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1. 外观设计

USD983895S1 Coffee maker toy 有权
公开(公告)号：USD983895S1
公开(公告)日：2023-04-18
申请号：US29841115
申请日：2022-06-02
申请人： Zihong Guo
设计人： Zihong Guo

2. 发明授权

US09205969B2 Temperature-stabilized storage systems 有权
标题翻译：温度稳定的存储系统
公开(公告)号：US09205969B2
公开(公告)日：2015-12-08
申请号：US12658579
申请日：2010-02-08
申请人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
IPC分类号： B65D81/38 , B65G1/127 , B01L9/06
CPC分类号： B65D81/3802 , B65D81/3811 , B65D81/3813 , B65D81/3823 , B65D81/3825 , B65D81/3834 , B65D81/3888 , B65D81/3897 , B65D2203/10 , Y10T29/49826
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.
摘要翻译：基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元存储区域和至少一个储存材料分配器单元，其中所述至少一个储存的材料分配器单元包括一个或多个互锁。

3. 发明授权

US08235975B2 Light transmission system for photoreactive therapy 有权
标题翻译：用于光反应治疗的光传输系统
公开(公告)号：US08235975B2
公开(公告)日：2012-08-07
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

4. 发明申请

US20120089207A1 LIGHT TRANSMISSION SYSTEM FOR PHOTOREACTIVE THERAPY 有权
标题翻译：用于光敏治疗的光传输系统
公开(公告)号：US20120089207A1
公开(公告)日：2012-04-12
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

5. 发明申请

US20090036773A1 METHODS AND APPARATUS FOR ENGAGEMENT AND COUPLING OF AN INTRACAVITORY IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND PROBE 有权
标题翻译：入侵和联合成像和高强度聚焦超声探头的方法和装置
公开(公告)号：US20090036773A1
公开(公告)日：2009-02-05
申请号：US11831048
申请日：2007-07-31
申请人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
发明人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
IPC分类号： A61B8/12 , A61N7/00
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔允许流体流过盖子。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

6. 发明申请

US20080033519A1 LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE 审中-公开
标题翻译：光生成装置用于静脉内使用
公开(公告)号：US20080033519A1
公开(公告)日：2008-02-07
申请号：US11834572
申请日：2007-08-06
申请人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N1/05 , A61M29/02 , F21S2/00
CPC分类号： A61N5/062 , A61B2018/2261 , A61N5/0601 , A61N2005/0602 , A61N2005/063 , A61N2005/0652
摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.
摘要翻译：光源被结合到导丝中，以使能够将光疗法添加到不具有该能力的导管的能力。在一个示例性实施例中，实心导线包括导电芯，并且将光源添加到形成在导丝的远端中的隔室。在另一示例性实施例中，光源阵列包括在中空导丝的远端中。多个开口形成在围绕阵列的中空导丝的壁中，使得光能够穿过开口。导体通过导丝的中空中心从阵列延伸到中空导丝的近端。中空导丝可以用导电材料涂覆，使得导丝上的涂层用作导体。

7. 发明申请

US20050228260A1 Light generating device to intravascular use 有权
标题翻译：发光装置用于血管内使用
公开(公告)号：US20050228260A1
公开(公告)日：2005-10-13
申请号：US10799357
申请日：2004-03-12
申请人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B18/22 , A61M20060101 , A61N1/00 , A61N5/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

8. 发明申请

US20050131510A1 Device for distal protection and treatment of blood vessels 审中-公开
标题翻译：远端保护和治疗血管的装置
公开(公告)号：US20050131510A1
公开(公告)日：2005-06-16
申请号：US10888572
申请日：2004-07-09
申请人： James Chen , David Shine , Gary Lichttenegger , Zihong Guo , Phillip Burwell , Steven Daly
发明人： James Chen , David Shine , Gary Lichttenegger , Zihong Guo , Phillip Burwell , Steven Daly
IPC分类号： A61B17/22 , A61M20060101 , A61N1/05 , A61N5/06
CPC分类号： A61N5/062 , A61B2017/22051 , A61N5/0601 , A61N2005/0652
摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.
摘要翻译：用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括光源和包括形状记忆聚合物的远端保护装置。另一个装置是具有两个气囊的导管和在它们之间延伸的套管。在套管内，导管包括光源和扩张构件。

9. 发明申请

US20050128742A1 Light generating device that self centers within a lumen to render photodynamic therapy 审中-公开
标题翻译：自发中心在光腔内产生光动力治疗的发光装置
公开(公告)号：US20050128742A1
公开(公告)日：2005-06-16
申请号：US10888567
申请日：2004-07-08
申请人： James Chen , Zihong Guo , Gary Lichttenegger , David Shine , Phillip Burwell
发明人： James Chen , Zihong Guo , Gary Lichttenegger , David Shine , Phillip Burwell
IPC分类号： A61B20060101 , A61N5/06 , A61N5/067 , A61N5/10 , F21S2/00
CPC分类号： A61N5/0601 , A61M2025/1047 , A61N5/062 , A61N2005/0652 , A61N2005/1003
摘要： A light generating device for illuminating tissue adjacent to a body lumen while a distal end of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen has a port adjacent to an array of light sources, to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.
摘要翻译：一种发光装置，用于在装置的远端位于管腔中心的同时照射邻近体腔的组织，以进行光动力学治疗。该装置可以封闭或移动体液，而不使用气球。在一个实施例中，冲洗内腔具有与光源阵列相邻的端口，以移位否则可能吸收光的体液。另一实施例采用在第一位置和第二位置之间移动的定心构件。定心构件将装置居中在内腔中，并且优选地由形状记忆材料形成。在另一个实施例中，该装置包括可独立定位的外护套和内部构件，使得定心构件能够选择性地定位。定心构件可以是非多孔的，使得定心构件也阻塞流体流动。

10. 外观设计

USD983894S1 Whale toaster toy 有权
公开(公告)号：USD983894S1
公开(公告)日：2023-04-18
申请号：US29841114
申请日：2022-06-02
申请人： Zihong Guo
设计人： Zihong Guo

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