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1. 发明申请

US20120221101A1 ADJUSTABLE ANNULOPLASTY RING ACTIVATION SYSTEM 审中-公开
标题翻译：可调节的静脉环激活系统
公开(公告)号：US20120221101A1
公开(公告)日：2012-08-30
申请号：US13405002
申请日：2012-02-24
申请人： Shawn Moaddeb , Samuel Shaolian , James Huntington Dabney , Conrad Sawicz , Jay A. Lenker
发明人： Shawn Moaddeb , Samuel Shaolian , James Huntington Dabney , Conrad Sawicz , Jay A. Lenker
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0038 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： An adjustable annuloplasty device is described. The device includes a body member comprising a shape memory material, the body member configured to be placed at or near a base of a valve of a heart. The device further includes a hysteretic material configured to undergo magnetic hysteresis in response to a first activation energy, the hysteretic material being in thermal communication with the shape memory material. The body member may have a first size of a body member dimension in a first configuration and a second size of the body member dimension in a second configuration. When the body member is in position in the heart, a change from the first configuration to the second configuration changes a size of a dimension of the annulus of the valve.
摘要翻译：描述了可调环形成形术装置。所述装置包括主体部件，所述主体部件包括形状记忆材料，所述主体部件构造成放置在心脏的阀的基部处或附近。该器件还包括缓冲材料，其被配置成响应于第一激活能量而经历磁滞，所述滞后材料与形状记忆材料热连通。主体构件可以具有第一构造的主体构件尺寸的第一尺寸和具有第二构造的主体构件尺寸的第二尺寸。当身体构件在心脏中的位置时，从第一构型到第二构造的变化改变了瓣膜的环的尺寸的大小。

2. 发明授权

US08449604B2 Adjustable prosthetic valve implant 失效
标题翻译：可调式假体瓣膜植入物
公开(公告)号：US08449604B2
公开(公告)日：2013-05-28
申请号：US12544163
申请日：2009-08-19
申请人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay A. Lenker
发明人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay A. Lenker
IPC分类号： A61F2/24
CPC分类号： A61F2/2469 , A61F2/07 , A61F2/2418 , A61F2/2445 , A61F2/90 , A61F2002/075 , A61F2210/0023 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0078 , A61F2250/0004 , A61F2250/0007 , A61F2250/001
摘要： A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
摘要翻译：描述了用于治疗患病主动脉瓣的假体植入物。假体植入物包括构造成位于患者的主动脉中的基本上管状的主体，位于患者的主动脉瓣处或附近。主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。假体植入物还包括至少一个位于体内或身体上的可调节元件，并且至少部分地围绕内腔的圆周延伸。所述至少一个可调节元件包括形状记忆材料，并且响应于施加激活能量而可从第一配置转变为第二配置，其中所述第一配置和第二配置的尺寸至少为所述至少一个可调元件。当至少一个可调节元件处于第二构造时，至少一个可调元件可接合主动脉的根部，主动脉瓣的环和患者的左心室中的至少一个。

3. 发明申请

US20100185274A1 ADJUSTABLE PROSTHETIC VALVE IMPLANT 失效
标题翻译：可调式前置阀门植入
公开(公告)号：US20100185274A1
公开(公告)日：2010-07-22
申请号：US12544163
申请日：2009-08-19
申请人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay A. Lenker
发明人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay A. Lenker
IPC分类号： A61F2/06
CPC分类号： A61F2/2469 , A61F2/07 , A61F2/2418 , A61F2/2445 , A61F2/90 , A61F2002/075 , A61F2210/0023 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0078 , A61F2250/0004 , A61F2250/0007 , A61F2250/001
摘要： A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
摘要翻译：描述了用于治疗患病主动脉瓣的假体植入物。假体植入物包括构造成位于患者的主动脉中的基本上管状的主体，位于患者的主动脉瓣处或附近。主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。假体植入物还包括至少一个位于体内或身体上的可调节元件，并且至少部分地围绕内腔的圆周延伸。所述至少一个可调节元件包括形状记忆材料，并且响应于施加激活能量而可从第一配置转变为第二配置，其中所述第一配置和第二配置的尺寸至少为所述至少一个可调元件。当至少一个可调节元件处于第二构造时，至少一个可调元件可接合主动脉的根部，主动脉瓣的环和患者的左心室中的至少一个。

4. 发明申请

US20070135913A1 Adjustable annuloplasty ring activation system 审中-公开
标题翻译：可调节瓣环成形术激活系统
公开(公告)号：US20070135913A1
公开(公告)日：2007-06-14
申请号：US11638501
申请日：2006-12-14
申请人： Shawn Moaddeb , Samuel Shaolian , James Dabney , Conrad Sawicz , Jay Lenker
发明人： Shawn Moaddeb , Samuel Shaolian , James Dabney , Conrad Sawicz , Jay Lenker
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0038 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： An adjustable annuloplasty device is described. The device includes a body member comprising a shape memory material, the body member configured to be placed at or near a base of a valve of a heart. The device further includes a hysteretic material configured to undergo magnetic hysteresis in response to a first activation energy, the hysteretic material being in thermal communication with the shape memory material. The body member may have a first size of a body member dimension in a first configuration and a second size of the body member dimension in a second configuration. When the body member is in position in the heart, a change from the first configuration to the second configuration changes a size of a dimension of the annulus of the valve.
摘要翻译：描述了可调环形成形术装置。所述装置包括主体部件，所述主体部件包括形状记忆材料，所述主体部件构造成放置在心脏的阀的基部处或附近。该器件还包括缓冲材料，其被配置成响应于第一激活能量而经历磁滞，所述滞后材料与形状记忆材料热连通。主体构件可以具有第一构造的主体构件尺寸的第一尺寸和具有第二构造的主体构件尺寸的第二尺寸。当身体构件在心脏中的位置时，从第一构型到第二构造的变化改变了瓣膜的环的尺寸的大小。

5. 发明申请

US20060206140A1 Adjustable embolic aneurysm coil 审中-公开
标题翻译：可调栓塞动脉瘤线圈
公开(公告)号：US20060206140A1
公开(公告)日：2006-09-14
申请号：US11362418
申请日：2006-02-23
申请人： Samuel Shaolian , Shawn Moaddeb , James Hill
发明人： Samuel Shaolian , Shawn Moaddeb , James Hill
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B2017/00867 , A61B2017/00871
摘要： Methods and devices are provided for treatment of an aneurysm within a patient. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, the size and/or shape of the embolic coils can be adjusted to provide optimal filling of the aneurysm. In certain embodiments, the devices include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. A material having enhanced absorption characteristics with regard to a desired heating energy may be used in order to facilitate heating and adjustment of the embolic coil.
摘要翻译：提供了用于治疗患者内的动脉瘤的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，可以调节栓塞线圈的尺寸和/或形状以提供动脉瘤的最佳填充。在某些实施例中，装置包括响应温度变化和/或暴露于磁场的形状记忆材料。可以使用具有关于期望的加热能量的增强的吸收特性的材料，以便于栓塞线圈的加热和调节。

6. 发明申请

US20060252983A1 Dynamically adjustable gastric implants and methods of treating obesity using dynamically adjustable gastric implants 审中-公开
标题翻译：动态调节胃植入物和使用动态可调节的胃植入物治疗肥胖的方法
公开(公告)号：US20060252983A1
公开(公告)日：2006-11-09
申请号：US11351788
申请日：2006-02-10
申请人： Nicholas Lembo , Shawn Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson
发明人： Nicholas Lembo , Shawn Moaddeb , Emanuel Shaoulian , Samuel Shaolian , Michael Henson
IPC分类号： A61F2/00 , A61B17/08 , A61F13/00
CPC分类号： A61F5/0079 , A61F5/0053 , A61F5/0086 , A61F2002/044
摘要： Implants for treatment of obesity may be placed within the stomach and/or esophagus or around the outside surface of the stomach and/or esophagus. The implants comprise at least a portion constructed of a shape memory material. The implants are thus adapted to be implanted in a deformed shape, and then to be transformed through the application of activation energy into a memorized shape. The shape and/or size transformation induces a change in shape of the stomach and/or esophagus, thus altering the normal digestive path of food entering the patient's gastrointestinal tract.
摘要翻译：用于治疗肥胖的植入物可以放置在胃和/或食道内或胃和/或食道的外表面周围。植入物包括由形状记忆材料构成的至少一部分。因此，植入物适于以变形的形状植入，然后通过将活化能量施加到记忆形状中而变形。形状和/或尺寸转换引起胃和/或食道的形状变化，从而改变进入患者胃肠道的食物的正常消化道。

7. 发明申请

US20070142907A1 Adjustable prosthetic valve implant 审中-公开
标题翻译：可调式假体瓣膜植入物
公开(公告)号：US20070142907A1
公开(公告)日：2007-06-21
申请号：US11638473
申请日：2006-12-14
申请人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay Lenker
发明人： Shawn Moaddeb , Samuel Shaolian , Emanuel Shaoulian , Jay Lenker
IPC分类号： A61F2/24 , A61F2/94
CPC分类号： A61F2/2469 , A61F2/07 , A61F2/2418 , A61F2/2445 , A61F2/90 , A61F2002/075 , A61F2210/0023 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0078 , A61F2250/0004 , A61F2250/0007 , A61F2250/001
摘要： A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
摘要翻译：描述了用于治疗患病主动脉瓣的假体植入物。假体植入物包括构造成位于患者的主动脉中的基本上管状的主体，位于患者的主动脉瓣处或附近。主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。假体植入物还包括至少一个位于体内或身体上的可调节元件，并且至少部分地围绕内腔的圆周延伸。所述至少一个可调节元件包括形状记忆材料，并且响应于施加激活能量而可从第一配置转变为第二配置，其中所述第一配置和第二配置的尺寸至少为所述至少一个可调元件。当至少一个可调节元件处于第二构造时，至少一个可调元件可接合主动脉的根部，主动脉瓣的环和患者的左心室中的至少一个。

8. 发明申请

US20070073098A1 Method and apparatus for adjusting body lumens 审中-公开
标题翻译：用于调节体腔的方法和装置
公开(公告)号：US20070073098A1
公开(公告)日：2007-03-29
申请号：US11525480
申请日：2006-09-22
申请人： Jay Lenker , George Kick , Samuel Shaolian , Shawn Moaddeb , Mike Henson
发明人： Jay Lenker , George Kick , Samuel Shaolian , Shawn Moaddeb , Mike Henson
IPC分类号： A61F2/02
CPC分类号： A61B17/12 , A61B17/12009 , A61B17/12013 , A61B17/3468 , A61B2017/00827 , A61B2017/22054 , A61B2017/22069 , A61B2017/306 , A61B2017/3486
摘要： Disclosed is a device and method for accessing the lower esophageal sphincter through the esophagus. In one embodiment, a catheter is inserted through the mouth or nose of a patient and advanced to the region of the diaphragm. Under fluoroscopy or endoscopy, a hollow needle at the distal end of the catheter punctures the wall of the esophagus from the inside so that the distal end of the needle is positioned outside the esophagus. An implant is next advanced out through the hollow needle to the region outside the sphincter where it is deflected and coerced to bluntly dissect around the circumference of the esophagus, where the implant is left in place to heal. The hollow needle is removed and the esophageal wall is allowed to heal. Subsequent diametric adjustment of the implant allows for tightening or loosening of the sphincter to minimize gastric reflux. The device and method can also be used to treat the pyloric or other body sphincters, hollow organs, or ducts.
摘要翻译：公开了一种通过食道进入下食管括约肌的装置和方法。在一个实施例中，导管穿过患者的嘴或鼻插入并前进到隔膜的区域。在荧光透视或内窥镜检查下，导管远端的中空针头从内侧穿刺食道的壁，使得针的远端位于食道外部。然后将植入物通过中空针前进到括约肌外部的区域，在那里它被偏转并胁迫以在食道周围钝化解剖，植入物留在原位以愈合。取出空心针，食管壁被治愈。随后的植入物的直径调整允许收缩或松开括约肌以最小化胃反流。该装置和方法还可用于治疗幽门或其他身体括约肌，中空器官或管道。

9. 发明申请

US20120191009A1 METHOD AND APPARATUS FOR IN VIVO SURVEILLANCE OF CIRCULATING BIOLOGICAL COMPONENTS 审中-公开
标题翻译：循环生物组分的血液监测方法和装置
公开(公告)号：US20120191009A1
公开(公告)日：2012-07-26
申请号：US13333876
申请日：2011-12-21
申请人： David Hoon , Bret Taback , Samuel Shaolian
发明人： David Hoon , Bret Taback , Samuel Shaolian
IPC分类号： A61B5/15
CPC分类号： A61B5/14735 , A61B5/14546 , A61B5/6851 , A61B5/6862 , A61B2562/0285 , B82Y30/00 , G01N33/54366
摘要： The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis.
摘要翻译：本发明一般涉及使用收集探针体内收集循环分子，肿瘤细胞和其他生物学标记物。探针配置为在活体内长时间放置以提供足够的生物标志物用于分析。

10. 发明申请

US20080183285A1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：US20080183285A1
公开(公告)日：2008-07-31
申请号：US12031652
申请日：2008-02-14
申请人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
发明人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2210/0023 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离超过两个侧向部分之间的距离。

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