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1. 发明申请

US20090143351A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20090143351A1
公开(公告)日：2009-06-04
申请号：US12359490
申请日：2009-01-26
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D401/06 , C07D205/08 , A61P7/00 , C07D401/04 , A61K31/4427
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

2. 发明授权

US07501404B2 Substituted azetidinones 有权
标题翻译：取代的氮杂环丁酮
公开(公告)号：US07501404B2
公开(公告)日：2009-03-10
申请号：US11398438
申请日：2006-04-04
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： C07D205/08 , C07D205/085 , C07D401/14 , C07D401/12 , C07D401/06 , C07D403/12 , C07D403/14 , C07D403/04 , A61K31/397 , A61K31/506 , A61K31/4427 , A61K31/41
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

3. 发明申请

US20100144698A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20100144698A1
公开(公告)日：2010-06-10
申请号：US12703610
申请日：2010-02-10
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsveltelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D205/04 , A61P9/00 , A61P7/00
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

4. 发明申请

US20070105832A1 Substituted azetidinones 有权
标题翻译：取代的氮杂环丁酮
公开(公告)号：US20070105832A1
公开(公告)日：2007-05-10
申请号：US11398438
申请日：2006-04-04
申请人： Thomas Bannister , Cassandra Celatka , Nizal Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael Rynkiewicz , Kerry Spear , James Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael Rynkiewicz , Kerry Spear , James Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D205/08
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

5. 发明申请

US20080146811A1 Compounds and Methods For Treatment of Thrombosis 审中-公开
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：US20080146811A1
公开(公告)日：2008-06-19
申请号：US11658121
申请日：2005-07-22
申请人： Hongfeng Deng , Jian Lin , Zihong Guo , Harold V. Meyers , Sherin S. Abdel-Meguid , Robert E. Babine
发明人： Hongfeng Deng , Jian Lin , Zihong Guo , Harold V. Meyers , Sherin S. Abdel-Meguid , Robert E. Babine
IPC分类号： C07D401/12 , C07D209/14
CPC分类号： C07D471/04 , C07D209/42 , C07D401/14 , C07D405/12
摘要： The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.
摘要翻译：本发明提供了用于治疗血栓栓塞障碍的化合物，药物组合物和方法，例如动脉血管栓塞性疾病，静脉心血管血栓栓塞障碍或心脏腔室中的血栓栓塞性疾病。

6. 外观设计

USD983895S1 Coffee maker toy 有权
公开(公告)号：USD983895S1
公开(公告)日：2023-04-18
申请号：US29841115
申请日：2022-06-02
申请人： Zihong Guo
设计人： Zihong Guo

7. 发明授权

US09205969B2 Temperature-stabilized storage systems 有权
标题翻译：温度稳定的存储系统
公开(公告)号：US09205969B2
公开(公告)日：2015-12-08
申请号：US12658579
申请日：2010-02-08
申请人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Geoffrey F. Deane , Lawrence Morgan Fowler , William Gates , Zihong Guo , Roderick A. Hyde , Edward K. Y. Jung , Jordin T. Kare , Nathan P. Myhrvold , Nathan Pegram , Nels R. Peterson , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
IPC分类号： B65D81/38 , B65G1/127 , B01L9/06
CPC分类号： B65D81/3802 , B65D81/3811 , B65D81/3813 , B65D81/3823 , B65D81/3825 , B65D81/3834 , B65D81/3888 , B65D81/3897 , B65D2203/10 , Y10T29/49826
摘要： A substantially thermally sealed storage container includes an outer assembly, including one or more sections of ultra efficient insulation material substantially defining at least one thermally sealed storage region, and an inner assembly, including at least one heat sink unit within the at least one thermally sealed storage region, and at least one stored material dispenser unit, wherein the at least one stored material dispenser unit includes one or more interlocks.
摘要翻译：基本上热密封的存储容器包括外部组件，其包括基本上限定至少一个热密封存储区域的一个或多个超高效绝缘材料部分和内部组件，所述内部组件包括至少一个热密封的至少一个散热器单元存储区域和至少一个储存材料分配器单元，其中所述至少一个储存的材料分配器单元包括一个或多个互锁。

8. 发明授权

US08235975B2 Light transmission system for photoreactive therapy 有权
标题翻译：用于光反应治疗的光传输系统
公开(公告)号：US08235975B2
公开(公告)日：2012-08-07
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

9. 发明申请

US20120089207A1 LIGHT TRANSMISSION SYSTEM FOR PHOTOREACTIVE THERAPY 有权
标题翻译：用于光敏治疗的光传输系统
公开(公告)号：US20120089207A1
公开(公告)日：2012-04-12
申请号：US13274192
申请日：2011-10-14
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

10. 发明申请

US20090036773A1 METHODS AND APPARATUS FOR ENGAGEMENT AND COUPLING OF AN INTRACAVITORY IMAGING AND HIGH INTENSITY FOCUSED ULTRASOUND PROBE 有权
标题翻译：入侵和联合成像和高强度聚焦超声探头的方法和装置
公开(公告)号：US20090036773A1
公开(公告)日：2009-02-05
申请号：US11831048
申请日：2007-07-31
申请人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
发明人： Michael P. H. Lau , Gregory Paul Darlington , Michael J. Connolly , Zihong Guo
IPC分类号： A61B8/12 , A61N7/00
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4272 , A61B8/4281 , A61B8/445 , A61B17/2202 , A61B17/2256 , A61B17/4241 , A61B2017/2253 , A61B2017/4216 , A61B2018/00029 , A61B2090/3782 , A61B2090/3784 , A61N7/022
摘要： A combined imaging/HIFU probe includes an imaging scan head, a HIFU transducer, and an outlet port that delivers a flow of fluid across the HIFU transducer. At least a portion of the body cavity is filled with fluid in which the probe is immersed. The fluid provides a coupling for transmission of ultrasound energy between the probe and the patient. A flow of fluid may also be used to flush obstructions from an area of tissue near the HIFU transducer. Further described herein is a cuff to help retain fluid in the body cavity, a regulator to regulate fluid flow with respect to the body cavity according to a desired fluid pressure, and a cover for the HIFU transducer that has at least one perforation defined therethrough to allow fluid to flow through the cover. Further disclosed herein are methods of deploying a combined imaging/HIFU probe in a body cavity.
摘要翻译：组合的成像/ HIFU探头包括成像扫描头，HIFU换能器和输出流体穿过HIFU换能器的出口。体腔的至少一部分填充有探针浸入其中的流体。流体提供用于在探针和患者之间传输超声能量的耦合。流体流也可用于冲洗HIFU换能器附近的组织区域的障碍物。本文进一步描述的是用于帮助保持体腔中的流体的袖带，根据期望的流体压力调节流体相对于体腔的流体的调节器，以及用于HIFU换能器的覆盖物，其具有至少一个穿过其定义的穿孔允许流体流过盖子。本文进一步公开的是将组合成像/ HIFU探针部署在体腔中的方法。

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