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    • 1. 发明授权
    • Adjustable prosthetic valve implant
    • 可调式假体瓣膜植入物
    • US08449604B2
    • 2013-05-28
    • US12544163
    • 2009-08-19
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay A. Lenker
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay A. Lenker
    • A61F2/24
    • A61F2/2469A61F2/07A61F2/2418A61F2/2445A61F2/90A61F2002/075A61F2210/0023A61F2220/0008A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0078A61F2250/0004A61F2250/0007A61F2250/001
    • A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
    • 描述了用于治疗患病主动脉瓣的假体植入物。 假体植入物包括构造成位于患者的主动脉中的基本上管状的主体,位于患者的主动脉瓣处或附近。 主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。 假体植入物还包括至少一个位于体内或身体上的可调节元件,并且至少部分地围绕内腔的圆周延伸。 所述至少一个可调节元件包括形状记忆材料,并且响应于施加激活能量而可从第一配置转变为第二配置,其中所述第一配置和第二配置的尺寸至少为 所述至少一个可调元件。 当至少一个可调节元件处于第二构造时,至少一个可调元件可接合主动脉的根部,主动脉瓣的环和患者的左心室中的至少一个。
    • 2. 发明申请
    • ADJUSTABLE PROSTHETIC VALVE IMPLANT
    • 可调式前置阀门植入
    • US20100185274A1
    • 2010-07-22
    • US12544163
    • 2009-08-19
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay A. Lenker
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay A. Lenker
    • A61F2/06
    • A61F2/2469A61F2/07A61F2/2418A61F2/2445A61F2/90A61F2002/075A61F2210/0023A61F2220/0008A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0078A61F2250/0004A61F2250/0007A61F2250/001
    • A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
    • 描述了用于治疗患病主动脉瓣的假体植入物。 假体植入物包括构造成位于患者的主动脉中的基本上管状的主体,位于患者的主动脉瓣处或附近。 主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。 假体植入物还包括至少一个位于体内或身体上的可调节元件,并且至少部分地围绕内腔的圆周延伸。 所述至少一个可调节元件包括形状记忆材料,并且响应于施加激活能量而可从第一配置转变为第二配置,其中所述第一配置和第二配置的尺寸至少为 所述至少一个可调元件。 当至少一个可调节元件处于第二构造时,至少一个可调元件可接合主动脉的根部,主动脉瓣的环和患者的左心室中的至少一个。
    • 4. 发明申请
    • Adjustable prosthetic valve implant
    • 可调式假体瓣膜植入物
    • US20070142907A1
    • 2007-06-21
    • US11638473
    • 2006-12-14
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay Lenker
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay Lenker
    • A61F2/24A61F2/94
    • A61F2/2469A61F2/07A61F2/2418A61F2/2445A61F2/90A61F2002/075A61F2210/0023A61F2220/0008A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0078A61F2250/0004A61F2250/0007A61F2250/001
    • A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
    • 描述了用于治疗患病主动脉瓣的假体植入物。 假体植入物包括构造成位于患者的主动脉中的基本上管状的主体,位于患者的主动脉瓣处或附近。 主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。 假体植入物还包括至少一个位于体内或身体上的可调节元件,并且至少部分地围绕内腔的圆周延伸。 所述至少一个可调节元件包括形状记忆材料,并且响应于施加激活能量而可从第一配置转变为第二配置,其中所述第一配置和第二配置的尺寸至少为 所述至少一个可调元件。 当至少一个可调节元件处于第二构造时,至少一个可调元件可接合主动脉的根部,主动脉瓣的环和患者的左心室中的至少一个。
    • 6. 发明申请
    • ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT
    • 可调节心脏瓣膜植入物,具有选择性的尺寸调整
    • US20080183285A1
    • 2008-07-31
    • US12031652
    • 2008-02-14
    • Emanuel ShaoulianSamuel ShaolianShahram MoaddebRichard S. Rhee
    • Emanuel ShaoulianSamuel ShaolianShahram MoaddebRichard S. Rhee
    • A61F2/24
    • A61F2/2445A61F2/2448A61F2210/0014A61F2210/0023A61F2210/009A61F2250/0001A61F2250/0004
    • Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.
    • 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置,例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能,射频能量,光能和磁能。 因此,随着身体结构改变尺寸和/或形状,可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中,装置包括前部,后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置的第一形状和第二配置的第二形状,并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离超过两个侧向部分之间的距离。
    • 8. 发明申请
    • Adjustable cardiac valve implant with coupling mechanism
    • 可调节心脏瓣膜植入物与联接机构
    • US20050288776A1
    • 2005-12-29
    • US11123851
    • 2005-05-06
    • Emanuel ShaoulianSamuel ShaolianShahram Moaddeb
    • Emanuel ShaoulianSamuel ShaolianShahram Moaddeb
    • A61F2/00A61F2/02A61F2/24
    • A61F2/2448A61F2/2445A61F2210/0014A61F2210/0023A61F2250/0001A61F2250/0004A61F2250/0082
    • Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.
    • 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置,例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能,射频能量,光能和磁能。 因此,随着身体结构改变尺寸和/或形状,可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中,这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。 管状构件包括容置端和插入端,所述插入端构造成与管状构件的容置端相连,使得管状构件基本上形成环的形状。 插入端构造成相对于插座端移动以改变环的圆周。
    • 9. 发明申请
    • METHODS AND SYSTEMS FOR CARDIAC REMODELING VIA RESYNCHRONIZATION
    • 通过再次心脏再造的方法和系统
    • US20080051840A1
    • 2008-02-28
    • US11773311
    • 2007-07-03
    • Shahram MoaddebSamuel ShaolianEmanuel Shaoulian
    • Shahram MoaddebSamuel ShaolianEmanuel Shaoulian
    • A61N1/368
    • A61N1/3627
    • Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.
    • 提供了系统,方法和装置,用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。 加强元件可以包括磁性和/或形状的记忆材料,并且被配置成重塑心脏,以便在对电刺激的响应期间增强心脏的机械能。 在一些实施例中,至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。 诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。 另外或在其它实施例中,至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。
    • 10. 发明申请
    • Dynamically adjustable implants and methods for reshaping tissue
    • 动态调整植入物和重塑组织的方法
    • US20060241747A1
    • 2006-10-26
    • US11123874
    • 2005-05-06
    • Emanuel ShaoulianShahram MoaddebSamuel Shaolian
    • Emanuel ShaoulianShahram MoaddebSamuel Shaolian
    • A61F2/24A61F2/86
    • A61F2/2451A61F2250/0001A61F2250/0039
    • Tissue shaping methods and devices are provided. The devices can be adjusted within the body of a patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. In one example, the device is positioned within the coronary sinus of the patient so as to effect changes in at least one dimension of the mitral valve annulus. The device may also advantageously include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. In one example, the shape memory material is responsive to energy, such as electromagnetic or acoustic energy, applied from an energy source located outside the coronary sinus. A material having enhanced absorption characteristics with respect to the desired heating energy may also be used to facilitate heating and adjustment of the tissue shaping device.
    • 提供组织成形方法和装置。 可以以侵入性或非侵入性方式在患者体内调节装置,例如通过经皮或外部给予患者身体的能量。 在一个示例中,装置定位在患者的冠状窦内,以便实现二尖瓣环的至少一个维度的变化。 该装置还可以有利地包括响应温度变化和/或暴露于磁场的形状记忆材料。 在一个示例中,形状记忆材料响应于从位于冠状窦外侧的能量源施加的能量,例如电磁或声能。 相对于期望的加热能量具有增强的吸收特性的材料也可用于促进组织整形装置的加热和调节。