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    • 2. 发明申请
    • Adjustable prosthetic valve implant
    • 可调式假体瓣膜植入物
    • US20070142907A1
    • 2007-06-21
    • US11638473
    • 2006-12-14
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay Lenker
    • Shawn MoaddebSamuel ShaolianEmanuel ShaoulianJay Lenker
    • A61F2/24A61F2/94
    • A61F2/2469A61F2/07A61F2/2418A61F2/2445A61F2/90A61F2002/075A61F2210/0023A61F2220/0008A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0078A61F2250/0004A61F2250/0007A61F2250/001
    • A prosthetic implant for treating a diseased aortic valve is described. The prosthetic implant includes a substantially tubular body configured to be positioned in an aorta of a patient, at or near the patient's aortic valve. The body includes a lumen extending through the body from a proximal end to a distal end of the body; and an adjustable frame surrounding the lumen. The prosthetic implant further includes at least one adjustable element located in or on the body and extending at least partially around a circumference of the lumen. The at least one adjustable element includes a shape memory material and is transformable, in response to application of an activation energy, from a first configuration to a second configuration, wherein the first configuration and second configuration differ in a size of at least one dimension of the at least one adjustable element. The at least one adjustable element may engage at least one of a root of the aorta, an annulus of the aortic valve, and the patient's left ventricle, when the at least one adjustable element is in the second configuration.
    • 描述了用于治疗患病主动脉瓣的假体植入物。 假体植入物包括构造成位于患者的主动脉中的基本上管状的主体,位于患者的主动脉瓣处或附近。 主体包括从身体的近端延伸穿过主体的内腔到远端; 以及围绕管腔的可调节框架。 假体植入物还包括至少一个位于体内或身体上的可调节元件,并且至少部分地围绕内腔的圆周延伸。 所述至少一个可调节元件包括形状记忆材料,并且响应于施加激活能量而可从第一配置转变为第二配置,其中所述第一配置和第二配置的尺寸至少为 所述至少一个可调元件。 当至少一个可调节元件处于第二构造时,至少一个可调元件可接合主动脉的根部,主动脉瓣的环和患者的左心室中的至少一个。
    • 4. 发明授权
    • Expandable trans-septal sheath
    • 可扩展的跨隔皮
    • US08900214B2
    • 2014-12-02
    • US12058455
    • 2008-03-28
    • Edward J. NanceJay LenkerHyun T. Nguyen
    • Edward J. NanceJay LenkerHyun T. Nguyen
    • A61M31/00A61M25/06A61B18/00A61M25/00A61B17/34A61B17/00
    • A61M25/0662A61B17/3439A61B17/3478A61B2017/00243A61B2017/00247A61B2017/00278A61B2017/3425A61B2018/00392A61F2/2427A61M2025/0024
    • Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, low cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the vascular system and has utility in the performance of procedures in the left atrium. The access route is through the inferior vena cava to the right atrium, where a trans-septal puncture, followed by advancement of the catheter is completed. The distal end of the sheath is maintained in the first, low cross-sectional configuration during advancement to the right atrium and through the atrial septum into the left atrium. The distal end of the sheath is subsequently expanded using a radial dilatation device. In an exemplary application, the sheath is utilized to provide access for a diagnostic or therapeutic procedure such as electrophysiological mapping of the heart, radio-frequency ablation of left atrial tissue, placement of left atrial implants, mitral valve repair, or the like.
    • 公开了一种可膨胀的经腔护套,用于在处于第一低截面区域构造的情况下引入身体,并且随后将护套的远端的至少一部分膨胀至第二扩大横截面构造。 护套被配置为用于血管系统,并且可用于执行左心房中的手术。 进入路径是通过下腔静脉到右心房,其中穿透穿刺,随后导管的前进完成。 鞘的远端在前进到右心房并通过心房隔膜进入左心房时保持在第一,低横截面构型。 随后使用径向扩张装置使护套的远端膨胀。 在示例性应用中,护套用于提供用于诊断或治疗过程的通路,例如心脏的电生理映射,左心房组织的射频消融,左心房植入物的放置,二尖瓣修复等。
    • 5. 发明授权
    • Expandable iliac sheath and method of use
    • 可扩展髂骨鞘及使用方法
    • US08668668B2
    • 2014-03-11
    • US12258233
    • 2008-10-24
    • Joseph BishopJay LenkerEdward J. NanceHuan T. NguyenMark T. Jones
    • Joseph BishopJay LenkerEdward J. NanceHuan T. NguyenMark T. Jones
    • A61M31/00A61M37/00A61M5/178
    • A61M29/02A61F2/2427A61M25/005A61M25/0662A61M25/104A61M2025/0024A61M2025/0681
    • Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, small cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the vascular system and has utility in the introduction and removal of implant delivery catheters. The access route is through the femoral arteries and the iliac arteries into the aorta. The distal end of the sheath is maintained in the first, low cross-sectional configuration during advancement to the arteries into the aorta. The distal end of the sheath is subsequently expanded using a radial dilatation device, which is removed prior to the introduction of implant delivery catheters. In an exemplary application, the sheath includes a supported proximal end, a supported distal end, and a collapsible center section. Certain configurations of the sheath are capable of being inserted in a first, small cross-sectional configuration, being expanded diametrically to a second, larger cross-sectional configuration, and then being reduced to a diametrically small size for removal.
    • 公开了一种可膨胀的经腔护套,用于在第一小截面区域构造中引入身体,并且随后将护套的远端的至少一部分膨胀至第二扩大横截面构造。 鞘被配置为用于血管系统,并且可用于引入和移除植入物输送导管。 进入路径是通过股动脉和髂动脉进入主动脉。 护套的远端在进入主动脉的动脉中保持在第一,低横截面构型。 随后使用径向扩张装置使护套的远端膨胀,该径向扩张装置在引入植入物输送导管之前被移除。 在示例性应用中,护套包括支撑的近端,支撑的远端和可折叠的中心部分。 护套的某些构造能够以第一小截面构造插入,沿直径扩大到第二较大横截面形状,然后被减小到径向较小的尺寸以便移除。