and systems are provided for characterizing a battery. A property of the battery is measured. A dynamic characteristic of the battery is determined from a second order linear dynamic model.
摘要翻译：提供了用于表征电池的方法和系统。测量电池的性能。电池的动态特性由二阶线性动力学模型确定。

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