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1. 发明授权

US5645702A Low voltage miniaturized column analytical apparatus and method 失效
标题翻译：低压小型化柱分析仪和方法
公开(公告)号：US5645702A
公开(公告)日：1997-07-08
申请号：US483217
申请日：1995-06-07
申请人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
发明人： Klaus E. Witt , Patrick Kaltenbach , Fritz Bek , Sally A. Swedberg , Laurie S. Mittelstadt
IPC分类号： G01N27/447 , G01N30/02 , G01N30/60 , G01N27/26
CPC分类号： G01N27/44773 , G01N30/02 , G01N30/60
摘要： A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are positioned along the elongate separation compartment. The elongate separation compartment has first and second opposing sides along its elongate dimension. Each set of antenna contains a plurality of antennas. One antenna from each set is associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on the opposing sides of the separation compartment. Each set of the antennas is associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along the elongate separation compartment toward an exit end of the separation compartment. The detector can detect a target substance passing out of the elongate separation compartment.
摘要翻译：提供了一种小型化的柱分析装置，其具有包含具有细长隔离室的主体的小型化柱装置。两个或更多组间隔开的天线沿着细长分隔室定位。细长分离隔室具有沿其细长尺寸的第一和第二相对侧。每组天线包含多个天线。每组中的一个天线与至少一个其他组中的一个天线相关联，以在分隔室的相对侧上沿分隔室形成重复的天线序列。每组天线与不同的振荡电势相关联，以沿着细长分隔室提供多个振荡电场，以沿着细长隔离室将目标物质拉向分离室的出口端。检测器可以检测出从细长隔离室流出的目标物质。

2. 发明授权

US06264892B1 Miniaturized planar columns for use in a liquid phase separation apparatus 有权
标题翻译：用于液相分离装置的小型平面柱
公开(公告)号：US06264892B1
公开(公告)日：2001-07-24
申请号：US09480922
申请日：2000-01-11
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： G01N2726
CPC分类号： G01N30/6095 , B01L3/502707 , B01L3/502715 , B01L3/5055 , B01L7/54 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N27/44704 , G01N27/44708 , G01N27/44721 , G01N27/44773 , G01N27/44791 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , Y10T156/1064 , G01N2030/0035
摘要： Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the methods of the invention include associated laser-ablated features required for function, such as on-device reservoirs or makeup flow compartments, analyte detection means and sample injection means. The miniaturized columns can be used in an apparatus intended for analysis of either small and/or macromolecular solutes in the liquid phase which employs chromatographic, electrophoretic or electrochromatographic separation means. The apparatus can include a variety of optional injection means, manifolds, keeper means, post column collection means, and combinations thereof.
摘要翻译：描述了用于液相分离装置的微型平面柱装置。这些器件包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明的方法形成的器件包括功能所需的相关的激光烧蚀特征，例如器件上储存器或补充流动隔室，分析物检测装置和样品注入装置。小型化柱可用于用于分析液相中的小分子和/或大分子溶质的装置，其使用色谱，电泳或电色谱分离装置。该装置可以包括各种可选的注射装置，歧管，保持装置，柱后收集装置及其组合。

3. 发明授权

US6033628A Miniaturized planar columns for use in a liquid phase separation apparatus 失效
标题翻译：用于液相分离装置的小型平面柱
公开(公告)号：US6033628A
公开(公告)日：2000-03-07
申请号：US656281
申请日：1998-04-27
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , G01N27/26 , G01N30/00 , G01N33/50
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： In a method of forming a microchannel and/or microcavity structure by bonding together two elements (1, 2) having opposed plane surfaces of the same or different material, one or both surfaces having open channels and/or cavities, bonding is effected by applying to one or both element surfaces (1, 2) a thin layer (3) of a solution of a material capable of fusing with and having a lower melting point than that of the material or materials of the two element surfaces (1, 2) in a solvent which substantially does not dissolve the element surface material or materials. The solvent is then removed, and the two elements (1, 2) are brought together and heated to a temperature where the dissolved material is caused to melt but not the element surface material or materials.
摘要翻译： PCT No.PCT / US95 / 13365 Sec。 371日期：1998年4月27日 102（e）日期1998年4月27日PCT提交1995年10月16日PCT公布。公开号WO96 / 12546 日期：1996年5月2日在通过将具有相同或不同材料的相对平面的两个元件（1,2）结合在一起形成微通道和/或微腔结构的方法中，一个或两个表面具有开放的通道和/或腔，通过向一个或两个元件表面（1,2）施加能够熔化并且具有比两个元件表面的材料或材料的熔点低的材料的溶液的薄层（1） 1,2）在基本上不溶解元件表面材料或材料的溶剂中。然后除去溶剂，将两个元件（1,2）放在一起并加热至使溶解的材料熔化而不是元件表面材料或材料的温度。

4. 发明授权

US5658413A Miniaturized planar columns in novel support media for liquid phase analysis 失效
标题翻译：用于液相分析的新颖载体介质中的小型平面柱
公开(公告)号：US5658413A
公开(公告)日：1997-08-19
申请号：US482245
申请日：1995-06-07
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , B32B31/00
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.
摘要翻译：描述了用于液相分析的微型平面柱装置，该装置包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明形成的装置包括功能所需的相关的激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构造的微型柱可用于在液相中的小分子和/或大分子溶质上进行的任何分析系统，并且可以使用色谱，电泳，电色谱分离装置或其任何组合。

5. 发明授权

US6093362A Miniaturized planar columns in novel support media for liquid phase analysis 有权
标题翻译：用于液相分析的新颖载体介质中的小型平面柱
公开(公告)号：US6093362A
公开(公告)日：2000-07-25
申请号：US249531
申请日：1999-02-11
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , B29C33/40 , B28B1/48
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.
摘要翻译：描述了用于液相分析的微型平面柱装置，该装置包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明形成的装置包括功能所需的相关的激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构造的微型柱可用于在液相中的小分子和/或大分子溶质上进行的任何分析系统，并且可以使用色谱，电泳，电色谱分离装置或其任何组合。

6. 发明授权

US5882571A Method for making miniaturized planar columns in novel support media for liquid phase analysis 失效
标题翻译：用于液相分析的新型载体介质中的小型化平面柱的制备方法
公开(公告)号：US5882571A
公开(公告)日：1999-03-16
申请号：US824620
申请日：1997-03-27
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , B29C33/40 , B28B1/48
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.
摘要翻译：描述了用于液相分析的微型平面柱装置，该装置包括通过在各种新型支撑衬底中的激光烧蚀制造的微结构。根据本发明形成的装置包括功能所需的相关的激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构造的微型柱可用于在液相中的小分子和/或大分子溶质上进行的任何分析系统，并且可以使用色谱，电泳，电色谱分离装置或其任何组合。

7. 发明授权

US5804022A Method for making miniaturized planar columns in novel support media for liquid phase analysis 失效
公开(公告)号：US5804022A
公开(公告)日：1998-09-08
申请号：US914297
申请日：1997-08-18
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01D15/08 , B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , G01N37/00 , B32B31/00
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44704 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , B29L2031/756 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606 , Y10T156/1064
摘要： Miniaturized planar column devices are described for use in liquid phase analysis, the devices comprising microstructures fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the invention include associated laser-ablated features required for function, such as analyte detection means and fluid communication means. Miniaturized columns constructed under the invention find use in any analysis system performed on either small and/or macromolecular solutes in the liquid phase and may employ chromatographic, electrophoretic, electrochromatographic separation means, or any combination thereof.

8. 发明授权

US5571410A Fully integrated miniaturized planar liquid sample handling and analysis device 失效
公开(公告)号：US5571410A
公开(公告)日：1996-11-05
申请号：US486024
申请日：1995-06-07
申请人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01L3/00 , B01L3/02 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , B01D15/08
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L2400/0421 , B01L2400/0442 , B01L2400/0487 , B01L3/0268 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606
摘要： A miniaturized total analysis system (".mu.-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The .mu.-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The .mu.-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. .mu.-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.

9. 再颁专利

USRE36350E Fully integrated miniaturized planar liquid sample handling and analysis device 失效
标题翻译：完全集成的小型化平面液体样品处理和分析装置
公开(公告)号：USRE36350E
公开(公告)日：1999-10-26
申请号：US127556
申请日：1998-07-30
申请人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Sally A. Swedberg , Patrick Kaltenbach , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01L3/00 , B01L3/02 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , B01D15/08
CPC分类号： G01N30/6095 , B01L3/502707 , B01L7/54 , G01N27/44708 , G01N27/44773 , G01N27/44791 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2400/0415 , B01L2400/0421 , B01L2400/0442 , B01L2400/0487 , B01L3/0268 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606
摘要： A miniaturized total analysis system (".mu.-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The .mu.-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The .mu.-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. .mu.-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.
摘要翻译：描述了包括小型化平面柱装置的小型化总分析系统（“mu-TAS”）用于液相分析。 mu-TAS包括通过在各种新型支撑衬底中的激光烧蚀制造的微观结构。 mu -TAS包括用于集成样品分析所需的相关激光烧蚀特征，例如分析物检测装置和流体连通装置。根据本发明构建的mu-TAS可用于检测和分析液相中的小分子和/或大分子溶质的任何分析系统，并且可以使用色谱分离装置，电泳分离装置，电色谱分离装置或其组合。

10. 发明授权

US5641400A Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems 失效
标题翻译：在微型平面柱装置和小型化总分析系统中使用温度控制装置
公开(公告)号：US5641400A
公开(公告)日：1997-06-24
申请号：US546629
申请日：1995-10-23
申请人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
发明人： Patrick Kaltenbach , Sally A. Swedberg , Klaus E. Witt , Fritz Bek , Laurie S. Mittelstadt
IPC分类号： B01L3/00 , B01L7/00 , B29C65/02 , B81B1/00 , B81C1/00 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/30 , G01N30/60 , B01D15/08
CPC分类号： B01L7/54 , B01L3/5027 , B01L3/502707 , B01L7/525 , G01N27/44708 , G01N27/44773 , G01N27/44791 , G01N30/6095 , B01L2200/025 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/1822 , B01L2400/0415 , B01L2400/0421 , B01L3/502715 , B01L3/5055 , B29C65/02 , B29C66/54 , B29C66/549 , G01N2030/285 , G01N2030/3007 , G01N2030/3015 , G01N2030/303 , G01N27/44721 , G01N30/02 , G01N30/60 , G01N30/6047 , G01N30/6052 , G01N30/606
摘要： Miniaturized planar column devices and miniaturized total analysis systems for liquid phase analysis are disclosed. The systems include a temperature control device for regulating temperature, preferably a thermoelectric device comprising Peltier elements.
摘要翻译：公开了用于液相分析的小型化平面柱装置和小型化总分析系统。该系统包括用于调节温度的温度控制装置，优选包括珀尔帖元件的热电装置。

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